LOCUS       NM_172054               5194 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus thioredoxin domain containing 9 (Txndc9), transcript
            variant 1, mRNA.
ACCESSION   NM_172054 XM_978892 XM_978943 XM_978974
VERSION     NM_172054.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5194)
  AUTHORS   Ma,F., Hou,L. and Yang,L.
  TITLE     Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes
  JOURNAL   Biomed Res Int 2017, 6265890 (2017)
   PUBMED   28626760
  REMARK    GeneRIF: results demonstrated that Txndc9 is crucial for mouse
            oocyte maturation by regulating spindle assembly, polar body
            extrusion, and redox status.
REFERENCE   2  (bases 1 to 5194)
  AUTHORS   Ogawa,S., Matsubayashi,Y. and Nishida,E.
  TITLE     An evolutionarily conserved gene required for proper microtubule
            architecture in Caenorhabditis elegans
  JOURNAL   Genes Cells 9 (2), 83-93 (2004)
   PUBMED   15009089
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114583.7.
            
            On Mar 13, 2023 this sequence version replaced NM_172054.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153857.1, AK028525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC114583.7         144962-145096
            136-344             AC114583.7         146364-146572
            345-463             AC114583.7         148095-148213
            464-718             AC114583.7         151748-152002
            719-5194            AC114583.7         154426-158901
FEATURES             Location/Qualifiers
     source          1..5194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 16.37 cM"
     gene            1..5194
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="thioredoxin domain containing 9"
                     /db_xref="GeneID:98258"
                     /db_xref="MGI:MGI:2138153"
     exon            1..135
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /inference="alignment:Splign:2.1.0"
     exon            136..344
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..836
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="isoform a is encoded by transcript variant 1; ATP
                     binding protein associated with cell differentiation;
                     thioredoxin domain-containing protein 9"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 9 isoform
                     a"
                     /protein_id="NP_742051.1"
                     /db_xref="CCDS:CCDS14898.1"
                     /db_xref="GeneID:98258"
                     /db_xref="MGI:MGI:2138153"
                     /translation="MEGNGSVDMFSEVLENQFLQAAKLVENHLDSEIQKLDQIGEDEL
                     ELLKEKRLAALRKAQQQKQEWLSKGHGEYREIGSERDFFQEVKESEKVVCHFYRDTTF
                     RCKILDRHLAILAKKHLETKFLKLNVEKAPFLCERLRIKVIPTLALLRDGKTQDYVVG
                     FTDLGNTDDFTTETLEWRLGCSDVINYSGNLMEPPFQSQKKFGTNFTKLEKKTIRGKK
                     YDSDSDDD"
     exon            345..463
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /inference="alignment:Splign:2.1.0"
     exon            464..718
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /inference="alignment:Splign:2.1.0"
     exon            719..5194
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1105
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="major polyA site"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="hexamer: ATTAAA"
     polyA_site      1389
                     /gene="Txndc9"
                     /gene_synonym="APACD"
     regulatory      3288..3293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="hexamer: TATAAA"
     polyA_site      3309
