LOCUS       NM_173755               5192 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2O (Ube2o), mRNA.
ACCESSION   NM_173755 XM_109923
VERSION     NM_173755.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5192)
  AUTHORS   Tian C, Chen Z, Wang L, Si J, Kang J, Li Y, Zheng Y, Gao Y,
            Nuermaimaiti R, You MJ and Zheng G.
  TITLE     Over expression of ubiquitin-conjugating enzyme E2O in bone marrow
            mesenchymal stromal cells partially attenuates acute myeloid
            leukaemia progression
  JOURNAL   Br J Haematol 200 (4), 476-488 (2023)
   PUBMED   36345807
  REMARK    GeneRIF: Over expression of ubiquitin-conjugating enzyme E2O in
            bone marrow mesenchymal stromal cells partially attenuates acute
            myeloid leukaemia progression.
REFERENCE   2  (bases 1 to 5192)
  AUTHORS   Cheng J, Zheng H, Liu C, Jin J, Xing Z and Wu Y.
  TITLE     Age-Associated UBE2O Reduction Promotes Neuronal Death in
            Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 93 (3), 1083-1093 (2023)
   PUBMED   37182872
  REMARK    GeneRIF: Age-Associated UBE2O Reduction Promotes Neuronal Death in
            Alzheimer's Disease.
REFERENCE   3  (bases 1 to 5192)
  AUTHORS   Ma M, Zhang C, Cao R, Tang D, Sang X, Zou S, Wang X, Xu H, Liu G,
            Dai L, Tian Y, Gao X and Fu X.
  TITLE     UBE2O promotes lipid metabolic reprogramming and liver cancer
            progression by mediating HADHA ubiquitination
  JOURNAL   Oncogene 41 (48), 5199-5213 (2022)
   PUBMED   36273042
  REMARK    GeneRIF: UBE2O promotes lipid metabolic reprogramming and liver
            cancer progression by mediating HADHA ubiquitination.
REFERENCE   4  (bases 1 to 5192)
  AUTHORS   Vila IK, Park MK, Setijono SR, Yao Y, Kim H, Badin PM, Choi S,
            Narkar V, Choi SW, Chung J, Moro C, Song SJ and Song MS.
  TITLE     A muscle-specific UBE2O/AMPKalpha2 axis promotes insulin resistance
            and metabolic syndrome in obesity
  JOURNAL   JCI Insight 4 (13), 128269 (2019)
   PUBMED   31292296
  REMARK    GeneRIF: Through phenotype analysis of high-fat diet-induced
            obesity and metabolic syndrome mice with muscle-, fat-, or
            liver-specific knockout of Ube2o, study identified Ube2o as an
            essential regulator of glucose and lipid metabolism programs in
            skeletal muscle, but not in adipose or liver tissue.
            Mechanistically, Ube2o acted as a ubiquitin ligase and targeted
            AMPKalpha2 for ubiquitin-dependent degradation in skeletal muscles.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5192)
  AUTHORS   Chen S, Yang J, Zhang Y, Duan C, Liu Q, Huang Z, Xu Y, Zhou L and
            Xu G.
  TITLE     Ubiquitin-conjugating enzyme UBE2O regulates cellular clock
            function by promoting the degradation of the transcription factor
            BMAL1
  JOURNAL   J Biol Chem 293 (29), 11296-11309 (2018)
   PUBMED   29871923
  REMARK    GeneRIF: This work identifies UBE2O as a critical regulator in the
            ubiquitin-proteasome system, which modulates BMAL1 transcriptional
            activity and circadian function by promoting BMAL1 ubiquitination
            and degradation under normal physiological conditions.
REFERENCE   6  (bases 1 to 5192)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 5192)
  AUTHORS   Tomsig JL, Snyder SL and Creutz CE.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   8  (bases 1 to 5192)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5192)
  AUTHORS   Berleth ES and Pickart CM.
  TITLE     Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis
            involving a thiol relay?
  JOURNAL   Biochemistry 35 (5), 1664-1671 (1996)
   PUBMED   8634298
REFERENCE   10 (bases 1 to 5192)
  AUTHORS   Wefes I, Mastrandrea LD, Haldeman M, Koury ST, Tamburlin J, Pickart
            CM and Finley D.
