LOCUS       NM_001205312            4873 bp    mRNA    linear   ROD 28-MAR-2023
DEFINITION  Mus musculus tyrosine kinase 2 (Tyk2), transcript variant 1, mRNA.
ACCESSION   NM_001205312
VERSION     NM_001205312.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4873)
  AUTHORS   Moritsch S, Modl B, Scharf I, Janker L, Zwolanek D, Timelthaler G,
            Casanova E, Sibilia M, Mohr T, Kenner L, Herndler-Brandstetter D,
            Gerner C, Muller M, Strobl B and Eferl R.
  TITLE     Tyk2 is a tumor suppressor in colorectal cancer
  JOURNAL   Oncoimmunology 11 (1), 2127271 (2022)
   PUBMED   36185806
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4873)
  AUTHORS   Poelzl A, Lassnig C, Tangermann S, Hromadova D, Reichart U, Gawish
            R, Mueller K, Moriggl R, Linkermann A, Glosmann M, Kenner L,
            Mueller M and Strobl B.
  TITLE     TYK2 licenses non-canonical inflammasome activation during
            endotoxemia
  JOURNAL   Cell Death Differ 28 (2), 748-763 (2021)
   PUBMED   32929218
REFERENCE   3  (bases 1 to 4873)
  AUTHORS   Gracey E, Hromadova D, Lim M, Qaiyum Z, Zeng M, Yao Y, Srinath A,
            Baglaenko Y, Yeremenko N, Westlin W, Masse C, Muller M, Strobl B,
            Miao W and Inman RD.
  TITLE     TYK2 inhibition reduces type 3 immunity and modifies disease
            progression in murine spondyloarthritis
  JOURNAL   J Clin Invest 130 (4), 1863-1878 (2020)
   PUBMED   32149730
  REMARK    GeneRIF: TYK2 inhibition reduces type 3 immunity and modifies
            disease progression in murine spondyloarthritis.
REFERENCE   4  (bases 1 to 4873)
  AUTHORS   Natarajan K, Meganathan V, Mitchell C and Boggaram V.
  TITLE     Organic dust induces inflammatory gene expression in lung
            epithelial cells via ROS-dependent STAT-3 activation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 317 (1), L127-L140 (2019)
   PUBMED   31042082
  REMARK    GeneRIF: The study shows that poultry dust controls the induction
            of immune and inflammatory mediator expression via a cellular
            pathway involving oxidative stress-mediated STAT3 activation by
            TYK2 and EGFR tyrosine kinases.
            Erratum:[Am J Physiol Lung Cell Mol Physiol. 2019 Aug
            1;317(2):L303. PMID: 31386817]
REFERENCE   5  (bases 1 to 4873)
  AUTHORS   Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ,
            Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M,
            Jackson SW, Cerosaletti K, Buckner JH and Rawlings DJ.
  TITLE     The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate
            Signals Required to Generate Specialized T Cell Subsets
  JOURNAL   Front Immunol 10, 44 (2019)
   PUBMED   30740104
  REMARK    GeneRIF: TYK2(P) diminishes IL-12, IL-23, and IFN I signaling and
            that its protective effect is most likely manifest in the setting
            of autoimmune triggers that concurrently dysregulate at least two
            of these important signaling cascades.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4873)
  AUTHORS   Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu
            N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman
            D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de
            Waal-Malefyt R, Hannum C, Bazan JF and Kastelein RA.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
REFERENCE   7  (bases 1 to 4873)
  AUTHORS   Shimoda K, Kato K, Aoki K, Matsuda T, Miyamoto A, Shibamori M,
            Yamashita M, Numata A, Takase K, Kobayashi S, Shibata S, Asano Y,
            Gondo H, Sekiguchi K, Nakayama K, Nakayama T, Okamura T, Okamura S,
            Niho Y and Nakayama K.
  TITLE     Tyk2 plays a restricted role in IFN alpha signaling, although it is
            required for IL-12-mediated T cell function
  JOURNAL   Immunity 13 (4), 561-571 (2000)
   PUBMED   11070174
REFERENCE   8  (bases 1 to 4873)
  AUTHORS   Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H,
            Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K and
            Muller M.
