LOCUS       NM_001282014            2740 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus tyrosinase-related protein 1 (Tyrp1), transcript
            variant 2, mRNA.
ACCESSION   NM_001282014
VERSION     NM_001282014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2740)
  AUTHORS   Nasim,S., Abujamra,B.A., Chaparro,D., Nogueira,P.D.S., Riva,A.,
            Hutcheson,J.D. and Kos,L.
  TITLE     Multiple cell types including melanocytes contribute to
            elastogenesis in the developing murine aortic valve
  JOURNAL   Sci Rep 14 (1), 25481 (2024)
   PUBMED   39461968
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2740)
  AUTHORS   Van Hook,M.J. and McCool,S.
  TITLE     Enhanced Synaptic Inhibition in the Dorsolateral Geniculate Nucleus
            in a Mouse Model of Glaucoma
  JOURNAL   eNeuro 11 (7) (2024)
   PUBMED   38937109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2740)
  AUTHORS   Yang,Y., Yang,Z., Lv,M., Jia,A., Li,J., Liao,B., Chen,J., Wu,Z.,
            Shi,Y., Xia,Y., Yao,D. and Chen,K.
  TITLE     Morphological disruption and visual tuning alterations in the
            primary visual cortex in glaucoma (DBA/2J) mice
  JOURNAL   Neural Regen Res 19 (1), 220-225 (2024)
   PUBMED   37488870
REFERENCE   4  (bases 1 to 2740)
  AUTHORS   Liu,Y., Cheng He,R., Munguba,G.C. and Lee,R.K.
  TITLE     Parvalbumin expression changes with retinal ganglion cell
            degeneration
  JOURNAL   Front Neurosci 17, 1227116 (2023)
   PUBMED   37901418
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2740)
  AUTHORS   Chen,Y., Wu,C., Peng,S., Guo,D., Ouyang,H., Wei,Y., Ju,R., Ding,X.,
            Xie,Z. and Liu,C.
  TITLE     Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse
            and Human Persistent Fetal Vasculature (PFV)
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 8 (2023)
   PUBMED   36867129
REFERENCE   6  (bases 1 to 2740)
  AUTHORS   Johnson,D.R. and Wallace,M.E.
  TITLE     Crinkly-tail, a mild skeletal mutant in the mouse
  JOURNAL   J Embryol Exp Morphol 53, 327-333 (1979)
   PUBMED   536693
REFERENCE   7  (bases 1 to 2740)
  AUTHORS   Morse,H.C. 3rd, Chused,T.M., Hartley,J.W., Mathieson,B.J.,
            Sharrow,S.O. and Taylor,B.A.
  TITLE     Expression of xenotropic murine leukemia viruses as cell-surface
            gp70 in genetic crosses between strains DBA/2 and C57BL/6
  JOURNAL   J Exp Med 149 (5), 1183-1196 (1979)
   PUBMED   221612
REFERENCE   8  (bases 1 to 2740)
  AUTHORS   Guenet,J.L., Salzgeber,B. and Tassin,M.T.
  TITLE     Repeated epilation: a genetic epidermal syndrome in mice
  JOURNAL   J Hered 70 (2), 90-94 (1979)
   PUBMED   479550
REFERENCE   9  (bases 1 to 2740)
  AUTHORS   LaVail,J.H., Nixon,R.A. and Sidman,R.L.
  TITLE     Genetic control of retinal ganglion cell projections
  JOURNAL   J Comp Neurol 182 (3), 399-421 (1978)
   PUBMED   102659
REFERENCE   10 (bases 1 to 2740)
  AUTHORS   Taylor,B.A., Bedigian,H.G. and Meier,H.
  TITLE     Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in
            recombinant inbred lines
  JOURNAL   J Virol 23 (1), 106-109 (1977)
   PUBMED   196096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148332.1, BC076598.1 and AL670884.7.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148332.1, AK148370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2188              AK148332.1         1-2188
            2189-2722           BC076598.1         2187-2720
            2723-2740           AL670884.7         97725-97742
FEATURES             Location/Qualifiers
     source          1..2740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 37.89 cM"
     gene            1..2740
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /note="tyrosinase-related protein 1"
                     /db_xref="GeneID:22178"
                     /db_xref="MGI:MGI:98881"
     exon            1..189
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     exon            190..659
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1888
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /EC_number="1.14.18.-"
                     /note="5,6-dihydroxyindole-2-carboxylic acid oxidase;
                     catalase B; DHICA oxidase; brown locus protein; iris
                     stromal atrophy"
                     /codon_start=1
                     /product="5,6-dihydroxyindole-2-carboxylic acid oxidase
                     precursor"
                     /protein_id="NP_001268943.1"
                     /db_xref="CCDS:CCDS18290.1"
                     /db_xref="GeneID:22178"
                     /db_xref="MGI:MGI:98881"
                     /translation="MKSYNVLPLAYISLFLMLFYQVWAQFPRECANIEALRRGVCCPD
                     LLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCN
                     DNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFV
                     IATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGP
                     AFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTL
                     ISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPEPQDVT
                     QCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPTGKYDPAVRSLHNLAHLFLNGTGGQTH
                     LSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNT
                     EMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAALLLVAAIFGVASCLIRSRSTKN
                     EANQPLLTDHYQRYAEDYEELPNPNHSMV"
     exon            660..982
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1187
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1355
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1535
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1682
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2740
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2701..2706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /note="hexamer: AATAAA"
     polyA_site      2722
                     /gene="Tyrp1"
                     /gene_synonym="b; brown; isa; Oca3; TRP-1; TRP1; Tyrp"
                     /note="major polyA site"
ORIGIN      
        1 gaagggatta gtgagagctg gaagagagga ccagcccctc ccagtgtgag gaatctggct
       61 tgggatttac tgtctggcag aaaatctctt cgggcaatta acagctggca tcaggggaaa
      121 agcagacatc caacaacact agctctgaag gagatcagca gagaaacctt ccagggattc
      181 atggtactgc tgtattttca tctgagcacc cctgtcttct ccatgcaaag agcagcatag
      241 gagacctgtg ttctgaactc ttgcttcgag aagaatgaaa tcttacaacg tcctccccct
      301 agcctatatc tcccttttcc tgatgctgtt ttatcaggtt tgggctcagt ttccacgaga
      361 gtgtgccaat attgaggctc tgagacgtgg ggtgtgttgc ccagacctgc tcccttcctc
      421 tggaccgggg actgaccctt gtggctcatc atcaggaaga ggcaggtgtg tggctgtgat
      481 tgcagactcc cgaccccaca gccgccatta tccccacgat ggtaaagatg accgagaagc
      541 ctggcctctg aggttcttta atagaacatg tcagtgcaat gataatttct caggacacaa
      601 ctgtgggact tgccgtcctg ggtggagagg agctgcatgc aaccagaaaa ttctcacagt
      661 caggagaaat cttctagact taagtccaga agaaaagagc cactttgtca gggccttgga
      721 tatggcgaag cgcacaactc accctcaatt tgtcattgcc acaaggaggt tagaagacat
      781 actgggacca gatggcaaca caccacaatt tgagaacatt tccgtttata actactttgt
      841 ttggacacac tattattcag tcaaaaaaac cttcctcggg acaggacagg aaagctttgg
      901 ggatgtggat ttctctcacg aaggacccgc ttttctcaca tggcacaggt accatctgct
      961 gcagctggag agagacatgc aggagatgct gcaggagcct tctttctccc ttccttactg
     1021 gaattttgca actgggaaaa acgtctgcga tgtctgcact gatgacttga tgggatccag
     1081 aagcaacttc gattctactc ttataagccc caactctgtc ttttctcaat ggagagtggt
     1141 ctgtgaatcc ttggaagagt acgataccct gggaacactt tgtaacagca ctgagggtgg
     1201 accaatcagg agaaacccag ctggaaatgt agggagacca gcagtgcagc gtcttcctga
     1261 gccacaggat gtcactcagt gcttggaggt ccgtgtattt gacacacctc ctttttattc
     1321 caattctaca gacagttttc gaaatacagt ggaaggttac agtgctccca cgggaaaata
     1381 tgaccctgct gttcgaagcc ttcacaacct ggcccacctc ttcctgaatg gaacgggagg
     1441 acaaacccat ttgtctccca atgatcctat ttttgtcctc ctgcacactt tcactgatgc
     1501 ggtctttgac gaatggctaa ggaggtataa cgccgatatt tctaccttcc cgttggaaaa
     1561 cgcacctatt ggacataaca ggcaatacaa catggtgcca ttctggcctc cagttaccaa
     1621 cacagaaatg tttgttactg ctccagacaa tctgggatat gcttatgaag ttcaatggcc
     1681 aggtcaggag tttactgtat ctgaaatcat taccattgct gtagtggctg cgttgttact
     1741 tgtagctgcc attttcgggg ttgcttcttg tctgatccgt tctagaagca ccaagaatga
     1801 agccaaccag cctctcctca ctgatcacta tcaacgctat gctgaggact atgaggagct
     1861 cccgaatcct aaccactcca tggtctgata gccgcctgcc catccccgca cgcagcaggt
     1921 tgggaagcaa cctgattgaa acacagctgt caaccgtatt tcctttggct tccttctttt
     1981 cttcccaaga tagatgtggt ttggaattaa agcattgctc tccagtgatg acagtttaga
     2041 ctccttttaa tgggttttaa taattagttc tattgaagat ggcaaattat accagttgtg
     2101 tgatatctga gaggataatt ggatgaactt ggtggtattc taaagatggc ctgtatgctg
     2161 tgaaaaagca atgctttgtt tacacaggaa aaataagttt gatgtaaaat ctctatttca
     2221 aatatatgag tgcccattct tatggagtta acatgtgaat gcattgttat tgttggtact
     2281 aatcaaaagt tataaaagca gccatgttga ttagttacaa caaatcacat gacattataa
     2341 acaaatagaa tcctgattat ctttctgaaa ctgctctcat tttgctttca gcgtattatt
     2401 tggcctcagg tgcaaggcca ccacaaagtc acagtccttg ccacacatgg taaagacgaa
     2461 agcttcactt gctggaacac atctgctctt gcatatttgc caatgtgttc cctagctcag
     2521 ttctctggac atgaaactgc ctgggccaca gttcacctct aattctcgta tcttagaggc
     2581 ctgcgaggaa ggtatcagtc agaggacaca atgttctgtg catcttatca aatgttgtat
     2641 ttcatttcaa cagcattgtt acaccactta tcagccttct gtgtatttca aaataaatat
     2701 aataaaatct tctttcattg gttccaggtt ttcaaaaatt
//
