LOCUS       NM_019392               4005 bp    mRNA    linear   ROD 03-APR-2023
DEFINITION  Mus musculus TYRO3 protein tyrosine kinase 3 (Tyro3), transcript
            variant 1, mRNA.
ACCESSION   NM_019392 XM_917628 XM_925058 XM_925059 XM_925060 XM_925061
            XM_925062
VERSION     NM_019392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4005)
  AUTHORS   Thivisol UMCC, Binder MD, Hannan AJ and Pang TY.
  TITLE     Loss of Tyro3 causes anxiety-relevant behavioural changes in female
            mice
  JOURNAL   Brain Res 1807, 148319 (2023)
   PUBMED   36898476
  REMARK    GeneRIF: Loss of Tyro3 causes anxiety-relevant behavioural changes
            in female mice.
REFERENCE   2  (bases 1 to 4005)
  AUTHORS   Zhong F, Cai H, Fu J, Sun Z, Li Z, Bauman D, Wang L, Das B, Lee K
            and He JC.
  TITLE     TYRO3 agonist as therapy for glomerular disease
  JOURNAL   JCI Insight 8 (1), e165207 (2023)
   PUBMED   36454644
  REMARK    GeneRIF: TYRO3 agonist as therapy for glomerular disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4005)
  AUTHORS   Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu TV,
            Beitzen-Heineke A, Vargas-Delgado ME, Pantel K, Bokemeyer C,
            Bhamidipati S, Darwish IS, Masuda E, Burstyn-Cohen T, Alberto EJ,
            Ghosh S, Rothlin C, Hesse E, Taipaleenmaki H, Ben-Batalla I and
            Loges S.
  TITLE     Regulation of bone homeostasis by MERTK and TYRO3
  JOURNAL   Nat Commun 13 (1), 7689 (2022)
   PUBMED   36509738
  REMARK    GeneRIF: Regulation of bone homeostasis by MERTK and TYRO3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4005)
  AUTHORS   Akalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu
            XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M,
            Finnemann SC, Iavarone A, Lasorella A, Rothlin CV and Ghosh S.
  TITLE     Tissue-specific modifier alleles determine Mertk loss-of-function
            traits
  JOURNAL   Elife 11, e80530 (2022)
   PUBMED   35969037
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4005)
  AUTHORS   Biesecker LG, Giannola DM and Emerson SG.
  TITLE     Identification of alternative exons, including a novel exon, in the
            tyrosine kinase receptor gene Etk2/tyro3 that explain differences
            in 5' cDNA sequences
  JOURNAL   Oncogene 10 (11), 2239-2242 (1995)
   PUBMED   7784069
REFERENCE   6  (bases 1 to 4005)
  AUTHORS   Schulz NT, Paulhiac CI, Lee L and Zhou R.
  TITLE     Isolation and expression analysis of tyro3, a murine growth factor
            receptor tyrosine kinase preferentially expressed in adult brain
  JOURNAL   Brain Res Mol Brain Res 28 (2), 273-280 (1995)
   PUBMED   7723626
REFERENCE   7  (bases 1 to 4005)
  AUTHORS   Lai C and Lemke G.
  TITLE     An extended family of protein-tyrosine kinase genes differentially
            expressed in the vertebrate nervous system
  JOURNAL   Neuron 6 (5), 691-704 (1991)
   PUBMED   2025425
REFERENCE   8  (bases 1 to 4005)
  AUTHORS   Wilks AF.
  TITLE     Two putative protein-tyrosine kinases identified by application of
            the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (5), 1603-1607 (1989)
   PUBMED   2466296
REFERENCE   9  (bases 1 to 4005)
  AUTHORS   Hanks SK, Quinn AM and Hunter T.
  TITLE     The protein kinase family: conserved features and deduced phylogeny
            of the catalytic domains
  JOURNAL   Science 241 (4861), 42-52 (1988)
   PUBMED   3291115
  REMARK    Review article
REFERENCE   10 (bases 1 to 4005)
  AUTHORS   Williams,C.L., Rosenblatt,J.S. and Hall,W.G.
  TITLE     Inhibition of suckling in weaning-age rats: a possible serotonergic
            mechanism
  JOURNAL   J Comp Physiol Psychol 93 (3), 414-429 (1979)
   PUBMED   479391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066058.1.
