LOCUS       NM_177823               2953 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ubiquitin associated and SH3 domain containing, A
            (Ubash3a), mRNA.
ACCESSION   NM_177823 XM_992313
VERSION     NM_177823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2953)
  AUTHORS   Tsai,Y.L., Arias-Badia,M., Kadlecek,T.A., Lwin,Y.M., Srinath,A.,
            Shah,N.H., Wang,Z.E., Barber,D., Kuriyan,J., Fong,L. and Weiss,A.
  TITLE     TCR signaling promotes formation of an STS1-Cbl-b complex with
            pH-sensitive phosphatase activity that suppresses T cell function
            in acidic environments
  JOURNAL   Immunity 56 (12), 2682-2698 (2023)
   PUBMED   38091950
REFERENCE   3  (bases 1 to 2953)
  AUTHORS   Chen,Y.G., Ciecko,A.E., Khaja,S., Grzybowski,M., Geurts,A.M. and
            Lieberman,S.M.
  TITLE     UBASH3A deficiency accelerates type 1 diabetes development and
            enhances salivary gland inflammation in NOD mice
  JOURNAL   Sci Rep 10 (1), 12019 (2020)
   PUBMED   32694640
  REMARK    GeneRIF: UBASH3A deficiency accelerates type 1 diabetes development
            and enhances salivary gland inflammation in NOD mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2953)
  AUTHORS   Yin,Y., Frank,D., Zhou,W., Kaur,N., French,J.B. and Carpino,N.
  TITLE     An unexpected 2-histidine phosphoesterase activity of suppressor of
            T-cell receptor signaling protein 1 contributes to the suppression
            of cell signaling
  JOURNAL   J Biol Chem 295 (25), 8514-8523 (2020)
   PUBMED   32371395
REFERENCE   5  (bases 1 to 2953)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2953)
  AUTHORS   Mikhailik,A., Ford,B., Keller,J., Chen,Y., Nassar,N. and Carpino,N.
  TITLE     A phosphatase activity of Sts-1 contributes to the suppression of
            TCR signaling
  JOURNAL   Mol Cell 27 (3), 486-497 (2007)
   PUBMED   17679096
REFERENCE   7  (bases 1 to 2953)
  AUTHORS   Carpino,N., Turner,S., Mekala,D., Takahashi,Y., Zang,H.,
            Geiger,T.L., Doherty,P. and Ihle,J.N.
  TITLE     Regulation of ZAP-70 activation and TCR signaling by two related
            proteins, Sts-1 and Sts-2
  JOURNAL   Immunity 20 (1), 37-46 (2004)
   PUBMED   14738763
REFERENCE   8  (bases 1 to 2953)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 2953)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 2953)
  AUTHORS   Wattenhofer,M., Shibuya,K., Kudoh,J., Lyle,R., Michaud,J.,
            Rossier,C., Kawasaki,K., Asakawa,S., Minoshima,S., Berry,A.,
            Bonne-Tamir,B., Shimizu,N., Antonarakis,S.E. and Scott,H.S.
  TITLE     Isolation and characterization of the UBASH3A gene on 21q22.3
            encoding a potential nuclear protein with a novel combination of
            domains
  JOURNAL   Hum Genet 108 (2), 140-147 (2001)
   PUBMED   11281453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY227020.1, AK040572.1, BC027561.1 and BB736706.1.