                     /gene="Txndc9"
                     /gene_synonym="APACD"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="hexamer: AGTAAA"
     polyA_site      3490
                     /gene="Txndc9"
                     /gene_synonym="APACD"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="hexamer: AATAAT"
     polyA_site      3575
                     /gene="Txndc9"
                     /gene_synonym="APACD"
     regulatory      5170..5175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc9"
                     /gene_synonym="APACD"
                     /note="hexamer: AATAAA"
     polyA_site      5194
                     /gene="Txndc9"
                     /gene_synonym="APACD"
ORIGIN      
        1 gtagccaatg aagtggcgga gttaacagcc ccttctctgc ccttaacaat tgctgcgagg
       61 ttgaaacctg tgtgaacccg gtgggtattc ttgatctgcg gcttcctctc tccgtaggcc
      121 tcatcaatag tccagcacca agaccactta gaacaatgga aggtaatgga tccgtcgaca
      181 tgttctcaga agtcctggag aaccagttcc tccaggccgc taagctggtg gagaatcact
      241 tggactctga aattcagaaa ctggatcaga ttggtgaaga tgaactggag ctgctcaaag
      301 aaaagaggct ggcggcgctc aggaaggctc agcagcagaa acaagagtgg ctttccaaag
      361 ggcacgggga gtacagagaa atcggcagcg agagagactt ctttcaagag gtcaaggaga
      421 gtgagaaagt ggtttgccat ttctacagag acaccacatt caggtgtaaa atactagaca
      481 gacatttggc aattctggcc aaaaagcatc ttgaaaccaa gtttttgaag ctgaatgtgg
      541 aaaaggcacc attcctctgt gagagactgc ggatcaaggt catccccacg ctagctctct
      601 taagagatgg caagacgcaa gattatgttg ttggattcac cgacctagga aatacagatg
      661 acttcactac agaaacttta gaatggagac ttggttgttc tgatgttatc aattacagtg
      721 gaaatttaat ggagccacca tttcagagcc aaaagaaatt tgggacaaac tttacaaagc
      781 tggaaaagaa aactatccga ggaaagaaat acgattccga ttctgatgat gactagactg
      841 tgctgtactt taaaaccttc cgtctgtctg tctgtctgtc tgtctacttc agagttaagt
      901 gtgttttcta aattcctaaa ttccactgat ttcggcccat tgaccatctg acactcttat
      961 cccagcctgt acactgtttg accattttgt ctgcagtcat tgtgtataac ttgagagaaa
     1021 catactttaa attacctggg agggtctgaa ttctctattt ttgtgattga ttttatcata
     1081 acgtgattct tctatcttca aaccattcac atgtctgttt ttaatctcct gagttagaga
     1141 taggaatttg cccactattg taagagccaa tgagtgacca tccactgggc accacatgca
     1201 cttccttgtc cgtgatccgc ttcgtggaat gggtttcagg aactgttaaa gactcactca
     1261 tggtgactct gctgatgata gcggcaggaa acccagggtg tgagcacatc gccttattta
     1321 aatagtcctc attgcacacg cacattatga gacctgcaaa aatataatta aaccgttttt
     1381 gagtggtaac ataaggaact ccattggctg ctcagtaaaa caactttagc aaaggtgaaa
     1441 tttctaaaag tgtgagtctg gaaactatga gatcatatag caaacaaaaa cattttaaaa
     1501 aaaatatagg ccatgtgctt agcatgaaca gaaataatct gatgcccaga aataaataag
     1561 ccttggtaag aaaagagtat agcatcaact actgagatgg ctcaatggag aaaggcactt
     1621 accacaaaac ttggggactg ggcccactgg tggaaggaaa gaaaagattc ctgcaagatg
     1681 tcgtttaaca tacacaatac aggaaataca aatgagttga actacagggg tcttggggtt
     1741 tgagagcagt ctaaaacaac acaaaggggc tggagagaag gctcggcagt taagagcact
     1801 tgagatggct tcctggcacc tacatggtgg cacacagcca tccactagct cccattctag
     1861 gactctgatg ccttctgacc tccaaggcca ccaagcacag cagtgctcag tggtgagggg
     1921 ttccttcagg taagccaggc tgttctggtg aattgacaca cccaccttcc aagaagccca
     1981 ccagatgtgg gctttgacga ggctgtttcc tccagacgag tttgcagtag agaggaatcc
     2041 catttgtgtt actgcgactg agaaggcagg atccaggcac caccttgaga gggaactgag
     2101 ccacacttgg agtctgagaa tggagaacag ccatccaaca gacaacctag gagatggtta
     2161 tggagagtgg gagggctacg tgcaagagac aagttagggc agtacagtgc acagggaaaa
     2221 accctgccct ggatgccagg accagattac atcaagaata aacgtgcctg tagccctact
     2281 cctgaggtca tcgggtggac cggctggtga tgttatctag gtagcggtac ggccacagat
