LOCUS       NM_023738               3162 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus ubiquitin-like modifier activating enzyme 7 (Uba7),
            mRNA.
ACCESSION   NM_023738
VERSION     NM_023738.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3162)
  AUTHORS   Kespohl,M., Bredow,C., Klingel,K., Voss,M., Paeschke,A.,
            Zickler,M., Poller,W., Kaya,Z., Eckstein,J., Fechner,H.,
            Spranger,J., Fahling,M., Wirth,E.K., Radoshevich,L., Thery,F.,
            Impens,F., Berndt,N., Knobeloch,K.P. and Beling,A.
  TITLE     Protein modification with ISG15 blocks coxsackievirus pathology by
            antiviral and metabolic reprogramming
  JOURNAL   Sci Adv 6 (11), eaay1109 (2020)
   PUBMED   32195343
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3162)
  AUTHORS   Fan,J.B., Miyauchi,S., Xu,H.Z., Liu,D., Kim,L.J.Y., Burkart,C.,
            Cheng,H., Arimoto,K.I., Yan,M., Zhou,Y., Gyorffy,B.,
            Knobeloch,K.P., Rich,J.N., Cang,H., Fu,X.D. and Zhang,D.E.
  TITLE     Type I Interferon Regulates a Coordinated Gene Network to Enhance
            Cytotoxic T Cell-Mediated Tumor Killing
  JOURNAL   Cancer Discov 10 (3), 382-393 (2020)
   PUBMED   31974171
REFERENCE   3  (bases 1 to 3162)
  AUTHORS   Shaabani,N., Honke,N., Nguyen,N., Huang,Z., Arimoto,K.I., Lazar,D.,
            Loe,T.K., Lang,K.S., Prinz,M., Knobeloch,K.P., Zhang,D.E. and
            Teijaro,J.R.
  TITLE     The probacterial effect of type I interferon signaling requires its
            own negative regulator USP18
  JOURNAL   Sci Immunol 3 (27) (2018)
   PUBMED   30266866
REFERENCE   4  (bases 1 to 3162)
  AUTHORS   Napolitano,A., van der Veen,A.G., Bunyan,M., Borg,A., Frith,D.,
            Howell,S., Kjaer,S., Beling,A., Snijders,A.P., Knobeloch,K.P. and
            Frickel,E.M.
  TITLE     Cysteine-Reactive Free ISG15 Generates IL-1beta-Producing CD8alpha+
            Dendritic Cells at the Site of Infection
  JOURNAL   J Immunol 201 (2), 604-614 (2018)
   PUBMED   29891555
REFERENCE   5  (bases 1 to 3162)
  AUTHORS   Kimmey,J.M., Campbell,J.A., Weiss,L.A., Monte,K.J., Lenschow,D.J.
            and Stallings,C.L.
  TITLE     The impact of ISGylation during Mycobacterium tuberculosis
            infection in mice
  JOURNAL   Microbes Infect 19 (4-5), 249-258 (2017)
   PUBMED   28087453
REFERENCE   6  (bases 1 to 3162)
  AUTHORS   Yin,X., Cong,X., Yan,M. and Zhang,D.E.
  TITLE     Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7)
            does not accelerate lung cancer development in K-rasLA2 mice
  JOURNAL   Lung Cancer 63 (2), 194-200 (2009)
   PUBMED   18571763
  REMARK    GeneRIF: Ube1l is not a tumor suppressor gene in K-ras(LA2) lung
            cancer mouse model.
REFERENCE   7  (bases 1 to 3162)
  AUTHORS   Kim,K.I., Yan,M., Malakhova,O., Luo,J.K., Shen,M.F., Zou,W., de la
            Torre,J.C. and Zhang,D.E.
  TITLE     Ube1L and protein ISGylation are not essential for alpha/beta
            interferon signaling
  JOURNAL   Mol Cell Biol 26 (2), 472-479 (2006)
   PUBMED   16382139
  REMARK    GeneRIF: UBE1L and protein ISGylation are not critical for
            IFN-alpha/beta signaling via JAK/STAT activation.
