LOCUS       NM_019949               1402 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2L 6 (Ube2l6), mRNA.
ACCESSION   NM_019949
VERSION     NM_019949.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1402)
  AUTHORS   Cheng,Y., Zhang,M., Xu,R., Fu,L., Xue,M., Xu,C., Tang,C., Fang,T.,
            Liu,X., Sun,B. and Chen,L.
  TITLE     p53 accelerates endothelial cell senescence in diabetic retinopathy
            by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
  JOURNAL   Exp Gerontol 188, 112391 (2024)
   PUBMED   38437929
  REMARK    GeneRIF: p53 accelerates endothelial cell senescence in diabetic
            retinopathy by enhancing FoxO3a ubiquitylation and degradation via
            UBE2L6.
REFERENCE   2  (bases 1 to 1402)
  AUTHORS   Li,Y., Dong,X., He,W., Quan,H., Chen,K., Cen,C. and Wei,W.
  TITLE     Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed
            Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation
  JOURNAL   Obes Facts 17 (1), 24-36 (2024)
   PUBMED   37820603
  REMARK    GeneRIF: Ube2L6 Promotes M1 Macrophage Polarization in High-Fat
            Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1
            Activation.
REFERENCE   3  (bases 1 to 1402)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1402)
  AUTHORS   Marcelin,G., Liu,S.M., Schwartz,G.J. and Chua,S.C. Jr.
  TITLE     Identification of a loss-of-function mutation in Ube2l6 associated
            with obesity resistance
  JOURNAL   Diabetes 62 (8), 2784-2795 (2013)
   PUBMED   23557705
  REMARK    GeneRIF: we have identified a loss-of-function mutation in Ube2l6
            that contributes to the chromosome 2 obesity quantitative trait
            locus.
REFERENCE   5  (bases 1 to 1402)
  AUTHORS   Wood,L.M., Sankar,S., Reed,R.E., Haas,A.L., Liu,L.F., McKinnon,P.
            and Desai,S.D.
  TITLE     A novel role for ATM in regulating proteasome-mediated protein
            degradation through suppression of the ISG15 conjugation pathway
  JOURNAL   PLoS One 6 (1), e16422 (2011)
   PUBMED   21298066
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1402)
  AUTHORS   Makki,M.S., Heinzel,T. and Englert,C.
  TITLE     TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple
            levels
  JOURNAL   Nucleic Acids Res 36 (12), 4067-4078 (2008)
   PUBMED   18535006
REFERENCE   7  (bases 1 to 1402)
  AUTHORS   Giannakopoulos,N.V., Luo,J.K., Papov,V., Zou,W., Lenschow,D.J.,
            Jacobs,B.S., Borden,E.C., Li,J., Virgin,H.W. and Zhang,D.E.
  TITLE     Proteomic identification of proteins conjugated to ISG15 in mouse
            and human cells
  JOURNAL   Biochem Biophys Res Commun 336 (2), 496-506 (2005)
   PUBMED   16139798
REFERENCE   8  (bases 1 to 1402)
  AUTHORS   Kim,K.I., Giannakopoulos,N.V., Virgin,H.W. and Zhang,D.E.
  TITLE     Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme
            for protein ISGylation
  JOURNAL   Mol Cell Biol 24 (21), 9592-9600 (2004)
   PUBMED   15485925
  REMARK    GeneRIF: Ubc8 is a major ISG15-conjugating enzyme responsible for
            protein ISGylation upon interferon stimulation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152113.1 and CJ300190.1.
