LOCUS       NM_176860               3826 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ubiquitin associated and SH3 domain containing, B
            (Ubash3b), transcript variant 1, mRNA.
ACCESSION   NM_176860 XM_916233
VERSION     NM_176860.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3826)
  AUTHORS   Tsai,Y.L., Arias-Badia,M., Kadlecek,T.A., Lwin,Y.M., Srinath,A.,
            Shah,N.H., Wang,Z.E., Barber,D., Kuriyan,J., Fong,L. and Weiss,A.
  TITLE     TCR signaling promotes formation of an STS1-Cbl-b complex with
            pH-sensitive phosphatase activity that suppresses T cell function
            in acidic environments
  JOURNAL   Immunity 56 (12), 2682-2698 (2023)
   PUBMED   38091950
REFERENCE   2  (bases 1 to 3826)
  AUTHORS   Yin,Y., Frank,D., Zhou,W., Kaur,N., French,J.B. and Carpino,N.
  TITLE     An unexpected 2-histidine phosphoesterase activity of suppressor of
            T-cell receptor signaling protein 1 contributes to the suppression
            of cell signaling
  JOURNAL   J Biol Chem 295 (25), 8514-8523 (2020)
   PUBMED   32371395
REFERENCE   3  (bases 1 to 3826)
  AUTHORS   Frank,D., Naseem,S., Russo,G.L., Li,C., Parashar,K., Konopka,J.B.
            and Carpino,N.
  TITLE     Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced
            Antifungal Response to Candida albicans
  JOURNAL   mBio 9 (4), e00782-18 (2018)
   PUBMED   30018105
  REMARK    GeneRIF: Bone marrow-derived dendritic cells (BMDCs) lacking
            Protein Tyrosine Phosphatase Sts-1 expression have an enhanced
            ability to inhibit Candida albicans growth and contribute
            significantly to the resistance of Sts-/- mice. Within BMDCs, the
            Sts phosphatases negatively regulate the activation of select
            pathways downstream of the key fungal pathogen pattern recognition
            receptor Dectin-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3826)
  AUTHORS   Zhou,Y., Abraham,S., Renna,S., Edelstein,L.C., Dangelmaier,C.A.,
            Tsygankov,A.Y., Kunapuli,S.P., Bray,P.F. and McKenzie,S.E.
  TITLE     TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc
            Receptor for IgG IIA (FcgammaRIIA) Signaling Pathway and
            Heparin-Induced Thrombocytopenia in Mice
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (12), 2315-2323 (2016)
   PUBMED   27765766
  REMARK    GeneRIF: The absence of TULA-2 and also the relative level of
            TULA-2 expression modulates FcgammaRIIA-mediated platelet
            reactivity and heparin-induced thrombocytopenia in vivo.
REFERENCE   5  (bases 1 to 3826)
  AUTHORS   Reppschlager,K., Gosselin,J., Dangelmaier,C.A., Thomas,D.H.,
            Carpino,N., McKenzie,S.E., Kunapuli,S.P. and Tsygankov,A.Y.
  TITLE     TULA-2 Protein Phosphatase Suppresses Activation of Syk through the
            GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346,
            a Regulatory Site of Syk
  JOURNAL   J Biol Chem 291 (43), 22427-22441 (2016)
   PUBMED   27609517
  REMARK    GeneRIF: dephosphorylation of Tyr(P)(346) may be considered an
            important 'checkpoint' in the regulation of Syk activation process.
            Putative biological functions of TULA-2-mediated dephosphorylation
            of Tyr(P)(346) may include deactivation of receptor-activated Syk
            or suppression of Syk activation by suboptimal stimulation.
            Erratum:[J Biol Chem. 2017 Mar 10;292(10):4360. doi:
            10.1074/jbc.A116.743732.. PMID: 28283589]
REFERENCE   6  (bases 1 to 3826)
  AUTHORS   Mikhailik,A., Ford,B., Keller,J., Chen,Y., Nassar,N. and Carpino,N.
  TITLE     A phosphatase activity of Sts-1 contributes to the suppression of
            TCR signaling
  JOURNAL   Mol Cell 27 (3), 486-497 (2007)
   PUBMED   17679096
REFERENCE   7  (bases 1 to 3826)
  AUTHORS   Kim,Y.K., Choi,H.Y., Kim,N.H., Lee,W., Seo,D.W., Kang,D.W.,
            Lee,H.Y., Han,J.W., Park,S.W. and Kim,S.N.
  TITLE     Reversine stimulates adipocyte differentiation and downregulates
            Akt and p70(s6k) signaling pathways in 3T3-L1 cells
  JOURNAL   Biochem Biophys Res Commun 358 (2), 553-558 (2007)
   PUBMED   17490611
  REMARK    GeneRIF: Taken together, our data clearly demonstrate the ability
            of reversine to stimulate adipocyte differentiation, which is
            independent of the Akt and p70(s6k) signaling pathways.
REFERENCE   8  (bases 1 to 3826)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3826)
  AUTHORS   Carpino,N., Turner,S., Mekala,D., Takahashi,Y., Zang,H.,
            Geiger,T.L., Doherty,P. and Ihle,J.N.
