LOCUS       NM_025356               3713 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2D 3 (Ube2d3),
            transcript variant 1, mRNA.
ACCESSION   NM_025356
VERSION     NM_025356.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3713)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3713)
  AUTHORS   Yang,M., Wang,Y., He,L., Shi,X. and Huang,S.
  TITLE     Comprehensive bioinformatics analysis reveals the role of
            cuproptosis-related gene Ube2d3 in myocardial infarction
  JOURNAL   Front Immunol 15, 1353111 (2024)
   PUBMED   38440726
  REMARK    GeneRIF: Comprehensive bioinformatics analysis reveals the role of
            cuproptosis-related gene Ube2d3 in myocardial infarction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3713)
  AUTHORS   Roman-Trufero,M., Ito,C.M., Pedebos,C., Magdalou,I., Wang,Y.F.,
            Karimi,M.M., Moyon,B., Webster,Z., di Gregorio,A., Azuara,V.,
            Khalid,S., Speck,C., Rodriguez,T. and Dillon,N.
  TITLE     Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin
            Signaling via Phosphoregulation of the E2 Enzyme UBE2D3
  JOURNAL   Mol Biol Evol 37 (7), 1986-2001 (2020)
   PUBMED   32145025
  REMARK    GeneRIF: Evolution of an Amniote-Specific Mechanism for Modulating
            Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3.
REFERENCE   4  (bases 1 to 3713)
  AUTHORS   Shi,Y., Yuan,B., Zhu,W., Zhang,R., Li,L., Hao,X., Chen,S. and
            Hou,F.
  TITLE     Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation
            in antiviral innate immunity
  JOURNAL   Nat Commun 8, 15138 (2017)
   PUBMED   28469175
  REMARK    GeneRIF: Together with Riplet, Ube2D3 promotes covalent conjugation
            of polyubiquitin chains to RIG-I, while Ube2N preferentially
            facilitates production of unanchored chains. In the presence of
            these chains, RIG-I induces MAVS aggregation directly on the
            mitochondria. Data thus reveal two essential mechanisms underlying
            the activation of RIG-I and MAVS for triggering innate immune
            signaling in response to viral infection in cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3713)
  AUTHORS   Frangini,A., Sjoberg,M., Roman-Trufero,M., Dharmalingam,G.,
            Haberle,V., Bartke,T., Lenhard,B., Malumbres,M., Vidal,M. and
            Dillon,N.
  TITLE     The aurora B kinase and the polycomb protein ring1B combine to
            regulate active promoters in quiescent lymphocytes
  JOURNAL   Mol Cell 51 (5), 647-661 (2013)
   PUBMED   24034696
REFERENCE   6  (bases 1 to 3713)
  AUTHORS   Shembade,N., Pujari,R., Harhaj,N.S., Abbott,D.W. and Harhaj,E.W.
  TITLE     The kinase IKKalpha inhibits activation of the transcription factor
            NF-kappaB by phosphorylating the regulatory molecule TAX1BP1
  JOURNAL   Nat Immunol 12 (9), 834-843 (2011)
   PUBMED   21765415
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3713)
  AUTHORS   Tokunaga,F., Sakata,S., Saeki,Y., Satomi,Y., Kirisako,T., Kamei,K.,
            Nakagawa,T., Kato,M., Murata,S., Yamaoka,S., Yamamoto,M., Akira,S.,
            Takao,T., Tanaka,K. and Iwai,K.
  TITLE     Involvement of linear polyubiquitylation of NEMO in NF-kappaB
            activation
  JOURNAL   Nat Cell Biol 11 (2), 123-132 (2009)
   PUBMED   19136968
REFERENCE   8  (bases 1 to 3713)
  AUTHORS   Ohbayashi,N., Okada,K., Kawakami,S., Togi,S., Sato,N., Ikeda,O.,
            Kamitani,S., Muromoto,R., Sekine,Y., Kawai,T., Akira,S. and
            Matsuda,T.
  TITLE     Physical and functional interactions between ZIP kinase and UbcH5
  JOURNAL   Biochem Biophys Res Commun 372 (4), 708-712 (2008)
   PUBMED   18515077
REFERENCE   9  (bases 1 to 3713)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 3713)
  AUTHORS   Kedar,V., McDonough,H., Arya,R., Li,H.H., Rockman,H.A. and
            Patterson,C.
