LOCUS       NM_028283               4595 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus uveal autoantigen with coiled-coil domains and ankyrin
            repeats (Uaca), transcript variant 1, mRNA.
ACCESSION   NM_028283
VERSION     NM_028283.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4595)
  AUTHORS   Dang,H.V., Sakai,T., Pham,T.A., Tran,D.H., Yorita,K., Shishido,Y.
            and Fukui,K.
  TITLE     Nucling, a novel apoptosis-associated protein, controls mammary
            gland involution by regulating NF-kappaB and STAT3
  JOURNAL   J Biol Chem 290 (40), 24626-24635 (2015)
   PUBMED   26269594
  REMARK    GeneRIF: Nucling plays an important role in mammary gland
            involution by regulating NF-kappaB and STAT3 signaling pathways
REFERENCE   2  (bases 1 to 4595)
  AUTHORS   Mori,Y., Matsui,T., Omote,D. and Fukuda,M.
  TITLE     Small GTPase Rab39A interacts with UACA and regulates the retinoic
            acid-induced neurite morphology of Neuro2A cells
  JOURNAL   Biochem Biophys Res Commun 435 (1), 113-119 (2013)
   PUBMED   23624502
  REMARK    GeneRIF: Findings indicate that UACA functions as a Rab39A effector
            in the retinoic acid-induced differentiation of Neuro2A cells.
REFERENCE   3  (bases 1 to 4595)
  AUTHORS   Kim,S.M., Sakai,T., Dang,H.V., Tran,N.H., Ono,K., Ishimura,K. and
            Fukui,K.
  TITLE     Nucling, a novel protein associated with NF-kappaB, regulates
            endotoxin-induced apoptosis in vivo
  JOURNAL   J Biochem 153 (1), 93-101 (2013)
   PUBMED   23071121
  REMARK    GeneRIF: Data from knockout mice suggest that nucling plays
            important role in induction of apoptosis in liver/hepatocytes
            damaged by cytotoxic stressors; nucling acts through modulation of
            NFkappaB signaling.
REFERENCE   4  (bases 1 to 4595)
  AUTHORS   Tran,N.H., Sakai,T., Kim,S.M. and Fukui,K.
  TITLE     NF-kappaB regulates the expression of Nucling, a novel apoptosis
            regulator, with involvement of proteasome and caspase for its
            degradation
  JOURNAL   J Biochem 148 (5), 573-580 (2010)
   PUBMED   20702393
  REMARK    GeneRIF: Nucling expression is induced by canonical NF-kappaB
            signalling pathway, whereas Nucling is undergoing proteasome
            degradation, as well as being cleaved by caspase system under
            stress conditions
REFERENCE   5  (bases 1 to 4595)
  AUTHORS   Sakai,T., Liu,L., Teng,X., Ishimaru,N., Mukai-Sakai,R., Tran,N.H.,
            Kim,S.M., Sano,N., Hayashi,Y., Kaji,R. and Fukui,K.
  TITLE     Inflammatory disease and cancer with a decrease in Kupffer cell
            numbers in Nucling-knockout mice
  JOURNAL   Int J Cancer 126 (5), 1079-1094 (2010)
   PUBMED   19637241
  REMARK    GeneRIF: Nucling deficiency could be a powerful tool to reveal the
            NF-kappaB-related molecular networks leading to hepatitis and
            hepatocellular carcinoma development.
REFERENCE   6  (bases 1 to 4595)
  AUTHORS   Sakai,T., Liu,L., Teng,X., Mukai-Sakai,R., Shimada,H., Kaji,R.,
            Mitani,T., Matsumoto,M., Toida,K., Ishimura,K., Shishido,Y.,
            Mak,T.W. and Fukui,K.
  TITLE     Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of
            stress-induced apoptosis
  JOURNAL   J Biol Chem 279 (39), 41131-41140 (2004)
   PUBMED   15271982
  REMARK    GeneRIF: Nucling recruits and transports the apoptosome complex
            during stress-induced apoptosis
REFERENCE   7  (bases 1 to 4595)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 4595)
  AUTHORS   Liu,L., Sakai,T., Sano,N. and Fukui,K.