  TITLE     Regulation of ZAP-70 activation and TCR signaling by two related
            proteins, Sts-1 and Sts-2
  JOURNAL   Immunity 20 (1), 37-46 (2004)
   PUBMED   14738763
REFERENCE   10 (bases 1 to 3826)
  AUTHORS   Carpino,N., Kobayashi,R., Zang,H., Takahashi,Y., Jou,S.T., Feng,J.,
            Nakajima,H. and Ihle,J.N.
  TITLE     Identification, cDNA cloning, and targeted deletion of p70, a
            novel, ubiquitously expressed SH3 domain-containing protein
  JOURNAL   Mol Cell Biol 22 (21), 7491-7500 (2002)
   PUBMED   12370296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150909.1, AK035764.1 and AC159820.2.
            
            On Oct 27, 2017 this sequence version replaced NM_176860.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154576.1, AK150909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               AK150909.1         1-568
            569-2643            AK035764.1         2-2076
            2644-3826           AC159820.2         136134-137316       c
FEATURES             Location/Qualifiers
     source          1..3826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 21.84 cM"
     gene            1..3826
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /note="ubiquitin associated and SH3 domain containing, B"
                     /db_xref="GeneID:72828"
                     /db_xref="MGI:MGI:1920078"
     exon            1..764
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..2553
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-associated and SH3 domain-containing protein B;
                     cbl-interacting protein p70; suppressor of T-cell receptor
                     signaling 1; T-cell ubiquitin ligand 2; tyrosine-protein
                     phosphatase STS1/TULA2"
                     /codon_start=1
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein B isoform 1"
                     /protein_id="NP_789830.1"
                     /db_xref="CCDS:CCDS23085.1"
                     /db_xref="GeneID:72828"
                     /db_xref="MGI:MGI:1920078"
                     /translation="MAAREELYSKVTPRRDRLQRPGTVKHGSALDVLLSMGFPRARAQ
                     KALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQ
                     ICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSN
                     FIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEK
                     LAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYSPQNDDELELVPGDFIFMSPME
                     QTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSYSILNTVSSSSLAFGDG
                     ALERRQYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYW
                     LSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNT
                     VIDHVYCSPSLRCVQTAHNILKGLQQDNHLKIRVEPGLFEWTKWVAGSTLPAWIPPSE
                     LAAANLSVDTTYRPHIPVSKLAISESYDTYINRSFQVTKEIISECKSKGNNILIVAHA
                     SSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHG
                     PTGGFNWRETLLQE"
     exon            765..818
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1005
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1204
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1374
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1583
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1716
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1837
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1960
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2053
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2198
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2305
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2415
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..3826
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3798..3803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /note="hexamer: AATAAA"
     polyA_site      3820
                     /gene="Ubash3b"
                     /gene_synonym="2810457I06Rik; p70; STS-1; TULA-2"
                     /note="major polyA site"
ORIGIN      
        1 gggtcttatg gcttagcctt ctggacctct cctccatccg tgcagagggt ttccattact
       61 gacctcgcca atgatcaaat gaaacgtgaa atgggctatt ctgaagcccg gaggcccaga
      121 tggatcgata tgcaagccaa gggcagagct acggctctgc gaatccaagc acactggcct
      181 acttctggag accttctgtc tagaagcaat tcctactatg gctggctgta atccagccag
      241 cccagcttgg gccggcgcgg gcgctttaag agaggggcgg ggcccggcgc aggcaaggca