  TITLE     Partial impairment of cytokine responses in Tyk2-deficient mice
  JOURNAL   Immunity 13 (4), 549-560 (2000)
   PUBMED   11070173
REFERENCE   9  (bases 1 to 4873)
  AUTHORS   Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK
            and Gubler U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
REFERENCE   10 (bases 1 to 4873)
  AUTHORS   Ruiz JC, Conlon FL and Robertson EJ.
  TITLE     Identification of novel protein kinases expressed in the myocardium
            of the developing mouse heart
  JOURNAL   Mech Dev 48 (3), 153-164 (1994)
   PUBMED   7893599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163637.4.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_001205312.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154438.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC163637.4         135900-136003
            105-256             AC163637.4         138464-138615
            257-476             AC163637.4         139832-140051
            477-594             AC163637.4         142194-142311
            595-742             AC163637.4         142617-142764
            743-975             AC163637.4         142966-143198
            976-1342            AC163637.4         145417-145783
            1343-1543           AC163637.4         146472-146672
            1544-1701           AC163637.4         146758-146915
            1702-1810           AC163637.4         150934-151042
            1811-2006           AC163637.4         151145-151340
            2007-2110           AC163637.4         151428-151531
            2111-2287           AC163637.4         151627-151803
            2288-2375           AC163637.4         151896-151983
            2376-2503           AC163637.4         152855-152982
            2504-2639           AC163637.4         155795-155930
            2640-2794           AC163637.4         156015-156169
            2795-2945           AC163637.4         156573-156723
            2946-3043           AC163637.4         156944-157041
            3044-3236           AC163637.4         157748-157940
            3237-3355           AC163637.4         158283-158401
            3356-3528           AC163637.4         159138-159310
            3529-3646           AC163637.4         159575-159692
            3647-3757           AC163637.4         161801-161911
            3758-4873           AC163637.4         161992-163107
FEATURES             Location/Qualifiers
     source          1..4873
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..4873
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /note="tyrosine kinase 2"
                     /db_xref="GeneID:54721"
                     /db_xref="MGI:MGI:1929470"
     exon            1..104
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..256
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..476
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..3892
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tyrosine kinase TYK2; non-receptor tyrosine-protein kinase
                     TYK2"
                     /codon_start=1
                     /product="non-receptor tyrosine-protein kinase TYK2
                     isoform 1"
                     /protein_id="NP_001192241.1"
                     /db_xref="CCDS:CCDS57656.1"
                     /db_xref="GeneID:54721"
                     /db_xref="MGI:MGI:1929470"
                     /translation="MVGTMPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEG
                     GEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDM
                     NLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGW
                     YVGNRAKSSHTSFSIHRSTPQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLC
                     HLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFRPGHL
                     SQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDPGPELP
                     SGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHLTESPQ
                     EPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFRLTA
                     DSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLILT
                     VAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDD
