LOCUS       NM_025692               2402 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus ubiquitin-like modifier activating enzyme 5 (Uba5),
            mRNA.
ACCESSION   NM_025692
VERSION     NM_025692.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Briere,L.C., Walker,M.A., High,F.A., Cooper,C., Rogers,C.A.,
            Callahan,C.J., Ishimura,R., Ichimura,Y., Caruso,P.A., Sharma,N.,
            Brokamp,E., Koziura,M.E., Mohammad,S.S., Dale,R.C., Riley,L.G.,
            Phillips,J.A., Komatsu,M. and Sweetser,D.A.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     A description of novel variants and review of phenotypic spectrum
            in UBA5-related early epileptic encephalopathy
  JOURNAL   Cold Spring Harb Mol Case Stud 7 (3), a005827 (2021)
   PUBMED   33811063
  REMARK    GeneRIF: A description of novel variants and review of phenotypic
            spectrum in UBA5-related early epileptic encephalopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Balce,D.R., Wang,Y.T., McAllaster,M.R., Dunlap,B.F., Orvedahl,A.,
            Hykes,B.L. Jr., Droit,L., Handley,S.A., Wilen,C.B., Doench,J.G.,
            Orchard,R.C., Stallings,C.L. and Virgin,H.W.
  TITLE     UFMylation inhibits the proinflammatory capacity of
            interferon-gamma-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33372156
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Yang,R., Wang,H., Kang,B., Chen,B., Shi,Y., Yang,S., Sun,L.,
            Liu,Y., Xiao,W., Zhang,T., Yang,J., Zhang,Y., Zhu,M., Xu,P.,
            Chang,Y., Jia,Y. and Huang,Y.
  TITLE     CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver
            development
  JOURNAL   Development 146 (2) (2019)
   PUBMED   30635284
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   Duan,R., Shi,Y., Yu,L., Zhang,G., Li,J., Lin,Y., Guo,J., Wang,J.,
            Shen,L., Jiang,H., Wang,G. and Tang,B.
  TITLE     UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar
            Ataxia
  JOURNAL   PLoS One 11 (2), e0149039 (2016)
   PUBMED   26872069
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2402)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   6  (bases 1 to 2402)
  AUTHORS   Tatsumi,K., Yamamoto-Mukai,H., Shimizu,R., Waguri,S., Sou,Y.S.,
            Sakamoto,A., Taya,C., Shitara,H., Hara,T., Chung,C.H., Tanaka,K.,
            Yamamoto,M. and Komatsu,M.
  TITLE     The Ufm1-activating enzyme Uba5 is indispensable for erythroid
            differentiation in mice
  JOURNAL   Nat Commun 2, 181 (2011)
   PUBMED   21304510
  REMARK    GeneRIF: The Ufm1-activating enzyme Uba5 is indispensable for
            erythroid differentiation in mice.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2402)
  AUTHORS   Tatsumi,K., Sou,Y.S., Tada,N., Nakamura,E., Iemura,S., Natsume,T.,
            Kang,S.H., Chung,C.H., Kasahara,M., Kominami,E., Yamamoto,M.,
            Tanaka,K. and Komatsu,M.
  TITLE     A novel type of E3 ligase for the Ufm1 conjugation system
  JOURNAL   J Biol Chem 285 (8), 5417-5427 (2010)
   PUBMED   20018847
REFERENCE   8  (bases 1 to 2402)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY768723.1, AK168907.1, AK077825.1, AK011151.1 and BB726528.1.
            
            On Apr 25, 2009 this sequence version replaced NM_025692.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077825.1, AK152029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY768723.1         2-7
            7-1390              AK168907.1         1-1384
            1391-1617           AK077825.1         1372-1598
            1618-1804           AK168907.1         1611-1797
            1805-2387           AK011151.1         365-947
            2388-2402           BB726528.1         405-419
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.28 cM"
     gene            1..2402
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /note="ubiquitin-like modifier activating enzyme 5"
                     /db_xref="GeneID:66663"
                     /db_xref="MGI:MGI:1913913"
     exon            1..330
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1387
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /note="ubiquitin-activating enzyme E1-domain containing 1;
                     UFM1-activating enzyme; ubiquitin-activating enzyme 5;
                     ubiquitin-activating enzyme E1 domain-containing protein
                     1"
                     /codon_start=1
                     /product="ubiquitin-like modifier-activating enzyme 5"
                     /protein_id="NP_079968.2"
                     /db_xref="CCDS:CCDS23457.1"
                     /db_xref="GeneID:66663"
                     /db_xref="MGI:MGI:1913913"