      301 gggcctgccc acaaggctgc ttttcctttt tgatccattc aaaaattact cattgcaaat
      361 tcccggacag ctcggggagg agaagctggt ggggcggagg acagagaagg ctgcagcggc
      421 gcaacgctgg gactccggga ccccgcgggc tgaggtcgga cccgcagcag ccaccggccc
      481 gcgccgagct ccagtggcct ctccaggaag cgtcagtctc cgcccggaga tctgggagca
      541 ccgcccccac cgtcctcccc ggacccccag tccccggcgc gcgggcgatg ggcggccact
      601 gagcgggcac tcggcaccgc gaccccagcc ctcggcatgg ccgcgcgcga ggagctgtac
      661 agcaaagtca ccccgcgcag ggaccgcctg cagcgcccgg gcacagtcaa gcatgggtcg
      721 gcgctggacg tgctcctgtc catgggcttt ccccgcgccc gcgcacaaaa agctctggca
      781 tccacgggag gaagaagcgt tcaggcagca tgtgactggt tgttctccca tgtgggtgac
      841 cccttcctgg atgaccccct gcctcgggag tatgtcctct acctccgccc gacagggcca
      901 ttagcccaga agctctctga cttctggcag cagtccaagc agatctgcgg gaagaacaag
      961 gcccacaaca tcttccccca catcactctc tgccagttct tcatgtgcga ggacagcaag
     1021 gtggatgctc tgggggaagc cctgcagact actgtcagtc gatggaaatg taagttctca
     1081 gccccactgc ccctggagct gtacacctcc tccaacttca tcgggctctt cgtgaaggaa
     1141 gacagcgctg aagtcctcaa gaagttcgcg gctgactttg ctgcagaggc tgcatccaaa
     1201 acagaagtgc acgtggagcc tcataagaag cagctgcatg tgacgctggc ctaccacttc
     1261 caagccagcc acctacccac cctagagaag cttgcccaga acattgacgt caagctagga
     1321 tgcgactggg tggccaccat attctctcgg gatatccggt ttgctaacca tgagacgtta
     1381 caggtgatct atccctattc acctcagaat gatgacgagc tggagctggt cccaggggac
     1441 ttcatcttca tgtctcccat ggaacagacc agcaccagtg agggctggat ttatggcacc
     1501 tcgctgacca ctggctgctc tgggctgctt cctgagaact acatcaccaa ggctgatgag
     1561 tgtagcacct ggatcttcca tggttcctac tccatcctaa ataccgtatc atccagctca
     1621 ctcgcgtttg gcgatggagc gttagagagg cggcagtatg aagatcaagg acttggggag
     1681 acaacacccc tcactatcat ctgccagccc atgcagcccc tgagagtcaa cagccagcct
     1741 ggaccccaga agcgatgcct ctttgtatgt cggcatgggg agaggatgga cgttgtattt
     1801 gggaagtact ggctgtccca atgctttgat gccaaaggcc gctacatacg caccaacctg
     1861 aacatgcctc acagtttacc tcagaggagc ggcggtttcc gggattacga gaaagatgct
     1921 ccaatcactg tgtttgggtg tatgcaagca agactagtgg gtgaagcctt gttagaaagt
     1981 aatactgtta ttgatcacgt gtattgctca ccatccctcc gctgcgttca gactgcacat
     2041 aatattttga aaggtttaca acaagacaat cacttgaaga ttcgagtgga gccgggctta
     2101 tttgaatgga caaagtgggt tgctgggagc acattaccgg catggatacc tccatcagag
     2161 ttagctgcag ccaacctgag tgttgataca acctacagac ctcacattcc agtcagcaaa
     2221 ttggcgattt cggaatccta tgacacctac atcaatagga gtttccaggt gacgaaagag
     2281 ataataagtg aatgcaaaag taaaggaaat aacattctga ttgtggccca cgcatcttcc
     2341 ctcgaagcgt gtacctgtca gctccaaggt ctatccccgc agaactcaaa ggacttcgta
     2401 caaatggtcc ggaagatccc atacctaggc ttctgttcct gcgaagaatt gggagaaact
     2461 ggaatatggc aactgacaga cccgcccatc cttcccctta cccatggccc cactgggggc
     2521 ttcaactgga gagagaccct cctgcaagaa taagctgcct gagagctggg aagaactggc
     2581 cttttgcaga tgagtcctca ggatgccctg tagcagtggg aaagcccacg ctgcattcaa
     2641 agcagacagc tcagaatcat ttagcatatt tcttttcatg cttaggggac ggtgagattg
     2701 tgagagaaag tcgtgattca gaggggaaat taaaaaaaaa aaaaaaacaa tccatctctc
     2761 tggacttgcc tagctaccaa ggctttggag aagtgtcttc ctaggctgag cacctgatgc
     2821 agcagaaact accatcctcc ttcaggctat gcatggctaa agagcctcat tcttctccca
     2881 gagagctgct ccctcccgga gaggcatgca agaggaagga ctgtgtctgg aatccaactg
     2941 gggagaggat agtctttttg tactccattt gcaagttagg gaaagccaca ctgaggagtg
     3001 ctttgatggt tgttagggac cgtaagaata gtcctgtgtc agacagcaga ttctaccctc
     3061 agcagactcc attcactgcc gctgtgaggc acccacttga ggtctcccga cattcaccct
     3121 ggtaccacac cacttgatct ccagagcaat ctggcccttc atgcttctat ctgtgaaatg
     3181 gggagaacag ccctttgcac gttgagatac tcaggaggga tcaagagaac gagtgatgtg
     3241 tgttgaatgg gaggtggagc tacttgcaga attttaacca agttgaaatt acccctgtga
     3301 tggccggatg aactgtgaag tccccaagcc tgcctgaatc aggacgtgtc tttccaccca
     3361 gactctagac tgtgttaagc agttaaggag attgacattt gaaaggatgt tatgttggat
     3421 tcactatttg gatcagcaaa aaacaaaaac agaaaacaaa aacacaaaaa gaaaaaaaaa
     3481 aacctccagt gcaatacaga tatttttaga aactataccg agggtcgtgt tgttggtcac
     3541 atacaggcca tgtccactgt agcagaatgt ccataggtta gcccatttta ggttgtccag
     3601 gaagcccagg gactaacgtg aatggtgaca gtcacaactg cactgcttct tttgctgccc
     3661 tctttgcttt tctatggtaa tttagaacag acgggaggga ggaccacttg aaggaagctg
     3721 gagagtcaga gcctatctgt gggctctcac tgcacctact tcctgtactt agagagagtg
     3781 tgtgtattta aaagaagaat aaatgacaat caaaccaaaa catccc
//
