LOCUS       NM_026132                620 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus thioredoxin domain containing 8 (Txndc8), transcript
            variant 1, mRNA.
ACCESSION   NM_026132
VERSION     NM_026132.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Jimenez,A., Prieto-Alamo,M.J., Fuentes-Almagro,C.A., Jurado,J.,
            Gustafsson,J.A., Pueyo,C. and Miranda-Vizuete,A.
  TITLE     Absolute mRNA levels and transcriptional regulation of the mouse
            testis-specific thioredoxins
  JOURNAL   Biochem Biophys Res Commun 330 (1), 65-74 (2005)
   PUBMED   15781233
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Jimenez,A., Zu,W., Rawe,V.Y., Pelto-Huikko,M., Flickinger,C.J.,
            Sutovsky,P., Gustafsson,J.A., Oko,R. and Miranda-Vizuete,A.
  TITLE     Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi
            apparatus-associated thioredoxin, is a specific marker of aberrant
            spermatogenesis
  JOURNAL   J Biol Chem 279 (33), 34971-34982 (2004)
   PUBMED   15181017
  REMARK    GeneRIF: SPTRX3 is a novel Golgi apparatus-associated thioredoxin,
            and has a role in aberrant spermatogenesis [SPTRX-3]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929406.10.
            
            On Feb 13, 2019 this sequence version replaced NM_026132.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015240.1, BY714796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL929406.10        80319-80439         c
            122-226             AL929406.10        78388-78492         c
            227-286             AL929406.10        73713-73772         c
            287-352             AL929406.10        71558-71623         c
            353-418             AL929406.10        56890-56955         c
            419-620             AL929406.10        55342-55543         c
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.87 cM"
     gene            1..620
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /note="thioredoxin domain containing 8"
                     /db_xref="GeneID:67402"
                     /db_xref="MGI:MGI:1914652"
     exon            1..121
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..481
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thioredoxin domain-containing protein 8; thioredoxin-6;
                     spermatid-specific thioredoxin-3"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 8 isoform
                     1"
                     /protein_id="NP_080408.3"
                     /db_xref="CCDS:CCDS18208.1"
                     /db_xref="GeneID:67402"
                     /db_xref="MGI:MGI:1914652"
                     /translation="MVKRIKNMSELKELFSDAGNKLVVVEFSAKWCGPCKTIAPVFQA
                     MSLKYQNVTFAQVDVDSSKELAEHCDITMLPTFQMFKYTQKVTPFSRLKRVLCCLRSG
                     PKSKMIFECHGADAKQLEKKIQELM"
     exon            122..226
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /inference="alignment:Splign:2.1.0"
     exon            227..286
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /inference="alignment:Splign:2.1.0"
     exon            287..352
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /inference="alignment:Splign:2.1.0"
     exon            353..418
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /inference="alignment:Splign:2.1.0"
     exon            419..620
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      493..498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /note="hexamer: AATATA"
     polyA_site      516
                     /gene="Txndc8"
                     /gene_synonym="4930429J24Rik; Sptrx-3; Sptrx3; Trx6"
                     /note="major polyA site"
ORIGIN      
        1 ctattccatc cagaatgcca tgatgaatgg gacagctacg gtgatcctcc acctgaacca
       61 acaggagagg gtcagcagca agtcccagat gttaatcatg gtgaagagga ttaagaacat
      121 gagtgaactg aaagaattgt tcagcgatgc tggaaacaag cttgtggtgg tagagttttc
      181 agcaaagtgg tgtggcccct gcaaaacaat tgctcctgtt ttccaggcaa tgtctttaaa
      241 ataccaaaat gtcacgtttg ctcaggtgga tgtggactca tctaaggaat tagctgaaca
      301 ttgtgacatc acaatgctac ccacattcca gatgttcaag tacacccaaa aggtcactcc
      361 attctcaaga ctcaaaagag tactgtgctg cctcagaagt ggaccgaaga gcaagatgat
      421 ttttgaatgt catggagctg atgctaaaca actggaaaag aagattcaag agctaatgta
      481 aacggccacc caaatatacc tgtgacattt cctaaagcag gagctaatgc tctgtgtctt
      541 gcatgccctg cgagctgttc tctattggtc tctcctgacg ctctgtcgga agaacgcggc
      601 attacaggac catgcttgac
//