                     CFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRT
                     NVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLM
                     SQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLAS
                     ALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPW
                     TAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEP
                     SSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHK
                     RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILR
                     TLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEG
                     MAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY
                     APECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTE
                     LLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVF
                     SVC"
     exon            477..594
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..742
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..975
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1342
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1543
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1701
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1810
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..2006
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2110
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2287
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2375
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2503
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2639
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2794
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2945
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3043
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3236
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3355
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3528
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3646
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3647..3757
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..4873
                     /gene="Tyk2"
                     /gene_synonym="JTK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcaggtagc caatggcaag tggcgcgtag gcggtggact tccagcggct ccccgaggca
       61 gtggggcggg gtccagggtc ccaagcctga gtactccgga aacggtcctg ctgacacagt
      121 accatgcagg accaggttgg aagatctttc cgtagcaacc gtctcaacat cttttcttca
      181 cctggggaaa tggaggacca gagaggttaa gtgcactgcc tgaggtcaca cagaaagttc
      241 caagacgcac tgccagccag cacattgaat ggtggggacc atgcctctgt gtgggcggag
      301 agccatcttg gaagacagca aggcagatgg cacagaagct cagcccctgg tgcccacagg
      361 atgcttgatg gtgctactgc attggcctgg gcctgagggc ggggagccct gggtcacctt
      421 cagccagaca tctctgactg cagaggaggt ctgcatccac atcgcacaca aagtcggcat
      481 cactccaccc tgcttgaatc tcttcgcact ctacaatgca caggctaagg tctggctgcc
      541 cccaaaccat attctggata catcccaaga catgaacctc tattttcgaa tgaggtttta
      601 cttccggaac tggcatggca tgaatcccca ggagccagct gtataccggt gtggtttccc
      661 aggggcagag acttcctcag accgggcaga gcaaggtgta cagctcttgg actctgcctc
      721 gtttgaatac ctttttgagc agggatggta tgttggcaat agagcaaaaa gctcccacac
      781 ctctttttct atccatcgct ctacccctca gggaaagcat gagttcatga acgatgtggt
      841 gtctctgcgg gacctgtcta gcgaggagga gatccaccac tttaagaatg agagcttagg
      901 catggccttc ctgcacctgt gtcaccttgc tctcagccga ggcgtccccc tggaggagat
      961 ggccagagag atcagcttca agaactgcat ccctcattcc ttccgacagc acatccggca
     1021 gcacaatgtg ctcacacgcc tgcggctcca cagagtcttc cgccgcttcc tgcgggcctt
     1081 ccggcctggc cacctctccc agcaggttgt gatggtgaag tacttggcta ccctggagcg
     1141 gctggctccg cgctttggct cagagcgcat acctgtgtgt catctggagg tcctggcaca
     1201 gcccgagagg gacccctgct acatccagaa cagtgggcag accgctgggg atccaggccc
     1261 agagctgcct tccgggcctc ccacccacga ggtactggtg acaggcaccg gaggtatcca
     1321 gtggcatccg ctgcagaccc aggaatctga gagaggtaac agcagaggga atccccacgg
     1381 cagccggtcg gggaagaagc ccaaagcccc caaggctgga gagcacctga cagagagccc
     1441 tcaggaacca ccttggacct acttctgtga cttccaggac atttcccacg tggtgctaaa
     1501 ggagcgtcgc gtgcacatcc acctccaaga caacaagtgc ttgttgctgt gcctctgttc
