LOCUS       NM_011662                592 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus TYRO protein tyrosine kinase binding protein (Tyrobp),
            mRNA.
ACCESSION   NM_011662
VERSION     NM_011662.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 592)
  AUTHORS   Wang,Q., Wu,Y., Jiang,G. and Huang,X.
  TITLE     Galectin-3 induces pathogenic immunosuppressive macrophages through
            interaction with TREM2 in lung cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 224 (2024)
   PUBMED   39135069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 592)
  AUTHORS   Zhou,X., Song,H., He,J., Han,W. and Li,Q.
  TITLE     Deciphering microglial activation and neuronal apoptosis
            post-traumatic brain injury: The role of TYROBP in inflammation
            regulation networks
  JOURNAL   Mol Med Rep 29 (6) (2024)
   PUBMED   38639190
  REMARK    GeneRIF: Deciphering microglial activation and neuronal apoptosis
            post-traumatic brain injury: The role of TYROBP in inflammation
            regulation networks.
REFERENCE   3  (bases 1 to 592)
  AUTHORS   Li,X., Jia,Y., Xiong,M., Gao,Y., Xu,X. and Ke,C.
  TITLE     MHC-I in the hippocampus promotes comorbid depressive symptoms in
            bone cancer pain via the upregulation of microglial TREM2/DAP12
            signaling
  JOURNAL   Behav Brain Res 461, 114843 (2024)
   PUBMED   38176616
  REMARK    GeneRIF: MHC-I in the hippocampus promotes comorbid depressive
            symptoms in bone cancer pain via the upregulation of microglial
            TREM2/DAP12 signaling.
REFERENCE   4  (bases 1 to 592)
  AUTHORS   Creus-Muncunill,J., Haure-Mirande,J.V., Mattei,D., Bons,J.,
            Ramirez,A.V., Hamilton,B.W., Corwin,C., Chowdhury,S., Schilling,B.,
            Ellerby,L.M. and Ehrlich,M.E.
  TITLE     TYROBP/DAP12 knockout in Huntington's disease Q175 mice
            cell-autonomously decreases microglial expression of
            disease-associated genes and non-cell-autonomously mitigates
            astrogliosis and motor deterioration
  JOURNAL   J Neuroinflammation 21 (1), 66 (2024)
   PUBMED   38459557
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 592)
  AUTHORS   Lawrence,A.R., Canzi,A., Bridlance,C., Olivie,N., Lansonneur,C.,
            Catale,C., Pizzamiglio,L., Kloeckner,B., Silvin,A., Munro,D.A.D.,
            Fortoul,A., Boido,D., Zehani,F., Cartonnet,H., Viguier,S.,
            Oller,G., Squarzoni,P., Candat,A., Helft,J., Allet,C., Watrin,F.,
            Manent,J.B., Paoletti,P., Thieffry,D., Cantini,L., Pridans,C.,
            Priller,J., Gelot,A., Giacobini,P., Ciobanu,L., Ginhoux,F.,
            Thion,M.S., Lokmane,L. and Garel,S.
  TITLE     Microglia maintain structural integrity during fetal brain
            morphogenesis
  JOURNAL   Cell 187 (4), 962-980 (2024)
   PUBMED   38309258
REFERENCE   6  (bases 1 to 592)
  AUTHORS   Yim,D., Jie,H.B., Lanier,L.L. and Kim,Y.B.
  TITLE     Molecular cloning, gene structure, and expression pattern of pig
            immunoreceptor DAP12
  JOURNAL   Immunogenetics 51 (6), 436-442 (2000)
   PUBMED   10866110
REFERENCE   7  (bases 1 to 592)
  AUTHORS   Bakker,A.B., Baker,E., Sutherland,G.R., Phillips,J.H. and
            Lanier,L.L.
  TITLE     Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor
            involved in the activation of myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9792-9796 (1999)
   PUBMED   10449773
REFERENCE   8  (bases 1 to 592)
  AUTHORS   Tomasello,E., Olcese,L., Vely,F., Geourgeon,C., Blery,M.,
            Moqrich,A., Gautheret,D., Djabali,M., Mattei,M.G. and Vivier,E.