            
            On Jan 17, 2008 this sequence version replaced NM_177823.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040572.1, AK169696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY227020.1         1-41
            42-576              AK040572.1         2-536
            577-606             BC027561.1         453-482
            607-2684            AK040572.1         568-2645
            2685-2953           BB736706.1         117-385
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.84 cM"
     gene            1..2953
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /note="ubiquitin associated and SH3 domain containing, A"
                     /db_xref="GeneID:328795"
                     /db_xref="MGI:MGI:1926074"
     exon            1..166
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1928
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /note="T-cell ubiquitin ligand 1; suppressor of T-cell
                     receptor signaling 2"
                     /codon_start=1
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein A"
                     /protein_id="NP_808491.2"
                     /db_xref="CCDS:CCDS50054.1"
                     /db_xref="GeneID:328795"
                     /db_xref="MGI:MGI:1926074"
                     /translation="MAAGETQLYAKVSNKLKGRSTPSLLDPLLAMGFPTHTALKALAA
                     TGRKTAEAAADWLHGHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESRRQCAKN
                     RAHEVFPHVTLCDFFTCEDQKVECLYEALRRAGDRILGSFPTLVPLVLHSSISYLGFF
                     INDSPADAIREFAMAFATEAAVLADCTIKPCTKQLHLTLAHKFYPHHQRTLEQLAKAI
                     QPSHSCQWTAALYSRDMRFVHYQTLKALFQYKPQNADELMLSAGDYIFVDPTQQEEAS
                     EGWAIGISHRTGCRGFLPENYTERANEADTWVKHRTYTFNLAMDLNSRKDFEASCRGN
                     GEPHTPSMSKSVSSIQALQATISRRGILVVRHGERVDQVFGKSWLQQCTTADGKYYRP
                     DLNFPRSLPRRSNGIKDFENDPPLSSCGIFQARLAGEALLDSGVRVTAVFASPALRCV
                     QTAKHILEELKLEKKLKIRVEPGIFEWMKWEASKATLTFLTLEELKEANFNVDLDYRP
                     ALPRCSLMPAESYDQYVERCAVSMGQIINTCPQDMGITLIVSHSSALDSCTRPLLGLP
                     PRECGDFAQLVRKIPSLGMCFCEENREDGKWDLVNPPVKTLTHGANSVFNWRNWISSN
                     "
     exon            167..220
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..407
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..606
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..776
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..985
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1112
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1212
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1335
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1428
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1573
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1680
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1790
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2953
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /note="hexamer: ATTATA"
     polyA_site      2645
                     /gene="Ubash3a"
                     /gene_synonym="5830413C03Rik; C330001M22; Sts-2; TULA;
                     TULA-1"
                     /note="major polyA site"
ORIGIN      
        1 tttatctagt ccttgcagtg agcaggcgcc tcttgtacag caagcaggaa gacatggctg
       61 cgggggagac acagctctat gccaaggtct ccaacaagct caagggccgc agcaccccct
      121 cactcctgga tcccctcctg gccatgggct tccccacaca taccgcgctc aaagcactag