REFERENCE   8  (bases 1 to 3162)
  AUTHORS   Giannakopoulos,N.V., Luo,J.K., Papov,V., Zou,W., Lenschow,D.J.,
            Jacobs,B.S., Borden,E.C., Li,J., Virgin,H.W. and Zhang,D.E.
  TITLE     Proteomic identification of proteins conjugated to ISG15 in mouse
            and human cells
  JOURNAL   Biochem Biophys Res Commun 336 (2), 496-506 (2005)
   PUBMED   16139798
REFERENCE   9  (bases 1 to 3162)
  AUTHORS   Kim,K.I., Giannakopoulos,N.V., Virgin,H.W. and Zhang,D.E.
  TITLE     Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme
            for protein ISGylation
  JOURNAL   Mol Cell Biol 24 (21), 9592-9600 (2004)
   PUBMED   15485925
REFERENCE   10 (bases 1 to 3162)
  AUTHORS   Persons,D.A., Paulson,R.F., Loyd,M.R., Herley,M.T., Bodner,S.M.,
            Bernstein,A., Correll,P.H. and Ney,P.A.
  TITLE     Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
  JOURNAL   Nat Genet 23 (2), 159-165 (1999)
   PUBMED   10508511
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL731808.26.
            
            On Apr 30, 2007 this sequence version replaced NM_023738.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004894.2, BC138843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL731808.26        79124-79270
            148-316             AL731808.26        79354-79522
            317-451             AL731808.26        79612-79746
            452-558             AL731808.26        79863-79969
            559-649             AL731808.26        80267-80357
            650-785             AL731808.26        80461-80596
            786-883             AL731808.26        80688-80785
            884-1030            AL731808.26        80886-81032
            1031-1201           AL731808.26        81409-81579
            1202-1309           AL731808.26        81766-81873
            1310-1390           AL731808.26        82022-82102
            1391-1546           AL731808.26        82183-82338
            1547-1712           AL731808.26        82413-82578
            1713-1918           AL731808.26        82657-82862
            1919-1983           AL731808.26        82951-83015
            1984-2131           AL731808.26        83101-83248
            2132-2206           AL731808.26        83320-83394
            2207-2360           AL731808.26        83586-83739
            2361-2443           AL731808.26        84434-84516
            2444-2536           AL731808.26        84761-84853
            2537-2728           AL731808.26        84947-85138
            2729-2821           AL731808.26        86654-86746
            2822-2922           AL731808.26        86820-86920
            2923-3162           AL731808.26        87374-87613
FEATURES             Location/Qualifiers
     source          1..3162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.07 cM"
     gene            1..3162
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /note="ubiquitin-like modifier activating enzyme 7"
                     /db_xref="GeneID:74153"
                     /db_xref="MGI:MGI:1349462"
     exon            1..147
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3052
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /note="ubiquitin-activating enzyme 7; ubiquitin-activating
                     enzyme E1 homolog"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 7"
                     /protein_id="NP_076227.1"
                     /db_xref="CCDS:CCDS40764.1"
                     /db_xref="GeneID:74153"