     2341 cctgaagact gcagcaccag caggcaagct cccatagcta cattcttcca gcaagacaaa
     2401 agcagagaca atgtgatgtc tcggttgctc ccacactccc agtgcacttg ggagaccacc
     2461 acagcagcct atcagccact tctggggatc cagtccaaga atgaaagccc ataggctgca
     2521 gagctaagtg cggccagtag aggacgctac tacataaagg tgggaagcta ttcaagtgga
     2581 gccaggtcct gtgggaatct gacacttgcc aaacagggct taaccttaga aaagagccct
     2641 ggttcaacag ccttcaccat cacatcagcc cctgagactc cccttgccct tctttctttg
     2701 accttctggc ctacccttgt atttaacttt tgttcaactc atagcgattc ttttatcctg
     2761 gtgttactca tctcatcatg aaatacttca ttttggttat gcattttttt ccactatctg
     2821 gcggtatttt tttcttttgt tcctctcaac tagactttca gcagtattta actttgtctt
     2881 actggggata gtctttactt ttttgtttta aaaatctcat gtttctattt tgttctttac
     2941 ttgaggggga aggttgggac ggggactttc tacattgccc tctgtaggcc aggctggcct
     3001 tgaactagag atctgcctcc ggaacttgtg aactaaaagg cagtgctgaa ctccccttct
     3061 taacatttat ctaattttga gttttaattt aattatttaa aaatctggaa tttttattat
     3121 gtatttttat gtattttttc tattctactc tctcttttcc cttccacgac attcttctct
     3181 accacttctc tttaactttt ggttcattta ctattatttc tctatttccc ttctttttta
     3241 tctcattcat ttgctaatgc tacattgacc ctaaataatt cttaatttat aaaattctat
     3301 agtacatgct cccgttctct gtttgatggt cacgggtggt gtactaatgg actttatttt
     3361 aggtgtattt ctatctgtgg ctgttgccac tacagtagct ccctttctca gtacagggca
     3421 gtagtaggga ctgagcccca agagcgagtt gcttactaag atttgcaagt aaaaccagga
     3481 gagaaccaaa ccaaagatgt gccaatttta tcagagaaac aacagatgta tggggtgtgg
     3541 gtgcaagcaa aataatatga ttatcaagaa tgtaacttta tattcattat ttttaaaagg
     3601 tggaagattt atgtcagcag aaaaggaagc agcgtagaat taacagtttt tatgtttgtg
     3661 tacatgtgtg tatatacaca tgtgtgcatg tgtagaggtc agaagacaac tccactatgt
     3721 gagttctttt ttaatgtata caagtacact gttgctctct tcagatacac ccagaagagg
     3781 gcacccatta cagatggttg tgagccacta tgcggttgct aggaattgaa gtcaggacct
     3841 ctgaaagagc agtcagtatg cttaaccact cagccatctc tccaaccccc ccccactctg
     3901 tgagttctaa gggttgaact caggtcatca aggttggccc agtgggtaaa gctgcatgtt
     3961 gccatgcctg acaacctgag tctgatgccc tgaccttctg cactgatcag taatctcagt
     4021 gtacccctag gatcagaagc agacagagga ctcttccagc tagcttgcac acactggtga
     4081 agaacccctt cctcacacaa ggtagaaaag gaaaggccaa aacccaatgg ttgtcctcta
     4141 tactccaggc acatactcac catgtccaca cagaagaaca tgcatacaca caagtttcct
     4201 taatccccca aggccccgat accaaaactg gttaagaaca caacaacaaa agaagttaca
     4261 ggtcacttca cttgatgtac atagaaacgt tctccataaa atgcatacaa aatcatattg
     4321 aagagatact aagatcaaat gtcatagcgc agttggtttt gcctgaggaa agggaggttt
     4381 aagcaaaaat aaagtcaatc aatcaatcaa tgttatgccc catgggcctg aggaaatggc
     4441 tcagtggtta agagtgctca gagctcttgc aaaggactct gctctggctc ccagcaccca
     4501 catcaggtgg ctcacaaccg ccacctataa ctctagttcc aagggatgtg acaccctatg
     4561 gaactttgaa gacactttca cgcatgtggt aaactcatac agcctcacac acttacacat
     4621 gataaacatt gaaaaaatgc tatcctacac acacacacac acacacaccc agccttaaag
     4681 gaaaaatcac atgataatcc ccacaaacac tggaaaggcc tttgacaaag ttcaattcta
     4741 aagaagctag gaataagaga agcacaatgt actggctagt tttgtgtcaa cttggcacag
     4801 ctggagttat cacagagaaa ggagctgcag tggaggaaat gcctccatga gatccagctg
     4861 taaggcattt tctcaattag tgatcaaggg ggaaaggccc cttgtgggtg gggccatctc
     4921 tgggctggta gtcttggttc tataagagag caggctgagc aagccagggg aagcaagcca
     4981 gtaaagaaca tccctccatg gcttctgcat cagttcctgc tttctgacct gcttgagttc
     5041 cagtcctgac ttccttggtg atgaacagca gtatggaaat gtaagctgaa taaacccttt
     5101 cctccccaac ttgcttcttg gtcatgatgt ttgtgcagga atagaaaccc tgactaagac
     5161 aaacaatata ataaagtggt gtatgaaaaa ctta
//