     1561 ccaggctgag gccctgtcct ttgtggccct ggtcgatggc tatttccgct tgactgctga
     1621 ctccagccac tatctgtgcc atgaggtggc acccccgagg ctggtgacta gcatccagaa
     1681 cggcatccat gggcccctga tggatccgtt tgtacaggcc aagctgtggc cagaggacgg
     1741 cctctacctg attcagtgga gcaccagcca cctgcaccgc ctgatcctta ccgtggccca
     1801 tcgaaacccg gctttcagta atggccctcg gggcctgcgc ctgcgaaagt tccccatcac
     1861 acagcagcct ggagcctttg tgctggatgg ctggggccgc tcctttgcca gcttggggga
     1921 ccttcggctc gccttgcagg gctgctcgtt gcgggccggt gatgactgtt tccccctgca
     1981 ccactgctgc ctgccccggc caagagaaat ctccaacctc gtcatcatgc gggggtctag
     2041 ggcccacacc cggcctctca acctcagtca gctcagcttc cacagggttc accaggatga
     2101 aatcacccag ctgtcccact tgggccaagg cacaaggacc aatgtgtatg agggccttct
     2161 aagagtggga ggccccgatg agggcaaagt ggacaatgga tgtccccctg agcctggtgg
     2221 gactagtggg cagcagcttc gagtggtgct caaagttctc gaccccagtc accatgatat
     2281 cgccttggcc ttctatgaga ctgctagcct catgagccag gtgtcacaca tgcacctggc
     2341 tttcctgcat ggtgtttgcg tgcgtggctc agagaatatc attgtgacag aattcgtaga
     2401 acatggtccc ttggatgtgt ggttacggcg acagaggggc caagtgccca tgacctggaa
     2461 gatggtcgtg gctcagcagc tggccagcgc cctcagctac ctggaggaca agaatctggt
     2521 tcacgggaat gtatgtggcc ggaacatcct gctggctcgc ctggggttgg aggagggtac
     2581 caaccccttc atcaagctaa gtgatcctgg tgtgggccag ggtgccctct ccagggaaga
     2641 gcgggtggag cgcatcccct ggacagctcc cgagtgcctg tctggaggga ccagtagctt
     2701 gggtactgcc acggacatgt ggggctttgg tgccaccctt cttgagatct gctttgatgg
     2761 ggaggcaccc ctgcagggtc gtggtccctc tgagaaagaa cggttctaca caaagaaaca
     2821 tcagctgcct gaaccctcat ccccagagct ggccacactc acccgccagt gcctgaccta
     2881 tgaaccagca cagcggccat ccttccgcac cattttgcgg gacctcacaa ggctgcagcc
     2941 acagaatcta gtcggcactt cggctgtgaa ctcagactca ccagcatcag accccactgt
     3001 tttccacaag cgctatttga aaaagatccg ggatttgggt gagggtcact ttggcaaggt
     3061 cagcctgtac tgctacgacc caaccaatga cggcactggc gagatggtgg ccgtgaaggc
     3121 cctgaaggaa gggtgcggtc cccagctccg ctcaggctgg cagcgggaga tcgagatcct
     3181 gcggacgctg taccacgaac atattgtcaa gtataaaggc tgctgtgagg accaaggaga
     3241 gaagtctgta cagctggtca tggagtacgt ccctctgggc agcctccgag actacctgcc
     3301 aaggcactgc gtagggctgg cgcagctcct gctgtttgcc cagcagatct gcgagggcat
     3361 ggcctacctg cacgctcagc actacattca ccgagacctc gccgcgcgca acgtgctgct
     3421 ggacaacgac aggctggtca agattggaga ctttggccta gccaaggctg tacctgaagg
     3481 ccacgagtac taccgagtgc gcgaggacgg ggacagccca gtgttctggt atgccccaga
     3541 atgcctgaag gagtgcaaat tttactatgc atctgatgtc tggtccttcg gggtaactct
     3601 gtatgagttg ttgacatact gtgactctaa ccagagtccc catatgaaat tcaccgagct
     3661 catcggccat acccagggcc agatgaccgt gctgaggctc acagagctgc tggaacgagg
     3721 agagaggctg cctcggcctg acaggtgtcc ctgtgagatc tatcacctca tgaagaactg
     3781 ctgggagaca gaggcctcct tccggcccac cttccagaat cttgtgccca tcctccagac
     3841 agcacaggag aagtaccaag gtcaggtgcc ttccgtgttc agcgtgtgct gacagtcaaa
     3901 ggcatcaggg acggccccac acagaggcct ccacacacct tataccttac tctgcctgga
     3961 aaccccacct gtgacctaag tttccttcct tggccctgag cctggccatg acctgaacag
     4021 accttgaata tgcaaagggg ctaattggga ttcctgagtc tattcgttct gggcccatct
     4081 tgtcttttca tggttgagac ccccatcttc attagctggg aagaaactgt ttgctttgcc
     4141 ggaggcccga gggctgtgtg ggggggtcca tcttcagcaa gatgtgcaga cagagtgaga
     4201 cttcaaagga agcagtaaca cttctgatca cccctaaacc actagccaag ctgcagtgtg
     4261 actggggagc cagtggggag catgggggag acctgggttc tgtccctagc tggttaagac
     4321 agacaccaac tagatcagtt cctggtatac aggaggcact cagtagctgc ttgttagagg
     4381 ctggggagat ggctccgtca gtgaagggca cacaaaagtg cttgctttgc aaggcttgag
     4441 ttcagttccc aggcctagtt agctctgcgt gggggcacat gcttgccatg gggaagcgga
     4501 gacaggcagc attgtggggc tcactggcaa gaagcctagg ccatccagtg acactcaggc
     4561 caactagagt ccctgcttca aaacaaatag tagagcaggg ccccgggaag aatacccaga
     4621 gttgccctct gacctctgca catacatttg catacacaca caggaaggcc atttgtcaca
     4681 tatgtgggac tctgccagtt ttaccctttc cttgctgtgt aacctcagga aactgtcttg
     4741 acctctctgg ccctcgcatc tcagctatgg ggatggtcag gctttctacc tcatagggct
     4801 gatgatgggt tgcatttaaa ttgcttaaga gagccacaga tgagtgttta ataaaagttt
     4861 atgtttattg ctg
//
