LOCUS       NM_009456               2616 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2L 3 (Ube2l3),
            transcript variant 1, mRNA.
ACCESSION   NM_009456
VERSION     NM_009456.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2616)
  AUTHORS   Mishra,V., Crespo-Puig,A., McCarthy,C., Masonou,T.,
            Glegola-Madejska,I., Dejoux,A., Dow,G., Eldridge,M.J.G.,
            Marinelli,L.H., Meng,M., Wang,S., Bennison,D.J., Morrison,R. and
            Shenoy,A.R.
  TITLE     IL-1beta turnover by the UBE2L3 ubiquitin conjugating enzyme and
            HECT E3 ligases limits inflammation
  JOURNAL   Nat Commun 14 (1), 4385 (2023)
   PUBMED   37474493
  REMARK    GeneRIF: IL-1beta turnover by the UBE2L3 ubiquitin conjugating
            enzyme and HECT E3 ligases limits inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2616)
  AUTHORS   Peris-Moreno,D., Malige,M., Claustre,A., Armani,A.,
            Coudy-Gandilhon,C., Deval,C., Bechet,D., Fafournoux,P., Sandri,M.,
            Combaret,L., Taillandier,D. and Polge,C.
  TITLE     UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation
            of Myofibrillar Actin and Myosin
  JOURNAL   Cells 10 (8), 1974 (2021)
   PUBMED   34440743
  REMARK    GeneRIF: UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the
            Degradation of Myofibrillar Actin and Myosin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2616)
  AUTHORS   Avagliano Trezza,R., Sonzogni,M., Bossuyt,S.N.V., Zampeta,F.I.,
            Punt,A.M., van den Berg,M., Rotaru,D.C., Koene,L.M.C., Munshi,S.T.,
            Stedehouder,J., Kros,J.M., Williams,M., Heussler,H., de
            Vrij,F.M.S., Mientjes,E.J., van Woerden,G.M., Kushner,S.A.,
            Distel,B. and Elgersma,Y.
  TITLE     Loss of nuclear UBE3A causes electrophysiological and behavioral
            deficits in mice and is associated with Angelman syndrome
  JOURNAL   Nat Neurosci 22 (8), 1235-1247 (2019)
   PUBMED   31235931
REFERENCE   4  (bases 1 to 2616)
  AUTHORS   Gonzalez-Barbosa,E., Mejia-Garcia,A., Bautista,E., Gonzalez,F.J.,
            Segovia,J. and Elizondo,G.
  TITLE     TCDD induces UbcH7 expression and synphilin-1 protein degradation
            in the mouse ventral midbrain
  JOURNAL   J Biochem Mol Toxicol 31 (10) (2017)
   PUBMED   28621812
REFERENCE   5  (bases 1 to 2616)
  AUTHORS   Eldridge,M.J.G., Sanchez-Garrido,J., Hoben,G.F., Goddard,P.J. and
            Shenoy,A.R.
  TITLE     The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1
            Target and Controls IL-1beta Secretion by Inflammasomes
  JOURNAL   Cell Rep 18 (5), 1285-1297 (2017)
   PUBMED   28147281
  REMARK    GeneRIF: UBE2L3 depletion increases pro-IL-1beta levels.
REFERENCE   6  (bases 1 to 2616)
  AUTHORS   Martinez-Noel,G., Niedenthal,R., Tamura,T. and Harbers,K.
  TITLE     A family of structurally related RING finger proteins interacts
            specifically with the ubiquitin-conjugating enzyme UbcM4
  JOURNAL   FEBS Lett 454 (3), 257-261 (1999)
   PUBMED   10431818
REFERENCE   7  (bases 1 to 2616)
  AUTHORS   Muller,U., Grams,A., Martinez-Noel,G., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Harbers,K.
