LOCUS       NM_009454               1562 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2E 3 (Ube2e3),
            transcript variant 1, mRNA.
ACCESSION   NM_009454 XM_912505 XM_922397 XM_922404
VERSION     NM_009454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   Chen BB, Coon TA, Glasser JR and Mallampalli RK.
  TITLE     Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase
            subunit, FBXL2, to regulate surfactant homeostasis
  JOURNAL   Mol Cell Biol 31 (9), 1905-1920 (2011)
   PUBMED   21343341
REFERENCE   2  (bases 1 to 1562)
  AUTHORS   Kong Q, Zeng W, Wu J, Hu W, Li C and Mao B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
REFERENCE   3  (bases 1 to 1562)
  AUTHORS   Plafker KS, Singer JD and Plafker SM.
  TITLE     The ubiquitin conjugating enzyme, UbcM2, engages in novel
            interactions with components of cullin-3 based E3 ligases
  JOURNAL   Biochemistry 48 (15), 3527-3537 (2009)
   PUBMED   19256485
REFERENCE   4  (bases 1 to 1562)
  AUTHORS   Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS,
            Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T and Scott
            HS.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   5  (bases 1 to 1562)
  AUTHORS   Bedard N, Hingamp P, Pang Z, Karaplis A, Morales C, Trasler J, Cyr
            D, Gagnon C and Wing SS.
  TITLE     Mice lacking the UBC4-testis gene have a delay in postnatal testis
            development but normal spermatogenesis and fertility
  JOURNAL   Mol Cell Biol 25 (15), 6346-6354 (2005)
   PUBMED   16024774
  REMARK    GeneRIF: UBC4-testis isoform plays a role in early maturation of
            the testis
REFERENCE   6  (bases 1 to 1562)
  AUTHORS   Plafker SM and Macara IG.
  TITLE     Importin-11, a nuclear import receptor for the
            ubiquitin-conjugating enzyme, UbcM2
  JOURNAL   EMBO J 19 (20), 5502-5513 (2000)
   PUBMED   11032817
REFERENCE   7  (bases 1 to 1562)
  AUTHORS   Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S and Weissman AM.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   8  (bases 1 to 1562)
  AUTHORS   Pestov DG, Grzeszkiewicz TM and Lau LF.
  TITLE     Isolation of growth suppressors from a cDNA expression library
  JOURNAL   Oncogene 17 (24), 3187-3197 (1998)
   PUBMED   9872334
REFERENCE   9  (bases 1 to 1562)
  AUTHORS   Harbers K, Muller U, Grams A, Li E, Jaenisch R and Franz T.
  TITLE     Provirus integration into a gene encoding a ubiquitin-conjugating
            enzyme results in a placental defect and embryonic lethality
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12412-12417 (1996)
   PUBMED   8901595
REFERENCE   10 (bases 1 to 1562)
  AUTHORS   Matuschewski K, Hauser HP, Treier M and Jentsch S.
  TITLE     Identification of a novel family of ubiquitin-conjugating enzymes
            with distinct amino-terminal extensions
  JOURNAL   J Biol Chem 271 (5), 2789-2794 (1996)
   PUBMED   8576256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC011477.1.
            
            [WARNING] On May 11, 2023 this sequence was replaced by
            NM_009454.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_912505.1, XM_922397.1, XM_922404.1, NM_009454.1.
            
            Transcript Variant: This variant (1), as well as variant 2, is a
            protein-coding variant. Variants 1 and 2 both encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011477.1, AK168072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..1562
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /note="ubiquitin-conjugating enzyme E2E 3"
                     /db_xref="GeneID:22193"
                     /db_xref="MGI:MGI:107412"
     exon            1..359
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..581
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1011
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /EC_number="2.3.2.23"
                     /note="ubiquitin-conjugating enzyme 4; ubiquitin-protein
                     ligase E3; ubiquitin carrier protein E3;
                     ubiquitin-conjugating enzyme E2-23 kDa;
                     ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog; E2
                     ubiquitin-conjugating enzyme E3"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 E3"
                     /protein_id="NP_033480.1"
                     /db_xref="CCDS:CCDS16167.1"
                     /db_xref="GeneID:22193"
                     /db_xref="MGI:MGI:107412"
                     /translation="MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQ
                     QKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPG
                     SVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTIS
                     KVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT"
     exon            582..632
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..765
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..913
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1539
                     /gene="Ube2e3"
                     /gene_synonym="Ubce4; ubcM2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgctgact gcgcgaccgg gaggagccga gccgagccga gccgagcgca gcggcgggag
       61 gctgagcgcg cggggggctc ccgcgtccct gcgccttcgc cttcggccgg cagagcgccc
      121 accccaccgt ggctcccgga gcgcggggcg gcgccaccct ccggccgcag cgcggcactg
      181 cacggccgcc tgcgactttc gatgttccac actcccgggc cggagcctcg gcggcggctt
      241 cttttcccgc ccccccggtg ccccccccag gctgcctcca tttcctcaag gaaggttcct
      301 cggcgctctc cctcccccac agcgtagcgg cgcacgagcg ggccgggcgg gcggccgaga
      361 agttttccca gagataagtt caccaagatg tccagtgaca ggcaaaggtc ggatgatgag
      421 agccctagca ccagcagtgg cagttcagat gcagatcagc gagaccctgc cgctccagag
      481 cccgaggaac aggaagaaag aaaaccttct gccacccagc agaagaaaaa caccaaactc
      541 tctagcaaaa cgactgctaa gttatccact agtgctaaaa gaattcagaa ggagctagca
      601 gagataaccc ttgatcctcc tcctaactgc agtgctgggc ctaaaggaga taacatttat
      661 gaatggaggt caactatact tggtccacca ggttctgtat atgaaggtgg tgtttttttt
      721 ctggatatca cattttcttc agattatcca tttaagccac caaaggttac tttccgtacc
      781 agaatctatc actgcaacat caacagtcag ggagtcatct gcctggatat tctgaaagac
      841 aactggagtc ctgctttgac tatttcaaag gttttgctct ctatttgttc ccttttgaca
      901 gattgcaacc ctgcggatcc tctggtcgga agcatagcca ctcagtattt gaccaacaga
      961 gcagaacatg acaggatagc cagacagtgg accaagagat acgcaacata attcacatca
     1021 tttgtatgca gtgtgaagga gcagaaggcc tcttcccact gtgctgcgga tctttatagc
     1081 ctttacaata cggacttctg tgtatatgtt atactgattc tactcttgtc tttatccttt
     1141 ggagactggg agactccccc aaaaggtaaa agctaccaag agtagaactt tgtagctgta
     1201 gattagttat gtttaaaatg cctacttgca agtcttgctt ctttgggata tcaaaatgta
     1261 ttttgtgatg tactaaggat actggtcctg aagtctacca aatattatag tgcattttag
     1321 cctaattcat tatctgtatg aagttataaa agtagctgta gatgactagg aattatgtca
     1381 tttgtattaa gcccagatct atttctgagt atgtggttca tgctgttgtg aaatgtttta
     1441 cctttgtcag tttgtaatga gaggatttcc ttctaccctt tgtagctcag agagcactga
     1501 tgtatcatct caaacacaat aaacatgctc ctgaaggcaa aaaaaaaaaa aaaaaaaaaa
     1561 aa
//
