LOCUS       NM_001009935            2801 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus thioredoxin interacting protein (Txnip), transcript
            variant 1, mRNA.
ACCESSION   NM_001009935
VERSION     NM_001009935.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2801)
  AUTHORS   Jiao,A., Liu,H., Wang,H., Yu,J., Gong,L., Zhang,H. and Fu,L.
  TITLE     piR112710 attenuates diabetic cardiomyopathy through inhibiting
            Txnip/NLRP3-mediated pyroptosis in db/db mice
  JOURNAL   Cell Signal 122, 111333 (2024)
   PUBMED   39102928
  REMARK    GeneRIF: piR112710 attenuates diabetic cardiomyopathy through
            inhibiting Txnip/NLRP3-mediated pyroptosis in db/db mice.
REFERENCE   2  (bases 1 to 2801)
  AUTHORS   Chen,Q., Hu,R., Qiu,H., Li,S., Xiang,P., Lu,Y., Wang,X., Wang,T.,
            Zhou,L., Zhang,W., Wen,E., Ma,L. and Yu,C.
  TITLE     REDD1 knockdown ameliorates endothelial cell senescence through
            repressing TXNIP-mediated oxidative stress
  JOURNAL   Mech Ageing Dev 221, 111962 (2024)
   PUBMED   39004152
  REMARK    GeneRIF: REDD1 knockdown ameliorates endothelial cell senescence
            through repressing TXNIP-mediated oxidative stress.
REFERENCE   3  (bases 1 to 2801)
  AUTHORS   Park,K.H., Kim,H.C., Won,Y.S., Yoon,W.K., Choi,I., Han,S.B. and
            Kang,J.S.
  TITLE     Vitamin D3 Upregulated Protein 1 Deficiency Promotes
            Azoxymethane/Dextran Sulfate Sodium-Induced Colorectal
            Carcinogenesis in Mice
  JOURNAL   Cancers (Basel) 16 (17), 2934 (2024)
   PUBMED   39272794
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2801)
  AUTHORS   Jolibois,J., Domingues,A., El Hamaoui,D., Awaida,R.,
            Berger-de-Gaillardo,M., Guerin,D., Smadja,D.M., Marquet-DeRouge,P.,
            Margaill,I., Rossi,E. and Nivet-Antoine,V.
  TITLE     Targeting TXNIP in endothelial progenitors mitigates IL-8-induced
            neutrophil recruitment under metabolic stress
  JOURNAL   Stem Cell Res Ther 15 (1), 225 (2024)
   PUBMED   39075518
  REMARK    GeneRIF: Targeting TXNIP in endothelial progenitors mitigates
            IL-8-induced neutrophil recruitment under metabolic stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2801)
  AUTHORS   Xue,Y., Zhou,Y. and Cepko,C.L.
  TITLE     Txnip deletions and missense alleles prolong the survival of cones
            in a retinitis pigmentosa mouse model
  JOURNAL   Elife 12, 90749 (2024)
   PUBMED   38727583
  REMARK    GeneRIF: Txnip deletions and missense alleles prolong the survival
            of cones in a retinitis pigmentosa mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2801)
  AUTHORS   Shike,T., Hirose,S., Kobayashi,M., Funabiki,K., Shirai,T. and
            Tomino,Y.
  TITLE     Susceptibility and negative epistatic loci contributing to type 2
            diabetes and related phenotypes in a KK/Ta mouse model
  JOURNAL   Diabetes 50 (8), 1943-1948 (2001)
   PUBMED   11473059
REFERENCE   7  (bases 1 to 2801)
  AUTHORS   Ludwig,D.L., Kotanides,H., Le,T., Chavkin,D., Bohlen,P. and
            Witte,L.
  TITLE     Cloning, genetic characterization, and chromosomal mapping of the
            mouse VDUP1 gene
  JOURNAL   Gene 269 (1-2), 103-112 (2001)
   PUBMED   11376942
REFERENCE   8  (bases 1 to 2801)
  AUTHORS   Pajukanta,P., Bodnar,J.S., Sallinen,R., Chu,M., Airaksinen,T.,
            Xiao,Q., Castellani,L.W., Sheth,S.S., Wessman,M., Palotie,A.,
            Sinsheimer,J.S., Demant,P., Lusis,A.J. and Peltonen,L.
