LOCUS       NM_001205231            2616 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus U2 small nuclear ribonucleoprotein auxiliary factor
            (U2AF) 2 (U2af2), transcript variant 1, mRNA.
ACCESSION   NM_001205231
VERSION     NM_001205231.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2616)
  AUTHORS   Yang,G., Xiang,J., Yang,X., Liu,X., Li,Y., Li,L., Kang,L., Liang,Z.
            and Yang,S.
  TITLE     Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to
            modulate renal fibrosis through alternative splicing-mediated
            upregulation of CCN2
  JOURNAL   Elife 13, 98524 (2024)
   PUBMED   39495216
  REMARK    GeneRIF: Nuclear translocation of SIRT4 mediates deacetylation of
            U2AF2 to modulate renal fibrosis through alternative
            splicing-mediated upregulation of CCN2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2616)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2616)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   4  (bases 1 to 2616)
  AUTHORS   Crisci,A., Raleff,F., Bagdiul,I., Raabe,M., Urlaub,H., Rain,J.C.
            and Kramer,A.
  TITLE     Mammalian splicing factor SF1 interacts with SURP domains of U2
            snRNP-associated proteins
  JOURNAL   Nucleic Acids Res 43 (21), 10456-10473 (2015)
   PUBMED   26420826
REFERENCE   5  (bases 1 to 2616)
  AUTHORS   Manceau,V., Kremmer,E., Nabel,E.G. and Maucuer,A.
  TITLE     The protein kinase KIS impacts gene expression during development
            and fear conditioning in adult mice
  JOURNAL   PLoS One 7 (8), e43946 (2012)
   PUBMED   22937132
REFERENCE   6  (bases 1 to 2616)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2616)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2616)
  AUTHORS   Davies,R.C., Calvio,C., Bratt,E., Larsson,S.H., Lamond,A.I. and
            Hastie,N.D.
  TITLE     WT1 interacts with the splicing factor U2AF65 in an
            isoform-dependent manner and can be incorporated into spliceosomes
  JOURNAL   Genes Dev 12 (20), 3217-3225 (1998)
   PUBMED   9784496
REFERENCE   9  (bases 1 to 2616)
  AUTHORS   Sailer,A., MacDonald,N.J. and Weissmann,C.
  TITLE     Cloning and sequencing of the murine homologue of the human
            splicing factor U2AF65
  JOURNAL   Nucleic Acids Res 20 (9), 2374 (1992)
   PUBMED   1594454
REFERENCE   10 (bases 1 to 2616)
  AUTHORS   Zamore,P.D., Patton,J.G. and Green,M.R.
  TITLE     Cloning and domain structure of the mammalian splicing factor U2AF
  JOURNAL   Nature 355 (6361), 609-614 (1992)
   PUBMED   1538748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162893.6.
            
            On Mar 28, 2022 this sequence version replaced NM_001205231.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X64587.1, AK078496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-620               AC162893.6         28585-29204
            621-756             AC162893.6         33271-33406
            757-801             AC162893.6         34078-34122
            802-905             AC162893.6         34412-34515
            906-1057            AC162893.6         34900-35051
            1058-1174           AC162893.6         36312-36428
            1175-1313           AC162893.6         37230-37368
            1314-1393           AC162893.6         41449-41528
            1394-1516           AC162893.6         41603-41725
            1517-1615           AC162893.6         42009-42107
            1616-1864           AC162893.6         42336-42584
            1865-2616           AC162893.6         46050-46801
FEATURES             Location/Qualifiers
     source          1..2616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.93 cM"
     gene            1..2616
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /note="U2 small nuclear ribonucleoprotein auxiliary factor
                     (U2AF) 2"
                     /db_xref="GeneID:22185"
                     /db_xref="MGI:MGI:98886"
     exon            1..620
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            621..756
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            757..801
