LOCUS       NM_180600               2952 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2Q family member 2
            (Ube2q2), transcript variant 1, mRNA.
ACCESSION   NM_180600 NM_172292 XM_973719
VERSION     NM_180600.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2952)
  AUTHORS   Wang,Z., Dong,H., Li,M. and Liang,X.B.
  TITLE     [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated
            protection on renal tubulointerstitial fibrosis]
  JOURNAL   Sheng Li Xue Bao 74 (1), 117-124 (2022)
   PUBMED   35199132
  REMARK    GeneRIF: [Ubiquitin-conjugating enzyme UBE2Q2 participates in
            HUWE1-mediated protection on renal tubulointerstitial fibrosis].
REFERENCE   2  (bases 1 to 2952)
  AUTHORS   Tan,Q., Yalamanchili,H.K., Park,J., De Maio,A., Lu,H.C., Wan,Y.W.,
            White,J.J., Bondar,V.V., Sayegh,L.S., Liu,X., Gao,Y.,
            Sillitoe,R.V., Orr,H.T., Liu,Z. and Zoghbi,H.Y.
  TITLE     Extensive cryptic splicing upon loss of RBM17 and TDP43 in
            neurodegeneration models
  JOURNAL   Hum Mol Genet 25 (23), 5083-5093 (2016)
   PUBMED   28007900
REFERENCE   3  (bases 1 to 2952)
  AUTHORS   Melner,M.H., Haas,A.L., Klein,J.M., Brash,A.R., Boeglin,W.E.,
            Nagdas,S.K., Winfrey,V.P. and Olson,G.E.
  TITLE     Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a
            novel ubiquitin-conjugating enzyme with implantation site-specific
            expression
  JOURNAL   Biol Reprod 75 (3), 395-406 (2006)
   PUBMED   16760379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042515.1, AK150776.1 and AI227508.1.
            
            On Sep 11, 2009 this sequence version replaced NM_180600.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083216.1, AK150776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AK042515.1         2-177
            177-2848            AK150776.1         2-2673
            2849-2952           AI227508.1         225-328
FEATURES             Location/Qualifiers
     source          1..2952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.84 cM"
     gene            1..2952
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /note="ubiquitin-conjugating enzyme E2Q family member 2"
                     /db_xref="GeneID:109161"
                     /db_xref="MGI:MGI:2388672"
     exon            1..458
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1403
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /EC_number="2.3.2.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-conjugating enzyme E2 Q2; ubiquitin-protein
                     ligase Q2; ubiquitin carrier protein Q2; E2
                     ubiquitin-conjugating enzyme Q2; ubiquitin-conjugating
                     enzyme E2Q (putative) 2"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform 1"
                     /protein_id="NP_850931.2"
                     /db_xref="CCDS:CCDS23201.1"
                     /db_xref="GeneID:109161"
                     /db_xref="MGI:MGI:2388672"
                     /translation="MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPPPP
                     PPPGSSLSPPPPLTLHCNITESYPSSSPIWFVDSDDPNLTSVLERLEDTKNNSSLRQQ
                     LKWLICDLCRLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEMAEDIEDLDHY
                     EMKEEEPINGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRD
                     VYRSQSYKAGIYSVELINDSLYDWHVKLHKVDSDSPLHSDLQILKEKEGIEYILLNFS
                     FKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLV
                     KGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG"
     exon            459..560
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..665
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            666..722
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..863
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            864..948
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1009
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1100
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1159
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1208