  TITLE     Nucling mediates apoptosis by inhibiting expression of galectin-3
            through interference with nuclear factor kappaB signalling
  JOURNAL   Biochem J 380 (Pt 1), 31-41 (2004)
   PUBMED   14961764
  REMARK    GeneRIF: Nucling was shown to interfere with NF-kappaB activation
            via the nuclear translocation process of NF-kappaB/p65, thus
            inhibiting the expression of galectin-3.
REFERENCE   9  (bases 1 to 4595)
  AUTHORS   Sakai,T., Liu,L., Shishido,Y. and Fukui,K.
  TITLE     Identification of a novel, embryonal carcinoma cell-associated
            molecule, nucling, that is up-regulated during cardiac muscle
            differentiation
  JOURNAL   J Biochem 133 (4), 429-436 (2003)
   PUBMED   12761289
  REMARK    GeneRIF: expressed specifically in cardiomuscular tissue and
            up-regulated during cardiac differentiation in the developing
            embryo
REFERENCE   10 (bases 1 to 4595)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156940.1 and AC160562.2.
            
            On Oct 27, 2017 this sequence version replaced NM_028283.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042415.1, SRR7652917.122832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC156940.1         35308-35558         c
            252-385             AC160562.2         209047-209180       c
            386-474             AC160562.2         203939-204027       c
            475-539             AC160562.2         201334-201398       c
            540-597             AC160562.2         200518-200575       c
            598-668             AC160562.2         199820-199890       c
            669-775             AC160562.2         199613-199719       c
            776-963             AC160562.2         195517-195704       c
            964-1001            AC160562.2         193785-193822       c
            1002-1079           AC160562.2         190803-190880       c
            1080-1187           AC160562.2         188861-188968       c
            1188-1220           AC160562.2         186597-186629       c
            1221-1319           AC160562.2         186322-186420       c
            1320-1356           AC160562.2         183619-183655       c
            1357-1409           AC160562.2         182536-182588       c
            1410-4118           AC160562.2         177737-180445       c
            4119-4271           AC160562.2         175835-175987       c
            4272-4337           AC160562.2         173593-173658       c
            4338-4595           AC160562.2         169589-169846       c
FEATURES             Location/Qualifiers
     source          1..4595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.93 cM"
     gene            1..4595
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /note="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats"
                     /db_xref="GeneID:72565"
                     /db_xref="MGI:MGI:1919815"
     exon            1..251
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..4409
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear membrane binding protein NUCLING; nuclear
                     membrane-binding protein"
                     /codon_start=1
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform 1"
                     /protein_id="NP_082559.1"
                     /db_xref="CCDS:CCDS23259.1"
                     /db_xref="GeneID:72565"
                     /db_xref="MGI:MGI:1919815"
                     /translation="MKSLKSRLWKQDAPGPTSPSSPTAVASTQSAEWNKYDDRLMKAA
                     ERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSA
                     GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGA
                     SVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAV
                     EVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGGGRELWRKGPPL
                     QQRNLSHTQDEGSVKSTQREQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGL
                     QLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHPGPGS
                     YPSNRKEDMLHKQGQMYTTEPQCASPGIPPHMHSRSMLRPLELSLPSQTSYSENEILK
                     KELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD
                     VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAE
                     VGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLK
                     ELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVR
                     AQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSL
                     TVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTK
                     NVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLK
                     KTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRN
                     LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIK
                     AQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKG
                     KQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKS
                     EREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCL
                     EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKE
                     VSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQAC
                     EEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITE
                     LLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVI
                     AIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGLVC"
     exon            252..385
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            386..474
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            475..539
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            540..597
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            598..668
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            669..775
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            776..963
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1001
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1079
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1187
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1220
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1319
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1356
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1409
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..4118
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4271
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4337
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     exon            4338..4595
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4501..4506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /note="hexamer: AATAAA"
     polyA_site      4529
                     /gene="Uaca"
                     /gene_synonym="2700059D02Rik; nucling"
                     /note="major polyA site"
ORIGIN      
        1 aggagacggg cccgattggc tgccggaggg acccggttga gcgaggcccc cggggcccca
       61 ggtggcaggt ggggcgggcc ccgcgcgctc cggggcgtca gcagctccgg ctcttgccct
      121 cgcagcccgc aatctggtgg gaacccggac ccttgagagc cgtggccatg aagagcctca
      181 agtcccgact gtggaagcag gacgcgcccg gccccacgtc accctcatcg cccaccgcgg
      241 tggccagcac gcaatcagcg gagtggaata agtacgatga ccggttgatg aaggctgctg
      301 aaagagggga tgtggagaaa gtgtcctcca tccttgccaa aaagggcgtc catcccggca
      361 agctagatgt ggaaggcaga tcggccttcc acgtcgtggc atccaaaggg aatctggagt
      421 gtctgaatgc catccttacg catggcattg atgttgcaac cagggacagt gcagggagga
      481 atgcgcttca cctggcagct aagtacggac acgcgttgtg cctgcagaaa cttctacagt
      541 acaactgtcc cactgagcat gtggaccttc aaggaagaac tgcccttcat gatgcagcca
      601 tggcagactg tccttccagc atccagctgc tctgtgacca cggggcctcc gtgaatgcca
      661 aagatataga cgggcggaca ccacttgttc tggcgactca gatgtgcagg ccgacaattt
      721 gtcagttgct gatagacaga ggggcagatg tcaattccag agacaaacaa aacaggacag
      781 ctctgatgct gggctgcgag tacggttgca gagatgccgt agaagtcctc gtgaaaaatg
      841 gtgccgacct gaccttgctg gatgcccttg gccacgacag ttcttactac gctagaattg
      901 gtgacaacct ggacatcctg aacctactga agacggcgtc agaaaacacc aacaaaggtg
      961 gcgggcgaga actttggagg aaaggaccgc ctttgcagca gcggaatttg tcacacactc
     1021 aggacgaagg aagcgtgaag tcaactcaga gggaacagag ggaaccccac agctttcagg
     1081 atctagagat tgaaaatgaa gatttaagag agaagttgag gaagattcag caagaacaaa
     1141 gaatcctcct ggataaagtc aatggcttac agttacagct gaatgaggaa gtaatggtcg
     1201 cagatgatct ggaaagcgag agagaaaagc tgaagtccct tttggcggct aaagaaaagc