  TITLE     Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that
            degrades cardiac troponin I
  JOURNAL   Proc Natl Acad Sci U S A 101 (52), 18135-18140 (2004)
   PUBMED   15601779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156618.5 and AK153111.1.
            
            On Oct 12, 2017 this sequence version replaced NM_025356.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.44625.1, AK049906.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC156618.5         130338-130374
            38-1557             AK153111.1         2-1521
            1558-3713           AC156618.5         157696-159851
FEATURES             Location/Qualifiers
     source          1..3713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.56 cM"
     gene            1..3713
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /note="ubiquitin-conjugating enzyme E2D 3"
                     /db_xref="GeneID:66105"
                     /db_xref="MGI:MGI:1913355"
     exon            1..164
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            165..319
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..739
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-protein ligase D3; ubiquitin-conjugating enzyme
                     E2D 3 (UBC4/5 homolog, yeast); ubiquitin carrier protein
                     D3; ubiquitin-conjugating enzyme E2-17 kDa 3;
                     ubiquitin-conjugating enzyme E2(17)KB 3; E2
                     ubiquitin-conjugating enzyme D3; (E3-independent) E2
                     ubiquitin-conjugating enzyme D3"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 D3 isoform 1"
                     /protein_id="NP_079632.1"
                     /db_xref="CCDS:CCDS38644.1"
                     /db_xref="GeneID:66105"
                     /db_xref="MGI:MGI:1913355"
                     /translation="MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSP
                     YQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKV
                     LLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM"
     exon            320..383
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..415
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            416..493
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..599
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..693
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..3713
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2174
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /note="major polyA site"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2679
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /note="major polyA site"
     regulatory      3675..3680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3697
                     /gene="Ube2d3"
                     /gene_synonym="1100001F19Rik; 9430029A22Rik"
ORIGIN      
        1 gaataggcgg ggggaggggc ggagcgtggc agctggcagt agttccgtca gagcggacat
       61 cttgtggctg tgccgtgcgc gtgagccccg tagggccggg gaggcaccag ctgccgcgcg
      121 gggaggaggc cgaggccgca gctcgaggga ggccccggcc ctctgcgcct gtgtctggca
      181 gagccggtgt gagaagaaga gacaaccctt ccccgccgcc gggataatca agaattttgg
      241 ccggaccttt gagtacacct cgggatagtg aggagcccgg cgaaaagcac agactatggc
      301 gctgaaacgg attaataagg aacttagtga tttggcccgt gaccctccag cacaatgttc
      361 tgcaggtcca gttggagatg acatgtttca ttggcaagcc acaattatgg gacctaatga
      421 cagcccatat caaggtggtg tattcttttt gacaattcat tttcctacag actacccctt
      481 caaaccacct aaggttgcat ttacaacaag aatttatcat ccaaatatta acagtaatgg
      541 cagcatttgt cttgatattc taagatcaca gtggtctcct gctttaacta tttctaaagt
      601 tcttttatcc atttgttcac tgctatgtga tccaaaccca gacgaccccc tagtgccaga
      661 gattgcacgg atctataaaa cagacagaga taagtacaac agaatatctc gggaatggac
