LOCUS       NM_011661               5959 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus tyrosinase (Tyr), transcript variant 1, mRNA.
ACCESSION   NM_011661
VERSION     NM_011661.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5959)
  AUTHORS   Nasim,S., Abujamra,B.A., Chaparro,D., Nogueira,P.D.S., Riva,A.,
            Hutcheson,J.D. and Kos,L.
  TITLE     Multiple cell types including melanocytes contribute to
            elastogenesis in the developing murine aortic valve
  JOURNAL   Sci Rep 14 (1), 25481 (2024)
   PUBMED   39461968
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5959)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   3  (bases 1 to 5959)
  AUTHORS   Rodrigues,P.F., Trsan,T., Cvijetic,G., Khantakova,D., Panda,S.K.,
            Liu,Z., Ginhoux,F., Cella,M. and Colonna,M.
  TITLE     Progenitors of distinct lineages shape the diversity of mature type
            2 conventional dendritic cells
  JOURNAL   Immunity 57 (7), 1567-1585 (2024)
   PUBMED   38821051
REFERENCE   4  (bases 1 to 5959)
  AUTHORS   Rodgers,L.T., Schulz Pauly,J.A., Maloney,B.J., Hartz,A.M.S. and
            Bauer,B.
  TITLE     Optimization, Characterization, and Comparison of Two
            Luciferase-Expressing Mouse Glioblastoma Models
  JOURNAL   Cancers (Basel) 16 (11), 1997 (2024)
   PUBMED   38893116
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5959)
  AUTHORS   Zhao,J., Kim,H.J., Montenegro,D., Dunaief,J.L. and Sparrow,J.R.
  TITLE     Iron overload and chelation modulates bisretinoid levels in the
            retina
  JOURNAL   Front Ophthalmol (Lausanne) 3, 1305864 (2023)
   PUBMED   38983013
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5959)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   7  (bases 1 to 5959)
  AUTHORS   Gluecksohn-Waelsch,S.
  TITLE     Genetic control of morphogenetic and biochemical differentiation:
            lethal albino deletions in the mouse
  JOURNAL   Cell 16 (2), 225-237 (1979)
   PUBMED   36985
  REMARK    Review article
REFERENCE   8  (bases 1 to 5959)
  AUTHORS   Cowing,C., Harris,D., Garabedian,C., Lukic,M. and Leskowitz,S.
  TITLE     Immunologic tolerance to heterologous immunoglobulin: its relation
            to in vitro filtration by macrophages
  JOURNAL   J Immunol 119 (1), 256-262 (1977)
   PUBMED   68973
REFERENCE   9  (bases 1 to 5959)
  AUTHORS   Freund,J.G., Ahmed,A., Budd,R.E., Dorf,M.E., Sell,K.W.,
            Vannier,W.E. and Humphreys,R.E.
  TITLE     The L1210 leukemia cell bears a B lymphocyte specific, non-H-2
            linked alloantigen
  JOURNAL   J Immunol 117 (5 Pt.2), 1903-1905 (1976)
   PUBMED   62795
REFERENCE   10 (bases 1 to 5959)
  AUTHORS   Garland,R.C., Satrustegui,J., Gluecksohn-Waelsch,S. and Cori,C.F.
  TITLE     Deficiency in plasma protein synthesis caused by x-ray-incuded
            lethal albino alleles in mouse
  JOURNAL   Proc Natl Acad Sci U S A 73 (10), 3376-3380 (1976)
   PUBMED   62358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122517.2 and AC141329.4.