     1261 aacacgaaga aagcttaaga accatcgagg ccctgaaaaa cagatttaaa tattttgaga
     1321 gtgatcaccc aggacccgga agttacccga gtaaccgaaa agaagacatg ctgcataaac
     1381 aaggtcaaat gtacacgaca gagccacagt gtgcatcacc gggtatacct ccccatatgc
     1441 atagcaggtc tatgctaagg cctctggagt tgtctttacc cagtcagacc tcatactctg
     1501 aaaatgagat tttaaagaaa gaattggaaa ccttgcgaac ttactatgac tcggcaaaac
     1561 aggaccgact gaagttccaa aacgaactgg ctcacaaggt ggcggagtgc aaagccttag
     1621 ctctggagtg cgagagagtc aaggaagact cggacgaaca gatcaagcag ctggaagatg
     1681 ccctcaaaga cgtgcagaag aggatgtatg agtccgaagg gaaagtcaaa caaatgcaga
     1741 cccacttcct cgccctcaaa gagcacctga ccaacgaagc ggccacaggg agccaccgca
     1801 tcatcgagga actgagggag cagctgaaag acctgaaagg caaatatgaa ggcgcttcgg
     1861 ccgaggtagg caagctgcgg agccagatca aacagagcga gatgctggtg ggagagttca
     1921 agagagacga gggcaggctg gtggaagaga ataagcgatt gcagaaggaa tgcggcacat
     1981 gtgaagtcga gctggagagg agggggcgac gggtcgtgga actggagggc cagctgaagg
     2041 agctgggggc taagctggcc ctttctgtcc ccacagagaa atttgaaagc atgaagagct
     2101 cattatccaa tgacatcaat gagaaagtga aaaggctggc ggaggtgggg cgggactatg
     2161 aaagcgctca gggggaaatt cgacagctga agagggacct agagagtgtc agggcccagc
     2221 atatcaggcc ggaggagcat gaacagctca gaagcaggtt ggagcagaag tcgggagagc
     2281 tggggaagaa ggtgtcagag ctgaccctca aaaaccagac gctgcagaaa gacgtggaaa
     2341 aactccacgc cgacaacaaa cttctcaacc agcaggtgca cagcctcacg gtggagatga
     2401 aaacgcgcta cgtgcctcta agggtcagcg aagagatgaa gaagtcgcat gacgtaaacg
     2461 tggaggattt gaataagaag ctttcggagg caacacagag atacacagag aagaagcagg
     2521 aagcagagag actgctggcg gagaacgata agttgactaa gaatgtcagc cgcctggaag
     2581 ctgtgtttgt agctcccgag aaacatgaaa aggagctaat gggtctgaaa tccaatatcg
     2641 cagaactgaa aaagcaactg tctgagctta ataaaaaatg tggtgagggt caggagaaaa
     2701 tacgtgcact tatgtctgaa aacagcagct tgaaaaagac tctgagtagc cagtatgtgc
     2761 ctgccaagac ccacgaggag gtgaaggcct ccctgaacag caccgtggag aaaaccaaca
     2821 gagccttact ggaggcgaag aaaaggtttg acgacacgag ccaggaggtt tcaaaactaa
     2881 gagatgagaa cgaagtattg aggaggaacc tggagaacgt tcagaatcag atgaaggctg
     2941 actatgtgag cctggaggag cactcgagaa ggatgagcac ggtgagccag agtctgaagg
     3001 aggcacagga ggccaacgct gccatcctgg ccgaccaccg ccagggccag gaggagatcg
     3061 tctcgctcca cgctgaaatc aaggcccaga aaaaggagct ggacaccatc caggagtgca
     3121 tcaagctgaa gtacgcgccc cttgcccgct tggaagagtg tgagcgcaag ttcaaggcca
     3181 cagagaaagg actgaaggag cagttatcag agcagacgca caagtgtcgc cagagggacg
     3241 aagaggtcaa gaagggcaag caagagaacg agaggctgcg ggcggacctg gccgcccttc
     3301 agaaggagct gcaggatagg aacgctctgg cggaagaggc ccgggaagca gaaagagcgt
     3361 tgagtggcaa ggcagacgag ctcagcaagc agctgaagga cctgtcccaa aagtacagcg
     3421 acgtgaagag cgagagagag aagctggtag aagaaaaggc caagcaggcc tccgagatcc
     3481 tggcagccca aaatcttctg cagaagcagc cggtcccgct ggagcaggtg gaggctctga
     3541 aaaaatctct caacggcacc attgagcagt tgaaggagga gctgaggagt aagcagaggt
     3601 gtctggagcg cgagcagcag acggtgagcc agcttcagca gctgctggag aatcagaaga
     3661 actcctcggt gaccctggcg gagcacctga agctaaagga agccctcgag aaagaggttg
     3721 ggatcatgaa agccagcctg agagaaaagg aagaggaaag ccagaagaaa accaaggaag
     3781 tctccaaact ccagacggag gttcagacca ccaagcaggc gctgaagaac ttagagacca
     3841 gagaggtcgt cgacatgtcg aagtacaaag ccaccaagaa cgacttggag acccagattt
     3901 ccaacttaaa tgacaaactg gccagcctga acaggaagta cgaccaagcg tgtgaggaga
     3961 aggtctctgc caaggacgag aaggagctgc tccacctgag catcgagcag gagatcaggg
     4021 accagaagga gcgctgtgac aagtccctga cgaccatcat ggaactgcag cagaggatcc
     4081 aggagtccgc caagcagatc gaagccaagg acaataagat aactgaactt ctgaatgatg
     4141 tcgaaagact aaagcaggcg ctcaacggcc tttctcagct cacctacagc agtggcagcc
     4201 ccaccaagcg gcagagccag ctggtggata ctctgcagca gcgagtgagg gatctgcagc
     4261 agcagctggc tgatgctgac agacagcacc aagaagttat cgctatctac cggacacacc
     4321 tcctcagtgc cgcacagggc cacatggatg aagatgtgca ggcagcccta ctgcagatca
     4381 tacagatgcg acaaggcctt gtgtgctagc ggcagctgac ttggagcctg tcctgctggt
     4441 gctatgcatt ctgggtgcaa ctctgtgctc ttctgggcct tactctgata gtatcagtaa
     4501 aataaactat attttgttcc gttgttgaat tttacttttc tgagatgagt gtgtcaccga
     4561 gttttccagt ggattaaaag ttgatattct gtgtt
//