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1304
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1371
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2941
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2941
                     /gene="Ube2q2"
                     /gene_synonym="3010021M21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcctcctgcg ggtggagtcg gttacaaagg cagcagccgg cccggctccc gcacgctcgc
       61 tcgctccctc gctcgcacgc ccgcccgccg aggcctcgcg ctcctcgcca ttttccagcc
      121 gcgctcggac gcgggtcgcg gcggcgggga gaggcggagc cgcgagagcg cggcccgggc
      181 cggccccgcg gggcggtcgc ggccgtgacg gcggctcccg gccccggctc cctttcctca
      241 cccctcccgc tggagatgag gggaagatgt ccgtgtcagg gctcaaggcc gagctgaagt
      301 tcctggcgtc catcttcgac aagaaccacg agcgattccg catcgtcagc tggaagctgg
      361 acgagctgca ctgccagttc ctggtgccgc cgccgccacc accgccgggc agctcgcttt
      421 cgccgccgcc gccgctcaca cttcactgca acatcacgga atcttaccca tcttcttcac
      481 caatatggtt tgtggactct gatgacccaa atctgacatc agttctggaa cgcttagaag
      541 atactaagaa caacagttcg ctccgtcagc aattgaagtg gttgatatgt gacctctgca
      601 gattatataa ccttcctaag cacctggatg ttgagatgct agatcaacca ctacccacgg
      661 gtcagaatgg gacaactgaa gaagtaactt cagaagaaga ggaagaggag gagatggctg
      721 aagatataga agacttggat cactatgaga tgaaggaaga agaacctatt aatgggaaaa
      781 agtcagagga tgaagggatt gaaaaagaaa atttggcaat attagagaaa atcaggaaga
      841 ctcaaaggca agaccattta aatggtgcag tgtctgggtc agtacaagca tcagacagac
      901 tgatgaagga gctcagggac gtctacagat cacagagcta caaggcaggg atttattcag
      961 tggagctaat aaatgacagc ttatatgact ggcatgtcaa actacacaag gttgactctg
     1021 atagtccttt gcacagtgat cttcagatct taaaagaaaa agaaggcata gaatatattt
     1081 tgcttaactt ctcttttaag gataattttc catttgatcc tccgtttgtt agagtggtgt
     1141 tacctgttct ctcaggaggg tatgtgttgg gtggaggagc actttgtatg gaacttctca
     1201 caaaacaggg ctggagcagt gcctactcaa tagaatctgt catcatgcag atcaatgcca
     1261 ccttagtgaa aggcaaagcc cgggtgcagt ttggagcaaa taagaatcag tataatctag
     1321 cacgagccca acagtcctat aattccattg tacagataca tgagaaaaat ggctggtaca
     1381 cacctccaaa ggaagatggc taactacatt gacatatgtc tggaccaatg ttgctttaaa
     1441 gaaaatcgtt ccaacgtaca gacataagct tttgagtgcc cgtataacag cagtaccgaa
     1501 gatattagct aatagatcat ttagtggata atctgtcaac tgacatccag ttacagcctt
     1561 ttcattttgc tcactttagg tatcttggac tgagcagtgg ggcctttact gtatttttcc
     1621 tgataagtac acacaatagc cactccctac cacctctttc ttgaaaagtg aaatctttta
     1681 agcagggaag tgagcatccg tttactgcag ctgtgatttt tacagtaacc tttctatatt
     1741 gagcctatgg ggtatgaaga tttgcaaaat cttgtttgtt tagagccaat aaaagtttaa
     1801 ctgatggtca atactggttt agaaatttta ggtcttctaa accatagctt tttcaggtct
     1861 gaaataattt tattgccaaa attatgacag gaagcctcct cattaaattg ttacactttt
     1921 tcacggttgt gtgaaagttt gaactaatct aaaagtatga tcgtaattgt accatattag
     1981 cgtacagcaa aacgaggcag ccacttgtga gcagtaattt ccactggagc agcagggtcc
     2041 tagtggacca aacctgcttc ctgttggttc agcatttctt gtgaggaaga gccacagtgc
     2101 agagcctgaa gttctaaagt atgaggtcat tttacctttc catttattag cggggtgttg
     2161 caattgacga taaactaata aacttatgga atggttggca caaagacaga ctctttgagc
     2221 aaaattatga aagataccta aattggagat ccttaaattt ttgctgtagt catgcagtgg
     2281 cttttacatc agaagaccag taggagttca gcctgtgtta attctttttt aaaatgtgac
     2341 acagatcaat gtactttgca tttttattac ctttcctgaa tcaatcctct ttggttggta
     2401 atagactttt ttggatccat gtttgatttg aatctagcta cttaagcact tttaaaagaa
     2461 acctcgaagc acactcctgc acgacccagt acagagttaa acggcttttc ttatatattt
     2521 gatttgagat ttttttttta aactttgcaa accacatcta ggagatgtgg cacttgtgca
     2581 ttttatgtgt ggtgttagtt tctcttgatt ctgttggtta agagggcaga aaagatatct
     2641 ggtattcttg gtcacttggt taccctaaat atatgattgc cagtggctca gatgacaagt
     2701 gacaagacag aattcttcaa cacattatta agttccttat gcctaaggca aaatcttgaa
     2761 tacattattg aattctaatt tcctaatggc tagcagattg acagctgcac atttggcatg
     2821 ctttggggtt gggttttttt ttttttttga ttttattttt cattgcagat ttatttggca
     2881 atgtacagta aattttgtaa acttgcatca agtttatgaa taaagaacca tttaaaaatc
     2941 aaaaaaaaaa aa
//
