LOCUS       NM_026275               3312 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2R 2 (Ube2r2), mRNA.
ACCESSION   NM_026275 XM_912898
VERSION     NM_026275.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3312)
  AUTHORS   Rada,P., Rojo,A.I., Chowdhry,S., McMahon,M., Hayes,J.D. and
            Cuadrado,A.
  TITLE     SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent
            degradation of the Nrf2 transcription factor in a Keap1-independent
            manner
  JOURNAL   Mol Cell Biol 31 (6), 1121-1133 (2011)
   PUBMED   21245377
REFERENCE   2  (bases 1 to 3312)
  AUTHORS   Semplici,F., Meggio,F., Pinna,L.A. and Oliviero,S.
  TITLE     CK2-dependent phosphorylation of the E2 ubiquitin conjugating
            enzyme UBC3B induces its interaction with beta-TrCP and enhances
            beta-catenin degradation
  JOURNAL   Oncogene 21 (25), 3978-3987 (2002)
   PUBMED   12037680
REFERENCE   3  (bases 1 to 3312)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL954379.17
            and AL807823.6.
            
            On May 1, 2007 this sequence version replaced NM_026275.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075714.1, AK075703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AL954379.17        26748-26973
            227-313             AL954379.17        64768-64854
            314-411             AL807823.6         212654-212751       c
            412-546             AL807823.6         206710-206844       c
            547-3312            AL807823.6         202626-205391       c
FEATURES             Location/Qualifiers
     source          1..3312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.02 cM"
     gene            1..3312
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /note="ubiquitin-conjugating enzyme E2R 2"
                     /db_xref="GeneID:67615"
                     /db_xref="MGI:MGI:1914865"
     exon            1..226
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..766
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /EC_number="2.3.2.23"
                     /note="E2-CDC34B; ubiquitin-protein ligase R2; ubiquitin
                     carrier protein R2; ubiquitin-conjugating enzyme
                     E2-CDC34B; E2 ubiquitin-conjugating enzyme R2"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 R2"
                     /protein_id="NP_080551.1"
                     /db_xref="CCDS:CCDS18057.1"
                     /db_xref="GeneID:67615"
                     /db_xref="MGI:MGI:1914865"
                     /translation="MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVA
                     IFGPPNTLYEGGYFKAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVD
                     DPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKE
                     YAEIIRKQVSATKAEAEKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDE
                     DEEEEDADCYDDDDSGNEES"
     exon            227..313
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /inference="alignment:Splign:2.1.0"
     exon            314..411
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /inference="alignment:Splign:2.1.0"
     exon            412..546
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /inference="alignment:Splign:2.1.0"
     exon            547..3312
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1533..1538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /note="hexamer: AATAAA"
     polyA_site      1558
                     /gene="Ube2r2"
                     /gene_synonym="1200003M11Rik; Cdc34b; Ubc3b"
                     /note="major polyA site"
ORIGIN      
        1 cggtgcgcga ggactggggc cgcggccccg cacggccgcc gccgccgcga tggcccagca
       61 gcagatgacc agctcgcaga aagccctgat gcttgagctg aaatccctgc aggaggaacc
      121 ggtggagggc ttccggatca ccctggtgga tgagtccgac ctctacaact gggaggtggc
      181 catcttcgga ccccctaaca ccctctacga aggcggctac ttcaaggcac atattaagtt
