LOCUS       NM_019803               1982 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2G 2 (Ube2g2), mRNA.
ACCESSION   NM_019803
VERSION     NM_019803.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1982)
  AUTHORS   Neupane,S., Berardinelli,S.J., Cameron,D.C., Grady,R.C.,
            Komatsu,D.E., Percival,C.J., Takeuchi,M., Ito,A., Liu,T.W.,
            Nairn,A.V., Moremen,K.W., Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats is essential for
            ECM remodeling and signaling during bone development
  JOURNAL   Matrix Biol 107, 77-96 (2022)
   PUBMED   35167946
REFERENCE   2  (bases 1 to 1982)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1982)
  AUTHORS   Liu,W., Shang,Y., Zeng,Y., Liu,C., Li,Y., Zhai,L., Wang,P., Lou,J.,
            Xu,P., Ye,Y. and Li,W.
  TITLE     Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins
            to form Lys48-linked ubiquitin chains
  JOURNAL   EMBO J 33 (1), 46-61 (2014)
   PUBMED   24366945
REFERENCE   4  (bases 1 to 1982)
  AUTHORS   Wei,J., Mialki,R.K., Dong,S., Khoo,A., Mallampalli,R.K., Zhao,Y.
            and Zhao,J.
  TITLE     A new mechanism of RhoA ubiquitination and degradation: roles of
            SCF(FBXL19) E3 ligase and Erk2
  JOURNAL   Biochim Biophys Acta 1833 (12), 2757-2764 (2013)
   PUBMED   23871831
REFERENCE   5  (bases 1 to 1982)
  AUTHORS   Coon,T.A., Glasser,J.R., Mallampalli,R.K. and Chen,B.B.
  TITLE     Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora
            A, causing mitotic arrest
  JOURNAL   Cell Cycle 11 (4), 721-729 (2012)
   PUBMED   22306998
REFERENCE   6  (bases 1 to 1982)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 1982)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 1982)
  AUTHORS   Fang,S., Ferrone,M., Yang,C., Jensen,J.P., Tiwari,S. and
            Weissman,A.M.
  TITLE     The tumor autocrine motility factor receptor, gp78, is a ubiquitin
            protein ligase implicated in degradation from the endoplasmic
            reticulum
  JOURNAL   Proc Natl Acad Sci U S A 98 (25), 14422-14427 (2001)
   PUBMED   11724934
REFERENCE   9  (bases 1 to 1982)
  AUTHORS   Tiwari,S. and Weissman,A.M.
  TITLE     Endoplasmic reticulum (ER)-associated degradation of T cell
            receptor subunits. Involvement of ER-associated
            ubiquitin-conjugating enzymes (E2s)
  JOURNAL   J Biol Chem 276 (19), 16193-16200 (2001)
   PUBMED   11278356
REFERENCE   10 (bases 1 to 1982)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC153864.5.
