LOCUS       NM_138302               2377 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus thymidine phosphorylase (Tymp), mRNA.
ACCESSION   NM_138302
VERSION     NM_138302.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2377)
  AUTHORS   Du,L., Yue,H., Rorabaugh,B.R., Li,O.Q.Y., DeHart,A.R.,
            Toloza-Alvarez,G., Hong,L., Denvir,J., Thompson,E. and Li,W.
  TITLE     Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac
            Function in Mice With Acute Myocardial Infarction
  JOURNAL   J Am Heart Assoc 12 (7), e028023 (2023)
   PUBMED   36974758
REFERENCE   2  (bases 1 to 2377)
  AUTHORS   Belcher,A., Zulfiker,A.H.M., Li,O.Q., Yue,H., Gupta,A.S. and Li,W.
  TITLE     Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride
            Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (2), 668-682 (2021)
   PUBMED   33297751
REFERENCE   3  (bases 1 to 2377)
  AUTHORS   Li,S., Yang,H., Li,K., Fan,G., Deng,L. and Xu,C.
  TITLE     Thymidine phosphorylase promotes angiogenesis and tumour growth in
            intrahepatic cholangiocarcinoma
  JOURNAL   Cell Biochem Funct 38 (6), 743-752 (2020)
   PUBMED   32476180
  REMARK    GeneRIF: Thymidine phosphorylase promotes angiogenesis and tumour
            growth in intrahepatic cholangiocarcinoma.
REFERENCE   4  (bases 1 to 2377)
  AUTHORS   Tabata,S., Yamamoto,M., Goto,H., Hirayama,A., Ohishi,M.,
            Kuramoto,T., Mitsuhashi,A., Ikeda,R., Haraguchi,M., Kawahara,K.,
            Shinsato,Y., Minami,K., Saijo,A., Hanibuchi,M., Nishioka,Y.,
            Sone,S., Esumi,H., Tomita,M., Soga,T., Furukawa,T. and Akiyama,S.I.
  TITLE     Thymidine Catabolism as a Metabolic Strategy for Cancer Survival
  JOURNAL   Cell Rep 19 (7), 1313-1321 (2017)
   PUBMED   28514652
REFERENCE   5  (bases 1 to 2377)
  AUTHORS   Chapouly,C., Tadesse Argaw,A., Horng,S., Castro,K., Zhang,J.,
            Asp,L., Loo,H., Laitman,B.M., Mariani,J.N., Straus Farber,R.,
            Zaslavsky,E., Nudelman,G., Raine,C.S. and John,G.R.
  TITLE     Astrocytic TYMP and VEGFA drive blood-brain barrier opening in
            inflammatory central nervous system lesions
  JOURNAL   Brain 138 (Pt 6), 1548-1567 (2015)
   PUBMED   25805644
  REMARK    GeneRIF: data identify TYMP as an astrocyte-derived permeability
            factor, and suggest TYMP and VEGFA together promote blood-brain
            barrier breakdown.
REFERENCE   6  (bases 1 to 2377)
  AUTHORS   Jones,P.S., Savory,R., Barratt,P., Bell,A.R., Gray,T.J.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Bell,D.R.
  TITLE     Chromosomal localisation, inducibility, tissue-specific expression
            and strain differences in three murine
            peroxisome-proliferator-activated-receptor genes
  JOURNAL   Eur J Biochem 233 (1), 219-226 (1995)
   PUBMED   7588749
REFERENCE   7  (bases 1 to 2377)
  AUTHORS   Swendeman,S.L., Spielholz,C., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Sheffery,M.
  TITLE     Characterization of the genomic structure, chromosomal location,
            promoter, and development expression of the alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 269 (15), 11663-11671 (1994)
   PUBMED   8157699
REFERENCE   8  (bases 1 to 2377)
  AUTHORS   Okamoto,K., Wakamiya,M., Noji,S., Koyama,E., Taniguchi,S.,
            Takemura,R., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Muramatsu,M. et al.
