LOCUS       NM_145420               1448 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2D 1 (Ube2d1), mRNA.
ACCESSION   NM_145420
VERSION     NM_145420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Xiao Y, Qiao G, Tang J, Tang R, Guo H, Warwar S, Langdon WY, Tao L
            and Zhang J.
  TITLE     Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by
            Controlling Cbl-b Degradation
  JOURNAL   J Immunol 195 (9), 4218-4227 (2015)
   PUBMED   26416283
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Wei J, Mialki RK, Dong S, Khoo A, Mallampalli RK, Zhao Y and Zhao
            J.
  TITLE     A new mechanism of RhoA ubiquitination and degradation: roles of
            SCF(FBXL19) E3 ligase and Erk2
  JOURNAL   Biochim Biophys Acta 1833 (12), 2757-2764 (2013)
   PUBMED   23871831
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Starita LM, Pruneda JN, Lo RS, Fowler DM, Kim HJ, Hiatt JB,
            Shendure J, Brzovic PS, Fields S and Klevit RE.
  TITLE     Activity-enhancing mutations in an E3 ubiquitin ligase identified
            by high-throughput mutagenesis
  JOURNAL   Proc Natl Acad Sci U S A 110 (14), E1263-E1272 (2013)
   PUBMED   23509263
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR and
            MacKintosh C.
  TITLE     ZNRF2 is released from membranes by growth factors and, together
            with ZNRF1, regulates the Na+/K+ATPase
  JOURNAL   J Cell Sci 125 (Pt 19), 4662-4675 (2012)
   PUBMED   22797923
  REMARK    Erratum:[J Cell Sci. 2022 Mar 15;135(6):. PMID: 35267011]
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Tokumoto M and Satoh M.
  TITLE     [Cadmium induces p53-dependent apoptosis through the inhibition of
            Ube2d family gene expression]
  JOURNAL   Nihon Eiseigaku Zasshi 67 (4), 472-477 (2012)
   PUBMED   23095357
  REMARK    GeneRIF: Its gene expression is inhibited through p53 dependent
            apoptosis, which is induced by cadmium exposure.(review)
            Review article
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K,
            Deshayes K, Fairbrother WJ and Vucic D.
  TITLE     c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor
            alpha (TNFalpha)-induced NF-kappaB activation
  JOURNAL   J Biol Chem 283 (36), 24295-24299 (2008)
   PUBMED   18621737
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Ohbayashi N, Okada K, Kawakami S, Togi S, Sato N, Ikeda O, Kamitani
            S, Muromoto R, Sekine Y, Kawai T, Akira S and Matsuda T.
  TITLE     Physical and functional interactions between ZIP kinase and UbcH5
  JOURNAL   Biochem Biophys Res Commun 372 (4), 708-712 (2008)
   PUBMED   18515077
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Brooks WS, Helton ES, Banerjee S, Venable M, Johnson L, Schoeb TR,
            Kesterson RA and Crawford DF.
  TITLE     G2E3 is a dual function ubiquitin ligase required for early
            embryonic development
  JOURNAL   J Biol Chem 283 (32), 22304-22315 (2008)
   PUBMED   18511420
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Knutson M, Menzies S, Connor J and Wessling-Resnick M.
  TITLE     Developmental, regional, and cellular expression of SFT/UbcH5A and
            DMT1 mRNA in brain
  JOURNAL   J Neurosci Res 76 (5), 633-641 (2004)
   PUBMED   15139022
  REMARK    GeneRIF: significantly elevated levels of SFT/UbcH5A mRNA in the
            neonatal mouse and its localization to choroid plexus suggest that
            this factor may contribute to the rapid rate of brain iron uptake
            that occurs in the early postnatal period
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Perissi V, Aggarwal A, Glass CK, Rose DW and Rosenfeld MG.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY111155.1, AK148364.1 and AI836420.1.
            
            [WARNING] On May 15, 2023 this sequence was replaced by
            NM_145420.3.