  TITLE     Induction of ubiquitin-conjugating enzymes during terminal
            erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 4982-4986 (1995)
   PUBMED   7761435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK129431.1, U20780.1 and BC051108.1.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_173755.4.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_109923.5, NM_173755.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129431.1, SRR7652917.281289.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               AK129431.1         1-552
            553-959             U20780.1           215-621
            960-1287            AK129431.1         960-1287
            1288-1915           U20780.1           949-1576
            1916-4981           BC051108.1         261-3326
            4982-5192           AK129431.1         4982-5192
FEATURES             Location/Qualifiers
     source          1..5192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.42 cM"
     gene            1..5192
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /note="ubiquitin-conjugating enzyme E2O"
                     /db_xref="GeneID:217342"
                     /db_xref="MGI:MGI:2444266"
     exon            1..436
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3901
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /EC_number="2.3.2.24"
                     /note="ubiquitinating enzyme E2-230 kDa; ubiquitin-protein
                     ligase O; ubiquitin carrier protein O;
                     ubiquitin-conjugating enzyme E2 of 230 kDa;
                     ubiquitin-conjugating enzyme E2-230K; E2/E3 hybrid
                     ubiquitin-protein ligase UBE2O"
                     /codon_start=1
                     /product="(E3-independent) E2 ubiquitin-conjugating enzyme
                     UBE2O"
                     /protein_id="NP_776116.2"
                     /db_xref="CCDS:CCDS25670.1"
                     /db_xref="GeneID:217342"
                     /db_xref="MGI:MGI:2444266"
                     /translation="MADPAAPAPAQAQAAAAPTPAAAPAAAAPPPAPATDSASGPSSD
                     SGPEAGSQRLLFSHDLVSGRYRGSVHFGLVRLIHGEDSDSEGDDDGRGSSGCSEAGGA
                     GHEEGRASPLRRGYVRVQWYPEGVKQHVKETKLKLEDRSVVPRDVVRHMRSTDSQCGT
                     VIDVNIDCAVKLIGTNCIIYPVNSKDLQHIWPFMYGDYIAYDCWLGKVYDLKNQIILK
                     LSNGARCSMNTEDGAKLYDVCPHVSDSGLFFDDSYGFYPGQVLIGPAKIFSSVQWLSG
                     VKPVLSTKSKFRVVVEEVQVVELKVTWITKSFCPGGTDSVSPPPSIITQENLGRVKRL
                     GCFDHAQRQLGERCLYVFPAKVEPAKIAWECPEKNCAQGEGSMAKKVKRLLKKQVVRI
                     MSCTPDTQCPRDHSMEDPDKKGEARAGSEIGSASPEEQPDGSASPVEMQDEGSEELQE
                     TCEPLPPFLLKEGGDDGLHSAEQDADDEAADDTDDTSSVTSSASSTTSSQSGSGTGRK
                     KSIPLSIKNLKRKHKRKKNKVTRDFKPGDRVAVEVVTTMTSADVMWQDGSVECNIRSN
                     DLFPVHHLDNNEFCPGDFVVDKRVQSCPDPAVYGVVQSGDHVGRTCMVKWFKLRPSGD
                     DVELIGEEEDVSVYDIADHPDFRFRTTDIVIRIGNTEDGALPKEDEPSVGQVARVDVS
                     SKVEVVWADNSKTIILPQHLYNIESEIEESDYDSVEGSSSGASSDEWEDDSDSWETDN
                     GLVDDEHPKIEELAAILPAEQPTAPEEDKGVVISEEAATAAIQGAVAMAAPVAGLMEK
                     AGKDGPPKSFRELKEAIKILESLKNMTVEQLLTGSPTSPTVEPEKPTREKKFLDDIKK
                     LQENLKKTLDNVAIAEEEKMEAVPDTERKEEKPEVQSPVKAEWPSETPVLCQQCGGRP
                     GVTFTSAKGEVFSVLEFAPSNHSFKKIEFQPPEAKKFFSTVRKEMALLATSLPDGIMV
                     KTFEDRMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQCSGRLNPNL
                     YDNGKVCVSLLGTWIGKGTERWTSKSSLLQVLISIQGLILVNEPYYNEAGFDSDRGLQ
                     EGYENSRCYNEMALIRVVQSMTQLVRRPPEVFEQEIRQHFSVGGWRLVNRIESWLETH
                     AMQERAQVMPNGALKDSSSLEPMAAAELSDSGREEPEDVGMAPGEASQGSDSEGGAQG
                     PASASRDHTEQTETAPDASAPPSVRPKRRRKSYRSFLPEKSGYPDIGFPLFPLSKGFI
                     KSIRGVLTQFRAALLEAGMPESTEDK"
     exon            437..496