            
            On Nov 17, 2006 this sequence version replaced NM_019803.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010321.1, AK146554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC153864.5         93282-93377
            97-132              AC153864.5         101687-101722
            133-178             AC153864.5         101810-101855
            179-297             AC153864.5         112421-112539
            298-438             AC153864.5         114430-114570
            439-1982            AC153864.5         115408-116951
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1982
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /note="ubiquitin-conjugating enzyme E2G 2"
                     /db_xref="GeneID:22213"
                     /db_xref="MGI:MGI:1343188"
     exon            1..96
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..551
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-conjugating enzyme 7 homolog;
                     ubiquitin-protein ligase G2; ubiquitin carrier protein G2;
                     E2 ubiquitin-conjugating enzyme G2"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 G2"
                     /protein_id="NP_062777.2"
                     /db_xref="CCDS:CCDS56722.1"
                     /db_xref="GeneID:22213"
                     /db_xref="MGI:MGI:1343188"
                     /translation="MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGP
                     EDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMG
                     YESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQ
                     KSLGL"
     exon            97..132
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /inference="alignment:Splign:2.1.0"
     exon            133..178
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /inference="alignment:Splign:2.1.0"
     exon            179..297
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /inference="alignment:Splign:2.1.0"
     exon            298..438
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1982
                     /gene="Ube2g2"
                     /gene_synonym="1110003O05Rik; D10Xrf369; UBC7; Ubc7p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcggga ccggcgcgga tgtggcgagg ctgctgaacg caggttccgc ggtatggcgg
       61 ggacggcgtt gaagaggctg atggccgagt ataagcaatt aaccctgaat cctccagaag
      121 gaatcgtggc aggccccatg aatgaagaga atttttttga atgggaggca ttgatcatgg
      181 gccctgaaga cacttgtttt gagtttggtg tttttcccgc catcctgagt ttcccacttg
      241 actacccctt gagccctccg aagatgagat tcacctgtga gatgttccat cccaacatct
      301 atcctgatgg cagagtctgc atctccatcc tgcatgctcc aggtgatgat cccatgggtt
      361 atgagagcag tgccgagcgg tggagcccag tgcagagtgt ggagaagatc ctgctttctg
      421 ttgtgagcat gctggcagag cccaacgatg agagtggagc aaacgtagat gcttccaaga
      481 tgtggcggga tgaccgggag cagttctaca agatcgccaa gcagattgtc cagaagtctc
      541 tggggctctg aggctacccc tgtgcacact gagcactctg ctcgagaacc tgtggcgaca
      601 gcgctgccat gccaacacca acacaggcag tgcagagcca cagcccccgt tgtttcttcc
      661 tttccaccca agccaggcag ctccctagat catgactggg ataatgacag ctgctgcgct
      721 gctaaagact cctcctgctg tgttgtgtgc gcacctcagg gagggcccag gctgtcctca
      781 ctacctctct cagccatggg gtcctcacct ctgctccttc ctgcagtgcc gagggcctgt
      841 cctgttgtct gccagggact ggatactaat gctgctccct cttgggacat ggggccttgg
      901 aaaagcagtg caggcctgtt gtccctgcct ctcagttccc aggtgtccca ggaagcattt
      961 tgagcttctt ttgacacttt gcacttagaa gcctaggttg cctttggcat ggtgacagaa
     1021 gcttgctata tgagtcacag atgtcaccat agccccttcc aggggatgct ttgtaaatgg
     1081 gttcatgaga agaggggaca tgggtcagca agactgctgc tttttctggt tgcatccatg
     1141 tctgagttag tggtgcacac tcgaccgaca ggcgggactg tcagagcttt agtgtgggtc
     1201 tcctgggggc cctgcataca cactgcacca gggttagctc ttggattaga ttgttgttcg
     1261 ctgtcagggt tggagggaat ctgccactgg gtgctcagca gaggagctcc ttctgaactg
     1321 gatgggctgg ggagctgcta tggtgcaggc cagggtggag ggggtctgac agcaggacct
     1381 gctgagccac agggcccgag ccgaccccac aagcaataac agatgtggag tgcggtggat
     1441 gcttggcctt ttctaaacag gttacattta aacacgagtt tctattttta agatacagct
     1501 tatcaggggg tgtgtggccg atctcactgc gcattgtctg cttctgtccc atgcccacat
     1561 gtcagtggcc agcactgtgc atgtttcatg gtgttcatag ttcccagccc tggggctcca
     1621 gggggcacct gtgggcacct tgtgctttcc ttctcggggg agcccagtct gtttgaaacg
     1681 caacagagtc tggtgttggg aggtgcagga agggggttgt accgaaatag tattgcaggc
     1741 cactgagatg aaggcctctc tgtaaggaag tggtctgtgt ggggtgatgt ccacacacag
     1801 agtggtcaca gggcatgtcg ctgtcctcag gcctccctgg caagtgcggg aggaagagag
     1861 gcagtctctt tgcaaaacaa agtattttta ttcatttgta tttattaaat gaaaaaaaat
     1921 tctctgttgt ccctcttctg agatggactt taattgctgt taaataaaat tgtgtacctg
     1981 tc
//
