LOCUS       NM_011664               1165 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus ubiquitin B (Ubb), transcript variant 1, mRNA.
ACCESSION   NM_011664
VERSION     NM_011664.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1165)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 1165)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   3  (bases 1 to 1165)
  AUTHORS   Pinson,M.R., Chung,D.D., Mahnke,A.H., Salem,N.A., Osorio,D.,
            Nair,V., Payne,E.A., Del Real,J.J., Cai,J.J. and Miranda,R.C.
  TITLE     Gag-like proteins: Novel mediators of prenatal alcohol exposure in
            neural development
  JOURNAL   Alcohol Clin Exp Res 46 (4), 556-569 (2022)
   PUBMED   35187673
REFERENCE   4  (bases 1 to 1165)
  AUTHORS   Park,C.W., Jung,B.K. and Ryu,K.Y.
  TITLE     Disruption of the polyubiquitin gene Ubb reduces the self-renewal
            capacity of neural stem cells
  JOURNAL   Biochem Biophys Res Commun 527 (2), 372-378 (2020)
   PUBMED   32321641
  REMARK    GeneRIF: Disruption of the polyubiquitin gene Ubb reduces the
            self-renewal capacity of neural stem cells.
REFERENCE   5  (bases 1 to 1165)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1165)
  AUTHORS   Ishiguro,T., Nakajima,M., Naito,M., Muto,T. and Tsuruo,T.
  TITLE     Identification of genes differentially expressed in B16 murine
            melanoma sublines with different metastatic potentials
  JOURNAL   Cancer Res 56 (4), 875-879 (1996)
   PUBMED   8631027
REFERENCE   7  (bases 1 to 1165)
  AUTHORS   Voss,G.C. and Jockusch,H.
  TITLE     Genetic mapping of members of the polyubiquitin gene subfamily
            coding for UbB
  JOURNAL   Mamm Genome 7 (2), 169 (1996)
   PUBMED   8835546
REFERENCE   8  (bases 1 to 1165)
  AUTHORS   Finch,J.S., St John,T., Krieg,P., Bonham,K., Smith,H.T., Fried,V.A.
            and Bowden,G.T.
  TITLE     Overexpression of three ubiquitin genes in mouse epidermal tumors
            is associated with enhanced cellular proliferation and stress
  JOURNAL   Cell Growth Differ 3 (5), 269-278 (1992)
   PUBMED   1321656
  REMARK    Erratum:[Cell Growth Differ 1992 Aug;3(8):566]
REFERENCE   9  (bases 1 to 1165)
  AUTHORS   Finch,J.S., Bonham,K., Krieg,P. and Bowden,G.T.
  TITLE     Murine polyubiquitin mRNA sequence
  JOURNAL   Nucleic Acids Res 18 (7), 1907 (1990)
   PUBMED   2159627
REFERENCE   10 (bases 1 to 1165)
  AUTHORS   Melber,K., Krieg,P., Furstenberger,G. and Marks,F.
  TITLE     Molecular cloning of sequences activated during multi-stage
            carcinogenesis in mouse skin
  JOURNAL   Carcinogenesis 7 (2), 317-322 (1986)
   PUBMED   3004776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596181.10.
            
            On Jul 8, 2022 this sequence version replaced NM_011664.4.
            
            Summary: This gene encodes ubiquitin, one of the most conserved
            proteins known. Ubiquitin has a major role in targeting cellular
            proteins for degradation by the 26S proteosome. It is also involved
            in the maintenance of chromatin structure, the regulation of gene
            expression, and the stress response. Ubiquitin is synthesized as a
            precursor protein consisting of either polyubiquitin chains or a
            single ubiquitin moiety fused to an unrelated protein. This gene
            consists of four direct repeats of the ubiquitin coding sequence
            with no spacer sequence. Consequently, the protein is expressed as
            a polyubiquitin precursor with a final amino acid after the last
            repeat. Pseudogenes of this gene are located on chromosomes 3 and
            14. Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100341.1, AK010413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL596181.10        122556-122648       c
            94-1165             AL596181.10        120940-122011       c
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.46 cM"
     gene            1..1165
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /note="ubiquitin B"
                     /db_xref="GeneID:22187"
                     /db_xref="MGI:MGI:98888"
     exon            1..93
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1165
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1017
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /note="Polyubiquitin-B"
                     /codon_start=1
                     /product="polyubiquitin-B precursor"
                     /protein_id="NP_035794.1"
                     /db_xref="CCDS:CCDS24826.1"
                     /db_xref="GeneID:22187"
                     /db_xref="MGI:MGI:98888"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENV
                     KAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTL
                     TGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST
                     LHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGK
                     QLEDGRTLSDYNIQKESTLHLVLRLRGGY"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /note="major polyA site"
ORIGIN      
        1 cagtgacgag aggctttgtc cggttcggcg gtctttctgt gagggtgttt cgacgcgctg
       61 ggcggtttgt gctttcatca catttgttaa caggtcaaaa tgcagatctt cgtgaagacc
      121 ctgaccggca agaccatcac cctagaggtg gagcccagtg acaccatcga gaacgtgaag
      181 gccaagatcc aggataaaga gggcatcccc cctgaccagc agaggctgat ctttgccggc
      241 aagcagctgg aagatggccg caccctctct gattacaaca tccagaagga gtcaaccctg
      301 cacctggtcc ttcgcctgag aggtggcatg cagatcttcg tgaagaccct gaccggcaag
      361 accatcaccc tggaggtgga gcccagtgac accatcgaga acgtgaaggc caagatccag
      421 gataaagagg gcatcccccc tgaccagcag aggctgatct ttgccggcaa gcagctggaa
      481 gatggccgca ccctctctga ttacaacatc cagaaagagt caaccctgca cctggtcctc
      541 cgtctgaggg gtggcatgca gatcttcgtg aagaccctga ctggcaagac catcaccctg
      601 gaggtggagc ccagtgacac catcgagaac gtgaaggcca agatccagga taaagagggc
      661 atcccccctg accagcagag gctgatcttt gccggcaagc agctggaaga tggccgcacc
      721 ctctctgatt acaacatcca gaaggagtca accctgcacc tggtccttcg cctgagaggt
      781 ggcatgcaga tcttcgtgaa gaccctgacc ggcaagacca tcaccttgga ggtggagccc
      841 agtgacacca tcgagaatgt gaaggccaag atccaggata aagagggcat cccccctgac
      901 cagcagaggc tgatctttgc cggcaagcag ctagaagatg gccgcactct ctctgattac
      961 aacatccaga aagagtcgac cctgcacctg gtcctccgtc tgaggggtgg ctattaatta
     1021 ttcggtctgc attcccagtg ggcagtgatg gcattactct gcactctagc cacttgcccc
     1081 aatttaagtt tagaaattac aagtttcaat aatagctgaa cctctgttaa aaaatgttaa
     1141 taaaggtttt gttgcatggt aagca
//