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            497..607
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            608..705
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            706..769
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            770..913
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1023
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1174
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1647
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1802
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1915
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2044
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2134
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2834
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2971
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3175
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3233
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..5192
                     /gene="Ube2o"
                     /gene_synonym="9630022H21; B230113M03Rik; E2-230K;
                     mKIAA1734"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgccgcc gcccgagact cgcgcagagc agttatggcg gatcccgcag cgcccgcacc
       61 cgcccaggcc caggccgccg ccgccccgac cccggccgca gcccccgccg ccgccgcccc
      121 gccgcccgcg cccgctacgg actcggcctc agggccgtcc tccgactccg gccccgaagc
      181 aggctcacag cgcctgctgt tctcccacga cctggtgtcc ggccgttacc gcggctcggt
      241 gcacttcggg ctggtacgcc tcatccacgg cgaggactcg gactcggagg gcgacgatga
      301 cggccgcggc agctcgggct gctccgaggc cgggggcgcg ggccacgagg agggccgggc
      361 cagccctctg cggcgcggct acgtgcgcgt ccagtggtac ccggagggcg tcaagcagca
      421 tgtgaaggag accaagctga aactggagga ccgctctgtg gtgccccggg atgtggttcg
      481 acacatgcgc tcaactgaca gccagtgtgg cacggtgata gatgtcaaca ttgactgtgc
      541 cgtcaagctc atcggcacca actgcatcat ctaccctgtc aacagcaagg acctccagca
      601 catctggccc ttcatgtatg gagactatat cgcctatgac tgctggctgg ggaaggtcta
      661 tgacttgaag aaccagatca tcctcaagtt gtctaatggt gccaggtgct ccatgaacac
      721 agaagatggt gccaaactct acgatgtctg ccctcacgtc agcgactcgg gtctcttctt
      781 tgatgactct tatggcttct acccaggcca agtccttatt ggcccagcca agatcttctc
      841 cagtgtccag tggctctctg gggtcaagcc tgtactcagc accaagagca agttccgtgt
      901 ggtggtggag gaggtgcagg ttgtagaact gaaagtcacg tggattacca agagcttctg
      961 ccccggcggc acggacagcg ttagcccccc accttccatc atcactcagg aaaacctagg
     1021 cagggtgaag cgtctcggat gctttgacca tgctcagcgg cagcttgggg aacgctgtct
     1081 gtatgtcttc ccagccaagg tagagccggc caagattgcc tgggaatgtc cagaaaaaaa
     1141 ctgcgcccag ggggagggct ctatggccaa gaaggtgaag cgtctgttga agaagcaagt
     1201 tgtgagaatc atgtcctgca ccccagatac ccagtgtcct agggaccatt ccatggaaga
     1261 cccagacaag aaaggggaag ccagagccgg gagtgaaata gggtctgcta gcccggagga
     1321 gcaacctgat ggatcagcca gccccgtgga gatgcaggat gaggggtcgg aggagcttca
     1381 ggagacatgc gagccactgc cccccttcct cttgaaggag ggtggagatg acgggctgca
     1441 ctcggcagag caggacgcag atgatgaggc ggctgacgat acagatgaca ccagctctgt
     1501 gacctcctcc gccagctcta ctacctcctc ccagagtggc agtggcactg gtcgtaaaaa
     1561 gagcattccc ttgtccatca aaaacttgaa gcgaaaacac aagaggaaga agaataaggt
     1621 cacccgtgac ttcaagcctg gagacagggt ggcagtggag gttgtgacca cgatgacctc
     1681 agctgatgtg atgtggcaag atggctctgt ggaatgcaac atccgctcca acgacctttt
     1741 ccctgtgcac cacctggaca acaatgagtt ctgccctggg gacttcgtgg tggacaagcg
     1801 agtccagagc tgcccagacc ctgctgtcta tggtgtggtg cagtctgggg atcatgttgg
     1861 ccgtacctgc atggtgaagt ggttcaagct gcgaccaagt ggggatgacg tggagctcat
     1921 tggagaagag gaggacgtga gcgtctatga cattgctgac caccctgact ttcgcttccg
     1981 cacaactgac attgtcatcc gcattggtaa cacggaggat ggggctctac ccaaggagga
     2041 tgagccctca gtgggccagg tggcccgagt ggatgtcagc agcaaagtgg aagtggtgtg
     2101 ggctgacaac tcgaaaacca tcatcctgcc acagcactta tacaacatcg agtctgagat
