LOCUS       NM_026785                931 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus ubiquitin-conjugating enzyme E2C (Ube2c), mRNA.
ACCESSION   NM_026785
VERSION     NM_026785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 931)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   2  (bases 1 to 931)
  AUTHORS   Wang,L., Zhao,S., Wang,Y., Liu,J. and Wang,X.
  TITLE     UBE2C promotes the proliferation of acute myeloid leukemia cells
            through PI3K/AKT activation
  JOURNAL   BMC Cancer 24 (1), 497 (2024)
   PUBMED   38637730
  REMARK    GeneRIF: UBE2C promotes the proliferation of acute myeloid leukemia
            cells through PI3K/AKT activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 931)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 931)
  AUTHORS   Yamanaka,T., Kurosawa,M., Yoshida,A., Shimogori,T., Hiyama,A.,
            Maity,S.N., Hattori,N., Matsui,H. and Nukina,N.
  TITLE     The transcription factor NF-YA is crucial for neural progenitor
            maintenance during brain development
  JOURNAL   J Biol Chem 300 (2), 105629 (2024)
   PUBMED   38199563
REFERENCE   5  (bases 1 to 931)
  AUTHORS   Zhao,R., Liu,Y., Wang,Z., Zhang,J., Zhang,W., Zhou,X.,
            Tsedendorj,S., Enkhtur,A., Feng,D. and Wang,H.
  TITLE     UBE2C-mediated Autophagy Inhibition via Ubiquitination of SIRT1
            Contributes to Endometrial Cancer Progression
  JOURNAL   Mol Cancer Res 21 (6), 564-577 (2023)
   PUBMED   36930831
  REMARK    GeneRIF: UBE2C-mediated Autophagy Inhibition via Ubiquitination of
            SIRT1 Contributes to Endometrial Cancer Progression.
REFERENCE   6  (bases 1 to 931)
  AUTHORS   Li,S.Z., Song,Y., Zhang,H.H., Jin,B.X., Liu,Y., Liu,W.B.,
            Zhang,X.D. and Du,R.L.
  TITLE     UbcH10 overexpression increases carcinogenesis and blocks ALLN
            susceptibility in colorectal cancer
  JOURNAL   Sci Rep 4, 6910 (2014)
   PUBMED   25376843
  REMARK    GeneRIF: UbcH10 overexpression increases carcinogenesis and blocks
            ALLN susceptibility in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 931)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 931)
  AUTHORS   van Ree,J.H., Jeganathan,K.B., Malureanu,L. and van Deursen,J.M.
  TITLE     Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes
            chromosome missegregation and tumor formation
  JOURNAL   J Cell Biol 188 (1), 83-100 (2010)
   PUBMED   20065091
  REMARK    GeneRIF: results identify UbcH10 as a prominent protooncogene that
            causes whole chromosome instability and tumor formation over a wide
            gradient of overexpression levels
REFERENCE   9  (bases 1 to 931)
  AUTHORS   Trimarchi,J.M., Stadler,M.B. and Cepko,C.L.
  TITLE     Individual retinal progenitor cells display extensive heterogeneity
            of gene expression
  JOURNAL   PLoS One 3 (2), e1588 (2008)
   PUBMED   18270576
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 931)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003722.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026785.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003722.1, BU514529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-931               AK003722.1         2-932
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.27 cM"
     gene            1..931
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /note="ubiquitin-conjugating enzyme E2C"
                     /db_xref="GeneID:68612"
                     /db_xref="MGI:MGI:1915862"
     exon            1..152
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..591
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="ubcH10; ubiquitin-protein ligase C; ubiquitin
                     carrier protein C; E2 ubiquitin-conjugating enzyme C;
                     (E3-independent) E2 ubiquitin-conjugating enzyme C"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 C"
                     /protein_id="NP_081061.1"
                     /db_xref="CCDS:CCDS17055.1"
                     /db_xref="GeneID:68612"
                     /db_xref="MGI:MGI:1915862"
                     /translation="MASQNRDPAAASVAAVRKGAEPCGGAARGPVGKRLQQELMILMT
                     SGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPC
                     YHPNVDTQGNICLDILKDKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPT
                     AFKKYLQETYSKQVSSQDP"
     exon            153..180
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /inference="alignment:Splign:2.1.0"
     exon            181..267
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /inference="alignment:Splign:2.1.0"
     exon            268..472
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /inference="alignment:Splign:2.1.0"
     exon            473..532
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /inference="alignment:Splign:2.1.0"
     exon            533..931
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      931
                     /gene="Ube2c"
                     /gene_synonym="1110015A16Rik; D2Ertd695e"
                     /note="putative"
ORIGIN      
        1 gcagttgccc tttcctctcc acactcctgt ctcggtgcca gtacctctgg gatggcctca
       61 caaaaccgcg acccagctgc tgccagcgtt gccgcggttc gaaaaggagc cgagccctgc
      121 gggggcgccg cccgaggccc tgtgggcaag cggctacagc aggaactgat gatcctcatg
      181 acatctggtg acaaaggaat ctccgccttc cctgagtcag acaacctgtt caagtgggtg
      241 gggaccatcc acggagcagc cggcaccgta tatgaagacc tgaggtacaa actctcccta
      301 gagttcccca gcggctaccc ttacaacgca cccacagtga agttcctcac accctgctac
      361 caccccaacg tggacaccca gggcaacatc tgcctggaca tcctcaagga taagtggtct
      421 gcactatatg atgtcaggac tatcttgctc tctatccaga gcctgctagg agaacccaac
      481 atcgatagcc ctttgaacac acacgctgcg gaactctgga aaaaccccac agcatttaag
      541 aaatacctgc aagaaaccta ttcaaagcag gtctccagcc aagatccctg atgcaagctg
      601 gccgccctgc ccctcttttg tgttgtcttt tttcttagac tatctgtcct ttctccttga
      661 tttctaaact atgttatttt tgttttgttt cgtttttaaa ttaagtctgc ttgactagcc
      721 gggcgtggtg gcgctcgcct ttaatcccag cactcgggag gcagaggcag gcggatttct
      781 gagttcaagg ccaacctggt ctacaaagta agctccagga cagccagggc tatacagaga
      841 aaccctgtct cgaaaaacaa aaaataaata aattaagtct gcttgaaccc ttaacaatgt
      901 atattaaata aatacacatt gattgttttg t
//