      241 tcctattgat tacccatatt caccacctac cttcagattc ttgaccaaaa tgtggcaccc
      301 caacatttat gagaatggag atgtatgcat ttcaattctt catccgcctg tagatgaccc
      361 gcagagtgga gagctaccct ctgaaaggtg gaaccctact cagaacgtta ggactatcct
      421 gttaagtgtg atctcactgc ttaatgagcc caacaccttt tctccagcca atgtggatgc
      481 ttcagtcatg ttcaggaaat ggagggacag caaaggaaaa gacaaggaat atgctgagat
      541 cattaggaaa caggtctcag ccactaaagc tgaggcggag aaggatggag tgaaggtccc
      601 cacaaccctg gcagaatact gcatcaaaac taaagtgcct tccaatgaca acagctcaga
      661 tttgctttat gacgacttgt atgacgacga cattgatgat gaagatgaag aggaagaaga
      721 tgccgactgt tatgatgatg atgattctgg aaatgaggag tcgtgacatg ttccttcagt
      781 gcccctgtac tgccctgacg tctcaggcca aagggaggga gcaagtgggg atctacagtg
      841 gccactcagc aaaaacttac tcccggggcg gggaagcaaa cagcccctgc tgaccctttg
      901 cggatctcag tttgctcctt ttatggacct ttactggaga gagttccctc cacagaatgt
      961 ctgaagtctt gcattctttc ccttccatca ctgtattgat tcttttttaa aaacagccac
     1021 cacccctcaa actcccacct cacctcatct ctgcagaatg ttcacagcaa aacacctttg
     1081 tctgttttta gattcttgaa gaattagtct gttcaagaca ttgtgtttaa agctgggagc
     1141 ccactgggag tccacaagtg ctgcatatat tgggtagcaa aagaaaatgg gaaaaaaaga
     1201 aaaaaaaaaa acaacaaaac caaaaaaaaa taaaataaaa aaataaaaat aaaaaaagcc
     1261 cacaaaacaa acttaaaaaa aaaaaaaagc caatttgcca agggttagct gctcctttcc
     1321 attagcgtgt gtgcatctgt tcagccccgt ggtggtgagt tttgtttctt tcccttccta
     1381 aggctgggct gcggtgggca tcagggactt actctcgcta agtctgatga aatgtgctgc
     1441 ctcagtgaca ccatcccaac atggaggctg cagctactct gaggagctat cagattttgt
     1501 tttttggaat tgattgggat ctgaaagcct gaaataaata ttcatacttt acatagaacc
     1561 gagcacttgg ttgctattta ttttaaaggt gggataactt tttccaccag aaagtggggg
     1621 aggggaggtg gttagtgtgt gtgcgttcct ggttctgaaa ccacagaagg cctatcccag
     1681 tgttggctga tgcctcgggg gaaggaagag tgagggctgc ggcgggagga tgcagcccag
     1741 gtactcataa gagggttgat ttaagtagcc actttaatta ctcagtgtta gtcctacatg
     1801 catgggttaa gattgtgctg tctttgagct gcgtatcttg atagtgacaa ctgtggatgt
     1861 gtgcagcttg ggactggtcc ttttcctcac tggagatgat ctggacttct tgtactttgg
     1921 ccaaggagtg caagcagaaa tggtgtgcgg agcttcccct ggccccagct gactccaggc
     1981 agccttgttt cctgggtgtc agtcacacgt ggctccccca agcctgagct ccggtagctt
     2041 catcctagac ttgaaagagg gttttgttta gcaaactgtc taagtaaagc cagacttcaa
     2101 ggatagggct taagattcgt gtgtgccagg gtcacagctc ggaaccaaag ggcagaggga
     2161 aactgggaag gactgaccct ctggttaagt agacagacca tgcttcctcc tctcatggtt
     2221 ccctttcctt tctgatctca gggttttcat tctctcttca cactcctgaa cgaatgctat
     2281 ttccctggct tcaaaagttc ggtctgttat caaatgagaa tgtttagtgg tgaacagtga
     2341 aatttagtga gtttacagtc agggctgtac ctgagtctcc tgactcagga acacagtaaa
     2401 gagacatttc gagtttgttg ctcccagata gcctgcagat agatgtacag ccaaatcctc
     2461 tctgatcctc cttccccagt gcccacctgc ctaccactga aagttcaata gccagttgtt
     2521 tggccttact ctcttggcac cctaaaacta accctttcca tactaaagca ccccagtcaa
     2581 gggcaggtta ggcacctggc cagtgggagg ccccgctggc ctgtggtgcg tgttaactcg
     2641 gaggcagaga ggcaagagga agtgggcctc agcctgtggt gggggtggtc agttccaagg
     2701 ctgtgtggac ttaggcagcc cagatgctgc agtctaaact gagttaacat gcacacactt
     2761 aggtccctga acacctgtcc tgtgggaaaa gccttgagtg cattaatttt cccttttggg
     2821 aatagatagt tttggggtgc aagtagaagt tttgagcagt tgtgctgttt gcctggtgtg
     2881 agatgaacgt gactcctctg ggtctatcca ggcctcgctg agtgcgtgct ctttatcctg
     2941 atcccactgt tgcccctccc tctccgtcgc ccggctttct cattctagaa ctctcttaac
     3001 cacactacgt ttgtaatcac ttctccctcc tggcctggcc accatttgct gggtccctcg
     3061 tgtttgatcc tggccactgg aaggggaatt gccccctccc cagccctcat caaccaggtt
     3121 tacatttaca actttaaaag attcagatgc aatttcaact gaaaccagca gacatcctga
     3181 ccttactagt tttcttagtt ttcattgtag atggtttttc agtttaacga atgagaagtt
     3241 tatctgatgc tttttgttgg cttccccttt agtggtttgt ctctttctgc ccacctgtct
     3301 aataaaactg tg
//
