LOCUS       NM_001037742            1448 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tRNA-yW synthesizing protein 5 (Tyw5), transcript
            variant 1, mRNA.
ACCESSION   NM_001037742 XM_283610 XM_900562 XM_900566 XM_900570 XM_900575
            XM_900579 XM_907447 XM_920365 XM_920379 XM_920383 XM_920391
            XM_920399
VERSION     NM_001037742.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Kato,M., Araiso,Y., Noma,A., Nagao,A., Suzuki,T., Ishitani,R. and
            Nureki,O.
  TITLE     Crystal structure of a novel JmjC-domain-containing protein, TYW5,
            involved in tRNA modification
  JOURNAL   Nucleic Acids Res 39 (4), 1576-1585 (2011)
   PUBMED   20972222
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161493.6, BU697704.1, BC132289.1 and BC099495.1.
            
            On Jan 30, 2008 this sequence version replaced NM_001037742.1.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site and lacks an alternate in-frame exon in the 5' coding
            region, compared to variant 4. The resulting protein (isoform 1) is
            shorter than isoform 4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132289.1, SRR7345562.3885695.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC161493.6         147925-147957       c
            34-227              BU697704.1         1-194
            228-1349            BC132289.1         77-1198
            1350-1448           BC099495.1         1092-1190
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.78 cM"
     gene            1..1448
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /note="tRNA-yW synthesizing protein 5"
                     /db_xref="GeneID:68736"
                     /db_xref="MGI:MGI:1915986"
     exon            1..291
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1161
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /EC_number="1.14.11.42"
                     /note="isoform 1 is encoded by transcript variant 1; jmjC
                     domain-containing protein C2orf60 homolog; tRNA
                     yW-synthesizing enzyme 5; tRNA wybutosine-synthesizing
                     protein 5; tRNA(Phe)
                     (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
                     /codon_start=1
                     /product="tRNA wybutosine-synthesizing protein 5 isoform
                     1"
                     /protein_id="NP_001032831.2"
                     /db_xref="CCDS:CCDS14966.2"
                     /db_xref="GeneID:68736"
                     /db_xref="MGI:MGI:1915986"
                     /translation="MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKW
                     TVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISED
                     EKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTH
                     YDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYE
                     CSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAV
                     QILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE"
     exon            292..446
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            447..516
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..561
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..699
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            700..787
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            788..904
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1413
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1411
                     /gene="Tyw5"
                     /gene_synonym="1110034B05Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgctgccgcc gcctcgggtg agtcctctca tttcggctgt gttagccctc agcccaggcc
       61 gaagccctcg ggctccccgc cgtgcgcact tcgaaccagc cgccgccctc tggggtcagt
      121 cacctacgcg gaccatttct tccggagtag tgtttccagg ggaaatcacg cgtggaagaa
      181 ctcgtccaaa ttcccaggcc tgtgaatttc accatggctg agcagcgtct tccggtaccc
      241 cggctgcggg gcgtctcccg ggagcagttc atggagcatc tttatccaca gagaaagcct
      301 cttgtgttgg aaggactcga cttaggatct tgtacaagca aatggacagt ggattacctg
      361 agtcaagttg gaggaacgaa agaagtgaaa attcacgttg ctgcagttcc acagatggac
      421 ttcattagta agaattttgt ctatagaact ttacctttta acaagttggt ccagagagca
      481 gccgaagaaa cacataaaga attcttcatt tcagaggatg agaaatacta cttacggtca
      541 cttggagaag acccaaggaa ggatgttgca gacatcagac agcagttccc atcattagga
      601 ggagatatta catttccaat gttcttcaga gaggagcagt tcttttccag tgtttttcga
      661 attagttcac ctggattaca gctctggact cactatgatg taatggataa ctttttaata
      721 caagtgacag gaaagaagcg aattacactg ttcaatcctc gggatgcaca atatttatat
      781 ttatcaggtt ctaaatcaga agtgctgaat atcgacagcc cagacctgga taaataccca
      841 ctctttccta aagcaaggag gtatgagtgc tccctggaag ctggagatgt cctcttcatt
      901 cctgctttat ggttccataa tgtagtttct gaagagtttg gagtgggggt gaatatcttc
      961 tggaagcacc ttccatcgga atgctatgac acaacagata cctatggcaa caaagatcct
     1021 gtagcggcat ccagagctgt gcagatcttg gacagagctt tgaaaacact ggctgaatta
     1081 ccagaggaat acagggactt ctatgcacgc caaatggtct tacgtattca agacaaagcc
     1141 tacagcaaga actttgagta aaaaatgaac taaatgtaat acaattttaa aaataaataa
     1201 aaagcagctc aagtatttga aaactataac aagataaaaa atttaaagat gttttttaaa
     1261 ataggaaaga taagtctgag atttatagta taaaaggaga tgtatatctg atatctactg
     1321 gtatagattg aaaatgctta acgggaccat tctttagctt taagatgtaa ataaaatttg
     1381 gagttaataa aaaatctatt gaatcacact acaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaa
//
