LOCUS       NM_145367               2671 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus thioredoxin domain containing 5 (Txndc5), transcript
            variant 1, mRNA.
ACCESSION   NM_145367 XM_975097
VERSION     NM_145367.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Sanchez-Marco,J., Bidooki,S.H., Abuobeid,R., Barranquero,C.,
            Herrero-Continente,T., Arnal,C., Martinez-Beamonte,R., Lasheras,R.,
            Surra,J.C., Navarro,M.A., Rodriguez-Yoldi,M.J., Arruebo,M.,
            Sebastian,V. and Osada,J.
  TITLE     Thioredoxin domain containing 5 is involved in the hepatic storage
            of squalene into lipid droplets in a sex-specific way
  JOURNAL   J Nutr Biochem 124, 109503 (2024)
   PUBMED   37898391
  REMARK    GeneRIF: Thioredoxin domain containing 5 is involved in the hepatic
            storage of squalene into lipid droplets in a sex-specific way.
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Xie,H., Wang,Y.H., Liu,X., Gao,J., Yang,C., Huang,T., Zhang,L.,
            Luo,X., Gao,Z., Wang,T., Yan,T., Liu,Y., Yang,P., Yu,Q., Liu,S.,
            Wang,Y., Xiong,F., Zhang,S., Zhou,Q. and Wang,C.Y.
  TITLE     SUMOylation of ERp44 enhances Ero1alpha ER retention contributing
            to the pathogenesis of obesity and insulin resistance
  JOURNAL   Metabolism 139, 155351 (2023)
   PUBMED   36427672
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Zhou,J., Wu,Y., Rauova,L., Koma,G., Wang,L., Poncz,M., Li,H.,
            Liu,T., Fong,K.P., Bennett,J.S., Kunapuli,S.P. and Essex,D.W.
  TITLE     A novel role for endoplasmic reticulum protein 46 (ERp46) in
            platelet function and arterial thrombosis in mice
  JOURNAL   Blood 139 (13), 2050-2065 (2022)
   PUBMED   34752599
  REMARK    GeneRIF: A novel role for endoplasmic reticulum protein 46 (ERp46)
            in platelet function and arterial thrombosis in mice.
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Chen,X., Li,C., Liu,J., He,Y., Wei,Y. and Chen,J.
  TITLE     Inhibition of ER stress by targeting the IRE1alpha-TXNDC5 pathway
            alleviates crystalline silica-induced pulmonary fibrosis
  JOURNAL   Int Immunopharmacol 95, 107519 (2021)
   PUBMED   33691254
  REMARK    GeneRIF: Inhibition of ER stress by targeting the IRE1alpha-TXNDC5
            pathway alleviates crystalline silica-induced pulmonary fibrosis.
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Wrammert,J., Kallberg,E. and Leanderson,T.
  TITLE     Identification of a novel thioredoxin-related protein, PC-TRP,
            which is preferentially expressed in plasma cells
  JOURNAL   Eur J Immunol 34 (1), 137-146 (2004)
   PUBMED   14971039
  REMARK    GeneRIF: PC-TRP was expressed at high levels in all plasma cells
            isolated from bone marrow or lamina propria.
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Knoblach,B., Keller,B.O., Groenendyk,J., Aldred,S., Zheng,J.,
            Lemire,B.D., Li,L. and Michalak,M.
  TITLE     ERp19 and ERp46, new members of the thioredoxin family of
            endoplasmic reticulum proteins
  JOURNAL   Mol Cell Proteomics 2 (10), 1104-1119 (2003)
   PUBMED   12930873
  REMARK    GeneRIF: both ERp19 and ERp46 and their respective mRNAs are highly
            expressed in the liver as compared with other tissues
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK225023.1, AK224971.1 and AY243534.1.
