LOCUS       NM_172712               5101 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ubiquitin-like modifier activating enzyme 6 (Uba6),
            mRNA.
ACCESSION   NM_172712
VERSION     NM_172712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5101)
  AUTHORS   Zhang,L., Jiang,L., Yu,L., Li,Q., Tian,X., He,J., Zeng,L., Yang,Y.,
            Wang,C., Wei,Y., Jiang,X., Li,J., Ge,X., Gu,Q., Li,J., Wu,D.,
            Sadler,A.J., Yu,D., Xu,D., Gao,Y., Yuan,X. and He,B.
  TITLE     Inhibition of UBA6 by inosine augments tumour immunogenicity and
            responses
  JOURNAL   Nat Commun 13 (1), 5413 (2022)
   PUBMED   36109526
  REMARK    GeneRIF: Inhibition of UBA6 by inosine augments tumour
            immunogenicity and responses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5101)
  AUTHORS   Lee,J.Y., An,E.K., Hwang,J., Jin,J.O. and Lee,P.C.W.
  TITLE     Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell
            Differentiation
  JOURNAL   Cells 11 (1), 105 (2021)
   PUBMED   35011668
  REMARK    GeneRIF: Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1
            Cell Differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5101)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5101)
  AUTHORS   Kim,M.J., Han,K.H., Yum,M.S. and Lee,P.C.W.
  TITLE     Early-stage paired housing improves social interaction in neuronal
            Uba6-deficient mice
  JOURNAL   Biochem Biophys Res Commun 514 (2), 545-549 (2019)
   PUBMED   31060776
  REMARK    GeneRIF: Early-stage paired housing improves social interaction in
            neuronal Uba6-deficient mice as a model of autism spectrum
            disorder.
REFERENCE   5  (bases 1 to 5101)
  AUTHORS   Lee,J.Y., Kwak,M. and Lee,P.C.
  TITLE     Impairment of social behavior and communication in mice lacking the
            Uba6-dependent ubiquitin activation system
  JOURNAL   Behav Brain Res 281, 78-85 (2015)
   PUBMED   25523030
REFERENCE   6  (bases 1 to 5101)
  AUTHORS   Lee,P.C., Dodart,J.C., Aron,L., Finley,L.W., Bronson,R.T.,
            Haigis,M.C., Yankner,B.A. and Harper,J.W.
  TITLE     Altered social behavior and neuronal development in mice lacking
            the Uba6-Use1 ubiquitin transfer system
  JOURNAL   Mol Cell 50 (2), 172-184 (2013)
   PUBMED   23499007
  REMARK    GeneRIF: Uba6 and Use1 promote proteasomal turnover of Ube3a in
            mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation
            in vitro.
REFERENCE   7  (bases 1 to 5101)
  AUTHORS   Hogarth,C.A., Mitchell,D., Evanoff,R., Small,C. and Griswold,M.
  TITLE     Identification and expression of potential regulators of the
            mammalian mitotic-to-meiotic transition
  JOURNAL   Biol Reprod 84 (1), 34-42 (2011)
   PUBMED   20826732
REFERENCE   8  (bases 1 to 5101)
  AUTHORS   Chiu,Y.H., Sun,Q. and Chen,Z.J.
  TITLE     E1-L2 activates both ubiquitin and FAT10
  JOURNAL   Mol Cell 27 (6), 1014-1023 (2007)
   PUBMED   17889673
  REMARK    GeneRIF: The identification of an E1-like protein, termed E1-L2,
            that activates both ubiquitin and another ubiquitin-like protein,
            FAT10, is reported.
REFERENCE   9  (bases 1 to 5101)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
REFERENCE   10 (bases 1 to 5101)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC063048.1.