            
            [WARNING] On May 11, 2023 this sequence was replaced by
            NM_019392.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_925058.1, XM_925059.1, XM_925060.1, XM_925061.1, XM_925062.1,
            XM_917628.1, NM_019392.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066058.1, U18933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..4005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..4005
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /note="TYRO3 protein tyrosine kinase 3"
                     /db_xref="GeneID:22174"
                     /db_xref="MGI:MGI:104294"
     exon            1..370
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2919
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /EC_number="2.7.10.1"
                     /note="isoform A precursor is encoded by transcript
                     variant 1; tyrosine-protein kinase receptor TYRO3;
                     tyrosine-protein kinase DTK; tyrosine-protein kinase RSE;
                     tyrosine-protein kinase TIF; receptor tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor TYRO3 isoform A
                     precursor"
                     /protein_id="NP_062265.2"
                     /db_xref="CCDS:CCDS16611.1"
                     /db_xref="GeneID:22174"
                     /db_xref="MGI:MGI:104294"
                     /translation="MALRRSMGWPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTV
                     SQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDA
                     GLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVT
                     IYWWRGLTKVGGPAPSPSVLNVTGVTQRTEFSCEARNIKGLATSRPAIVRLQAPPAAP
                     FNTTVTTISSYNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLR
                     NLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEE
                     VIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQKDLILRVCASNAIGD
                     GPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKETRF
                     GQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQF
                     TLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD
                     HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR
                     FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS
                     KLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNR
                     LKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIE
                     RAEQPTESGSPEVHCGERSSSEAGDGSGVGAVGGIPSDSRYIFSPGGLSESPGQLEQQ
                     PESPLNENQRLLLLQQGLLPHSSC"
     exon            371..554
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..655
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..826
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..913
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1029
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1207
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1353
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1498
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1628
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1729
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1825
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1906
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1999
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2121
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2231
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2391
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2528
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..3989
                     /gene="Tyro3"
                     /gene_synonym="Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif;
                     tk19-1; TK19-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgggcggg cgggccggga ggaggcggcg gctcgcagaa gaacatgaat cagcggcggc
       61 ggcggcggcg gctgtggaag gagcgcggtg gcccagccgc agccccgggg actcctcgct
      121 gctgacggcg gtggccgcgg ctctaggcgg ccgcgggtcc gggacgcccg ggccgagcgc
      181 cgccccccgc ccctcccgcg ggcctcccgc ccctcctccg ccaccctcct ctctgcgctc
      241 gcgggccggg cccggcatgg tgcggcgtcg ccgccgatgg cgctgaggcg gagcatgggg
      301 tggccggggc tccggccgct gctgctggcg ggactggctt ctctgctgct ccccgggtct
      361 gcggccgcag gcctgaagct catgggcgcc ccagtgaaga tgaccgtgtc tcaggggcag
      421 ccagtgaagc tcaactgcag cgtggagggg atggaggacc ctgacatcca ctggatgaag
