LOCUS       NM_023137                947 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ubiquitin D (Ubd), mRNA.
ACCESSION   NM_023137
VERSION     NM_023137.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Clavreul,L., Bernard,L., Cotte,A.K., Hennuyer,N., Bourouh,C.,
            Devos,C., Helleboid,A., Haas,J.T., Verrijken,A., Gheeraert,C.,
            Derudas,B., Guille,L., Chevalier,J., Eeckhoute,J., Vallez,E.,
            Dorchies,E., Van Gaal,L., Lassailly,G., Francque,S., Staels,B. and
            Paumelle,R.
  TITLE     The ubiquitin-like modifier FAT10 is induced in MASLD and impairs
            the lipid-regulatory activity of PPARalpha
  JOURNAL   Metabolism 151, 155720 (2024)
   PUBMED   37926201
  REMARK    GeneRIF: The ubiquitin-like modifier FAT10 is induced in MASLD and
            impairs the lipid-regulatory activity of PPARalpha.
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Brockmann,F., Catone,N., Wunsch,C., Offensperger,F., Scheffner,M.,
            Schmidtke,G. and Aichem,A.
  TITLE     FAT10 and NUB1L cooperate to activate the 26S proteasome
  JOURNAL   Life Sci Alliance 6 (8), e202201463 (2023)
   PUBMED   37188463
  REMARK    GeneRIF: FAT10 and NUB1L cooperate to activate the 26S proteasome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 947)
  AUTHORS   Chen,C., Li,X., Zhou,T., Su,Y., Yu,B., Jin,J., Xie,J., Shen,Y.,
            Wan,R. and Hong,K.
  TITLE     Ubiquitin like protein FAT10 repressed cardiac fibrosis after
            myocardial ischemic via mediating degradation of Smad3 dependent on
            FAT10-proteasome system
  JOURNAL   Int J Biol Sci 19 (3), 881-896 (2023)
   PUBMED   36778114
  REMARK    GeneRIF: Ubiquitin like protein FAT10 repressed cardiac fibrosis
            after myocardial ischemic via mediating degradation of Smad3
            dependent on FAT10-proteasome system.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 947)
  AUTHORS   Zhao,L., Liu,D., Zhong,C., Tang,S., Li,X., Zhu,M. and Li,C.
  TITLE     Evaluating the role of Ubiquitin D gene expression in types of
            leukemia
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (9), 125-128 (2022)
   PUBMED   36905264
  REMARK    GeneRIF: Evaluating the role of Ubiquitin D gene expression in
            types of leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 947)
  AUTHORS   Ross,M.J., Wosnitzer,M.S., Ross,M.D., Granelli,B., Gusella,G.L.,
            Husain,M., Kaufman,L., Vasievich,M., D'Agati,V.D., Wilson,P.D.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     Role of ubiquitin-like protein FAT10 in epithelial apoptosis in
            renal disease
  JOURNAL   J Am Soc Nephrol 17 (4), 996-1004 (2006)
   PUBMED   16495380
  REMARK    GeneRIF: Immunohistochemical studies demonstrated increased FAT10
            expression in a model of HIV-associated nephropathy.
REFERENCE   7  (bases 1 to 947)
  AUTHORS   Raasi,S., Schmidtke,G. and Groettrup,M.
  TITLE     The ubiquitin-like protein FAT10 forms covalent conjugates and
            induces apoptosis
  JOURNAL   J Biol Chem 276 (38), 35334-35343 (2001)
   PUBMED   11445583
REFERENCE   8  (bases 1 to 947)
  AUTHORS   Blanchette,P., Gilchrist,C.A., Baker,R.T. and Gray,D.A.
  TITLE     Association of UNP, a ubiquitin-specific protease, with the pocket
            proteins pRb, p107 and p130
  JOURNAL   Oncogene 20 (39), 5533-5537 (2001)
   PUBMED   11571651
REFERENCE   9  (bases 1 to 947)
  AUTHORS   Raasi,S., Schmidtke,G., de Giuli,R. and Groettrup,M.
