LOCUS       NP_035794                305 aa            linear   ROD 01-MAY-2025
DEFINITION  polyubiquitin-B precursor [Mus musculus].
ACCESSION   NP_035794
VERSION     NP_035794.1
DBSOURCE    REFSEQ: accession NM_011664.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 305)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (residues 1 to 305)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   3  (residues 1 to 305)
  AUTHORS   Pinson,M.R., Chung,D.D., Mahnke,A.H., Salem,N.A., Osorio,D.,
            Nair,V., Payne,E.A., Del Real,J.J., Cai,J.J. and Miranda,R.C.
  TITLE     Gag-like proteins: Novel mediators of prenatal alcohol exposure in
            neural development
  JOURNAL   Alcohol Clin Exp Res 46 (4), 556-569 (2022)
   PUBMED   35187673
REFERENCE   4  (residues 1 to 305)
  AUTHORS   Park,C.W., Jung,B.K. and Ryu,K.Y.
  TITLE     Disruption of the polyubiquitin gene Ubb reduces the self-renewal
            capacity of neural stem cells
  JOURNAL   Biochem Biophys Res Commun 527 (2), 372-378 (2020)
   PUBMED   32321641
  REMARK    GeneRIF: Disruption of the polyubiquitin gene Ubb reduces the
            self-renewal capacity of neural stem cells.
REFERENCE   5  (residues 1 to 305)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 305)
  AUTHORS   Ishiguro,T., Nakajima,M., Naito,M., Muto,T. and Tsuruo,T.
  TITLE     Identification of genes differentially expressed in B16 murine
            melanoma sublines with different metastatic potentials
  JOURNAL   Cancer Res 56 (4), 875-879 (1996)
   PUBMED   8631027
REFERENCE   7  (residues 1 to 305)
  AUTHORS   Voss,G.C. and Jockusch,H.
  TITLE     Genetic mapping of members of the polyubiquitin gene subfamily
            coding for UbB
  JOURNAL   Mamm Genome 7 (2), 169 (1996)
   PUBMED   8835546
REFERENCE   8  (residues 1 to 305)
  AUTHORS   Finch,J.S., St John,T., Krieg,P., Bonham,K., Smith,H.T., Fried,V.A.
            and Bowden,G.T.
  TITLE     Overexpression of three ubiquitin genes in mouse epidermal tumors
            is associated with enhanced cellular proliferation and stress
  JOURNAL   Cell Growth Differ 3 (5), 269-278 (1992)
   PUBMED   1321656
  REMARK    Erratum:[Cell Growth Differ 1992 Aug;3(8):566]
REFERENCE   9  (residues 1 to 305)
  AUTHORS   Finch,J.S., Bonham,K., Krieg,P. and Bowden,G.T.
  TITLE     Murine polyubiquitin mRNA sequence
  JOURNAL   Nucleic Acids Res 18 (7), 1907 (1990)
   PUBMED   2159627
REFERENCE   10 (residues 1 to 305)
  AUTHORS   Melber,K., Krieg,P., Furstenberger,G. and Marks,F.
  TITLE     Molecular cloning of sequences activated during multi-stage
            carcinogenesis in mouse skin
  JOURNAL   Carcinogenesis 7 (2), 317-322 (1986)
   PUBMED   3004776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596181.10.
            
            Summary: This gene encodes ubiquitin, one of the most conserved
            proteins known. Ubiquitin has a major role in targeting cellular
            proteins for degradation by the 26S proteosome. It is also involved
            in the maintenance of chromatin structure, the regulation of gene
            expression, and the stress response. Ubiquitin is synthesized as a
            precursor protein consisting of either polyubiquitin chains or a
            single ubiquitin moiety fused to an unrelated protein. This gene
            consists of four direct repeats of the ubiquitin coding sequence
            with no spacer sequence. Consequently, the protein is expressed as
            a polyubiquitin precursor with a final amino acid after the last
            repeat. Pseudogenes of this gene are located on chromosomes 3 and
            14. Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100341.1, AK010413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.46 cM"
     Protein         1..305
                     /product="polyubiquitin-B precursor"
                     /note="Polyubiquitin-B"
                     /calculated_mol_wt=34237
     mat_peptide     1..76
                     /product="Ubiquitin. /id=PRO_0000114801"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CG49.1)"
                     /calculated_mol_wt=8565
     Region          1..76
                     /region_name="Ubl_ubiquitin"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin;
                     cd01803"
                     /db_xref="CDD:340501"
     Site            order(6..9,11,34..37,40,42,44,46..49,68..76)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:340501"
     Site            order(8..12,31..35,40,42,44,46..49,68,70..76)
                     /site_type="other"
                     /note="E1 interaction site [polypeptide binding]"
                     /db_xref="CDD:340501"
     Site            54
                     /site_type="other"
                     /note="Interacts with activating enzyme; propagated from
                     UniProtKB/Swiss-Prot (P0CG49.1)"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PINK1.
