LOCUS       NP_001291974             522 aa            linear   ROD 02-MAY-2024
DEFINITION  UDP-N-acetylhexosamine pyrophosphorylase isoform 1 [Mus musculus].
ACCESSION   NP_001291974
VERSION     NP_001291974.1
DBSOURCE    REFSEQ: accession NM_001305045.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 522)
  AUTHORS   Yang,S., Jin,S., Xian,H., Zhao,Z., Wang,L., Wu,Y., Zhou,L., Li,M.
            and Cui,J.
  TITLE     Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to
            facilitate innate immune response
  JOURNAL   Mol Cell 83 (2), 298-313 (2023)
   PUBMED   36603579
  REMARK    GeneRIF: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to
            facilitate innate immune response.
REFERENCE   3  (residues 1 to 522)
  AUTHORS   Cibi,D.M., Mia,M.M., Guna Shekeran,S., Yun,L.S., Sandireddy,R.,
            Gupta,P., Hota,M., Sun,L., Ghosh,S. and Singh,M.K.
  TITLE     Neural crest-specific deletion of Rbfox2 in mice leads to
            craniofacial abnormalities including cleft palate
  JOURNAL   Elife 8, e45418 (2019)
   PUBMED   31241461
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 522)
  AUTHORS   Yi,J., Lu,L., Yanger,K., Wang,W., Sohn,B.H., Stanger,B.Z.,
            Zhang,M., Martin,J.F., Ajani,J.A., Chen,J., Lee,J.S., Song,S. and
            Johnson,R.L.
  TITLE     Large tumor suppressor homologs 1 and 2 regulate mouse liver
            progenitor cell proliferation and maturation through antagonism of
            the coactivators YAP and TAZ
  JOURNAL   Hepatology 64 (5), 1757-1772 (2016)
   PUBMED   27531557
REFERENCE   5  (residues 1 to 522)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 522)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123650.7 and AC119893.9.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147139.1, AK036243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     Protein         1..522
                     /product="UDP-N-acetylhexosamine pyrophosphorylase isoform
                     1"
                     /EC_number="2.7.7.23"
                     /EC_number="2.7.7.83"
                     /note="UDP-N-acetylhexosamine pyrophosphorylase; sperm
                     associated antigen 2; antigen X;
                     protein-pyrophosphorylation enzyme;
                     UDP-N-acetylgalactosamine pyrophosphorylase"
                     /calculated_mol_wt=58452
     Region          88..410
                     /region_name="UDPGlcNAc_PPase"
                     /note="UDPGlcNAc pyrophosphorylase catalayzes the
                     synthesis of UDPGlcNAc; cd04193"
                     /db_xref="CDD:133036"
     Site            order(108,110..111,165,196,220,222..223,251..252,289..290,
                     303..304,327,383,407)
                     /site_type="active"
                     /note="substrate binding site [active]"
                     /db_xref="CDD:133036"
     Site            order(115,285,303..305,373,398)
                     /site_type="active"
                     /note="dimerization interface [active]"
                     /db_xref="CDD:133036"
     CDS             1..522
                     /gene="Uap1"
                     /gene_synonym="AgX; AGX-1; AGX-2; AGX1; ESTM38; SPAG2"
                     /coded_by="NM_001305045.3:84..1652"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS83632.1"
                     /db_xref="GeneID:107652"
                     /db_xref="MGI:MGI:1334459"
ORIGIN      
        1 mnvndlkqrl sqagqehllq fwnelseaqq velymelqam nfeelnsffr kaigefdrss
       61 hqekvdarme pvprqvlgsa trdqeqlqaw eseglsqisq nkvavlllag gqgtrlgvsy
      121 pkgmydvglp shktlfqiqa erilklqqla ekhhgnkcti pwyimtsgrt mestkefftk
      181 hkffglkken vvffqqgmlp amsfdgkiil eeknkvsmap dgngglyral aaqnivedme
      241 qrgicsihvy cvdnilvkva dprfigfciq kgadcgakvv ektnptepvg vvcrvdgvyq
      301 vveyseisla taqrrssdgr llfnagnian hfftvpflkd vvnvyepqlq hhvaqkkipy
      361 vdsqghfikp dkpngikmek fvfdifqfak kfvvyevlre defsplknad sqngkdnptt
      421 arhalmslhh cwvlnagghf idengsrlpa iprsatngks eaitadvnhn lkdandvpiq
      481 ceisplisya geglegyvad kefhapliid engvhelvkn gi
//
