LOCUS       NM_025299               4043 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus thioredoxin-like 4A (Txnl4a), transcript variant 1,
            mRNA.
ACCESSION   NM_025299
VERSION     NM_025299.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Pessa,H.K., Will,C.L., Meng,X., Schneider,C., Watkins,N.J.,
            Perala,N., Nymark,M., Turunen,J.J., Luhrmann,R. and Frilander,M.J.
  TITLE     Minor spliceosome components are predominantly localized in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8655-8660 (2008)
   PUBMED   18559850
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Reuter,K., Nottrott,S., Fabrizio,P., Luhrmann,R. and Ficner,R.
  TITLE     Identification, characterization and crystal structure analysis of
            the human spliceosomal U5 snRNP-specific 15 kD protein
  JOURNAL   J Mol Biol 294 (2), 515-525 (1999)
   PUBMED   10610776
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131065.16.
            
            On Jun 2, 2020 this sequence version replaced NM_025299.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 5, and 6 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004039.1, AV449025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC131065.16        168360-168435
            77-266              AC131065.16        168688-168877
            267-370             AC131065.16        180238-180341
            371-4043            AC131065.16        183713-187385
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 53.34 cM"
     gene            1..4043
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="thioredoxin-like 4A"
                     /db_xref="GeneID:27366"
                     /db_xref="MGI:MGI:1351613"
     exon            1..76
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            77..266
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..542
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="isoform a is encoded by transcript variant 1;
                     thioredoxin-like 4; thioredoxin-like protein 4A; DIM1
                     protein homolog; thioredoxin-like U5 snRNP protein
                     U5-15kD; spliceosomal U5 snRNP-specific 15 kDa protein"
                     /codon_start=1
                     /product="thioredoxin-like protein 4A isoform a"
                     /protein_id="NP_079575.1"
                     /db_xref="CCDS:CCDS29365.1"
                     /db_xref="GeneID:27366"
                     /db_xref="MGI:MGI:1351613"
                     /translation="MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV
                     LYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKI
                     NWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY"
     exon            267..370
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            371..4043
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      698..703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="hexamer: AATAAA"
     polyA_site      723
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="major polyA site"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="hexamer: AATAAA"
     polyA_site      1725
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="hexamer: ATTAAA"
     polyA_site      1864
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
                     /note="hexamer: AATAAA"
     polyA_site      4043
                     /gene="Txnl4a"
                     /gene_synonym="D18Wsu98e; Dim1; Txnl4; U5-15kD; U5-15kDa"
ORIGIN      
        1 gtcagcgcgt gacggcgcgg gaggagctgg tgctgggtgg aggacgcggt gtttgggccg
       61 cgtgggctca cacgaggtag ctcgcggcgt ccggccgcgc aggcgcgctc aagatgtcgt
      121 acatgcttcc gcatctgcac aatggctggc aggtagacca ggccatcctt tcggaggagg
      181 accgcgtggt cgtcattcgt ttcggacacg actgggaccc cacttgcatg aagatggacg
      241 aggttctgta cagcatcgcc gaaaaggtta aaaattttgc agttatttat cttgtggata
      301 ttacagaagt gcctgacttc aacaagatgt acgagctgta tgacccctgc actgtcatgt
      361 tcttcttcag aaacaaacat atcatgattg atttgggcac tggcaacaac aacaagatca
      421 actgggccat ggaagacaag caagaaatgg ttgacatcat agagaccgtg taccgtggcg
      481 cccgcaaagg ccggggtctg gtggtgtctc ccaaggacta ttctaccaag tacagatact
      541 gagccctgcc ctcaggctgt gcaaaggaca ctgagagcct cttccacata gaaatactct
      601 gctctcgtag cctctggaaa ggccctgcag cccgacattg ctgtagagct ggaggatccg
