LOCUS       NM_024187                907 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus U2 small nuclear ribonucleoprotein auxiliary factor
            (U2AF) 1 (U2af1), transcript variant 1, mRNA.
ACCESSION   NM_024187
VERSION     NM_024187.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 907)
  AUTHORS   Gurule,N.J., Malcolm,K.C., Harris,C., Knapp,J.R., O'Connor,B.P.,
            McClendon,J., Janssen,W.J., Lee,F.F.Y., Price,C., Osaghae-Nosa,J.,
            Wheeler,E.A., McMahon,C.M., Pietras,E.M., Pollyea,D.A. and Alper,S.
  TITLE     Myelodysplastic neoplasm-associated U2AF1 mutations induce host
            defense defects by compromising neutrophil chemotaxis
  JOURNAL   Leukemia 37 (10), 2115-2124 (2023)
   PUBMED   37591942
  REMARK    GeneRIF: Myelodysplastic neoplasm-associated U2AF1 mutations induce
            host defense defects by compromising neutrophil chemotaxis.
REFERENCE   3  (bases 1 to 907)
  AUTHORS   Wedge,E., Ahmadov,U., Hansen,T.B., Gao,Z., Tulstrup,M., Come,C.,
            Nonavinkere Srivatsan,S., Ahmed,T., Jespersen,J.S.,
            Schlotmann,B.C., Schollkopf,C., Raaschou-Jensen,K., Odum,N.,
            Kjems,J., Bak,R.O., Walter,M.J., Gronbaek,K. and Kristensen,L.S.
  TITLE     Impact of U2AF1 mutations on circular RNA expression in
            myelodysplastic neoplasms
  JOURNAL   Leukemia 37 (5), 1113-1125 (2023)
   PUBMED   36922625
  REMARK    GeneRIF: Impact of U2AF1 mutations on circular RNA expression in
            myelodysplastic neoplasms.
REFERENCE   4  (bases 1 to 907)
  AUTHORS   Wadugu,B.A., Nonavinkere Srivatsan,S., Heard,A., Alberti,M.O.,
            Ndonwi,M., Liu,J., Grieb,S., Bradley,J., Shao,J., Ahmed,T.,
            Shirai,C.L., Khanna,A., Fei,D.L., Miller,C.A., Graubert,T.A. and
            Walter,M.J.
  TITLE     U2af1 is a haplo-essential gene required for hematopoietic cancer
            cell survival in mice
  JOURNAL   J Clin Invest 131 (21) (2021)
   PUBMED   34546980
  REMARK    GeneRIF: U2af1 is a haplo-essential gene required for hematopoietic
            cancer cell survival in mice.
REFERENCE   5  (bases 1 to 907)
  AUTHORS   Kim,S.P., Srivatsan,S.N., Chavez,M., Shirai,C.L., White,B.S.,
            Ahmed,T., Alberti,M.O., Shao,J., Nunley,R., White,L.S.,
            Bednarski,J., Pehrson,J.R. and Walter,M.J.
  TITLE     Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1)
            regulates B-lymphopoiesis in mice
  JOURNAL   Cell Rep 36 (9), 109626 (2021)
   PUBMED   34469727
  REMARK    GeneRIF: Mutant U2AF1-induced alternative splicing of H2afy
            (macroH2A1) regulates B-lymphopoiesis in mice.
REFERENCE   6  (bases 1 to 907)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 907)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 907)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 907)
  AUTHORS   Shepard,J., Reick,M., Olson,S. and Graveley,B.R.
  TITLE     Characterization of U2AF(6), a splicing factor related to U2AF(35)
  JOURNAL   Mol Cell Biol 22 (1), 221-230 (2002)
   PUBMED   11739736
REFERENCE   10 (bases 1 to 907)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150872.1.
            
            On Jul 31, 2009 this sequence version replaced NM_024187.3.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 2 are the same length, as are isoforms 1 and 2; however, their
            sequences vary slightly.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150872.1, CA979558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.02 cM"
     gene            1..907
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /note="U2 small nuclear ribonucleoprotein auxiliary factor
                     (U2AF) 1"
                     /db_xref="GeneID:108121"
                     /db_xref="MGI:MGI:98884"
     exon            1..102
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..778
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /note="U2 small nuclear ribonucleoprotein auxiliary factor
                     (U2AF) 1 (MGD|MGI:98884 GB|AK088979, evidence: BLASTN,
                     99%, match=874); putative; isoform 1 is encoded by
                     transcript variant 1; splicing factor U2AF 35 kDa subunit;
                     U2 auxiliary factor 35 kDa subunit; U2 snRNP auxiliary
                     factor small subunit"
                     /codon_start=1
                     /product="splicing factor U2AF 35 kDa subunit isoform 1"
                     /protein_id="NP_077149.2"
                     /db_xref="CCDS:CCDS28611.1"
                     /db_xref="GeneID:108121"
                     /db_xref="MGI:MGI:98884"
                     /translation="MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQ
                     TIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVC
                     DNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEM
                     GECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGG
                     GGGGRERDRRRSRDRERSGRF"
     exon            103..190
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            191..257
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            258..307
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            308..406
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..540
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..633
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..907
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      885..890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /note="putative"
     polyA_site      907
                     /gene="U2af1"
                     /gene_synonym="2010107D16Rik"
                     /note="putative"
ORIGIN      
        1 gagggacgtc ggcgtagtcg gcagcgtcgg ctgccgtgcc tgagtcgtcc gctcgaaaat
       61 ggcggaatac ttggcctcca tcttcggcac cgaaaaagac aaagtcaact gttcatttta
      121 tttcaaaatc ggagcatgtc gtcatggaga cagatgttct cggttgcaca ataaaccaac
      181 ctttagccag accattgccc tcttgaacat ttaccgtaac cctcaaaact cttcccagtc
      241 tgctgacggt ttgcgctgtg ctgtgagcga cgtggagatg caggagcact atgatgagtt
      301 ctttgaggaa gtcttcactg agatggaaga gaagtacggg gaagtcgagg agatgaacgt
      361 ctgcgacaac ctaggggacc acctggtggg gaacgtgtat gtcaagtttc gacgtgagga
      421 ggatgcagag aaagccgtga tcgacttgaa taaccgttgg tttaatggac agccgatcca
      481 tgcagagctg tccccagtaa ctgacttcag ggaagcctgc tgccgccagt atgaaatggg
      541 agagtgcaca agagggggct tctgcaactt catgcatttg aagcccatct caagagagct
      601 acgacgggag ctgtatgggc gccggcgcaa gaagcataga tccaggtccc gatccaggga
      661 acggcgttcc cgatccagag accgtggacg cggtggtgga ggtggaggtg gaggtggcgg
      721 aggacgggag cgtgacagga ggcggtcaag agaccgggag agatctggac gattctgagc
      781 cgagcccttt ttaccgtgtg tctgctagac agtgttgtag ttggttgaca agccagttca
      841 taatgggatt ttttttttta aaaaacaaca aagatgggtt tctgaataaa ctttgtagtg
      901 atacagt
//