                     /db_xref="MGI:MGI:1349462"
                     /translation="MDEELYSRQLYVLGLPAMQRIQEAKVLLCGLQGLGAEVAKNLVL
                     TGVGSLTLHDPHPTCWADLAAQCFLSEESLGRNRAEASQAQLAQLNEAVQISVHSGDI
                     TEDLLQGFQVVVLTDSKLEDQLKVGPLCHKHGVRFLMAETRGLVGRLFCDFGEDFTVL
                     DPTEVEPMTAAIQDISQGFPGIVTLRGDTKRHSFHDGDLVIFSDIEGMVELNSCSPQS
                     VRVQKDGSLEIGDTTTFSRYLRGGVVTEVKRPKTVRHKPLDIALLQPHVVAQNTQEVQ
                     RAHCLHQAFHVLHKFQQLHGRLPKPWDPDDAETVVELAQDLEPLKGTEEESLDEALLR
                     TIALSSAGTLSPMAAIMGGVAAQEVLKAISRKFMPLDQWLYFDALECLPEDETLLPSP
                     EDCQPRNCRYDGQIAVFGTDLQEKLSDQHYLLVGAGAIGCEMLKVFALVGLGVRANGG
                     VTVADMDYIERSNLSRQFLFRPKDVRRPKAEVAAAAAHRLNPDLRATPYTCPLDPTTE
                     DIYDDSFFSRVNGVVAALDSFQARHYVAARCTHYLKPLLEAGTQGTWGSASVFVPYVT
                     EAYRGPASDAASEDAPYPVCTLRHIPSSMEHSVQWAQDQFEGLFRLSTETINCYQQTC
                     TSLSATDRTETLALLQQVMGVLRTRPQTWQDCVVWALGHWQLCFHDKVLEGGTQFSSG
                     SNKCPHPLQFDPNHDMHFLYVLAAANLYARMHGLPGSQSQPALRELLTRLLESDSRPQ
                     NLFSAEHGQEQLKELQETLDDWRKGPPLKPVLFVKDDDSNFHVDFVVAATDLRCQNYG
                     ILPVNHARIKQIVGRIIPAIATSTAVVAGLLGLELYKVVSGLRSHGTFRHSYLHLAEN
                     HFIRSAPSAPAVQSFRDLKWTCWDRLKVPAVQPERTLKSLLAHLQEEHGLKVEMLLHH
                     QALLYSSGWSSEKQAQHLCLRVTELVQHVTGWKPKPGLKVLVFELSCEGEEEEMAFPP
                     LHYEL"
     exon            148..316
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            317..451
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            452..558
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            559..649
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            650..785
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            786..883
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1030
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1201
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1309
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1390
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1546
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1712
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1918
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1983
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2131
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2206
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2360
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2443
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2536
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2728
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2821
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2922
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3162
                     /gene="Uba7"
                     /gene_synonym="1300004C08Rik; Ube1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaagcag aaagagagct gtaaccagca gcaaccagcg ctttggggcc tgtttgcctt
       61 gttttccttg ccccctcctg tgagccctac agcctcctct ccagccccac gactgaggat
      121 ggatgaagag ttatactcca ggcagctgta tgtactgggc ctgcctgcta tgcagaggat
      181 ccaggaagcc aaagtcttgc tatgtggcct gcagggtctg ggagctgagg tggccaagaa
      241 cctagtcctt acaggtgtgg gcagcctcac cctgcatgat ccccatccca cctgctgggc
      301 tgacttggct gctcagtgtt tcctttcaga agagagcttg ggaaggaaca gggctgaggc
      361 ctctcaggcg caattggctc agctcaatga agctgtccag atctccgtcc acagtggcga