            
            On Mar 4, 2023 this sequence version replaced NM_011661.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M24560.1, D00440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-898               AC122517.2         86366-87263
            899-1115            AC122517.2         95758-95974
            1116-1263           AC122517.2         107249-107396
            1264-1445           AC141329.4         145939-146120       c
            1446-5959           AC141329.4         132773-137286       c
FEATURES             Location/Qualifiers
     source          1..5959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 49.01 cM"
     gene            1..5959
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /note="tyrosinase"
                     /db_xref="GeneID:22173"
                     /db_xref="MGI:MGI:98880"
     exon            1..898
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1681
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /EC_number="1.14.18.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; monophenol monooxygenase; albino locus protein"
                     /codon_start=1
                     /product="tyrosinase isoform 1 precursor"
                     /protein_id="NP_035791.1"
                     /db_xref="CCDS:CCDS52304.1"
                     /db_xref="GeneID:22173"
                     /db_xref="MGI:MGI:98880"
                     /translation="MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGS
                     PCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGN
                     CKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMN
                     NGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLW
                     EQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIIC
                     SRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDR
                     TANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAF
                     VDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYS
                     YLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKK
                     QPQEERQPLLMDKDDYHSLLYQSHL"
     exon            899..1115
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1263
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1445
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..5959
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccagggg ttgctggaaa agaagtctgt gacactcatt aacctattgg tgcagatttt
       61 gtatgatcta aaggagaaaa tgttcttggc tgttttgtat tgccttctgt ggagtttcca
      121 gatctctgat ggccattttc ctcgagcctg tgcctcctct aagaacttgt tggcaaaaga
      181 atgctgccca ccatggatgg gtgatgggag tccctgcggc cagctttcag gcagaggttc
      241 ctgccaggat atccttctgt ccagtgcacc atctggacct cagttcccct tcaaaggggt
      301 ggatgaccgt gagtcctggc cctctgtgtt ttataatagg acctgccagt gctcaggcaa
      361 cttcatgggt ttcaactgcg gaaactgtaa gtttggattt gggggcccaa attgtacaga
      421 gaagcgagtc ttgattagaa gaaacatttt tgatttgagt gtctccgaaa agaataagtt
      481 cttttcttac ctcactttag caaaacatac tatcagctca gtctatgtca tccccacagg
      541 cacctatggc caaatgaaca atgggtcaac acccatgttt aatgatatca acatctacga
      601 cctctttgta tggatgcatt actatgtgtc aagggacaca ctgcttgggg gctctgaaat
      661 atggagggac attgattttg cccatgaagc accagggttt ctgccttggc acagactttt
