LOCUS       NM_009455               1386 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2E 1 (Ube2e1), mRNA.
ACCESSION   NM_009455 XM_906354
VERSION     NM_009455.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1386)
  AUTHORS   Pasupala,N., Morrow,M.E., Que,L.T., Malynn,B.A., Ma,A. and
            Wolberger,C.
  TITLE     OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating
            enzyme UBE2E1 by preventing its autoubiquitination
  JOURNAL   J Biol Chem 293 (47), 18285-18295 (2018)
   PUBMED   30282802
  REMARK    GeneRIF: OTUB1 depletion dramatically destabilizes the
            E2-conjugating enzyme UBE2E1 in both mouse and human OTUB1 knockout
            cell lines.
REFERENCE   2  (bases 1 to 1386)
  AUTHORS   Han,X., Gui,B., Xiong,C., Zhao,L., Liang,J., Sun,L., Yang,X.,
            Yu,W., Si,W., Yan,R., Yi,X., Zhang,D., Li,W., Li,L., Yang,J.,
            Wang,Y., Sun,Y.E., Zhang,D., Meng,A. and Shang,Y.
  TITLE     Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking
            system in neural development
  JOURNAL   Mol Cell 55 (3), 482-494 (2014)
   PUBMED   25018020
REFERENCE   3  (bases 1 to 1386)
  AUTHORS   Yanjiang,X., Hongjuan,H., Tiantian,G., Yan,Z., Zhijun,H. and
            Qiong,W.
  TITLE     Expression patterns of ubiquitin conjugating enzyme UbcM2 during
            mouse embryonic development
  JOURNAL   Gene Expr 15 (4), 163-170 (2012)
   PUBMED   22783725
  REMARK    GeneRIF: UbcM2 may play potential roles in the development of mouse
            diverse tissues and organs, particularly in the development of
            brain and skeleton.
REFERENCE   4  (bases 1 to 1386)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
REFERENCE   5  (bases 1 to 1386)
  AUTHORS   Plafker,K.S., Singer,J.D. and Plafker,S.M.
  TITLE     The ubiquitin conjugating enzyme, UbcM2, engages in novel
            interactions with components of cullin-3 based E3 ligases
  JOURNAL   Biochemistry 48 (15), 3527-3537 (2009)
   PUBMED   19256485
  REMARK    GeneRIF: UbcM2, in concert with substrate adaptors, engages
            activated cullin3 ligases, thus suggesting that class III ubiquitin
            conjugating enzymes are novel regulators of cullin ligases.
REFERENCE   6  (bases 1 to 1386)
  AUTHORS   Hu,Y., Nguyen,T.T., Bui,K.C., Demello,D.E. and Smith,J.B.
  TITLE     A novel inflammation-induced ubiquitin E3 ligase in alveolar type
            II cells
  JOURNAL   Biochem Biophys Res Commun 333 (1), 253-263 (2005)
   PUBMED   15936721
REFERENCE   7  (bases 1 to 1386)
  AUTHORS   Plafker,S.M. and Macara,I.G.
  TITLE     Ribosomal protein L12 uses a distinct nuclear import pathway
            mediated by importin 11
  JOURNAL   Mol Cell Biol 22 (4), 1266-1275 (2002)
   PUBMED   11809816
REFERENCE   8  (bases 1 to 1386)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   9  (bases 1 to 1386)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   10 (bases 1 to 1386)
  AUTHORS   Matuschewski,K., Hauser,H.P., Treier,M. and Jentsch,S.
  TITLE     Identification of a novel family of ubiquitin-conjugating enzymes
            with distinct amino-terminal extensions
  JOURNAL   J Biol Chem 271 (5), 2789-2794 (1996)
   PUBMED   8576256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK090177.1.