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            802..905
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1057
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1174
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1313
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1393
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1516
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1615
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1864
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2616
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /note="hexamer: ATTAAA"
     polyA_site      2616
                     /gene="U2af2"
                     /gene_synonym="65kDa"
                     /note="major polyA site"
ORIGIN      
        1 agaatcgggc ttaatctcta gaggggcggt gagcgagcgc tggaaacctt cggaaagagc
       61 cgaaggcccg gacggttagg attgttggaa gtgactgacc gcttggacag ggtcggcgag
      121 gggtgggacg gatttccaga ggaggccaga gacagacggt ttgagttgta ggaaaatccg
      181 tgtctttaga gggggctggt gtcggggaac gcgaagactc gcggaatcct ccgaacgttg
      241 aaacgctagt ttccgaaaag ttaccgaaac tcgggcagcc ggcataatcc tcgcttcggg
      301 tgattttgac ggcgaccgcc gccttccgac tgctccgtcc gagaacagcc gacaggcttc
      361 ggagccgagc tcggggaagt tccggggggg ggcgggtcgg gcgggacgag ggggtggagc
      421 ctgggagggg cggggcttgg ggcttgatta ggtaggcgac ggagtgccgg cgggggccgg
      481 aagtagccga agccagcggc ggaagtagcc ggagcgggcg ggcggcaagg cgaggcgaga
      541 gctgcacagg gccctacgcg gccgcctaag catgtcggac ttcgacgagt tcgagcggca
      601 gctcaacgag aataaacaag agcgggacaa ggagaatcgg cacaggaagc gtagtcacag
      661 tcgctctcga agccgagatc gaaagcgcag gagcaggagc cgagatcggc gcaaccggga
      721 ccagcgcagt gcctctcggg ataggagacg acgaagcaaa cctttgacca gaggcgctaa
      781 agaggagcac ggtggattga ttcgttctcc ccgccatgag aagaagaaga aggtgcgtaa
      841 atactgggac gtgccaccgc ctggctttga gcacatcacc ccaatgcagt acaaggccat
      901 gcaagctgcg ggtcagattc cagccactgc ccttctcccg accatgactc ctgatggtct
      961 ggctgtgacc ccaacgccag tgcctgtggt tgggagccag atgaccagac aggccagacg
     1021 tctctacgtg ggcaacatcc cttttggcat tactgaggag gctatgatgg acttcttcaa
     1081 cgcccagatg cgcttgggag ggttgactca ggcccctggc aacccagtct tggctgtgca
     1141 gataaatcaa gacaagaatt ttgccttttt ggagttccgg tcagtggatg agacgaccca
     1201 ggccatggca tttgatggca tcatcttcca gggccagtca ttgaagattc gaaggcctca
     1261 tgactatcag ccattgcctg gcatgtcaga gaacccctct gtttatgtgc ctggagttgt
     1321 atccactgta gtcccagatt ctgcccacaa gctgttcatc gggggtttgc ccaattacct
     1381 aaatgatgac caggtaaaag agctgctgac atcctttggg cctctcaagg ccttcaactt
     1441 ggttaaggat agtgccacag ggctctccaa gggctatgcc ttctgtgagt acgtggacat
     1501 caacgtcaca gatcaggcca ttgcggggct gaatgggatg cagctagggg acaagaagct
     1561 gcttgtccag agggcgagtg tgggagccaa gaatgccacg ctggtgagcc tcccgagcac
     1621 catcaatcag acacctgtga cccttcaagt gcccggcctg atgagctctc aggtgcagat
     1681 gggcggtcac ccaactgagg tcctgtgcct catgaacatg gtgctgcctg aggagctgct
     1741 ggacgatgag gagtatgagg agattgtaga ggacgtacga gacgagtgca gcaagtatgg
     1801 gttggtcaaa tccattgaaa ttccccgccc cgtggacggc gtcgaggtgc ctggctgtgg
     1861 aaagatcttc gtggagttca cctctgtgtt tgactgccag aaagccatgc agggtctaac
     1921 cggtcgcaag ttcgccaaca gagtggtggt cacaaaatac tgtgaccctg attcttacca
     1981 ccgtcgggac ttctggtaga ggtggctggg ggagggtggg ggcagggctg gctggggact
     2041 ttccccccac ctgtcccctc ctcctttccc ccctcttgaa gaagatgggc agaggagtga
     2101 cagccgaatg acagccggca gcaactggaa tggcagcaat taaggggggt ggggggtggg
     2161 gggctagggc aggaagggga ctgggcaagt gcacacaggc ccacacagac acatgcaccc
     2221 acacagacac agagggaacg ggctgggatg gggactgtgt gcacagcagg gcgggtagga
     2281 cctccacagc cccttcccaa acagcctctt atcccttaca cccctttcct cctctcttcc
     2341 cccatggtag gaacatagcg tgtttatatt ttatggccaa actattttga attttgttgt
     2401 ctggccctca gtgccctgcc ctctcccttt gcaggaccac agctcccgtc ctttggcttc
     2461 tggtccttcc tgttctccac cctggtttct taagtagttg gttcttctcc ttagtcttcc
     2521 tgactcaacc cgtggtctct gtcccgctcc ccctctctgt ggcagtttca tatttgctaa
     2581 tacgaatttg ctcattaaac attttgttgt atttta
//