      721 cttgttattg tgggaacaag aaattcgaga actaactggg gatgagaact tcactgttcc
      781 atactgggat tggagagatg cagaaaactg tgacatttgc acagatgagt acttgggagg
      841 tcgtcaccct gaaaatccta acttactcag cccagcatcc ttcttctcct cctggcagat
      901 catttgtagc agatcagaag agtataatag ccatcaggtt ttatgcgatg gaacacctga
      961 gggaccacta ttacgtaatc ctggaaacca tgacaaagcc aaaaccccca ggctcccatc
     1021 ttcagcagat gtggaatttt gtctgagttt gacccagtat gaatctggat caatggatag
     1081 aactgccaat ttcagcttta gaaacacact ggaaggattt gccagtccac tcacagggat
     1141 agcagatcct tctcaaagta gcatgcacaa tgccttacat atctttatga atggaacaat
     1201 gtcccaagta cagggatcgg ccaacgatcc catttttctt cttcaccatg cttttgtgga
     1261 cagtattttt gaacaatggc tgcgaaggca ccgccctctt ttggaagttt acccagaagc
     1321 caatgcacct atcggccata acagagactc ttacatggtt cctttcatac cgctctatag
     1381 aaatggtgat ttcttcataa catccaagga tctgggatat gactacagct acctccaaga
     1441 gtcagatcca ggcttttaca gaaattatat tgagccttac ttggaacaag ccagtcgtat
     1501 ctggccatgg cttcttgggg cagcactggt gggagctgtt attgctgcag ctctctctgg
     1561 gcttagcagt aggctatgcc ttcagaagaa gaagaagaag aagcaacccc aggaggaaag
     1621 gcagccactc ctcatggaca aagacgacta ccacagcttg ctgtatcaga gccatctgtg
     1681 aacatcctag gaaacagagt gggactgaaa ggttttacct cactcgacct atttgttggt
     1741 gtttctacaa atttaaacta gtataaaaca tagaccatag ctgtttggct ttttttcaga
     1801 cccatgtttt ttcctaagtc ctagtttcta agaaatgact gggatttgct aaaatatata
     1861 tatatatata aataataact tactaatagc taaataaaat ttcctcttac aactaattga
     1921 gctggttttt atgaatgtgt cttaattatt taaacttgag gcacattttt gttttcctta
     1981 cttcattgtg aatttccaag aaaaatattc tctctctctc tctctctcgt gtgtttgtgt
     2041 gtatgtgtgt gttaactgat tcaaacaatt ttgaaaatct tggattgata gaaatgattc
     2101 attaatttat gaaattattt cattaatgat taggaaagac gaataattac taaattagta
     2161 acagaggaga acatctgcca gcttttatta attgtcattt aagttacctt atctaccttc
     2221 tgtgactggt ggaaaaatat caggcaagag atgggaatgc tctgcctaat aggatagtgg
     2281 ctcctggaag gagtgggtta ttactagaga ttattacctg aagtttacca tagccagaaa
     2341 attaatcaaa acagatgact cagtaacatc tgaagcttca agtcggcttg actgcaatct
     2401 gaaatcatca agcccaagag ccaaaggaat gggaacagcg atgggaaact atctgaatca
     2461 gattctagtg tgatagtgtc aggggcacat gggtcatctt tgagaccttc acacctgttg
     2521 agtcaccaaa atttgctgtg aatgtaaatt tttactgtaa attaattttt tcttttcttt
     2581 ttaaaaagat ttatttatta ttatacataa gtacactgta gctgtcttca gacacaccag
     2641 aagagggtgt cagatctcat tacagatggt tgtgagccac catgtggttg ctgggatttg
     2701 aactcaggac ctctggaaga acagtcagtg ctcttacccg ctgagccatc tcgccagccc
     2761 agtaaatttt tactttagtg aaagtaaaat ttaagtttta gtttttagtt tagtaaaatt
     2821 ttaggaagca aatttttagt tttctaaact aatttttttt tctagtactg gacatcaacc
     2881 cagtgccttg tatatgcaat gcaagcattt tcttgtactc tgctacctag catgtatata
     2941 taaatctacc caacaaatgt tcattacagc tgacaagggt ctttataaac tcagtgtttc
     3001 cctttatcac aatacaattc cctcctttgc cacttcatgt catcatagaa tattgttttt
     3061 ttctctagcg gttcaaggta tgtatttgta tagcagtcac acctttgata aaagttacca
     3121 tctctttgat tatatattct cattatggta acaaaattat attatgacta tttcaatata
     3181 tctgaaagtt tcattaaatt ctcattaact ttgtatattt cagtcttgct tattgtgaag
     3241 cttttataaa ttgcttcact tttttctgaa attgtcctgt tgctacatca ttctgttaag
     3301 aaataaataa gtggcaatat tttccccctt tcttcttcct ctaggctttt aaaattaatt
