LOCUS       NM_019883                568 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ubiquitin A-52 residue ribosomal protein fusion
            product 1 (Uba52), transcript variant 1, mRNA.
ACCESSION   NM_019883 XM_489863
VERSION     NM_019883.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 568)
  AUTHORS   Li,H., Huo,Y., He,X., Yao,L., Zhang,H., Cui,Y., Xiao,H., Xie,W.,
            Zhang,D., Wang,Y., Zhang,S., Tu,H., Cheng,Y., Guo,Y., Cao,X.,
            Zhu,Y., Jiang,T., Guo,X., Qin,Y. and Sha,J.
  TITLE     A male germ-cell-specific ribosome controls male fertility
  JOURNAL   Nature 612 (7941), 725-731 (2022)
   PUBMED   36517592
REFERENCE   2  (bases 1 to 568)
  AUTHORS   Tiwari,S., Singh,A., Gupta,P. and Singh,S.
  TITLE     UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative
            Signaling during Early Phase of Parkinson's Disease
  JOURNAL   Cells 11 (23), 3770 (2022)
   PUBMED   36497031
  REMARK    GeneRIF: UBA52 Is Crucial in HSP90 Ubiquitylation and
            Neurodegenerative Signaling during Early Phase of Parkinson's
            Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 568)
  AUTHORS   Liu,H., He,L., Cheng,Q., Luo,W., Zhao,T. and Yang,D.
  TITLE     Validation of superior reference genes in mouse submandibular
            glands under developmental and functional regeneration states
  JOURNAL   Int J Mol Med 50 (5) (2022)
   PUBMED   36069228
REFERENCE   4  (bases 1 to 568)
  AUTHORS   Yamada,R., Oguri,A., Fujiki,K., Shirahige,K., Takezoe,H.,
            Takahashi,N. and Kanai,Y.
  TITLE     Single-cell transcriptional analysis reveals developmental
            stage-dependent changes in retinal progenitors in the murine early
            optic vesicle
  JOURNAL   Biochem Biophys Res Commun 543, 80-86 (2021)
   PUBMED   33548738
REFERENCE   5  (bases 1 to 568)
  AUTHORS   Kobayashi,M., Oshima,S., Maeyashiki,C., Nibe,Y., Otsubo,K.,
            Matsuzawa,Y., Nemoto,Y., Nagaishi,T., Okamoto,R., Tsuchiya,K.,
            Nakamura,T. and Watanabe,M.
  TITLE     The ubiquitin hybrid gene UBA52 regulates ubiquitination of
            ribosome and sustains embryonic development
  JOURNAL   Sci Rep 6, 36780 (2016)
   PUBMED   27829658
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 568)
  AUTHORS   Jennissen,H.P.
  TITLE     Ubiquitin and the enigma of intracellular protein degradation
  JOURNAL   Eur J Biochem 231 (1), 1-30 (1995)
   PUBMED   7628459
  REMARK    Review article
REFERENCE   7  (bases 1 to 568)
  AUTHORS   Webb,G.C., Baker,R.T., Coggan,M. and Board,P.G.
  TITLE     Localization of the human UBA52 ubiquitin fusion gene to chromosome
            band 19p13.1-p12
  JOURNAL   Genomics 19 (3), 567-569 (1994)
   PUBMED   8188300
REFERENCE   8  (bases 1 to 568)
  AUTHORS   Finch,J.S., St John,T., Krieg,P., Bonham,K., Smith,H.T., Fried,V.A.
            and Bowden,G.T.
  TITLE     Overexpression of three ubiquitin genes in mouse epidermal tumors
            is associated with enhanced cellular proliferation and stress
  JOURNAL   Cell Growth Differ 3 (5), 269-278 (1992)
   PUBMED   1321656
  REMARK    Erratum:[Cell Growth Differ 1992 Aug;3(8):566]
REFERENCE   9  (bases 1 to 568)
  AUTHORS   Chau,V., Tobias,J.W., Bachmair,A., Marriott,D., Ecker,D.J.,
            Gonda,D.K. and Varshavsky,A.
  TITLE     A multiubiquitin chain is confined to specific lysine in a targeted
            short-lived protein
  JOURNAL   Science 243 (4898), 1576-1583 (1989)
   PUBMED   2538923
REFERENCE   10 (bases 1 to 568)
  AUTHORS   St John,T., Gallatin,W.M., Siegelman,M., Smith,H.T., Fried,V.A. and
            Weissman,I.L.
  TITLE     Expression cloning of a lymphocyte homing receptor cDNA: ubiquitin
            is the reactive species
  JOURNAL   Science 231 (4740), 845-850 (1986)
   PUBMED   3003914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157774.5, AK018726.1 and AA271295.1.
            
            On Jan 24, 2017 this sequence version replaced NM_019883.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN832563.1, CN833725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN02415136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC157774.5         137483-137535
            54-539              AK018726.1         3-488
            540-568             AA271295.1         465-493
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..568
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /note="ubiquitin A-52 residue ribosomal protein fusion
                     product 1"
                     /db_xref="GeneID:22186"
                     /db_xref="MGI:MGI:98887"
     exon            1..80
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /inference="alignment:Splign:2.1.0"
     exon            81..194
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..478
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /note="ubiquitin/60S ribosomal fusion protein; 60S
                     ribosomal protein L40; ubiquitin-60S ribosomal protein
                     L40; ubiquitin-ribosomal protein eL40 fusion protein"
                     /codon_start=1
                     /product="ubiquitin-ribosomal protein eL40 fusion protein
                     precursor"
                     /protein_id="NP_063936.1"
                     /db_xref="CCDS:CCDS22371.1"
                     /db_xref="GeneID:22186"
                     /db_xref="MGI:MGI:98887"
                     /translation="MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI
                     FAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYAR
                     LHPRAVNCRKKKCGHTNNLRPKKKVK"
     exon            195..281
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /inference="alignment:Splign:2.1.0"
     exon            282..547
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      515..520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /note="hexamer: AATAAA"
     polyA_site      547
                     /gene="Uba52"
                     /gene_synonym="Cep52; D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcagg cgctctcaga ggagactagg gggtttccgg ttccgctgtc ctctttctct
       61 tcaacgaggc ggccgagcgg cagacgccaa catgcagatc ttcgtgaaga ccctgacggg
      121 caagaccatc actcttgagg tcgagcccag tgacaccatc gagaatgtca aggccaagat
      181 ccaagacaag gaaggcatcc cacctgacca gcagaggctg atattcgcgg gcaaacagct
      241 ggaggatggc cgcaccctgt ccgactacaa catccagaaa gagtccacct tgcacctggt
      301 gctgcgtctg cgcggtggca tcattgagcc atcccttcgt cagcttgccc agaagtacaa
      361 ctgtgacaag atgatctgcc gcaagtgcta cgcacgcctg caccctcgtg cagtcaactg
      421 ccgcaagaag aagtgcggcc ataccaacaa cctgcgcccc aagaagaagg tcaaataaag
      481 ctgtggtcat acctggcatg tgaccccggg accaaataaa gtccccttcc atccactgga
      541 gcagtaaaaa aaaaaaaaaa aaaaaaaa
//