  TITLE     A novel class of murine POU gene predominantly expressed in central
            nervous system
  JOURNAL   J Biol Chem 268 (10), 7449-7457 (1993)
   PUBMED   8463278
REFERENCE   9  (bases 1 to 2377)
  AUTHORS   Gorman,D.M., Itoh,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Miyajima,A.
  TITLE     Chromosomal localization and organization of the murine genes
            encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3,
            granulocyte/macrophage colony-stimulating factor, and interleukin 5
            receptors
  JOURNAL   J Biol Chem 267 (22), 15842-15848 (1992)
   PUBMED   1386365
REFERENCE   10 (bases 1 to 2377)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113976.13.
            
            On Feb 1, 2022 this sequence version replaced NM_138302.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060274.1, ERR2844020.300912.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC113976.13        154769-154863       c
            96-276              AC113976.13        154361-154541       c
            277-479             AC113976.13        154023-154225       c
            480-578             AC113976.13        153286-153384       c
            579-708             AC113976.13        152780-152909       c
            709-827             AC113976.13        152541-152659       c
            828-990             AC113976.13        152035-152197       c
            991-1221            AC113976.13        151716-151946       c
            1222-1362           AC113976.13        151467-151607       c
            1363-1542           AC113976.13        151207-151386       c
            1543-2377           AC113976.13        149415-150249       c
FEATURES             Location/Qualifiers
     source          1..2377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.86 cM"
     gene            1..2377
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /note="thymidine phosphorylase"
                     /db_xref="GeneID:72962"
                     /db_xref="MGI:MGI:1920212"
     exon            1..95
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            96..276
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1520
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /EC_number="2.4.2.4"
                     /note="endothelial cell growth factor 1
                     (platelet-derived); gliostatin; tdRPase; platelet derived
                     growth factor, endothelial cell"
                     /codon_start=1
                     /product="thymidine phosphorylase"
                     /protein_id="NP_612175.1"
                     /db_xref="CCDS:CCDS27747.1"
                     /db_xref="GeneID:72962"
                     /db_xref="MGI:MGI:1920212"
                     /translation="MAAPGTPPPSASGGGGGEPRQLPELIRLKRDGGHLREADIRNFV
                     HAVIDGRAQDTQIGAMLMAIRLQGMNLEETSVLTRALAESGQQLEWPKAWHQQLVDKH
                     STGGVGDKVSLVLAPALAACGCKVPMISGRSLGHTGGTLDKLESIPGFGVTQSPEQML
                     HILEEVGCCIVGQSAKLVPADGILYAARDVTATVDSVPLITASILSKKAVEGLSTLVV
                     DVKFGGAAVFPDQEKARELAKMLVRVGVSLGLKVAAALTAMDNPLGRSVGHTLEVEEA
                     LLCLDGAGPPDLRDLVIRLGGAILWISGQAETQDQGAARVAAALDDGSARRRFQLMLS
                     AQGVDPGLAKALCSGSPTQRRQLLPHAREQEELLAPADGIVECVRALPLARVLHDLGA
                     GRSRAGQPIRPGVGAEVLVDVGQCLSRGTPWLRVHLDGPALSSQQRRTLQGALVLSDR
                     APFKVPSPFAELVLPPTIAQP"
     exon            277..479
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            480..578
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            579..708
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            709..827