            
            On Nov 20, 2008 this sequence version replaced NM_019949.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008238.1, AK152113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1380              AK152113.1         2-1381
            1381-1402           CJ300190.1         420-441
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..1402
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /note="ubiquitin-conjugating enzyme E2L 6"
                     /db_xref="GeneID:56791"
                     /db_xref="MGI:MGI:1914500"
     exon            1..105
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..540
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-conjugating enzyme 8; E2
                     ubiquitin-conjugating enzyme L6; E2 ubiquitin conjugating
                     enzyme; ubiquitin-protein ligase L6; ubiquitin carrier
                     protein L6"
                     /codon_start=1
                     /product="ubiquitin/ISG15-conjugating enzyme E2 L6"
                     /protein_id="NP_064333.2"
                     /db_xref="CCDS:CCDS16194.2"
                     /db_xref="GeneID:56791"
                     /db_xref="MGI:MGI:1914500"
                     /translation="MMASKRVAKELESLSKELPPYLRQLSSDDANVLVWHMLLLPDQL
                     PYGLKAFQVRIDFPREYPFKPPTLRFTTKIYHPNVREDGLVCLPLISNENWKPYTKPY
                     QVLEALNVLVSKPNLEEPVRLELADLLTQNPEMFRKKAEEFTLKFGVDRPS"
     exon            106..201
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /inference="alignment:Splign:2.1.0"
     exon            202..388
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /inference="alignment:Splign:2.1.0"
     exon            389..1387
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1359..1364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2l6"
                     /gene_synonym="2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8"
                     /note="putative"
ORIGIN      
        1 gtgggcgggg ctcgggagct gcagttcaga gagcggtgtc ctgctggaat ctgctggtgc
       61 cccacgctcc aacccgagat gatggccagc aagcgagtgg cgaaagagct ggagagtctt
      121 tcgaaggagc tgccgccata ccttcgccaa ctgtctagtg acgatgccaa tgtgcttgtg
      181 tggcacatgc tcctgctgcc agaccagctt ccctatggcc tcaaagcctt ccaagtgcgg
      241 attgatttcc ccagggagta tccattcaag cctcccactt tgagattcac caccaagatc
      301 taccacccca acgtcaggga ggatggtctg gtgtgcctgc ccctcatcag caatgagaac
      361 tggaagcctt acaccaagcc ttatcaagtc ttggaggccc tcaatgtgct ggtgagtaaa
      421 ccgaatctgg aagagcctgt gcgtctggaa cttgctgacc tcctgactca gaacccggag
      481 atgttcagga agaaggcaga agagttcacc cttaaattcg gagtggaccg gccctcttaa
      541 ttctgttctg aagcctggat cgtctgctta gcagatggat atcaccgact ggtgcccgag
      601 gccttgggaa gctcaccctg tgcctaagtt ttcctttgta gttgctaatt atgaatcttg
      661 tacctggtgt gtatgtatgt gatggaggtg ggggggcctg tgtgatgtgt gctccttccc
      721 tgagctgtct ggctgtagat gtaccatccc cacatcctcc ttggcttcag agccagtggg
      781 agttaggtac acacagtttc aggcctgctt tccagctctc tctgtcttag gccacctttc
      841 aggccaattg gcagaaaatt gaatgcccca gggcccaggc accaaggggt gagaaaggca
      901 ggactctgct cagaaggcag agcctacaga aggtaccaaa tttactgttg agtgattgag
      961 attgaaagag tagtaaactc agtgctccaa ggtatgctaa tcataaaaca gatagtgaca
     1021 ttcctccacc cacccacttc ctgagttcaa ggagtattca ttcaaagaaa gtcaccttga
     1081 ctttctttga atgaatactg caatgcaaat gtgctattgt tagaggctct tagaaactgt
     1141 cttgagagtt aacaattacc aggtattcct tgtgacacct gtgactttgt acttccttgt
     1201 gactcttatc tggtattttt ggtattttcc aacaacgccc ttcccacctc cttgagttgt
     1261 gttttttttc ctttaaatac ccccttactc agctactcgg ggcgccacgg tcctctaccc
     1321 ctgcgtggtg tatgaccgtg ggcccgagag cgctcttgaa taaaaatcct cttgcaattt
     1381 gcagcaaaaa aaaaaaaaaa aa
//