     3361 ttagtattca tatattttta tcaaatcaaa catgcaattc tctatctgta gagattaacc
     3421 tgtgatcgat acaagtcatt ttaactagtg tccttatgag gctgacagca agcataaatc
     3481 attgatgttc agcatttata taagctttca tttatgagta gagtttgtca gtttatacaa
     3541 tagaatataa attataaaca agctattaat accacaaaag ccttaacatt atttagctgt
     3601 tgcaaactac atatgaacaa ctttagtaat tttcatgttc tatttaagtt ttatatgctt
     3661 caaatttatt atttggggcc tcttattgtt tttttatatg gcagcattct aggatggagt
     3721 gtgaagagat ttcttagcct caatccccat ctgatgccct atgggcagtg atggcttctg
     3781 tttgagggac actcagtttt ctattcgagt cctggtagag ttatcatgtt ctggtagaag
     3841 gattcaagcc cagtagtata ggtacaccat gccttataat gactgagcta ttacatttaa
     3901 aaaagaataa aagcatgaag ctgaggaggc agtgaggtgg gggtggatct gcggagagtc
     3961 acatggagaa gtggagggca gatttacatt atatcaaatt ttcaaaaaat aataaaatat
     4021 ttataaaatg taattgaacg aacaatatgt gggttggaat caaaactcat gtagaacttt
     4081 cttcagtcac tagatctgat tgattgtgaa ttgattatta gccatttaaa ctagtagact
     4141 cgagacttac cttaattatt tagttgccaa atttgggatc acaattgaat atgtctcctc
     4201 aaaaaatatc ttaaaaattc atagtaatca ctttcacttt ccttttgcct attttaaaat
     4261 atatgcattc tctttaatta aacagctctg catcctgttt gtcccatagg taaataaaat
     4321 gttgagtgtg aatatttagt gaaatatagt tcttaataaa tttgctttac taaaattatt
     4381 tttactttct tagtcttttt tttttttaga aaattaaaag taaatgtata gaagtaaaaa
     4441 gtttgttttc taaatcagtg ttctatatgt tgcataaact ggttcctact gctggatttt
     4501 gttggctttc cagtctcaga gcagtgtctg gattacaggt agatattgct gtactaggat
     4561 gaaagtagac tgttttaatg agagatactt tcaatttcac aggaaaggtg atttctatta
     4621 tgttaggcca ataatcctaa ctttaatggc atttcataat gggtgctgag ttaactgtct
     4681 gatgctgaaa ttatactaaa aataatgtgg tgatcatgga acctcaaaat aaaacaaaat
     4741 aaactaaaaa tttatcacct tttaaaaatc tagtattatc ttttcattaa ctagaaaaca
     4801 aatgttgaaa tgtttaaaaa gaaatattta gcaatataca caataattga ttaatttcag
     4861 tttaattttt aaaatatttt attctttctt aatgacaact actgtatgat ctggctcata
     4921 agtagtagcg gtagcagctt ttgcagagca tataccccct aaaatctgtg tcaatatact
     4981 atttgagttc cctgaacatc tgtttattac agtgctactc acaacaacta ggttgtggag
     5041 acaccccaga tgtctatcca cagacaaatg gatagagaaa ccatggcatg tatacatggt
     5101 ggaggtttgt tcagccataa agaagaatta aattatgtca tttgcaagaa aactaatgta
     5161 tttataattc atgatgatga atgcaatagg tcacactaaa aatcacgttt ttctatatta
     5221 tatatacata taagtgtata catgcacatt ttcaggagga actatttgtt ttttttttaa
     5281 cgcattctag aatgtagcag gaaagacaat attgtgggta gtttggggtt gcatcagtat
     5341 aagcaaagaa aaagttatac aagtatgaaa attttataat gagtacatta taaaatttgt
     5401 aatgtgtaca ataaatatat accaatatgc tgtataataa atatatacca atgattaaag
     5461 aaaaaatcca agtagttatg tattttactt ataaagacaa aatgaaatca gcattaactt
     5521 atttcacaga tatttcctag aatttggggg tataaagatg attaagacac ataaaccata
     5581 tgctacattg aaaaatgcaa gtggggtaat aggaaagtag ataactactt ataaaattat
     5641 gatggaaata atcattctag agtaatattc taaaacacaa tttaaaaagt aaggtcataa
     5701 aatagaaaaa taattaccca tctcaattct aagacataat tttttagatt agattaatct
     5761 cttctttaac aattataata gaaccttttc atcatttata tactggatgc atgtctaagc
     5821 actactctat ataatttctg cttgtcatat gaacactgag tatggttata ttactttatt
     5881 ttaatgatga agaagcttga ataacaaaga tattttaaga agtcaaaaac cctattaaat
     5941 tgtatgtatc acaattttt
//