      181 cggccacagg gaggaagaca gccgaggcgg cagcagactg gctgcatggt cactgcaatg
      241 acccttctct ggatgaccct atccctcagg agtatgctct cttcctctgc cccacgggcc
      301 ccttgctgga aaaactccaa gagttctgga gagagagcag acggcagtgt gcaaagaaca
      361 gagcacatga ggtcttccct cacgtgacac tctgtgactt tttcacgtgt gaagaccaga
      421 aggtggagtg cttgtatgag gctctgagac gtgcagggga caggatcctg ggctccttcc
      481 ccaccctggt tcctcttgtt ctccattctt ccatcagcta cctcggcttc ttcatcaacg
      541 acagccccgc tgacgccatc cgggaattcg ccatggcgtt tgccacagag gcggcagtcc
      601 tggcagactg taccatcaag ccctgcacca agcagctgca cctgaccttg gcccataagt
      661 tctaccctca ccatcaaagg accctggagc agctggccaa agccatccag cccagccact
      721 cctgccaatg gacagctgcc ctgtactccc gagacatgcg ttttgtgcac taccagaccc
      781 tgaaggcgct gttccagtac aaaccccaga atgcagatga gctaatgctc agtgctggtg
      841 actacatctt cgtggacccc actcagcaag aagaggccag cgagggctgg gccattggga
      901 tctcacatcg gactggctgc cggggcttct tgccagagaa ctacacggag cgagccaatg
      961 aggctgacac ctgggttaag cacaggacgt atacattcaa tctagccatg gacctgaact
     1021 ctaggaagga ttttgaagcc agttgcaggg gaaatgggga accccacact ccgtcaatgt
     1081 caaagagtgt tagcagcata caagctttgc aggctaccat ctcgaggaga ggcattctgg
     1141 tcgtacgtca tggcgagaga gtggaccagg tctttgggaa gtcttggcta cagcagtgta
     1201 ctactgctga tggaaaatac tacaggccag acctgaactt cccccgcagc ctgccaagga
     1261 ggagcaacgg catcaaagac tttgaaaacg atccaccgct atcatcctgt ggaattttcc
     1321 aggccagact tgccggagaa gccctgctgg acagcggcgt cagagtcacc gcggtcttcg
     1381 cgtctccagc cctgcgctgc gtgcagacag ccaagcacat cctagaagaa ctcaaactgg
     1441 agaagaagct gaagataaga gttgagcctg gaatcttcga gtggatgaag tgggaagcca
     1501 gcaaggccac actgaccttc ttgaccttgg aggagctgaa agaagcaaac ttcaatgttg
     1561 accttgatta taggccagca ttgccccgct gctccctcat gccagctgag agctatgacc
     1621 agtacgtgga gagatgtgcc gtgagcatgg ggcagatcat caacacatgc ccacaggaca
     1681 tgggcattac actcatcgtg agccacagct cagcgctcga ctcctgcaca aggccactcc
     1741 tcgggctccc acccagagaa tgtggggatt tcgcccaact ggtaagaaag attccatctc
     1801 tgggcatgtg cttctgtgag gaaaacagag aggacggaaa gtgggacctg gtgaatccgc
     1861 cagtaaagac gctgacacat ggggccaact cggtctttaa ctggagaaac tggatctcaa
     1921 gcaactgagg cagcccgagc tttccaggaa gaggtgactg ccctatgcca aggcacaagg
     1981 ggctgtgata atggttacaa aggcatccaa tgattacaaa gttatcctag cctctcgccc
     2041 agtgtgactg gaggaaagaa caaaacacac tcgatactca gggggaatag ccatggctca
     2101 gaccttcgtc actgccaccc atggatctgc tgtcctgcca gcctctgcag aggccagagc
     2161 agaggtctgg attaggatac cacattgcaa catgtgcact ggtttggaga gaacagagga
     2221 actgcctcac ttccaggaac tacagactcc ccgcacttga agatgccacc catctatttt
     2281 gtatgttctt aggagccctc cttattacta taaccatcgc tctttaggca gggccatacc
     2341 agctgaaaag ggagcaatgg tcaatgaaaa aagtggccag cccaccagat caaaaccagg
     2401 acagcagctg gcaccagcac tttaggggtt ccttgctgtt gctcggacac agagttggag
     2461 acagtagtgc ttgaaagcca tgcaaaattc ctaacgcaca gagacaaaat gtgtgattct
     2521 ggaggttagc ggggtctgtg ttcctctaca gattctagag gactcttccc cagccattcc
     2581 agaatccaga ggcctctgtc cttcctggca tcctatttat tatattatat tcctggcatc
     2641 tactacctta tgattctatt caaatcaatc agtttgggga aattctaagg cacggtcaca
     2701 tagcccctgc cttgagcctc ctgtctcaaa gacgccatga caaattgtgc tcagtagcct
     2761 aggatcttct ctcatcttaa gatccttggc aactaagcct gcaaagtccc ttagccacag
     2821 gggtcacttg ttcatggtcc cggaagttag gatgtgtctt agaaggccat cctccagcct
     2881 acctcagcct ctgttcttcc aagcacatta tggccgttgt accagggtct agacataaag
     2941 atctgtgcct cct
//