      721 tcagaagtat gccatgtgat gctaccttac agtcagaata acctgcatta tagctggaat
      781 aaactttaaa ttactgttcc ttttttgatt ttcttatccg gctgctcccc tatcagacct
      841 catctttttt aattttattt tttgtttacc tccctccatt cattcacatg ctcatctgag
      901 aagacttaag ttcttccagc tttggacaat aactgctttt agaaactgta aagtagttac
      961 acgagaacag ttgcccaaga ttcagaaatt tttttaaaaa ctggagcatg tgtattatgt
     1021 ggccaatgtc ttcactctaa cttggttatg agactaaacc aatcctcact gctctaacat
     1081 gctgaagaag ccatctgagg gggagggaga tggatgctca gctgtcacat caaaggaagc
     1141 agcattattc tagcagcatc cgttcttgtt taaaccttcc actgttagag gtttgaggtt
     1201 acatgatata ctttatgctc ataactgatg tggctggaga attggtattg aattatagca
     1261 tcagcagaac agaaaatgtg atgtatttta tgcatgtcaa taaaggaatg acctgttctt
     1321 gttctacaga gaatggaaat tggaagtcaa acaccctttg tattccaaaa tagggtctca
     1381 aaacattttg taattttcat ttaaattgtt aggaggcttg gagctattag ttaatctatc
     1441 ttccaatact gtttaatata gcactgaata aatgatgcga gttgtcaatg gatgagtgat
     1501 caactaatag ctctcctagt aattgattta tttttcttca ataaagttgc ataaaccaat
     1561 gagttagctg cctggattaa tcagtatggg aaacaatcct ttgtaaatgc aaagctgttt
     1621 ttgtatatac tgttgggatt tgcttcattg tttgacatca aatgatgatg taaagttcaa
     1681 aagagtgaat atattgccat gttcagttaa aatgcacagt ctgttacagg ttgacacatt
     1741 gcttgacctg atttatgcag aattaataag ctattcaaat agtgtagctt taatacgctg
     1801 cacatgattc tggcagccct agagttcata aatggacttg ggactcagca gttttgaaac
     1861 gtgtatatgg agtttaagaa atttattttc caggtgcatc cccttctaac taaaattttc
     1921 ttcatcttgt acacttaaca gctgaaaaag atatatatat atataaaact tgggagtaat
     1981 aatgggtcaa aatttacaaa ataaagtact gttttggtgt gggagttgtc atgaggctgt
     2041 gttgaagtga cttaactgtg ggatattgac tatccattga gatggatttg ttcagccatt
     2101 tacattaatg agcatttaaa tgcaacagat catttcgggt gacttaacat gaatgaataa
     2161 aaaagtcaat gctattggat tgtttgacaa gtgctatctg tgccactaaa tcttatgtag
     2221 taataagggc attaccattt ttcacccaag ttctgaacct gtagtttgac acctttttct
     2281 agctttgatt tctccattgc tttcttagtc ttgtatttga tttctagcac atgtgatgtt
     2341 cacttccata ttttgcactg cttatattta cgtgcaatct tattccttgt ccgcacacag
     2401 atgtggaaag ctagaaataa atgtaaaagc ttaatttttt ataaacattt aaatatgtaa
     2461 tttggacatg atttgttact taaggttctt taaactggaa gtgaagtgca tgccttctga
     2521 agatgttctg gctttattct gtaataagta tttacattgg aaaataccaa tttcgctata
     2581 cagttttttt tccacacacc cattttacct tttgcttaaa ttgtgggttc ttcagggtta
     2641 atgtcacgct aattaataaa acttttgggt tcaaatcaag tgttcccaca agggtaagaa
     2701 cagtattctt tgactcttaa aaagtccttt ctgagacctg tactcaaaac agctttatta
     2761 ggcctgtgtc gtgaaagcca gatatgacaa acatttttac aaagcagtgg atctctagtt
     2821 ggctttcaaa ttcctcccat ctaccacctt tggtatttac agagatgacg tccttaaacc
     2881 attgtcagaa ttaatgggta tgtccagttc tctttatctt tgacttgatg ctttatacaa
     2941 catttcatat gtcgcttcta agggaataag ccatagaggc ttctccaggt ttaagagaac
     3001 agagtacctg gaaaaccaac attctgaatg tatagacact ggactggact tgaggtcacc
     3061 tatgatgagg tttttaaaag aatctaagaa tttgctctct acccttccca gtagtgtgtg
     3121 gcatcactag tgctgggtat aggactaaag tgagtattag gttgaatatt gttgtagagt
     3181 atttgtgtgt cctatacctc ttaatgcata aattcctaaa tttaaacatg tctttagagt
     3241 ccagttggcc tgtcaatggt gaatttcctt ttgatttttt cttgggcagg tttgcaatgt
     3301 gataatcaga ttttttttta actgattata gattgtttcc ttgtgtgggt gtactcacat
     3361 ttaaaagtat gaaccacggt taactagtgg tctcaggggt agtgaaacac tcacttttta
     3421 tttactgggt tagttgaagt attcttaaga cactgatcat gctgtgttcg tgatttgggg
     3481 ggtgggtaat actaaaatta gtcatgtttt gtgttcacat aacaaaactg ttcaatgact
     3541 gttggttaca cttttaagtg aatttgtctc ctattttatg aggaacccaa tgcaagtcac
     3601 taaatgtctt aatagtgaca tctgcataag acttgtaata gctaaagtta attgagctta
     3661 aaggaattgt taccattaaa gtctgtgttt aaacacactt tggtcttact cag
//