      661 tgagatgagg gctacagagc cttagctagc tggagcaaat aaacatggcg agggagcagt
      721 ggggatctgc tgtgcttact gcgtgcaaat gtctttactc ccagtgtttg tcccaggagg
      781 ctgtctggtt ttgcatcttc gagcggttgc cagagctgtc aagcaaacta ccccagacat
      841 tttagctgga cagttctcga ggtgtgagcc tgaggcggct gggttctgga ttccatttga
      901 ggctgtgggc catctgcagc agccccttgg ttctggaggt tgttggccat ccttggtaaa
      961 ccttggattg ggcacacgtt atcccagtct ttgccgtttt ccttacaagt catgtgtatc
     1021 atgtgtatgt caatctcaaa acatacccta cttacaaaca ccagttacct tgcctggggc
     1081 cacctcacct ctgtacagcc tcatcttaac cgattacgta tgatagtcac tccaaatgag
     1141 gtcatggtct gagattctgg gcttaaacca tcaacatatt aatttggggt gacataaccc
     1201 ataagaatac ccagtcttaa tctctctcag catataaaac agcactgtga tccaggtagg
     1261 attcactcct gctgctggct gaggccaggc agccgagctc aaaacacaac tacgaaaaag
     1321 caattgcctg gcggcgcttc ccttcctcca ctcttcctca cagcatgtct gtgtcctgct
     1381 tcctaaggaa gcagggtcct cattccaccc agcacaagtc cccttatcta cgtcagcttc
     1441 ctcttgtttc ttctcttcct ggcaatgtgg agggacccgg gtctaccctc tcatctctaa
     1501 acacaaactc agaagagaaa gatgagcata ccaggagccg actctggacg agcgcctcag
     1561 tacccctgcc ccatgcatct ccatcgtacg cagtggcgaa cactcactgg acgcctggtg
     1621 ggtggacagt accttctgtt gttcacacac tgacccatta ggaaagctca ggagtgaagc
     1681 agatgtctga cctacaaata aacgcactcg tcagatgaac caaaacatga gtcctggctt
     1741 ggggtgccgc ttggtgatag aggtagtatt cagttcctag cttgcaaaaa gtcagattca
     1801 catgcagagc tgcaatgtaa cgcctagcac taatttgctc attaaaagaa tagtagaagc
     1861 cggacgtggt ggcgcatgcc tttaatccca gcactcggga ggcagaggca ggcggatttc
     1921 tgagttcgag gccagcctgg tctacaaagt gagttccagg acagccaggg ctacacagag
     1981 ataccctgtc tcgaaaaacc aaaaaagaaa aaaaaagaat agtagagcca aacatggtgg
     2041 tgcgtgcctt taattaacac cagcacgtgg gaggcagaag taggcagatc tctggttttg
     2101 aggccagtct gctggttatc tggcttatat agtgagacac tgtcaggggg aaaaaagttt
     2161 agctttcctc attggccatt ggctggtccc atgtggagtt gctcttgagt ccccacataa
     2221 gggaaactca gtgtctggag ccctcaagaa tgtccttaaa tccgatgtga caggagaaca
     2281 ctggtacaac cttgctctgt acatctactg aaggaaaagt aatgtgtgta catcactaat
     2341 gtgagaggac ctgcatgtct tagttagggt ttcattgctg tgaagagaca ccatgaccaa
     2401 ggcaactctg taacatttac ttggggctgg cttacaattt cagaggttca gtccattacc
     2461 agcatggcag gaagcatggc agcgtgttgg caggcatggt tctggagaag gagctgagag
     2521 ttctacatct agatcagaag tcagccagga tcagactctc tctgcaggca tccaggagga
     2581 tgagacatct gtattgggtg gaacctgagc atgggagcct caaggcccac ccccacagtg
     2641 acggacttcc tctaacaagg gcacgcctac cccaacgagg ccacacttcc taactgtgcc
     2701 acttcccctg ggccaggcat attcaaacca ccccatgggg aaagctactg ctagctggtc
     2761 gagctgagtc ggctttaagt tgacgctggt atcaatgtgg cctgtgctga ggtttgctgc
     2821 tgccactgag cagcttcatt cctgggacct tcactaactt gatccaagga gccttccagg
     2881 aaccacttct ggtgtcgatc tgatggtgat ggataccagg gctgaccgaa agcttcttcc
     2941 cagaggcgtt tcctgtcaac ctgcctacca ttgctctgtg taacagattg tctgcacaag
     3001 gtagacagag ccattttcat gcaggaaacg agctccctgg aggggtctag tgtggcctgt
     3061 gagcaatgtg ggaggccatg cctgatgtct acagagatcc tgaagatgga gaaagaagag
     3121 gctgccccag agaaggctgt gaccaaggag gaactgcagg aagaatggac tgcgccagtg
     3181 cctgagttcg ctgctgctca ggaaggggtt ggcagactgg tctgagtggt caggtgccct
     3241 tcctgcctgt ctggcagagc cttactcaag actggagtgg cagcctccga gggctggact
     3301 gcagctccca ctggccagcc actgaatgga aaccaacagc taccaaggtc acagaaaggt
     3361 tagcaactgt gcggtcttat ttttatgggg gtaaagccct gcagagtgag atctcttaag
     3421 acccagagtc cacagtgctt gcagtctggg atagttacag tccagaaagg tgagggacca
     3481 gatggagggt cagccacagt tgaccattgc tagggattag agccatggct ctcaaccttc
     3541 ctaatgctgt gaccctttag tagagttctt caagatgtgg tgacacccaa gcataacatt
     3601 ttgttactac ttgtcctggc tggttttgtg tgccaacttg acacaagctg gagttatcat
     3661 cacagagaaa ggagcttcag ttggggaagt gcctccatga gatccagctg tggggcattt
     3721 tctcagttgg tgatcaaggg gggagggccc attgtaggtg gtgccatccc tgggctggta
     3781 gtcttgggtt ctataagaaa gcaagctgag caagccaggg gaaacaagcc agtaaagacc
     3841 atccctccat ggcctctgca tcagctcttg cttcctgacc tgcttgagtt ccaggcctga
     3901 ctttgagaaa ttggagtcgt ccgaagttgc tggtgaggct atctcgcaaa gttcaatatg
     3961 ttatcatagc tggcactcct aggtatagac ccaagagaac agcaatgtag aagtgtaagc
     4021 tgaataaacc ctttcctccc caa
//