      481 gatggcaccg tggtccagaa tgcaagccag gtgtccatct ccatcagcga gcacagctgg
      541 attggcttac tcagcctaaa gtcagtggaa cggtctgatg ctggcctgta ctggtgccag
      601 gtgaaggatg gggaggaaac caagatttct cagtcagtat ggctcactgt cgaaggtgtg
      661 ccattcttca cagtggaacc aaaagatctg gcggtgccac ccaatgcccc ttttcagctg
      721 tcttgtgagg ctgtgggtcc tccagaaccc gtaaccattt actggtggag aggactcact
      781 aaggttgggg gacctgctcc ctctccctct gttttaaatg tgacaggagt gacccagcgc
      841 acagagtttt cttgtgaagc ccgcaacata aaaggcctgg ccacttcccg accagccatt
      901 gttcgccttc aagcaccgcc tgcagctcct ttcaacacca cagtaacaac gatctccagc
      961 tacaacgcta gcgtggcctg ggtgccaggt gctgacggcc tagctctgct gcattcctgt
     1021 actgtacagg tggcacacgc cccaggagaa tgggaggccc ttgctgttgt ggttcctgtg
     1081 ccacctttta cctgcctgct tcggaacttg gcccctgcca ccaactacag ccttagggtg
     1141 cgctgtgcca atgccttggg cccttctccc tacggcgact gggtgccctt tcagacaaag
     1201 ggcctagcgc cagccagagc tcctcagaat ttccatgcca ttcgtaccga ctcaggcctt
     1261 atcctggaat gggaagaagt gattcctgag gaccctgggg aaggccccct aggaccttat
     1321 aagctgtcct gggtccaaga aaatggaacc caggatgagc tgatggtgga agggaccagg
     1381 gccaatctga ccgactggga tccccagaag gacctgattt tgcgtgtgtg tgcctccaat
     1441 gcaattggtg atgggccctg gagtcagcca ctggtggtgt cttctcatga ccatgcaggg
     1501 aggcagggcc ctccccacag ccgcacatcc tgggtgcctg tggtcctggg cgtgctcacc
     1561 gccctgatca cagctgctgc cttggccctc atcctgcttc ggaagagacg caaggagacg
     1621 cgtttcgggc aagcctttga cagtgtcatg gcccgagggg agccagctgt acacttccgg
     1681 gcagcccgat ctttcaatcg agaaaggcct gaacgcattg aggccacatt ggatagcctg
     1741 ggcatcagcg atgaattgaa ggaaaagctg gaggatgtcc tcattccaga gcagcagttc
     1801 accctcggtc ggatgttggg caaaggagag tttggatcag tgcgggaagc ccagctaaag
     1861 caggaagatg gctccttcgt gaaagtggca gtgaagatgc tgaaagctga catcattgcc
     1921 tcaagcgaca tagaagagtt cctccgggaa gcagcttgca tgaaggagtt tgaccatcca
     1981 cacgtggcca agcttgttgg ggtgagcctc cggagcaggg ctaaaggtcg tctccccatt
     2041 cccatggtca tcctgccctt catgaaacat ggagacttgc acgcctttct gctcgcctcc
     2101 cgaatcgggg agaacccttt taacctgccc ctccagaccc tggtccggtt catggtggac
     2161 attgcctgtg gcatggagta cctgagctcc cggaacttca tccaccgaga cctagcagct
     2221 cggaattgca tgctggccga ggacatgaca gtgtgtgtgg ctgattttgg actctctcgg
     2281 aaaatctata gcggggacta ttatcgtcag ggctgtgcct ccaaattgcc cgtcaagtgg
     2341 ctggccctgg agagcttggc tgacaacttg tatactgtac acagtgatgt gtgggccttc
     2401 ggggtgacca tgtgggagat catgactcgt gggcagacgc catatgctgg cattgaaaat
     2461 gccgagattt acaactacct catcggcggg aaccgcctga agcagcctcc ggagtgcatg
     2521 gaggaagtgt atgatctcat gtaccagtgc tggagcgccg accccaagca gcgcccaagc
     2581 ttcacgtgtc tgcgaatgga actggagaac attctgggcc acctgtctgt gctgtccacc
     2641 agccaggacc ccttgtacat caacattgag agagctgagc agcctactga gagtggcagc
     2701 cctgaggtcc actgtggaga gcgatccagc agcgaggcag gggacggcag tggcgtgggg
     2761 gcagtaggtg gcatccccag tgactctcgg tacatcttca gccccggagg gctatccgag
     2821 tcaccagggc agctggagca gcagccagaa agccccctca atgagaacca gaggctgttg
     2881 ttgctgcagc aagggctact gcctcacagt agctgttaac cctcaggcag aggaaagttg
     2941 gggcccctgg ctctgctgac cgctgtgctg cctgactagg cccagtctga tcacagccca
     3001 ggcagcaagg tatggaggct cctgtggtag ccctcccaag ctgtgctggc gcctggacgg
     3061 accaaattgc ccaatcccag ttcttcctgc agccgctctg gccagcctgg catcagttca
     3121 ggccttggct tagaggaggt gagccagagc tggttgcctg aatgcaggca gctggcagga
     3181 ggggagggtg gctatgtttc catgggtacc atgggtgtgg atggcagtaa gggagggtag
     3241 caacagccct gtgggcccct accctcctgg ctgagctgct cctactttag tgcatgcttg
     3301 gagccgcctg cagcctggaa ctcagcactg cccaccacac ttgggccgaa atgccaggtt
     3361 tgcccctctt aagtcacaaa gagatgtcca tgtattgttc ccttttaggt gatgattagg
     3421 aagggattgg cacacttggg tccctaagcc ctatggcagg aaatggtggg atattctcag
     3481 gtctgaatcc tcatcatctt cctgattccc caccctgcaa aggcctggaa ctggctgtgg
     3541 ggctctgagg catgctgaag gacaaaaggt tacagagatc cgacttcaaa aggcagggtc
     3601 tgagtctggc aggtggagag gtgctaaggg gctggtccag gagtcaggca tttcaggacc
     3661 cctccaagct tctacagtct gtctgagcat gctaccaagc ccccagatac cccaaaacta
     3721 acagaggcag ttttgtctga gcccagccct cccacatgat gacccttagg tctaccctcc
     3781 tctctaaatg gacatcctcg tttgtcccaa gtctccagag agactactga tggctgatgt
     3841 gggtaagaaa agttccagga accagggctg gggtggaacc agggctgggg ttgaggcagg
     3901 ctcttgggca ggctcttgct gttaggaaca tttctaagct attaagttgc tgtttcaaaa
     3961 caaataaaat tgaaacataa agaatcaaaa aaaaaaaaaa aaaaa
//