  TITLE     Fine mapping of Hyplip1 and the human homolog, a potential locus
            for FCHL
  JOURNAL   Mamm Genome 12 (3), 238-245 (2001)
   PUBMED   11252174
REFERENCE   9  (bases 1 to 2801)
  AUTHORS   Junn,E., Han,S.H., Im,J.Y., Yang,Y., Cho,E.W., Um,H.D., Kim,D.K.,
            Lee,K.W., Han,P.L., Rhee,S.G. and Choi,I.
  TITLE     Vitamin D3 up-regulated protein 1 mediates oxidative stress via
            suppressing the thioredoxin function
  JOURNAL   J Immunol 164 (12), 6287-6295 (2000)
   PUBMED   10843682
REFERENCE   10 (bases 1 to 2801)
  AUTHORS   Castellani,L.W., Weinreb,A., Bodnar,J., Goto,A.M., Doolittle,M.,
            Mehrabian,M., Demant,P. and Lusis,A.J.
  TITLE     Mapping a gene for combined hyperlipidaemia in a mutant mouse
            strain
  JOURNAL   Nat Genet 18 (4), 374-377 (1998)
   PUBMED   9537422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122037.2.
            
            On Nov 17, 2006 this sequence version replaced NM_001009935.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089403.1, AK089304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               AC122037.2         91618-92146         c
            530-605             AC122037.2         91139-91214         c
            606-753             AC122037.2         90886-91033         c
            754-856             AC122037.2         90668-90770         c
            857-1113            AC122037.2         90258-90514         c
            1114-1270           AC122037.2         90009-90165         c
            1271-1422           AC122037.2         89744-89895         c
            1423-2801           AC122037.2         88246-89624         c
FEATURES             Location/Qualifiers
     source          1..2801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.93 cM"
     gene            1..2801
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /note="thioredoxin interacting protein"
                     /db_xref="GeneID:56338"
                     /db_xref="MGI:MGI:1889549"
     exon            1..529
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1473
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     upregulated by 1,25-dihydroxyvitamin D-3; thioredoxin
                     binding protein-2; vitamin D3 up-regulated protein 1;
                     hyperlipidemia 1"
                     /codon_start=1
                     /product="thioredoxin-interacting protein isoform 1"
                     /protein_id="NP_001009935.1"
                     /db_xref="CCDS:CCDS38555.1"
                     /db_xref="GeneID:56338"
                     /db_xref="MGI:MGI:1889549"
                     /translation="MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAV
                     RILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEEQPTAGENEMVIMRPGNKYEYKF
                     GFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAP
                     VSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVA
                     RHTYLANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILKVEYS
                     LLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPC
                     YMDIIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNN
                     NNNVQ"
     exon            530..605
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..753
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..856
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1113
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1270
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1422
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..2801
                     /gene="Txnip"
