LOCUS       NM_170760                864 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus U2 small nuclear RNA auxiliary factor 1-like 4
            (U2af1l4), mRNA.
ACCESSION   NM_170760
VERSION     NM_170760.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Preussner,M., Wilhelmi,I., Schultz,A.S., Finkernagel,F., Michel,M.,
            Moroy,T. and Heyd,F.
  TITLE     Rhythmic U2af26 alternative splicing controls PERIOD1 stability and
            the circadian clock in mice
  JOURNAL   Mol Cell 54 (4), 651-662 (2014)
   PUBMED   24837677
  REMARK    GeneRIF: Data suggest light-induced U2af26 alternative splicing to
            be a buffering mechanism that limits PERIOD1 induction, thus
            stabilizing the circadian clock against abnormal changes in
            light:dark conditions.
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Heyd,F., Carmo-Fonseca,M. and Moroy,T.
  TITLE     Differential isoform expression and interaction with the P32
            regulatory protein controls the subcellular localization of the
            splicing factor U2AF26
  JOURNAL   J Biol Chem 283 (28), 19636-19645 (2008)
   PUBMED   18460468
  REMARK    GeneRIF: Differential isoform expression and interaction with the
            P32 regulatory protein controls the subcellular localization of the
            splicing factor U2AF26
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Heyd,F., ten Dam,G. and Moroy,T.
  TITLE     Auxiliary splice factor U2AF26 and transcription factor Gfi1
            cooperate directly in regulating CD45 alternative splicing
  JOURNAL   Nat Immunol 7 (8), 859-867 (2006)
   PUBMED   16819553
REFERENCE   5  (bases 1 to 864)
  AUTHORS   Shepard,J., Reick,M., Olson,S. and Graveley,B.R.
  TITLE     Characterization of U2AF(6), a splicing factor related to U2AF(35)
  JOURNAL   Mol Cell Biol 22 (1), 221-230 (2002)
   PUBMED   11739736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC167970.4.
            
            On Nov 17, 2006 this sequence version replaced NM_170760.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060972.1, DV043681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC167970.4         56892-56951         c
            61-148              AC167970.4         56672-56759         c
            149-215             AC167970.4         56295-56361         c
            216-265             AC167970.4         56160-56209         c
            266-364             AC167970.4         55990-56088         c
            365-498             AC167970.4         55684-55817         c
            499-594             AC167970.4         55493-55588         c
            595-864             AC167970.4         54927-55196         c
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.61 cM"
     gene            1..864
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /note="U2 small nuclear RNA auxiliary factor 1-like 4"
                     /db_xref="GeneID:233073"
                     /db_xref="MGI:MGI:2678374"
     exon            1..60
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..679
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /note="U2 auxiliary factor 26; U2 small nuclear RNA
                     auxiliary factor 1-like protein 4; U2AF1-like 4"
                     /codon_start=1
                     /product="splicing factor U2AF 26 kDa subunit"
                     /protein_id="NP_739566.1"
                     /db_xref="CCDS:CCDS21100.1"
                     /db_xref="GeneID:233073"
                     /db_xref="MGI:MGI:2678374"
                     /translation="MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQ
                     TIVLLNLYRNPQNTAQTADGSHCHVSDVEVQEHYDNFFEEVFTELQEKYGEIEEMNVC
                     DNLGDHLVGNVYVKFRREEDAERAVAELNNRWFNGQAVHAELSPVTDFRESCCRQYEM
                     GECTRGGFCNFMHLRPISRNLRRQLYGRGPRHRSPPRSHTGHRPRERNRRRSPDHRHG
                     RF"
     exon            61..148
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     exon            149..215
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     exon            216..265
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     exon            266..364
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     exon            365..498
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     exon            499..594
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     exon            595..864
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /note="hexamer: AATAAA"
     polyA_site      864
                     /gene="U2af1l4"
                     /gene_synonym="U2af26"
                     /note="major polyA site"
ORIGIN      
        1 gagtgttcgg gtaaaaatgg ctgaatattt agcttcgata ttcgggactg agaaggacaa
       61 ggttaactgc tctttttact ttaagattgg agcctgccgg cacggggacc ggtgctcccg
      121 acttcacaac aaaccgactt tcagccagac catagtcctg ctcaacttgt accggaatcc
      181 acagaacaca gcccaaactg cagatggatc acactgtcac gtgagcgacg tggaggtgca
      241 agaacactat gataacttct ttgaggaggt attcacagaa ctgcaggaga agtatggaga
      301 gattgaagag atgaatgtgt gtgacaacct cggggaccac ctcgtgggca atgtctacgt
      361 taagttccgg cgggaggagg atgcagagcg ggctgtagcg gaactcaata accgctggtt
      421 caacgggcag gctgtgcatg ccgagctgtc tcctgtcact gacttccgag agtcctgctg
      481 ccggcagtat gagatggggg aatgcacccg aggtggcttc tgcaacttta tgcacctacg
      541 gcccatatct cggaacttgc gccggcagct ctatgggcga ggacccaggc ataggtcacc
      601 tccaaggtcc cacacaggtc accgtccccg agaaaggaac cgacgtcgtt ccccagacca
      661 ccggcatggt cgcttctgag acgggtgccc ttgctctcca cccaagggca tagatgttcc
      721 tgtccagcgt cccttttcaa agtgcccttc actctccagt cccagcatcc ccaggcttcg
      781 gagcttcata atataatctg ttcgacacag gaacctcctc ctcctgtccc tcctccaata
      841 aaggttaaga agtttgtcaa tcaa
//