                     /evidence=ECO:0000250|UniProtKB:P0CG47; propagated from
                     UniProtKB/Swiss-Prot (P0CG49.1)"
     Site            68
                     /site_type="other"
                     /note="Essential for function; propagated from
                     UniProtKB/Swiss-Prot (P0CG49.1)"
     Site            72
                     /site_type="other"
                     /note="Interacts with activating enzyme; propagated from
                     UniProtKB/Swiss-Prot (P0CG49.1)"
     mat_peptide     77..152
                     /product="Ubiquitin. /id=PRO_0000396188"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CG49.1)"
                     /calculated_mol_wt=8565
     Region          77..152
                     /region_name="Ubl_ubiquitin"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin;
                     cd01803"
                     /db_xref="CDD:340501"
     Site            order(82..85,87,110..113,116,118,120,122..125,144..152)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:340501"
     Site            order(84..88,107..111,116,118,120,122..125,144,146..152)
                     /site_type="other"
                     /note="E1 interaction site [polypeptide binding]"
                     /db_xref="CDD:340501"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P0CG47; propagated from
                     UniProtKB/Swiss-Prot (P0CG49.1)"
     mat_peptide     153..228
                     /product="Ubiquitin. /id=PRO_0000396189"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CG49.1)"
                     /calculated_mol_wt=8565
     Region          153..228
                     /region_name="Ubl_ubiquitin"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin;
                     cd01803"
                     /db_xref="CDD:340501"
     Site            order(158..161,163,186..189,192,194,196,198..201,220..228)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:340501"
     Site            order(160..164,183..187,192,194,196,198..201,220,222..228)
                     /site_type="other"
                     /note="E1 interaction site [polypeptide binding]"
                     /db_xref="CDD:340501"
     mat_peptide     229..304
                     /product="Ubiquitin. /id=PRO_0000396190"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CG49.1)"
                     /calculated_mol_wt=8565
     Region          229..304
                     /region_name="Ubl_ubiquitin"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin;
                     cd01803"
                     /db_xref="CDD:340501"
     Site            order(234..237,239,262..265,268,270,272,274..277,296..304)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:340501"
     Site            order(236..240,259..263,268,270,272,274..277,296,298..304)
                     /site_type="other"
                     /note="E1 interaction site [polypeptide binding]"
                     /db_xref="CDD:340501"
     CDS             1..305
                     /gene="Ubb"
                     /gene_synonym="Rps27a; Uba52; Ubb2; Ubc"
                     /coded_by="NM_011664.5:100..1017"
                     /db_xref="CCDS:CCDS24826.1"
                     /db_xref="GeneID:22187"
                     /db_xref="MGI:MGI:98888"
ORIGIN      
        1 mqifvktltg ktitleveps dtienvkaki qdkegippdq qrlifagkql edgrtlsdyn
       61 iqkestlhlv lrlrggmqif vktltgktit levepsdtie nvkakiqdke gippdqqrli
      121 fagkqledgr tlsdyniqke stlhlvlrlr ggmqifvktl tgktitleve psdtienvka
      181 kiqdkegipp dqqrlifagk qledgrtlsd yniqkestlh lvlrlrggmq ifvktltgkt
      241 itlevepsdt ienvkakiqd kegippdqqr lifagkqled grtlsdyniq kestlhlvlr
      301 lrggy
//