                     /gene_synonym="1200008J08Rik; Hyplip1; Tbp-2; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacactctcc tcctctggtc tcggggtttc cagagtttct ccagttgcgg aagacagctg
       61 ttatttttct cctgaaagct tttggcacag ccggcaggct gaaacttcca ggcacctttt
      121 ggaaaagttg ttagggtttg tttgaagctt tctttacatt ttcgtttggg ttttcaagcc
      181 ctgactttac ggaggcgagc tcttcgtttg ctttgaaggg ttcttaaaga tttttttcct
      241 ctccggcttt cgtttttctt gaacccactc ggctcaatca tggtgatgtt caagaagatc
      301 aagtcttttg aggtggtctt caacgacccc gagaaggtgt acggcagcgg ggagaaggtg
      361 gccggacggg taatagtgga agtgtgtgaa gttacccgag tcaaagccgt caggatcctg
      421 gcttgcggcg tggccaaggt cctgtggatg caagggtctc agcagtgcaa acagactttg
      481 gactacttgc gctatgaaga cacacttctc ctagaagagc agcctacagc aggtgagaac
      541 gagatggtga tcatgaggcc tggaaacaaa tatgagtaca agttcggctt cgagcttcct
      601 caagggcccc tgggaacatc ctttaaagga aaatatggtt gcgtagacta ctgggtgaag
      661 gcttttctcg atcgccccag ccagccaact caagaggcaa agaaaaactt cgaagtgatg
      721 gatctagtgg atgtcaatac ccctgaccta atggcaccag tgtctgccaa aaaggagaag
      781 aaagtttcct gcatgttcat tcctgatgga cgtgtgtcag tctctgctcg aattgacaga
      841 aaaggattct gtgaaggtga tgacatctcc atccatgctg actttgagaa cacgtgttcc
      901 cgaatcgtgg tccccaaagc ggctattgtg gcccgacaca cttaccttgc caatggccag
      961 accaaagtgt tcactcagaa gctgtcctca gtcagaggca atcacattat ctcagggact
     1021 tgcgcatcgt ggcgtggcaa gagcctcaga gtgcagaaga tcagaccatc catcctgggc
     1081 tgcaacatcc tcaaagtcga atactccttg ctgatctacg tcagtgtccc tggctccaag
     1141 aaagtcatcc ttgatctgcc cctagtgatt ggcagcaggt ctggtctgag cagccggaca
     1201 tccagcatgg ccagccggac gagctctgag atgagctgga tagacctaaa catcccagat
     1261 accccagaag ctcctccttg ctatatggac atcattcctg aagatcacag actagagagc
     1321 cccaccaccc ctctgctgga cgatgtggac gactctcaag acagccctat ctttatgtac
     1381 gcccctgagt tccagttcat gcccccaccc acttacactg aggtggatcc gtgcgtcctt
     1441 aacaacaaca acaacaacaa caacgtgcag tgagcctgca ggaaatgaag catctgtatt
     1501 agcgcatttc tttctgcctc tctgcttgaa ctccagtgtt tcagagactc agtctctaca
     1561 gcggggaacg ggtacacccc agccgctgac tcctcaagat gggtggcaat cagtaggcgg
     1621 gtctccggct tcaagtggtg cagaccagtg cccgcactgt ggcataggag tgtttgctgg
     1681 gtggatgtca gaacactctt agaaaaattg agacctgacc actttctcgg atgttggaaa
     1741 tgaagaactt gtttgtgttg actgagtcag ggcactgctg accttctggc gttgtctttc
     1801 caaggttttt gttttaaagg gacttttaaa ttgtctaaaa tatcagtaga ccatcatctg
     1861 tgccatgggg gacagagcca atttcaagtc atggccaaaa ttttgtaaga ggagtgtttt
     1921 tgtgtgtttt ttaaagtcag tgttcctttt ttatatcttt acaaagaaaa gaccttccac
     1981 ggctggtgag cacgcagcct gtgaaattcg gggcagctgc tccaagttga cttcaccctg
     2041 ggagcagtag tagctgtgcc cactgacggc cataaaagcc attttacagc cagttgcact
     2101 gtgttctctt gtaagcataa tcagatggga gaatctgtta tttccctgta accccttgga
     2161 attgattcta aggtgatgtt cttagcactt tagcttgtca attttgtttt agtctccgtt
     2221 atagatgtaa gctccaccag tctcttaagg attaagccca gtgacttgga gggtgggggt
     2281 tagggtctct atccctgaac attgtagacc caggctggcc tgagagatcc acctgcctct
     2341 gcctcctgag tgctgcgatc aaaggcccag cttggttatt gcttttgagg ctttctccca
     2401 acgcacagac ttgtgtaatt ctaacactaa tcctgtgaag ggttgtggtt gacagctgga
     2461 gcctgggtga cattctacat tgagatgccc cagcactgat cggggcacag aagcccccag
     2521 accccatttc ctgtccagtg ttgggagaaa gtgctgcttt cactgtggcc tcagccctgg
     2581 ctcggaagct cactaagcct tagcactttg tcctgtgtca gctccacctg agaactgtgc
     2641 agccagaatg tctgcgagct gatggaggtt tcggttttgt tgtttttgta ttttgtgtat
     2701 ctttttgtat gattaaaaac tatattttct acttatccaa atatattttc accccaaagt
     2761 ggggttatcc tttgtaaaaa aaaataaagt tttttaatga c
//
