LOCUS       NM_133835               3450 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubiquitin associated domain containing 1 (Ubac1),
            transcript variant 1, mRNA.
ACCESSION   NM_133835
VERSION     NM_133835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3450)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3450)
  AUTHORS   Bridoux,L., Bergiers,I., Draime,A., Halbout,M., Deneyer,N.,
            Twizere,J.C. and Rezsohazy,R.
  TITLE     KPC2 relocalizes HOXA2 to the cytoplasm and decreases its
            transcriptional activity
  JOURNAL   Biochim Biophys Acta 1849 (10), 1298-1311 (2015)
   PUBMED   26303204
  REMARK    GeneRIF: our data support that KPC2 regulates Hoxa2 by promoting
            its relocation to the cytoplasm.
REFERENCE   3  (bases 1 to 3450)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX243095.1, AK157857.1 and AK162577.1.
            
            On Oct 4, 2009 this sequence version replaced NM_133835.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157857.1, BC021811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               CX243095.1         1-171
            172-2081            AK157857.1         6-1915
            2082-3450           AK162577.1         762-2130
FEATURES             Location/Qualifiers
     source          1..3450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.29 cM"
     gene            1..3450
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /note="ubiquitin associated domain containing 1"
                     /db_xref="GeneID:98766"
                     /db_xref="MGI:MGI:1920995"
     exon            1..364
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1456
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative glialblastoma cell differentiation-related;
                     ubiquitin-associated domain-containing protein 1; UBA
                     domain-containing protein 1; E3 ubiquitin-protein ligase
                     subunit KPC2; kip1 ubiquitination-promoting complex
                     protein 2"
                     /codon_start=1
                     /product="ubiquitin-associated domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_598596.2"
                     /db_xref="CCDS:CCDS15795.1"
                     /db_xref="GeneID:98766"
                     /db_xref="MGI:MGI:1920995"
                     /translation="MFVQEEKIFAGKVLRLHICAADGAEWLEEATEDTSVEKLKESCL
                     KHGAHGSLEDPKNVTHHKLIHAASERVLSDSKTILEENIQDQDVLLLIKKRVPSPLPK
                     MADVSAEEKKKQEQKAPDKDAILRATANLPACSTDRTAVQTTMRDFQTELRKILVSLI
                     EVAQKLLALNPDAVELFKKANAMLDEDEDERVDETALRQLTEMGFPESRASKALRLNH
                     MSVPQAMEWLIEHSEDPAIDTPLPGHAAQAGASAAATTSSTSSEAAVGTSVEDEESRD
                     ELTEIFKKIRRKKEFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRK
                     PSPEELDQGIDPNSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPET
                     GPVMLQISRIFQTLNRT"
     exon            365..485
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..559
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..667
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..770
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..879
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1114
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1201
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1340
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..3450
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /note="hexamer: AATAAA"
     polyA_site      1861
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /note="major polyA site"
     regulatory      2060..2065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
                     /note="hexamer: ATTAAA"
     polyA_site      2081
                     /gene="Ubac1"
                     /gene_synonym="1110033G07Rik; GBDR1; Gdbr1; Kpc2; Ubadc1"
ORIGIN      
        1 cggctgcgac cgcgcgctcc gggcggctac ggcgacacgg gcagtggcag caagggtaca
       61 gctcctgccc cttcagtgac gggcggcgga gctgacagga gccggggcgg ggcggcggcg
      121 gccagcgaag gagcgcacgg cggcccggcc ccgcccctgg tcctcccgcc agcctcagtg