                     /translation="MADSVERLRQRVEELEQELARERTRRSGGDGHCGRTRIQEMSDE
                     VLDSNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFD
                     YDKVELANMNRLFFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMN
                     RISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMI
                     PGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGT
                     VSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPTQEAEPQEEAEVV
                     HEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKTEDSASEVTVEDSGES
                     LEDLMARMKNM"
     exon            331..376
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..466
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..576
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..663
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            664..748
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..853
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..981
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1117
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1196
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1303
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..2402
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /note="hexamer: AATAAA"
     polyA_site      1495
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
     regulatory      2369..2374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /note="hexamer: AATAAA"
     polyA_site      2389
                     /gene="Uba5"
                     /gene_synonym="5730525G14Rik; Ube1dc1"
                     /note="major polyA site"
ORIGIN      
        1 gtgccggaga cgtgtcttac tgggagcctt ggagccgctt cgccggtgtc tggacctgga
       61 aggctgtgtc tgttcctcct gcgcttcgtg ggcccagcga ggcagcgtgg ggaggcggcg
      121 acgacggcga cggcggcggt ccggcctggg atcggaggcc accgggagcc cagccatggc
      181 cgactcggtg gagcggctgc gacagcgggt tgaggagctg gagcaggaac tcgcccggga
      241 gagaacccgg cgctctggag gggacggcca ctgcggccgg acccgcatcc aggagatgag
      301 cgacgaggtg ttggattcca atccctacag ccgtctgatg gcattgaaac ggatgggaat
      361 tgtcagtgac tataagaaaa tccgtaccta cgctgtagca atagtaggtg ttggtggagt
      421 tggtagtgtg actgctgaaa tgctgacaag atgtggcatt ggtaagctgc tgctctttga
      481 ctatgataag gtggagctgg ccaacatgaa tcggcttttc ttccagccat atcaagcagg
      541 actgagtaag gtccacgcag cagaacacac cctgaggaac attaaccctg atgttctgtt
      601 tgaagtccac aactacaata tcaccacagt ggaacacttt gaacatttca tgaatagaat
      661 aagtaatggt ggattagaag aaggacaacc tgttgaccta gttcttagct gtgtggacaa
      721 ctttgaagct cgaatggcaa taaatacagc ttgtaatgaa cttggtcaga catggatgga
      781 atctggggtc agtgaaaatg cagtttccgg gcacatccag ctgatgatcc ctggagagtc
      841 ggcttgcttc gcgtgtgcgc caccacttgt agttgcttca aatattgatg aaaaaaccct
      901 gaaacgagaa ggcgtctgcg cagccagtct ccccaccacc atgggggtgg tggccgggat
      961 cttggtacaa aatgtactaa agtttctgtt aaaatttggc actgtcagtt tttaccttgg
     1021 atacaatgca atgcaggatt ttttccctac catgttcatg aagccaaacc ctcagtgtga
     1081 tgacaaaaac tgtagaaagc aacaagaaga atacaagaag agggcagcag cactgcccac
     1141 gcaggaggct gagccccagg aggaggcaga ggtggttcat gaggacaacg agtggggcat
     1201 tgagctggtg tctgaggttt cagaagagga actgaagaac tcttcaggtc ctgttcccac
     1261 cttacctgaa ggcattacag tggcatacac agtcccaaag aagacggagg attcggcttc
     1321 tgaagtaaca gtggaagact ccggcgaaag cttggaagat cttatggcca ggatgaagaa
     1381 tatgtagaca gtggctggct tctgtcttat tttctctgct tatgctagtc ccttggaatt
     1441 gaacaatcgg aactaataaa acttagcgcc gccttagttg gcatgtgtat cttcacggag
     1501 ttgttatgct gtgtggaact agtggtttcc tcctgcttcc gtatacaacc taatcagtac
     1561 cacagcgaca gaaagagaag gggtggacca tcccatccgt gtctgtggcc tacggctctg
     1621 gacgataaat agcacaaatg gaggatggac tgactgtgtg gcctggtggc tgtggctgac
     1681 aggtgtctga gtgaatggct tcctactgga cagttactca ctactactct gaccaggagt
     1741 gactttaaac agcctataga ataaaaacat caatgtaaat gagctaaata cctaataaaa
     1801 aatggaaaaa aaaaaaagaa aagaataaaa acatgcctca gataattctg gatgaaattg
     1861 aagcagaatg tcttcattgg tagtgtataa acccatggat tgaatattta agatgaagca
     1921 tagataaaag caagctatgt tcacggcaga cagaattacg ttcaggaaac attggttatc
     1981 ctcagatttt catcgatcaa ggaaaaggca tcgctctctg tagcggaagt gtctggtcac
     2041 catgttactg aagaacagac accgtccata ctttgtgcat catagagtgt tcctccatac
     2101 ttgattccat aaatactgac atgctagcaa ggcttgtctg agtggtgggc aaaacaactc
     2161 aaacctgcct ctgcagaggt gcacaggtat ttattccctg caagggctcc atttcccaag
     2221 tgtgaccact tcaattgtaa accgaggcct gatgtgaact attggtggtt taaccttgaa
     2281 gataggaaat gtatcattat gaatgtctaa attctatgta ttgagaaatg ttagtagcaa
     2341 gagttaaaag tgccattccc acttgtaaaa taaagttgta aagactcaat gcacctgctt
     2401 tg
//