  TITLE     Structure of the gene encoding the ubiquitin-conjugating enzyme
            Ubcm4, characterization of its promoter, and chromosomal location
  JOURNAL   Gene 224 (1-2), 109-116 (1998)
   PUBMED   9931461
REFERENCE   8  (bases 1 to 2616)
  AUTHORS   Harbers,K., Muller,U., Grams,A., Li,E., Jaenisch,R. and Franz,T.
  TITLE     Provirus integration into a gene encoding a ubiquitin-conjugating
            enzyme results in a placental defect and embryonic lethality
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12412-12417 (1996)
   PUBMED   8901595
REFERENCE   9  (bases 1 to 2616)
  AUTHORS   Matuschewski,K., Hauser,H.P., Treier,M. and Jentsch,S.
  TITLE     Identification of a novel family of ubiquitin-conjugating enzymes
            with distinct amino-terminal extensions
  JOURNAL   J Biol Chem 271 (5), 2789-2794 (1996)
   PUBMED   8576256
REFERENCE   10 (bases 1 to 2616)
  AUTHORS   Robinson,P.A., Leek,J.P., Thompson,J., Carr,I.M., Bailey,A.,
            Moynihan,T.P., Coletta,P.L., Lench,N.J. and Markham,A.F.
  TITLE     A human ubiquitin conjugating enzyme, L-UBC, maps in the
            Alzheimer's disease locus on chromosome 14q24.3
  JOURNAL   Mamm Genome 6 (10), 725-731 (1995)
   PUBMED   8563171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154667.2.
            
            On Mar 29, 2023 this sequence version replaced NM_009456.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049075.1, X97042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC154667.2         171052-171116       c
            66-161              AC154667.2         146029-146124       c
            162-348             AC154667.2         129607-129793       c
            349-2616            AC154667.2         121632-123899       c
FEATURES             Location/Qualifiers
     source          1..2616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.63 cM"
     gene            1..2616
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /note="ubiquitin-conjugating enzyme E2L 3"
                     /db_xref="GeneID:22195"
                     /db_xref="MGI:MGI:109240"
     exon            1..65
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..503
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /EC_number="2.3.2.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-conjugating enzyme 7; ubiquitin-protein ligase
                     L3; ubiquitin carrier protein L3; E2 ubiquitin-conjugating
                     enzyme L3"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 L3 isoform 1"
                     /protein_id="NP_033482.1"
                     /db_xref="CCDS:CCDS27997.1"
                     /db_xref="GeneID:22195"
                     /db_xref="MGI:MGI:109240"
                     /translation="MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNP
                     PYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTD
                     QVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD"
     exon            66..161
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /inference="alignment:Splign:2.1.0"
     exon            162..348
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /inference="alignment:Splign:2.1.0"
     exon            349..2616
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1624..1629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /note="hexamer: AATAAA"
     polyA_site      1655
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /note="hexamer: AATAAA"