      181 accttcactg gttcgggcgg cgggtgcagg cccgggcggc ggcgcgatgt tcgtgcagga
      241 ggagaagatc ttcgcgggca aggtgcttcg gctgcacatc tgcgcagccg acggcgccga
      301 gtggctggag gaggcgaccg aggacacatc ggtggagaag ctcaaggaga gttgcctcaa
      361 acatggtgct catgggagcc tagaagaccc caagaatgtg acccaccaca agctaataca
      421 tgctgcttca gagagggtgc tgagtgacag caaaacgatc ttggaagaaa acatccagga
      481 ccaagacgtc ttgttattga taaaaaagcg tgttccttct ccactcccta agatggctga
      541 cgtctcagca gaagaaaaga agaaacaaga gcaaaaggct ccagacaaag atgctattct
      601 tcgagcaacg gcaaacctgc ctgcctgcag cactgaccgg actgctgtcc agaccaccat
      661 gagagacttc cagacagaac tccggaagat cctcgtgtct ctcattgagg tggcacagaa
      721 gctgttagca ctgaatcccg atgcagttga attgtttaag aaggcaaatg ctatgctgga
      781 tgaagatgag gatgagcgag tggatgagac tgccttgcgg cagctcacag agatgggctt
      841 tcctgagagc agagcctcaa aggcccttcg gctgaaccac atgtcagtgc ctcaggccat
      901 ggagtggcta attgaacact cagaagatcc agctattgac acacctcttc caggccatgc
      961 tgctcaagca ggggccagtg ctgcagccac tacctcctcc acctcctctg aagctgctgt
     1021 gggaactagt gttgaagatg aggagtcccg ggatgagctc acagaaatct tcaagaagat
     1081 acgcaggaaa aaggaatttc gagcagatgc tcgggctgtc atttcgctga tggagatggg
     1141 ctttgacgag aaggaagtga ttgatgccct ccgagtgaac aacaaccagc agaacgctgc
     1201 ttgtgaatgg ctgctggggg accggaagcc atcccctgag gaattggacc agggcatcga
     1261 tcccaatagc cctctctttc aggccatcct ggacaaccca gtggtgcagc tgggtttgac
     1321 aaaccctaag acattgctag catttgaaga catgctggag aatccgctta acagcaccca
     1381 gtggatgaac gacccagaga cgggcccggt catgctgcag atctctagga tcttccagac
     1441 gctgaatcgc acgtaggtgg tacctactgt gctccttggc tgtgcagtct cagcagtctg
     1501 tgaggcagtg ggcacagggt tcagccggga tcttgcctgg accacagctt ctcggactct
     1561 cctttccaga cctaacagct tatcaacttc tgccacatgg cttgaaagtt gcagtcctag
     1621 cttctgacag gtgtctacag aaagtggctg ttgcattggg aaggtgaatg attgctgccc
     1681 gtccctccag atactctgct gggctcctga agtgctactt gaattgaccc ttaggtgttt
     1741 gcttgtggag cccaatgtat ttaaaagaag gcatgttctg atccaaagtg ttatgtcaag
     1801 tgtgctaatt taaccagact gactcacaga tggcttcttt aataaataaa cccttttcct
     1861 atttttactt gtgttacttc atggcagcaa ggacatcaca tgtatcccct aggccgtgta
     1921 cacattgtct ctgcccagag caggtgtcat tgccacttct ttctagatac tatttctctg
     1981 tgtagccctg gatgtcctaa aaatcactct gtaaaccagg ctgcccttga actcagaaat
     2041 ctgcctcctg agcgctggga ttaaaggcgc gtgccaccac ctctcagctt tcatggctac
     2101 ttcttcactt ggaaacctga atcctctgag cccagctcaa gttgggtttg gggctgtgac
     2161 atttcaagta gcaggccttc cccccagcca cagcagatgg agcagggtgt gtgtgtgtgt
     2221 gtgtgtacac tcacaggtgc atgtactcat gtgtaccttg tgccagaaca caaacgtggg
     2281 gatcacacct gccctactca ggagttggtt ctttccttcc accatggtcc cggggatcaa
     2341 gcccagctca tcaggttcct gcagcaagga cttaaaaaaa caaacactct tctgactcat
     2401 cttgctggct catgatctag tcccctttct gtgacccctg ctcagggtta ctgtaaaaag
     2461 catttagctc ttgagtgtgt ttaagcatgt ctgagaagct gcagcatagg tgaggtatag
     2521 gaatagctac agccttggct ggcactcacc ctgctggagc tgagccagaa gactctaaca
     2581 tggaaaagga gctcagcggc tggagtgttc gctgtacaag caaggggacc tgagttcaca
     2641 tcccagcacc aggtaaaaag ccaggcatgg cagcacacag ctgtaattcc agcatttgga
     2701 gatggtaagt ggagtttcga tcctgggggg ttaacaagat aagctggaaa gtgatagaag
     2761 acattagaca ctgactctgg catgtgtgtg caagcacaca tataacaaag actatgacgg
     2821 gatctgcctg tcttcctagt gcgttgaaga gtcatggttc agaatctccg agggagggtg
     2881 gagagatgac tcgtcactta agaccacttg ctgttcaagt ttaagtccca ggatccacat
     2941 tggatggctc acaaccgctt gtctgactcc aaccccagct ccaggaaagc cgatttcctc
     3001 ttgtagcctc tgtacacaca tccaaacaaa aataaagatc ttcacagaac ttcaaggaac
     3061 catctctatg ggctctggag gccatgggga gtgttctgta cttggggata ggtcctgatg
     3121 ctggtctttt gtccaggatc tgtgtgtgtg tggtgtgtgt gtgttctgca acactagtat
     3181 cctctgagac aagcattgtg ttcatgtaat aaaggagcta acacaaactg gctctgaaaa
     3241 ggggtcttcg tttggaaaga atagatttcc tgctctggct gtttgggttt ttttcatgtt
     3301 ttgtttgttt tgtttttcaa gacaggtttg tgtgtgtgtg tatgtagccc tggctgtcct
     3361 ggaactcact ctgtagacca ggctggcctt gaactcagaa attcacctgc ctttgcctcc
     3421 taagtgctgt aattaaatcc gtgtgccacc
//