            
            On Jan 24, 2014 this sequence version replaced NM_145367.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016252.1, AK225023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK225023.1         2-4
            4-2641              AK224971.1         1-2638
            2642-2671           AY243534.1         2607-2636
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 18.27 cM"
     gene            1..2671
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /note="thioredoxin domain containing 5"
                     /db_xref="GeneID:105245"
                     /db_xref="MGI:MGI:2145316"
     exon            1..297
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            298..447
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            448..553
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..650
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            651..766
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            767..853
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            854..994
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1077
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1207
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2650
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /note="hexamer: AATAAA"
     polyA_site      2650
                     /gene="Txndc5"
                     /gene_synonym="ERp46; PC-TRP"
                     /note="major polyA site"
ORIGIN      
        1 gtgggaggag ccggggcggg agcggcgccg cggaggggac ccgcggcacg agcgagagct
       61 cgccagcccc gccacgatgc ccccgcgccc aggacgcctc ctccagccgc tggccgggct
      121 gccggccctg gccacgctcc tgctgctgct cggggcgcgc aaaggcgccc gggcccagga
      181 ggtggaagcg gacagcgggg tcgagcagga cccgcacgcc aagcacctgt atacggccga
      241 catgttcacg cacgggatcc agagcgccgc gcacttcgtc atgttcttcg cgccctggtg
      301 tggacactgc cagcggctgc agccaacttg gaatgacctg ggagacaagt acaacagcat
      361 ggaggatgcc aaggtctacg tggccaaagt ggactgcacg gctgattccg acgtgtgctc
      421 tgcccaggga gtgcgaggat accccaccct gaagtttttt aagcctggac aagaagcagt
      481 gaagtaccag ggtcctagag actttgaaac actggaaaac tggatgctgc agacactgaa
      541 cgaggagcca gccacaccgg agccggaagc ggaaccaccc agagcccctg agctcaaaca
      601 ggggttgtat gagctctcgg ccaacaactt tgagctgcat gtttctcaag gcaaccactt
      661 tatcaagttc ttcgctccgt ggtgcggtca ctgcaaagct ctggctccaa cctgggagca
      721 gctggctctg ggccttgaac attctgaaac cgtcaagatt ggcaaggttg actgcacgca
      781 gcactacgct gtctgctcag agcatcaggt cagaggctat ccaactctgc tctggtttcg
      841 agatggcaag aaggtggatc agtacaaggg aaagcgggac ttggagtcac tgagagacta
      901 tgtgcagtcc cagctgcagg gttcagaggc agctccggag actgttgagc cgtcagaggc
      961 cccagtgatg gctgctgagc ccacgggtga caagggcact gtgctggcac tcaccgagaa
     1021 gagcttcgag gacactattg cacaggggat aaccttcgtc aagttctatg ctccgtggtg
     1081 tggccactgt aagaatctgg ctcctacctg ggaggagctc tctaaaaagg aattcccagg
     1141 cttgtcagat gtcaccatcg cagaagtgga ctgcaccgct gagcgcaatg tctgcagcaa
     1201 gtactcggta cgaggttatc ccacgttgct gcttttccga ggaggtgaaa aagtgggaga
     1261 acacaacgga ggtagagacc tcgactcctt acacagcttt gttctgcgcc aggcaaagga
     1321 tgaactatag gagaccccgg ggaagtcatc cagcctgggc ttaggcgtga cctcacacag
     1381 acacacgtgt tttcactgtg gttagtcaga aagctgaatg tattgagctt gtgttgcttc
     1441 ctgtgtgctc tctgagccac cacacactac ggaccttaag tttctctaat catggctcac
     1501 agtccctggg caaaccaaac gttttcagtg gcgatccatc ctgtaaccct tctcttgaca
     1561 gaattaaatt ggctcccttt gcaacttaaa atacagtcaa ggaaagccaa attgctgaac
     1621 tctgctggct cccagggatg taaggacatc atctcgcagg agcaatttgt tgcattgcct
     1681 gagttttggg aaggaggcct gcggcactgt tgacttagta aggtgtcggt ccatagtgta
     1741 cagatttcaa aacaaaagcc cacagagccc tggagatccc ttcatagcca ctgctgggtt
     1801 cctgggtctc attacttctc tagtggagag aggtaagcca taacaaatgg tacttctgat
     1861 gtgtgcccca aatactcatg ctgttcaaag gatcctcttg tctgcttcgc atagggtgga
     1921 gtgtggagat gtacgtcttc tgcagaaagg gagggtatgg gatgcaccac aaggtgggtc
     1981 ctcacccgat aggctttccc aggtccaagg accagggagt ctctgcagct cctctcgggc
     2041 cttcctagaa acagcttctg attctcttcc taagtagttc ttttagcagc tcgctttata
     2101 atctccacct taaaggaggc tgaccatctc tctaatgatt gagcagtggg attcatctga
     2161 cctccagacc aaagactgca gtcggcaggg ctgcccttgc ctaggaagcc caaggttgga
     2221 tatcgcatgg ctacttccgg ttcccgcctt ccaggttatt agacgccgct gctcgtaact
     2281 ctgtgaagat gcagcccacg tcatgcctct gtctgtcttg ttctcagaac cactgtgttt
     2341 gtgcccaggc ccttcaccta cctcccacga gcggggtgaa atcagcacct ggcacaagac
     2401 gtgtagcaag gagacttgaa accagaccac gtctgcttcc aaaacatcag gagcagaggc
     2461 gccccgccag cctgttatga acgtttatta ttaatcacgt gtgggtcaca gctgtccttg
     2521 gaaaccagtt ctgttggccc agctcacagt ggcttcagct tagcatcatg gtcttatatg
     2581 aaaagaaaac tcaagtggta caatttggtt tatactttct aaataaactt ttttttttta
     2641 aagaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