            
            On Apr 6, 2007 this sequence version replaced NM_009455.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090177.1, SRR1660815.440688.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1386              AK090177.1         2-1387
FEATURES             Location/Qualifiers
     source          1..1386
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..1386
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /note="ubiquitin-conjugating enzyme E2E 1"
                     /db_xref="GeneID:22194"
                     /db_xref="MGI:MGI:107411"
     exon            1..158
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /inference="alignment:Splign:2.1.0"
     exon            159..343
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..773
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="ubiquitin-conjugating enzyme 5; ubiquitin-protein
                     ligase E1; ubiquitin carrier protein E1;
                     ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog; E2
                     ubiquitin-conjugating enzyme E1; (E3-independent) E2
                     ubiquitin-conjugating enzyme E1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 E1"
                     /protein_id="NP_033481.1"
                     /db_xref="CCDS:CCDS26837.1"
                     /db_xref="GeneID:22194"
                     /db_xref="MGI:MGI:107411"
                     /translation="MSDDDSRASTSSSSSSSSNQQTEKEGSTPKKKESKVSMSKNSKL
                     LSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITF
                     TPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCN
                     PADPLVGSIATQYMTNRAEHDRMARQWTKRYAT"
     exon            344..394
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /inference="alignment:Splign:2.1.0"
     exon            395..527
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..675
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1386
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1386
                     /gene="Ube2e1"
                     /gene_synonym="Ubce5; ubcM2; UbcM3"
                     /note="putative"
ORIGIN      
        1 ggagcgtgtg cggccgggga agccattgcc tggttaatag ttgctgttgc tgcacttccg
       61 cttctctccc agtgagagcg agacacgagt ggccaggccc agtcgcagcc gcagcagcag
      121 ccgcggcggc ggcacggagc agccagacac aaagagaggg gccgttcgcg gggtggggtg
      181 gggggttcgc tatgtcggat gacgattcga gggccagcac cagctcctcg tcatcttcgt
      241 cctccaacca gcagaccgag aaagaaggca gcacccccaa gaagaaggag agtaaagtca
      301 gcatgagcaa aaattcgaag cttctctcca ccagcgctaa gaggatccag aaggagctgg
      361 cagacatcac tttagaccct ccgccaaact gcagtgctgg tcccaagggt gacaacatct
      421 atgagtggag atcaaccatt ctgggtcctc cagggtctgt gtatgaaggt ggagtattct
      481 tccttgacat tacttttaca ccagagtatc ctttcaagcc tccaaaggtt acatttcgta
      541 caagaattta tcactgtaat attaatagcc aaggagttat ttgcttggac atattgaaag
      601 acaactggag cccagcccta accatctcga aagtcctcct ttctatctgc tcactcctta
      661 cagactgcaa tcctgctgac cctttggtgg gaagtattgc cactcagtac atgaccaaca
      721 gagcagaaca cgacagaatg gccagacagt ggaccaagag atacgctaca taaactgggt
      781 tttcagttct tacatgactt gtctgtcaca gaagagagct gcttatgatt ttgaaagggt
      841 gggggtggga gttggtaaag agtaggctat ttctatatca gatattattc agtcttactt
      901 cccaggattt tgttgtaact taaggtatct tgctacagta gacaaactgg taatagcgac
      961 ttttagagct gaaactttgc aagattagct gacttttagt acaaaagaaa gcatgtgtag
     1021 atacttgtgt tccattgatc agcttaaatt tgtataggta catgtcattt atgtaaagtc
     1081 ctattttctt gttcaaaaaa aatggaattt gtttttcctt cttaaaagga aacaatggta
     1141 tttaacaagt ttgcaaagat gagtttgtta cctcgtatat gtaaaatgga cacctggcta
     1201 caagacacca tgtagttaat gtattttatc ttatatgcaa attacttcaa gggttgaatc
     1261 acaatttgtg gaaacctgta gtgaaatacc ttaagctgtt aactgtaagt gtggaatagg
     1321 aattgttcag tcaattggtt tagacttctt acgtctgcat ttgtgctaat aaacaatatt
     1381 aagaac
//