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            828..990
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1221
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1362
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1542
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..2377
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2353..2358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /note="hexamer: ATTAAA"
     polyA_site      2377
                     /gene="Tymp"
                     /gene_synonym="2900072D10Rik; Ecgf1; PD-ECGF; PDECGF;
                     Pdgfec; TP"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctctg tacctaagtc cacgcaggac tgagggataa caggctggaa ccgagccaga
       61 tccagaaaac tggtaaaggc ccctgaattg aatagactgg agcaatggca gctccaggga
      121 caccacctcc ctcggcctca gggggaggag gtggggagcc caggcagctg cctgagctga
      181 tccgcctgaa gcgagatgga gggcatctga gagaagcaga tatcagaaac ttcgtgcacg
      241 cggtgataga tggaagagca caggacacac aaattggggc catgctaatg gccattcggc
      301 tgcagggaat gaacctagaa gagacatctg tgctgactcg ggcccttgca gagtctgggc
      361 agcaactgga gtggcccaaa gcctggcacc agcagcttgt tgacaaacac tccacaggag
      421 gtgtgggtga caaggttagc ctggttctgg cacctgccct ggctgcatgc ggctgtaagg
      481 tgccaatgat cagcggccgc agtctgggac acacaggggg cacactggat aagctggaat
      541 cgattcctgg gttcggtgtc acccagagcc cagagcagat gctgcacatc cttgaggaag
      601 tcggctgctg cattgtcggc cagagtgcaa agctggttcc tgctgatggg atcctgtatg
      661 ctgcacgaga tgtgacagcc actgtggaca gtgtcccact cattacagct tcaatcctca
      721 gtaagaaggc cgtggaggga ctgtccactc tggtggtaga tgttaagttt gggggagctg
      781 cagtcttccc agaccaggag aaggcccgag aactggcaaa gatgttggtt agagtgggag
      841 tgagcctggg gctgaaggtc gccgcagccc tgaccgccat ggataaccct ctgggccgca
      901 gcgtgggcca taccctggag gtggaagaag cgttgctttg cctggatggt gcggggccgc
      961 cggatctgcg ggacctggtc attaggctag gaggcgccat tctttggatt agcggacagg
     1021 cggaaacaca agaccaaggc gccgcccgag tggccgcggc gttggatgac ggctccgcgc
     1081 ggcgccgctt ccagctgatg ctttcggcgc agggcgtgga ccccggccta gctaaagcat
     1141 tgtgctccgg gagccccacg caacgccggc agctgctgcc tcacgcccga gagcaagagg
     1201 agctgctcgc accggcagac ggcattgttg agtgcgtccg agcgctgccg ctggcccgtg
     1261 tgctgcacga cctcggagcc ggacgcagcc gagcggggca gccgatcaga ccgggagtgg
     1321 gtgccgaggt actggtcgac gtgggccagt gtttgtcccg agggacaccc tggctccgcg
     1381 tgcacctaga cggccctgcg ctcagcagtc agcagcgacg cactctccag ggggcgctcg
     1441 tgctatcaga tcgagcaccc ttcaaggtcc cttcaccctt cgctgaactt gtcctcccac
     1501 cgaccatcgc acagccctaa gtctcgaacc cagctcagcc aggagcttca ggtccacgat
     1561 gctactggct ctagggccca aagcttggcc caagctctct cagttcaaac ccctcctcag
     1621 gatctcagga ggtgaaactc tgcatagaaa ttcccgacac tgggcagggc agggccagcg
     1681 ccaaggccct gggctaagaa ctagactgct gatcacagcc ctgtttgggg ctgggctagg
     1741 ctgggcctgg ctggccgcga gggctgagaa ggaacagtgg cgccaacagc agcgtacaga
     1801 ggccctgcgc caggctgctg tgggccaggg tgacttcagc ctactagacc acaaaggcca
     1861 gcctcgatgc aaagccgact tccgaggcca gtgggtgctg atgtacttcg gttttactca
     1921 ctgccctgat atttgccccg atgagctgga aaagctagtg caggtggtgc ggaagctaga
     1981 ggcggagcct gacctgcccc tggtgcagcc tgtcttcatc actgtggacc cagaacgaga
     2041 tgacgtggca gccatggccc gctatgtgca agaattccac ccaagactgt taggtctgac
     2101 cggttctaca gaacaggtgg cccatgctag tcgcaactac cgcgtatact acagcgctgg
     2161 gcctaaggat gaggaccagg actacattgt ggaccactcc attgccatct atctgctcaa
     2221 ccctgatggt cttttcaccg attactatgg tcgcagcagg tcagcagagc agatcgtaga
     2281 gagtatacgt cggcacatag ctgccttcca cagtgtcttg ccctgaacta tacctattgc
     2341 ctaggccctg tcattaaatg gatgtactta atctgtg
//