            
            On Jun 20, 2009 this sequence version replaced NM_145420.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019464.1, AK148364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY111155.1         2-14
            14-1428             AK148364.1         2-1416
            1429-1448           AI836420.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10"
     gene            1..1448
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /note="ubiquitin-conjugating enzyme E2D 1"
                     /db_xref="GeneID:216080"
                     /db_xref="MGI:MGI:2384911"
     exon            1..162
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..582
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="E2(17)KB 1; ubiquitin-protein ligase D1; ubiquitin
                     carrier protein D1; ubiquitin-conjugating enzyme E2-17 kDa
                     1; ubiquitin-conjugating enzyme E2(17)KB 1;
                     ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog; E2
                     ubiquitin-conjugating enzyme D1; (E3-independent) E2
                     ubiquitin-conjugating enzyme D1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 D1"
                     /protein_id="NP_663395.1"
                     /db_xref="CCDS:CCDS35933.1"
                     /db_xref="GeneID:216080"
                     /db_xref="MGI:MGI:2384911"
                     /translation="MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSA
                     YQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKV
                     LLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM"
     exon            163..226
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
     exon            227..258
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
     exon            259..336
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
     exon            337..442
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
     exon            443..536
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1431
                     /gene="Ube2d1"
                     /gene_synonym="UBCH5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaagcgaa ggcggaaaca aaagagtccg gcgccgccgc ccgcacactc gcgcaccgcg
       61 cccgggcgca cacggagcag ccctgcgagg cggcagcccg ggacacgcgg acactccgca
      121 gcccccgccg cctgccccat ggcgctgaag cggatccaga aagaattaag tgatttacag
      181 cgtgatccac ctgcccactg ctcagcggga cccgtgggag atgacttgtt ccactggcaa
      241 gcaaccatca tggggccccc tgacagcgcc tatcaaggtg gagtcttctt cctcactgtc
      301 cactttccga cagactatcc ctttaaacca ccaaagattg ctttcacaac aaaaatctac
      361 cacccaaata taaacagcaa cgggagtatt tgtcttgaca tcctgaggtc ccagtggtcg
      421 cccgctttga ctgtatcgaa agtcttgctg tccatatgct cgctgctctg tgatcctaat
      481 ccagacgatc ccttagtacc agatattgca cagatctata aatcagacaa agaaaaatac
      541 aacaggcacg caagagaatg gactcagaaa tatgcaatgt aaagtttcaa acactttcac
      601 ttacgccaga gtactgtaaa atctatgtct tttccagcgt tagcattaag ccgggcgccg
      661 tttgccgtgt ccttcgttcc acgagccctt tggtttttac tcattttaag tgtgtttctg
      721 aagcaagaca aaacaaactt ccaagaatac cctggaaact ctgctgagag catttagtat
      781 tctgtgctca ttgaagagga cctttctttc ggtttccgag acacttggac cccctgcatc
      841 tccagcaaga tctgtgacgt gactgagaaa gcaaccagac gcttttcttt ctctgaaacg
      901 agacgttttt cacccgagaa acattgtatg tgccgtccaa gatgtcgtca cttttataca
      961 tctggattca gatctcattc ttcgttagct cactttataa tttgtatttt tttactgtat
     1021 agactaaata tattctatgt caactcctga ctcctcctcc ccacccccat cccccgtgaa
     1081 cagtattgaa gctcccaaca gctgatgatg aattaactgc ccccgcccct tgtcttagca
     1141 tattctgtgg gttgaatgcg tatttcttaa accggaactg atctgcacac tgtatttctc
     1201 agtatactga ttagaatgga gaaacacttg tttgggtttt attgtacttg acttaacttt
     1261 attgcaatgt gaattaattg cactgttagg taggaaggtg tgtgactttt ttttgttgtt
     1321 gctcttcacc tttgaccttt ttttttttct gtataggcaa tattatattg acacctttta
     1381 cagatctgac tgtagccttt tccatataaa taaaatgctt tttctactat taaaaaaaaa
     1441 aaaaaaaa
//