            
            On Dec 20, 2003 this sequence version replaced NM_172712.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063048.1, AK049603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5101
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..5101
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /note="ubiquitin-like modifier activating enzyme 6"
                     /db_xref="GeneID:231380"
                     /db_xref="MGI:MGI:1913894"
     exon            1..76
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..3167
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /EC_number="6.2.1.45"
                     /note="ubiquitin-activating enzyme 6; ubiquitin-activating
                     enzyme E1-like protein 2; ubiquitin-activating enzyme
                     E1-like 2"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 6"
                     /protein_id="NP_766300.1"
                     /db_xref="CCDS:CCDS19378.1"
                     /db_xref="GeneID:231380"
                     /db_xref="MGI:MGI:1913894"
                     /translation="MERSEPLAVLSCEEASCSSWGACGASKNLPTMTTESLEIDDGLY
                     SRQRYVLGDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAWDLG
                     TNFFLCEDDVVNERNRAEAVLHRIAELNPYVQVSSSSAPLDETTDLSFLEKYQCVVLT
                     EIKLTLQKKINNFCHSHCPPIKFISADVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFI
                     SNITQANPGIVTCLESHPHKLETGQFLTFREIHGMTGLNGSVQQITVISPFSFSIGDT
                     TKLDPYLHGGIAVQVKTPKTFCFEPLESQIKHPRCLIADFSKPEAPLEIHLAMLALDQ
                     FQENYNRKPNIRCQQDSDELLKLTVSINETLEEKPEVNADIVHWLSWTAQGFLPPLAA
                     AVGGVASQEVLKAVTGKFSPLCQWLYLEAADTVESLGNPGHEEFLPRGDRYDAIRACI
                     GNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTGREKGMVTVTDPDLIEKSNLNR
                     QFLFRPHHIQKPKSYTAAEATLKINPQLKIDAHLNKVCPATESIYSDEFYTKQDIIIT
                     ALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEEEIPF
                     CTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQAYPSAEDVLQKIQNGQSLEGC
                     FQVIKLLSRRPRIWSQCVELARLKFEKYFNHKALQLLHCFPLETRLKDGSLFWQSPKR
                     PPSPIKFDLNEPLHLSFLQSAAKLYATVYCIPFSEKDLSVNSLMDILSEVKIEEFKPS
                     NKVVQTDETARKPDHVPVSSEDERNAVFQLEEALSSNKATKSDLQMTVLSFEKDDDRN
                     GHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATSTAAVSGLVALEMIKVAG
                     GYPFDAYKNCFLNLAIPIIVFTETSEVRKTEIRNGISFTIWDRWTVHGKEDFTLSDFI
                     NAVKENYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPSTEKKYVDLTVSFAP
                     DADGDEDLPGPPVRYYFSHDTNE"
     exon            77..139
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            140..234
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..263
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            264..358
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..470
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..551
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..674
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..798
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..902
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..965
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1042
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1109
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1253
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1321
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1400
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1481
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1559
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1741
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1847
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1937
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2018
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2147