      421 catcactgag gacctactgc agggttttca ggtagtggtg ctgactgact ccaagctgga
      481 agaccagctg aaggtgggac ctttgtgtca caagcatgga gtccgcttcc tgatggctga
      541 aacccggggc cttgtggggc ggttattctg tgactttggt gaggacttca cagttttgga
      601 ccctactgag gtagaaccca tgacagctgc catccaggac atctctcagg gtttccccgg
      661 cattgtcacc ctgagaggag acaccaaaag acattccttc cacgatgggg acttggtgat
      721 tttctcagac attgaaggca tggttgaact caacagttgt tctccacagt ctgtccgtgt
      781 gcagaaagac gggtccttgg agattggaga tacgacaact ttctcccgtt acttgagagg
      841 tggggttgtc accgaagtca agagacccaa gaccgtgagg cataagcccc tggacatagc
      901 tctgcttcag ccccatgtgg tggctcagaa tactcaggaa gtacagcgtg ctcactgcct
      961 acatcaggcc ttccatgtac tgcacaagtt ccagcaactt catggccggc tacccaagcc
     1021 atgggatcct gatgatgcag agactgtggt ggagctggcc caggacctgg agccactaaa
     1081 agggacagaa gaagagtcac tggatgaggc tctcctccgc acaattgccc tgagtagtgc
     1141 tggtacctta agccccatgg cagccattat gggaggagtg gctgctcagg aggtcctaaa
     1201 ggccatctcc aggaagttca tgcccctgga tcagtggctg tactttgacg cccttgaatg
     1261 tcttccagaa gatgagacgc tccttcccag ccctgaggat tgtcagccaa gaaactgccg
     1321 atacgatggg caaattgctg tgtttggaac tgatcttcaa gagaaactga gtgaccaaca
     1381 ctacctcttg gtgggtgctg gtgccattgg ctgtgagatg ctcaaagtct ttgccctagt
     1441 gggcctcgga gttagggcga atggaggtgt gactgttgct gacatggatt acatagaacg
     1501 ctccaacctc agcaggcagt tcctcttcag gcccaaggat gttagaaggc ccaaggcaga
     1561 ggtggccgcc gcagcagccc atcgtctcaa cccagaccta cgagcgactc catatacctg
     1621 cccactggat cccaccacag aggatatcta cgatgacagc tttttctcca gggtgaacgg
     1681 tgttgttgct gctttggaca gcttccaggc ccggcactat gtcgctgctc gatgcaccca
     1741 ctatctgaag ccactgctgg aggccggcac ccagggcacc tgggggagtg cttcagtgtt
     1801 tgtgccctat gtgacagaag cctacagagg tcctgcctcg gatgcagctt ctgaggatgc
     1861 tccctaccct gtgtgtaccc tgaggcacat ccccagctcg atggagcaca gcgtgcagtg
     1921 ggcccaggat caatttgagg gactcttcag actatctaca gagaccatca actgctacca
     1981 acagacatgc acttccctgt cggccacgga taggacagag acactggcct tactgcagca
     2041 agtgatgggt gtcctgagaa ctcgcccaca gacctggcaa gactgtgtgg tgtgggctct
     2101 tggccactgg caactgtgct tccatgataa agtgcttgag ggtggaactc agttctcatc
     2161 aggatccaac aagtgtccac atcccttgca gtttgacccc aaccacgaca tgcatttcct
     2221 ctacgtactg gcagctgcca acctgtatgc acggatgcat gggctgcctg gctcacaaag
     2281 tcagcctgca ctcagggaac tgctgacgcg gctgctagag tctgattcca ggccccagaa
     2341 cctcttctct gctgagcatg gccaggaaca gttgaaggaa ctgcaggaaa ccctggacga
     2401 ctggaggaag gggcccccgc tgaagcctgt gctgtttgtg aaggatgatg acagcaactt
     2461 ccatgtggac tttgtggtag cagcgacaga cctgcgatgt cagaactacg ggatcctacc
     2521 agttaatcat gctcggatca agcaaatcgt gggccggatt atcccagcca ttgccaccag
     2581 tacagcagtt gtggcaggct tactgggcct ggagctgtat aaggtggtaa gcgggctccg
     2641 atcccatggt acctttcgtc acagctatct gcacctggct gaaaaccact tcatccgctc
     2701 agcgccttct gccccagccg tccagtcgtt ccgtgacctg aaatggacct gttgggaccg
     2761 cctgaaggtg cccgctgtgc agcctgaaag gacactgaag tcactgctgg cccatctcca
     2821 ggaagaacat ggactgaagg tggagatgct tctccaccac caggctctgc tctattcttc
     2881 aggatggtca tctgaaaagc aggctcaaca cctgtgcctc agggtgacag aactggttca
     2941 gcacgtgacc ggctggaagc ccaagcctgg gctgaaggtt ctggtgtttg agctgagctg
     3001 tgagggcgag gaggaagaaa tggccttccc acctctgcat tatgagctgt gacgaggtag
     3061 ccacaccacg ccaccacttg gccataacaa actctgcata aaattcctac atcttcagct
     3121 cacagcagat acttcaacaa taaaaacttg ttgacggaag gc
//
