LOCUS       NM_023305               2716 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubiquitin-associated protein 1 (Ubap1), transcript
            variant 1, mRNA.
ACCESSION   NM_023305
VERSION     NM_023305.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Lu,D., Zhi,Y., Su,H., Lin,X., Lin,J., Shi,Y., Yi,W., Hong,C.,
            Zhang,T., Fu,Z., Chen,L.Y., Zhao,Z., Li,R., Xu,Z., Chen,W., Wang,N.
            and Xu,D.
  TITLE     ESCRT-I protein UBAP1 controls ventricular expansion and cortical
            neurogenesis via modulating adherens junctions of radial glial
            cells
  JOURNAL   Cell Rep 43 (3), 113818 (2024)
   PUBMED   38402586
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Shimozono,K., Nan,H., Hata,T., Saito,K., Kim,Y.J., Nagatomo,H.,
            Ohtsuka,T., Koizumi,S. and Takiyama,Y.
  TITLE     Ubap1 knock-in mice reproduced the phenotype of SPG80
  JOURNAL   J Hum Genet 67 (12), 679-686 (2022)
   PUBMED   35962060
  REMARK    GeneRIF: Ubap1 knock-in mice reproduced the phenotype of SPG80.
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Nan,H., Ichinose,Y., Tanaka,M., Koh,K., Ishiura,H., Mitsui,J.,
            Mizukami,H., Morimoto,M., Hamada,S., Ohtsuka,T., Tsuji,S. and
            Takiyama,Y.
  TITLE     UBAP1 mutations cause juvenile-onset hereditary spastic paraplegias
            (SPG80) and impair UBAP1 targeting to endosomes
  JOURNAL   J Hum Genet 64 (11), 1055-1065 (2019)
   PUBMED   31515522
  REMARK    GeneRIF: Exome sequencing of genomic DNA from patients in four
            families was carried out, followed by Sanger sequencing of the
            UBAP1 gene. A mouse homolog of one UBAP1 frameshift mutation
            carried by one of the patients was created as a disease model.
            Functional properties of the UBAP1 wild type and UBAP1-mutant in
            mouse hippocampus neurons were examined.
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Lin,X., Su,H.Z., Dong,E.L., Lin,X.H., Zhao,M., Yang,C., Wang,C.,
            Wang,J., Chen,Y.J., Yu,H., Xu,J., Ma,L.X., Xiong,Z.Q., Wang,N. and
            Chen,W.J.
  TITLE     Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic
            paraplegia
  JOURNAL   Brain 142 (8), 2238-2252 (2019)
   PUBMED   31203368
REFERENCE   6  (bases 1 to 2716)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2716)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2716)
  AUTHORS   Qian,J., Yang,J., Zhang,X., Zhang,B., Wang,J., Zhou,M., Tang,K.,
            Li,W., Zeng,Z., Zhao,X., Shen,S. and Li,G.
  TITLE     Isolation and characterization of a novel cDNA, UBAP1, derived from
            the tumor suppressor locus in human chromosome 9p21-22
  JOURNAL   J Cancer Res Clin Oncol 127 (10), 613-618 (2001)
   PUBMED   11599797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127131.1 and BC065996.1.
            
            On Apr 27, 2007 this sequence version replaced NM_023305.2.
            
            Transcript Variant: This variant represents encodes the longest
            isoform (1). Variants 1 and 3 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065996.1, SRR1660819.30360.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY127131.1         3-54
            53-2716             BC065996.1         1-2664
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.43 cM"
     gene            1..2716
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /note="ubiquitin-associated protein 1"
                     /db_xref="GeneID:67123"
                     /db_xref="MGI:MGI:2149543"
     exon            1..236
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            237..277
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1752
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="ubiquitin-associated protein 1 isoform 1"
                     /protein_id="NP_075794.3"
                     /db_xref="CCDS:CCDS51140.1"
                     /db_xref="GeneID:67123"
                     /db_xref="MGI:MGI:2149543"
                     /translation="MASKKLGTDVHGTFSYLDDVPFKIGDKFKTPAKVGLPIGFSLPD
                     CLQVVREMQYDFSLEKKTIEWAEDIKLIQEAQREAERKAEEAEAKVNSKSGPEGDSKV
                     SFPKTHNTATMPPPINPILASLQHNNILTPTRVSSSATKQKVLSPPHTKADFNPADFE
                     CEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDSNTARGSSGAVLQDEEVLASL
                     EQATLDFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPTVSNIKSLSFPKLDSDDS
                     NQKTVKLASTFHSTSCLRSGASRSLLKPSTQSSASELNGDHTLGLSALNLNSGTEVPT
                     LTSSQMPSLSSVSVCTEESSPPDPCPTVTPLNFSVSQVPNMPSCPQAYLELQALSPSE
                     RQCVETVVNMGYSYDCVLRAMRKKGENIEQILDYLFAHGQLCEKGFDPLLVEEALEMH
                     QCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARAGAS"
     exon            278..402
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..1326
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1509
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1611
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..2697
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2697
                     /gene="Ubap1"
                     /gene_synonym="2700092A01Rik; NAG20; Ubap; UBAP-1"
                     /note="major polyA site"
ORIGIN      
        1 tgatgtcaga cgcctaaagg ggcggagcgt cgaggggaag gaggagggaa gtaggccttc
       61 aacatggcgg ctgtggtact ggtggtggct acggtgacgg tctggctcgg ggcgggtaga
      121 gttggaagag gtggtgtttg ctctccctag gggcagcggg agcccagcgg agactgagcc
      181 cgggaggccg ggcggcgcca gcacctttca gctttcggga cagcagcggc attcaggttc
      241 taaatggctt ctaagaagtt ggggacagat gttcatggga ctttcagtta ccttgacgat
      301 gtcccattta agataggaga caaattcaaa acaccagcga aagtgggtct gcctattggc
      361 ttctccttgc ctgactgctt acaggttgtc agagagatgc agtatgactt ctccttggaa
      421 aagaaaacca ttgagtgggc tgaagatatt aaactaatcc aagaagctca gcgggaagca
      481 gagcggaagg ccgaggaagc agaagctaaa gtgaattcca agagtggtcc agagggtgac
      541 agcaaagtga gcttccccaa gactcacaat acagccacaa tgccacctcc tattaacccc
      601 atccttgcca gcttacagca caacaacatc ctcactccaa ctcgggtcag cagtagtgcc
      661 acaaagcaga aagttctcag cccaccccac acaaaggcag acttcaatcc tgctgacttc
      721 gagtgtgaag aggacccatt tgataatctg gagttaaaaa ccattgatga gaaggaagag
      781 ctgagaaaca ttctggtagg aaccactgga cccataatgg ctcagttact ggacagtaac
      841 acagcccggg gaagctcggg ggctgtgtta caggatgagg aggtcttggc atccttggag
      901 caggcaacct tagacttcaa gcctcttcat aaacccaatg gctttataac cttaccacag
      961 ttgggcaact gtgaaaagat gtcgctgtct tccaaagtgt ccctcccccc tattcctaca
     1021 gtaagcaata tcaaatctct ctccttcccc aaacttgact ctgatgacag caatcagaag
     1081 acagtcaagc ttgcgagcac tttccatagc acatcctgcc tccgaagtgg cgcatcccgg
     1141 agtctcctaa agccttccac ccaaagcagt gccagtgagc tcaatgggga ccacactctt
     1201 gggctttcag ctttgaactt gaacagtggc acagaggtgc caacactgac atcctcccag
     1261 atgccttccc tgtctagcgt gtctgtgtgt acagaagaat catcacctcc agatccatgt
     1321 cccacagtaa cccctctaaa tttctcagtg tcacaagtgc ccaacatgcc tagctgtccc
     1381 caggcctatt tggaactgca ggcactgtct ccgagtgagc ggcaatgtgt agagacagta
     1441 gtcaacatgg gctactcata tgattgtgtc ctgagagcca tgagaaagaa aggagagaat
     1501 attgagcaga ttctcgacta tctctttgca cacggacagc tttgtgagaa gggttttgac
     1561 cctcttttag tggaagaggc tctggaaatg caccagtgtt cagaagaaaa gatgatggag
     1621 tttcttcagt taatgagcaa atttaaggaa atgggctttg aactgaaaga cattaaggaa
     1681 gttttgctat tacacaacaa tgaccaggac aatgctctgg aagacctcat ggcccgggct
     1741 ggagccagct gagacctggc cctgctacgg ccctgccaca gcaccaccat tccccaagga
     1801 ggctctgcac agctcacttg tggggaagac gggacatgct tccagatttt ctttgggggt
     1861 tagaaggtcg gatgtggagt tgacacttgt tagtctctgt gagcccaggc ctgagctggg
     1921 ggaaagtagg aagatttggg catatatgct ctctattggt tccttccata ttaaacatac
     1981 ctgtgttttg agaagtgtcc ttcccacttt gggctttcag aaggaatact tggttctttc
     2041 tggggtctct aatgttctca gccaaaacct ggcctggcta ccaagaagag tgggaagaca
     2101 ggaggagcag actgctgctg ttttggggct agatcctttc ctctcctctc tgctgcacca
     2161 ctgtcagact gggctctaac ccaagtggaa tgcaactgag agggtcttcc tgggcccgcc
     2221 ttccccgaca gccctagtgt tacactggtt ctggagtgtc tctgcggtac aaagatgcac
     2281 ttttcttcat ggggcaaagt ctgcctcttc tgccaggcag ttcccatttg cccctgtcca
     2341 gactgtttct tttggcttag accataatcc tctgctgccc ggggcattgg agcccctgtg
     2401 ctaggaagct gtcagttttg agtatcattg gccctttcca gcacatgggt gagaaaacag
     2461 gccacgactt gtcactcagc actaaccccc agttcttgaa cagcctcctc cagccctgct
     2521 ttaggatgac acaatgaata acacctaggc atagaaacca gtctctttgg tttgtttgta
     2581 ttatgttcta caatattaaa gatctaaata caaaggatat aatacagtct tgaatctaaa
     2641 gtaatttgct aactattttg attcttcaga gaactactaa taaaaatcta aaaggtaaaa
     2701 aaaaaaaaaa aaaaaa
//