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2199
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2263
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2333
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2405
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2523
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2717
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2845
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2933
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3028
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..5097
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4367..4372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /note="hexamer: ATTAAA"
     polyA_site      4394
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
     regulatory      4597..4602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /note="hexamer: AATAAA"
     polyA_site      4619
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /note="major polyA site"
     regulatory      4868..4873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /note="hexamer: AATAAA"
     polyA_site      4911
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
     regulatory      4975..4980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
                     /note="hexamer: ATTATA"
     polyA_site      4996
                     /gene="Uba6"
                     /gene_synonym="4930542H01; 5730469D23Rik; E1-L2; Ube1l2"
ORIGIN      
        1 aggcgatgga gcggtccgag ccgttggctg tgctttcctg tgaagaggcg tcctgctcct
       61 cctggggagc ctgcggtgca agtaaaaatt tacctaccat gacaacagaa tctttggaaa
      121 tcgatgatgg attatacagt cgccagagat atgttcttgg tgacacagca atgcagaaga
      181 tggccaagtc ctgtgtcttc ttaagtggta tgggtggtct tggagtggaa attgcaaaga
      241 atcttgttct tgcagggatt aaggccctaa caattcatga tacaaaaaaa tgccaagcat
      301 gggatctagg gaccaatttc ttcctgtgtg aagatgatgt tgttaatgag agaaacaggg
      361 ctgaagctgt acttcatcgt attgcagaac taaatccata tgttcaggtc tcatcatcct
      421 ctgcccctct tgatgaaacc acagacctct ctttcttaga aaaatatcag tgtgtagtat
      481 tgactgaaat aaaactgaca ttacaaaaga agatcaacaa tttttgccat tctcattgcc
      541 ctccaattaa gttcattagt gcagatgtac atggaatttg gtccaggttg ttttgtgatt
      601 ttggtgatga atttgaagtt tcagatacaa caggagaaga accaaaagaa attttcattt
      661 caaacataac gcaagctaat ccaggtattg tcacttgcct tgaaagtcat cctcacaagc
      721 ttgagacagg acagttccta acatttcgag aaattcatgg aatgacaggc ttaaatggat
      781 ctgtacaaca gataactgtc atatcaccat tttccttcag cattggtgat actacaaaac
      841 tggacccata tttacatgga ggcatagccg tgcaggtgaa gactcctaaa acattctgct
      901 ttgaacccct ggagagccag ataaaacatc caaggtgcct tattgcagat tttagcaaac
      961 ctgaggcacc tttagagatt catctcgcta tgcttgcctt ggaccagttt caggagaact
     1021 ataaccgtaa gccaaatatc agatgtcagc aggattcaga tgaactattg aagctaacag
     1081 tatctataaa tgaaaccttg gaagagaagc ctgaagtgaa tgctgacatt gtgcactggc
     1141 tttcgtggac tgcccaaggc tttttaccac cactcgctgc tgcagttgga ggtgttgcta
     1201 gccaagaagt cttaaaagct gtgacgggga agttctcgcc cttgtgtcaa tggttgtacc
     1261 ttgaagcagc agatactgtg gaatccctag gcaatcctgg gcatgaagag tttctcccac
     1321 gaggagatag atatgatgcc atacgtgcct gcattggaaa tacattgtgt cagaagctac
     1381 aaaatttgaa tatcttctta gtaggatgtg gtgccatagg ctgtgaaatg ttaaaaaatt
     1441 ttgcattact gggtgttggt acaggcagag agaaaggaat ggtaacagtt acagatcctg
     1501 acttgataga aaaatccaat ttaaacagac agttcctgtt tcgtcctcat cacatacaga
     1561 aacctaaaag ctatactgct gctgaagcaa ctctgaaaat aaatcctcaa ttaaaaatag
     1621 atgcacacct gaacaaagtt tgtccagcca ctgagagtat atacagtgat gaattttaca
     1681 ctaagcaaga tatcattatt acagcactag ataatgtgga agccaggaga tatgtagaca
     1741 gtcgctgttt agcaaatcta cggcctctct tagattctgg aacaatgggc accaagggac
     1801 atactgaaat tatcgtacct caattaactg aatcttataa tagtcatcga gacccccccg
     1861 aagaggaaat accattttgc actctaaagt cctttccagc agctatcgaa catactatcc
     1921 agtgggcaag agacaagttt gaaagttcct tctcccacaa accttcactg tttaacaagt