     polyA_site      2616
                     /gene="Ube2l3"
                     /gene_synonym="Ubce7; UbcM4"
                     /note="major polyA site"
ORIGIN      
        1 gcgatgcatt ttgggaaagc agcagcacca gatccaagat ggcggccagc aggaggctga
       61 tgaaggagct tgaagagatc cgcaaatgtg gaatgaaaaa cttccgtaac atccaggttg
      121 atgaagctaa tttattgact tggcaagggc ttattgttcc tgacaaccct ccatatgata
      181 agggagcctt cagaattgaa atcaactttc cagcagagta tccattcaaa ccacccaaga
      241 tcacatttaa aacaaagatc taccacccta acatcgatga gaaggggcag gtctgtctgc
      301 cagtcattag tgctgaaaac tggaagccag ccaccaagac tgaccaagta atccagtccc
      361 tcatagcact ggtgaatgac ccccagcctg agcacccact ccgggctgac ctagctgaag
      421 aatactctaa ggaccgtaaa aaattctgta agaatgctga agagtttaca aagaaatatg
      481 gggaaaagcg acctgtggac taaaatctgc catgagtgat tccagcaagt ttgagcagag
      541 accccgagca gtgcattcag acaccccgca aagcaggact ctgtggaaat tgacacgtgc
      601 caccaactgg cgtccgcttg tggcagttac taactttcta cagttttctt aatcaaaagt
      661 ggtctaggta acctgtaaag aaggattaaa aaattcagat gttctagttc tgcttgcttt
      721 gttttaaaaa tcactgcttt agtctacttc aaaagaatgg catttctttt cttgcccaaa
      781 tttactcaaa gttgcagtta gcccagaagg tttaaagaaa aaggttgttg tggtttcttc
      841 ccccttcccc tctccccact tttcgattcc cacttccaca gaccaaggcc ccagctcccc
      901 acagaggtgg ccgcagcact gacaacgttt cctgtgccaa cactgcctgt gggtaatgag
      961 tagctcacgc accccattcc agcttagtga tgtctttaaa aaattataaa acagtatcaa
     1021 tgccctgtcc caaaggaaca tccatgcaaa caaagagaag ccgtctttac gtaaaatttt
     1081 agcaaagggt ttccacaata ataatagacc cgacagacag acccccatgg tccctatctg
     1141 tagtcagact gtgctggctg ggtctctgca gggaacctgt tatagcaggt ttgtggtgac
     1201 cttggaggga gggtctgcca gcagagaata cagtgcgctt gtgtgatgga cttctcacag
     1261 tcagcagccc ttcctgaagc tgtggtagac ctggtcatca cagaccaaaa aaaaaaaaaa
     1321 aggccagaat attcttttga aatttcaagc ttctctacca ccaagctctg ataggatgtg
     1381 ccaaggagag ctcccactcc tgagcacagc aggccaccac tgccaccctc ctcacggctt
     1441 accctcagcg gggtcagcca cgatggctct gcctctctca gagcagctgc tgggacagcc
     1501 caggaacagg gtggcttttc cctccctctg gactccaaac ctttccagtc cggctccact
     1561 tgaagctcac tcaatatcct ttcagtgtgt tttatattgt tttgattgcc ttttttttgt
     1621 agaaataaaa tttgagctta gaatttatca tcaaatgaac tctgtcaaga tttgaatgtt
     1681 aaatgtcttt tcaagggaag tgggacggac tgtccttgac gcagtagtga caccctgagg
     1741 aagctgatgg cctgactgcc catgttcacc aactcacttc tgctactagg ggtctaatcc
     1801 tgtggagaag attgcctcaa gaaaccttgc tttctgcttt aaccttagtt ctataacttc
     1861 cgggctacct aggcttacag acttgggaga cagctctggg ttttgcctat aaaagaagta
     1921 agacatgtcc tctcaggcag tgtaacacta tttagttttc caagtgtttg gctcctgtga
     1981 tgcataaatg aactatgctt tagttcaagt tatgcatggg gcaggtttct ggagacttcc
     2041 atatgcccag gatggtcaga gccctgggcc tgtgtttcta catctgtctc ttcattggca
     2101 gaaaagtgac aatggatttt atttcactca tattcagatt tgtaataaaa tgccaaactc
     2161 tgtcagaatt gtcgaagcaa accaccattt tgttcatgtt gcttttctga atctagagat
     2221 agtccagctg tctcattgct tagctctacc tgcctgttac ccgtcactgc tctctgctca
     2281 ctatgggagg gtactcttat gccagcagcc cctctcaggg actctcagcc ccattgttga
     2341 caaccatggc ctgccctgcc ttggagtcag tggtgtccct ctgggcttgc atgccttgtc
     2401 ctgtccagcc ctgccctgag caggctttga gcaaggtggc agggagacct gtggagcagc
     2461 cacccacgcc tgacccaagc tggctcagga atccacatcc ccctggttcc ttgaagtgcc
     2521 cgggtctcgt cctgctcttc ccacaatggc agagaatagg ctttctaaga tgctgtgacc
     2581 ccattctgtc cttaataaaa atgttctcag acatta
//