     2161 tgaggagtct gactacgact ccgtggaagg cagctccagt ggggcctcct cggatgagtg
     2221 ggaggacgac agcgacagct gggagaccga caacgggctc gtggacgatg agcaccccaa
     2281 gatagaggag ctggccgcca tcttgcctgc cgagcagccc actgcccccg aggaggacaa
     2341 gggcgtggtc atcagtgagg aggcggccac ggctgccatc cagggcgccg tggccatggc
     2401 tgcccccgtg gcagggctga tggagaaagc tgggaaggac gggcctccca agagtttccg
     2461 ggagctgaag gaggccatca agatcctgga gagcctcaag aacatgactg tggagcagct
     2521 gctcacaggc tcgcccacct cgcccaccgt ggagcctgag aagccaaccc gagagaagaa
     2581 gtttttggac gatatcaaga agctacagga gaacctcaag aagaccctgg acaatgtggc
     2641 cattgctgag gaggagaaga tggaggcagt acccgacaca gagcgcaagg aggagaagcc
     2701 tgaggtgcag tccccagtga aagccgagtg gcccagtgag acacctgtgc tctgtcagca
     2761 gtgcggtggc aggcctggcg tcaccttcac cagcgccaag ggcgaggtct tctctgtgct
     2821 ggagtttgca ccctcaaacc actctttcaa gaagattgag ttccagcccc cggaagccaa
     2881 gaagttcttc agcacagtgc ggaaggagat ggctctgctg gccacctcgc tgcccgatgg
     2941 catcatggtc aagacttttg aggacagaat ggacctcttc tctgcactga tcaagggccc
     3001 cactcggact ccctatgaag acggcctcta cctatttgac atccagcttc ccaacatcta
     3061 ccctgcggtg cccccccact tttgctacct ctcccagtgc agtggccgcc tgaaccccaa
     3121 cctgtatgac aatgggaaag tgtgtgtcag cctcctaggt acctggattg gaaaggggac
     3181 agagaggtgg acaagcaagt ctagccttct ccaggtgctc atctccatcc aaggtctgat
     3241 cctggtgaat gaaccatact acaatgaagc tggctttgac agtgaccggg gcctgcagga
     3301 aggctatgag aacagtcgct gctacaacga gatggcatta atccgtgtgg tgcagtccat
     3361 gacccagttg gtgcgacgac ctcctgaggt cttcgaacag gagattcggc agcacttcag
     3421 tgtgggtggc tggcggctgg tgaaccgaat tgagtcctgg ctggaaaccc atgccatgca
     3481 ggagagggcc caggtgatgc ccaatggggc ccttaaagac agcagctctc tggagcccat
     3541 ggctgcagct gaactctcag actccggccg tgaagagcct gaagatgttg ggatggcccc
     3601 tggggaggcg tcccagggct cagactcaga gggtggagcc cagggccctg cctcagccag
     3661 cagagaccac acagagcaga ctgagacagc ccctgatgca tccgcacctc ccagcgttag
     3721 accaaagagg aggaggaaga gctaccgcag cttcctgcct gagaagagcg gttaccctga
     3781 catcggcttc cccctcttcc cactctccaa gggtttcatc aagagcatcc ggggggtcct
     3841 gacacagttc cgtgctgccc tgctggaggc gggcatgccc gaaagcacag aggacaagta
     3901 gctgcccatg cttgaaaggg agtgtcatgg tgggagaggt cagccgctgc ctgctccctc
     3961 ccttcctgag gtcctgcccc tcttcctgcc ccttcctgta cctaattgga gccttctgct
     4021 gccctctcct ccctgcggca agtttgatgc tgaagtgcaa gaagtgtccc aagatgctgc
     4081 gttctatccc tcagttatgt ttcaaaggca ggcacctgag gcactgggaa ctcactcagg
     4141 ttccccgtcg ccccaggcag agagtcctgg cacttgttct ctagctgtcc cttctcaggt
     4201 cagaggtggg gtgttgagga acctgcagat ggcaggaggg tgggcgtgcc ttgcatgaag
     4261 tgtggctgct cctgcagtgt tcccggtccc tctcctctcc agcttgacag tagcctcccc
     4321 acgtcccagc ccctcctgcg ccacacacca ggtccctcat cccctgtacc tccatctcgg
     4381 agctgtggct gctgtggctg gctctggcct gccagtgcgt tatagccctt aggcctattg
     4441 aacttactct ctaagagagg ataggacacc aggagaggct gcagccctca cgtgaacgga
     4501 gttgagaatg tgctgcctgg acagaaatgg ctacaggtgc cttgctcttc cagtccaaga
     4561 tggcagtgat aatggcagtc ctgcccagac ctgcctgtta tctgctccat ccagcctcat
     4621 tttatcccca ctgaggtgac aggagcatct gcacaaacca ggccagcgac aagggcctct
     4681 cccatccggt ggctcagcct ctccagtcag ccttggctta tagactctct gcaagggcag
     4741 tctgaggggg gaggctggcc ggcagcggga gctccccccc accccacagg cccagaggtt
     4801 tacaagtttc taagcttttg ataatgtgaa gctccaggta gagaggatgc ctgccggtga
     4861 gcacattaca gctcttgtcg tttctggtgt atgtaatatt taaggttgaa aaaataaatc
     4921 tcaaaagcaa agatactaat aactcttact agaaaaaaaa aaagacagac aaaatacaaa
     4981 acacaaaaaa agccaaagca tgatgcgtct tgtcagcctt aagtgggctc cacacctgtg
     5041 ctgtgccagg accaccgggg cagcagagcc ttgggaacac tcaccgggga catgggcctg
     5101 gtgggccatg cttcccgggc cattgttcac gtggagatgt gaatgcctac tgcttacaat
     5161 acctgtataa agtgctgtgt gattaaactt tt
//