     1981 tttggcaagc atatccctct gcagaagatg tcttacagaa gatacaaaat ggacaaagtt
     2041 tagaaggctg ttttcaagtt attaagctac ttagcagaag acctagaatt tggtcccagt
     2101 gtgtagagtt agcaagacta aagtttgaaa aatactttaa ccataaggct ctgcagcttc
     2161 ttcactgttt tcctcttgag acaagactaa aagatggcag tttgttttgg caatcaccaa
     2221 aaaggccgcc ttctccaata aaatttgatt taaatgaacc tttgcacctc agttttcttc
     2281 agagtgctgc aaaactatat gctacagtat attgtattcc gttttcagaa aaggacttat
     2341 cagtgaatag cctcatggac attctttcag aagttaaaat tgaggaattc aagccttcca
     2401 acaaggttgt tcaaacagac gaaactgcaa ggaagcccga ccatgttcct gtctccagtg
     2461 aagatgaaag gaatgctgtt ttccaactag aagaggctct ttcctctaac aaagctacca
     2521 aaagtgacct tcagatgaca gtgctttcat ttgaaaaaga tgatgaccgt aatggacaca
     2581 tagatttcat cacagctgct tccaaccttc gagccaaaat gtatagcatt gaaccagctg
     2641 accgttttaa aactaaacgc atagctggta aaattatacc tgctatagca acatctactg
     2701 ctgcagtttc tggcttggtt gctttggaga tgatcaaggt agctggtggc tatcccttcg
     2761 acgcttacaa aaactgtttc cttaatttag ccattccaat aatagtgttt acagagacat
     2821 ctgaagtaag aaaaactgaa atcagaaatg gaatatcatt tacaatttgg gacagatgga
     2881 ctgtacatgg aaaagaagat ttcaccctct cagatttcat aaatgctgtc aaagaaaact
     2941 atggaattga gccgacaatg gtggtgcagg gagtcaaaat gctttatgtc cctgtaatgc
     3001 caggtcatgc aaaaaggcta aagttaacaa tgcacaaact tgtgaagcct tccactgaga
     3061 agaaatatgt ggatcttact gtgtcatttg ccccagacgc tgatggagat gaagatttgc
     3121 ccggccctcc agtgagatac tacttcagtc atgacactaa tgagtagcat tgttaccgag
     3181 atactccagc actactttat tttggaaagt gtacttaatt cagaagctca gctcataata
     3241 ctgtggattt ctttttgcct taatgtaagg gaaccatcag tagggaactt actagagtgg
     3301 agaattacaa accattttga agcatagtac acatttgtct gttgctccct gcggttatga
     3361 tcacagcacc tttgaactgg aataccattt tctaatactt attaagccct gtggatgaaa
     3421 gaaggaacaa gaaatcattt atctatgacc agaagaaata aagatgaaga aattgaaaat
     3481 agtgaatttg tactattcag aaagttaaat ccttcttcaa cgttttcttt tttatttggt
     3541 atttgagacc cattatttca atataaatag tgtggcactg tgctgcttac atgattaggc
     3601 tttgaaaatt ccatagctga taggaagagg ggtggcagat aggtgatgag tagagattta
     3661 aaactgtagt tacagttagt gtcctgctac ctgtgctaac agtgtgatat attactccct
     3721 tccctaagtc aggattgtcc ctgatctgat cagtgttgta aacagtgagg taacatgaca
     3781 tgttaacttg gactaaatgt taacagtatt acatgcactc tgatagagaa tccataaatg
     3841 tgagcagata aatatggtta atcatttgat tgttaatata cctttatttt atttatctgg
     3901 aagtctaaac tagtcatagt atttaagacc aaaaattttt tataaaggga atattcttag
     3961 aaatagatga aagttacaaa ttaatttggt tgtctttttt tccctttcca gcaatgtaat
     4021 ggagaaaaaa aaaaaatata tatatatagt attttttttt aaaggaggca tgttatttca
     4081 ctcttcattc ccaaattggg gattgactga aatagaaaaa attatatttt tttagatttt
     4141 tctttactga aagaaatact ccattgcctg atgtgaacag ttgctactta tgatataatt
     4201 gggtccatta aaatatataa acaatacttg actgtaaaat cactgaaaac agccagtaag
     4261 tcttttttac aagggttatc acgcattcta aacaagtgct tacagcctct ggaagttact
     4321 tgcctggagt tcctattctt aagaccatta ctaaatactt tgatgaatta aaatttagat
     4381 tgcatcagta ttaactccaa tggtatctct ttatactcta tactttcttt ccatttacaa
     4441 acaatttatg atctctgtgg taaccagctt tttgtttcct ccttttacga agtgtccagt
     4501 tgggaaatgg ggtgagtttg tacaataaaa tgatctgttc attcagaggt ggagaaaagt
     4561 ggacagggtt tgttttaaag aactggctac ctttaaaata aactatagtt tttatcatat
     4621 cctacctttc ccattgttca taaattgaat ccatgaatat caaaggctct gtggcttaga
     4681 acttaatgac aaaaagaagt cctattttcc agttttcact ttgttttctc ttctttggta
     4741 gtaacgtatt ctgtaggtaa tcattcagga atcctcaaac atgaagcaat agcttggctc
     4801 tgtttactta agtctacacg tatctttgaa agtaaatgag agccatgctt tgtagagtgc
     4861 tttagtaaat aaaatcaacc aggtttggtt tgtttctaat taaatccaca accattttgt
     4921 cattgggttt tgtttttgtt tttctgtagg tagtgattat tactgtccta ctaaattata
     4981 ctgaactgga aagccataat gaagttaatg actttttttt tttgttcatt ttgtacttta
     5041 agattcttgg tactaaaata tagctattga atactgagtg caaaaaaaaa aaaaaaaaaa
     5101 a
//