  TITLE     A ubiquitin-like protein which is synergistically inducible by
            interferon-gamma and tumor necrosis factor-alpha
  JOURNAL   Eur J Immunol 29 (12), 4030-4036 (1999)
   PUBMED   10602013
REFERENCE   10 (bases 1 to 947)
  AUTHORS   Liu,Y.C., Pan,J., Zhang,C., Fan,W., Collinge,M., Bender,J.R. and
            Weissman,S.M.
  TITLE     A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to
            the spindle assembly checkpoint protein MAD2
  JOURNAL   Proc Natl Acad Sci U S A 96 (8), 4313-4318 (1999)
   PUBMED   10200259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008116.1, AK008552.1 and BF661521.1.
            
            On Dec 8, 2009 this sequence version replaced NM_023137.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008552.1, AK008116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AK008116.1         2-284
            284-832             AK008552.1         257-805
            833-947             BF661521.1         163-277
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..947
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /note="ubiquitin D"
                     /db_xref="GeneID:24108"
                     /db_xref="MGI:MGI:1344410"
     exon            1..81
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..549
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /note="ubiquitin-like protein FAT10; Diubiquitin"
                     /codon_start=1
                     /product="ubiquitin D"
                     /protein_id="NP_075626.1"
                     /db_xref="CCDS:CCDS28737.1"
                     /db_xref="GeneID:24108"
                     /db_xref="MGI:MGI:1344410"
                     /translation="MASVRTCVVRSDQWRLMTFETTENDKVKKINEHIRSQTKVSVQD
                     QILLLDSKILKPHRKLSSYGIDKETTIHLTLKVVKPSDEELPLFLVESKNEGQRHLLR
                     VRRSSSVAQVKEMIESVTSVIPKKQVVNCNGKKLEDGKIMADYNIKSGSLLFLTTHCT
                     GG"
     exon            82..937
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      671..676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /note="hexamer: ATTAAA"
     polyA_site      694
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /note="major polyA site"
     regulatory      914..919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /note="hexamer: AATAAA"
     polyA_site      932
                     /gene="Ubd"
                     /gene_synonym="FAT10"
                     /note="major polyA site"
ORIGIN      
        1 agctactcac atataagcag acacaaggac tcttttctta ttcagcctct gactacagac
       61 atggcttctg tccgcacctg tgttgtccgt tcagaccaat ggcggttaat gacctttgag
      121 accactgaga atgacaaagt gaagaagata aatgaacata ttaggtccca aaccaaggtc
      181 tctgtacagg accagatcct tctgctagac tccaaaatcc tcaagcccca tcgaaaattg
      241 tcatcctatg ggattgacaa ggaaaccact atccacctta ccctgaaggt ggtgaagccc
      301 agtgatgaag agctgccctt gtttctggtg gagtccaaaa acgaggggca aaggcacctc
      361 ctccgagttc gaagatccag ctcagtggcc caggtgaaag agatgatcga gagtgtgacc
      421 tctgtgatcc ctaagaagca ggttgtgaat tgcaacggaa agaagctgga agatggaaag
      481 atcatggctg actacaacat caagagtggc agtttgctct ttctgacaac acactgcact
      541 gggggatgac cacggggatg cggtgatgag aagctcaaag ccgatttcct ctgagctatt
      601 accaatcaca tctcttgatg atataaaaaa ttaacgagaa tgaaataaat atttgaggga
      661 agtggagtag attaaaagta tttgtcaagt ctgtgaatct tgtttctaac atagttcatt
      721 cgcagggttg ttgatgaggg caaaagctga acctttagtc aggtgtggtg gtgcaaactt
      781 aattccagga cttgggatgc aggggaaggt ggatcaatga atgattgttg aaccaaattg
      841 aattttaatt atagagtata gagaaagaat gtgttatgga atatgattgt ttaccataac
      901 tggatcatag tctaataaat tatttaaatt cagtcataaa aaaaaaa
//