  TITLE     Gene structure, expression pattern, and biological activity of
            mouse killer cell activating receptor-associated protein
            (KARAP)/DAP-12
  JOURNAL   J Biol Chem 273 (51), 34115-34119 (1998)
   PUBMED   9852069
REFERENCE   9  (bases 1 to 592)
  AUTHORS   Smith,K.M., Wu,J., Bakker,A.B., Phillips,J.H. and Lanier,L.L.
  TITLE     Ly-49D and Ly-49H associate with mouse DAP12 and form activating
            receptors
  JOURNAL   J Immunol 161 (1), 7-10 (1998)
   PUBMED   9647200
REFERENCE   10 (bases 1 to 592)
  AUTHORS   Lanier,L.L., Corliss,B.C., Wu,J., Leong,C. and Phillips,J.H.
  TITLE     Immunoreceptor DAP12 bearing a tyrosine-based activation motif is
            involved in activating NK cells
  JOURNAL   Nature 391 (6668), 703-707 (1998)
   PUBMED   9490415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA242315.1 and BC056450.1.
            
            On Jun 5, 2018 this sequence version replaced NM_011662.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056450.1, AK154480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AA242315.1         2-7
            7-592               BC056450.1         1-586
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.45 cM"
     gene            1..592
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /note="TYRO protein tyrosine kinase binding protein"
                     /db_xref="GeneID:22177"
                     /db_xref="MGI:MGI:1277211"
     exon            1..118
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..402
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /note="KAR-associated protein; DNAX-activation protein 12;
                     killer-activating receptor-associated protein; killer cell
                     activating receptor associated protein"
                     /codon_start=1
                     /product="TYRO protein tyrosine kinase-binding protein
                     precursor"
                     /protein_id="NP_035792.1"
                     /db_xref="CCDS:CCDS21089.1"
                     /db_xref="GeneID:22177"
                     /db_xref="MGI:MGI:1277211"
                     /translation="MGALEPSWCLLFLPVLLTVGGLSPVQAQSDTFPRCDCSSVSPGV
                     LAGIVLGDLVLTLLIALAVYSLGRLVSRGQGTAEGTRKQHIAETESPYQELQGQRPEV
                     YSDLNTQRQYYR"
     exon            119..145
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /inference="alignment:Splign:2.1.0"
     exon            146..292
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /inference="alignment:Splign:2.1.0"
     exon            293..336
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /inference="alignment:Splign:2.1.0"
     exon            337..575
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      556..561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /note="hexamer: AATAAA"
     polyA_site      569
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /note="major polyA site"
     polyA_site      575
                     /gene="Tyrobp"
                     /gene_synonym="DAP12; KARAP; Ly83"
                     /note="major polyA site"
ORIGIN      
        1 gtcacaccag gtcccaccag cccctggact gtggtgtcca gtgcatatct ggccaccatg
       61 ggggctctgg agccctcctg gtgccttctg ttccttcctg tcctcctgac tgtgggagga
      121 ttaagtcccg tacaggccca gagtgacact ttcccaagat gcgactgttc ttccgtgagc
      181 cctggtgtac tggctgggat tgttctgggt gacttggtgt tgactctgct gattgccctg
      241 gctgtgtact ctctgggccg cctggtctcc cgaggtcaag ggacagcgga agggacccgg
      301 aaacaacaca ttgctgagac tgagtcgcct tatcaggagc ttcagggtca gagaccagaa
      361 gtatacagtg acctcaacac acagaggcaa tattacagat gagcccactc tatgcccatc
      421 agcggcctga tgcccggatc cggtcattcc agatgcctac tcaacaagcc ctctctggga
      481 tcaggactcc cgttggaata cagatccaca gggtacctcc ctgagatatc tgacattgta
      541 ccatttctgt ccccaaataa aagacagagc aaaaaaaaaa aaaaaaaaaa aa
//
