LOCUS       NM_026559               1446 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus thioredoxin domain containing 17 (Txndc17), mRNA.
ACCESSION   NM_026559
VERSION     NM_026559.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Marti-Andres,P., Finamor,I., Torres-Cuevas,I., Perez,S.,
            Rius-Perez,S., Colino-Lage,H., Guerrero-Gomez,D., Morato,E.,
            Marina,A., Michalska,P., Leon,R., Cheng,Q., Juranyi,E.P.,
            Borbenyi-Galambos,K., Millan,I., Nagy,P., Miranda-Vizuete,A.,
            Schmidt,E.E., Martinez-Ruiz,A., Arner,E.S. and Sastre,J.
  TITLE     TRP14 is the rate-limiting enzyme for intracellular cystine
            reduction and regulates proteome cysteinylation
  JOURNAL   EMBO J 43 (13), 2789-2812 (2024)
   PUBMED   38811853
  REMARK    GeneRIF: TRP14 is the rate-limiting enzyme for intracellular
            cystine reduction and regulates proteome cysteinylation.
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Doka,E., Ida,T., Dagnell,M., Abiko,Y., Luong,N.C., Balog,N.,
            Takata,T., Espinosa,B., Nishimura,A., Cheng,Q., Funato,Y., Miki,H.,
            Fukuto,J.M., Prigge,J.R., Schmidt,E.E., Arner,E.S.J., Kumagai,Y.,
            Akaike,T. and Nagy,P.
  TITLE     Control of protein function through oxidation and reduction of
            persulfidated states
  JOURNAL   Sci Adv 6 (1), eaax8358 (2020)
   PUBMED   31911946
  REMARK    GeneRIF: Control of protein function through oxidation and
            reduction of persulfidated states.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Hong,S., Huh,J.E., Lee,S.Y., Shim,J.K., Rhee,S.G. and Jeong,W.
  TITLE     TRP14 inhibits osteoclast differentiation via its catalytic
            activity
  JOURNAL   Mol Cell Biol 34 (18), 3515-3524 (2014)
   PUBMED   25002534
  REMARK    GeneRIF: Results suggest that TRP14 regulates osteoclasts
            differentiation and bone resorption through its catalytic activity
            and that enhancing TRP14 may present a new strategy for preventing
            bone resorption diseases.
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Ago,T. and Sadoshima,J.
  TITLE     Thioredoxin and ventricular remodeling
  JOURNAL   J Mol Cell Cardiol 41 (5), 762-773 (2006)
   PUBMED   17007870
  REMARK    GeneRIF: In this review, we will summarize the cardiac effects of
            thioredoxin and the mechanisms by which thioredoxin mediates
            inhibition of ventricular remodeling.
            Review article
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Jeong,W., Yoon,H.W., Lee,S.R. and Rhee,S.G.
  TITLE     Identification and characterization of TRP14, a thioredoxin-related
            protein of 14 kDa. New insights into the specificity of thioredoxin
            function
  JOURNAL   J Biol Chem 279 (5), 3142-3150 (2004)
   PUBMED   14607844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076425.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026559.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076425.1, AK007595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1446              AK076425.1         1-1446
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.92 cM"
     gene            1..1446
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /note="thioredoxin domain containing 17"
                     /db_xref="GeneID:52700"
                     /db_xref="MGI:MGI:1289248"
     exon            1..215
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..442
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /note="thioredoxin-like 5; putative 42-9-9 protein;
                     protein 42-9-9; thioredoxin-like protein 5; 14 kDa
                     thioredoxin-related protein"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 17"
                     /protein_id="NP_080835.1"
                     /db_xref="CCDS:CCDS24980.1"
                     /db_xref="GeneID:52700"
                     /db_xref="MGI:MGI:1289248"
                     /translation="MATFEEVSVLGFEEFDKAVKEHEGKTIFAYFSGSKDTEGKSWCP
                     DCVEAEPVIREGLKHVTEDCVFIYCQVGDKPYWKDPNNDFRQKLKITAVPTLLKYGTP
                     QKLVESECCQSSLVEMIFSED"
     exon            216..297
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /inference="alignment:Splign:2.1.0"
     exon            298..373
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /inference="alignment:Splign:2.1.0"
     exon            374..1446
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      726..731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /note="hexamer: AATAAA"
     regulatory      739..744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /note="hexamer: AATACA"
     polyA_site      749
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /note="major polyA site"
     polyA_site      779
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
                     /note="hexamer: ATTAAA"
     polyA_site      960
                     /gene="Txndc17"
                     /gene_synonym="4831443O22Rik; D11Ertd672e; TRP14; Txnl5"
ORIGIN      
        1 acttgggccc cgccttgggg gcgcaggacc ctagggctcc tcccgtgctc ctctccgcac
       61 tgttgtaccc atggccacct tcgaggaggt gagcgtgctg ggcttcgagg agttcgacaa
      121 ggcagtgaag gagcatgagg gcaagaccat tttcgcctac ttcagcggtt ctaaggatac
      181 cgaagggaag agctggtgtc cggactgcgt ggaagctgag ccagtcattc gagaggggct
      241 gaagcatgtt accgaagact gtgtgttcat ctactgccaa gtaggagaca aaccttactg
      301 gaaagaccca aataatgact tcagacaaaa actgaaaata accgcagtgc ctacactact
      361 taaatatgga acacctcaaa aacttgtgga gtctgagtgc tgtcaatcca gccttgtgga
      421 gatgatcttc tctgaagatt aagatttgat gaccttgccg gactgtggtg gcacatgcct
      481 ttagtcccag cactcgggag acagaggcag ctggatctct ttgagtttga ggctacctgg
      541 tctacaagtt gagttcaagg acagccagag ctacagagta aaaccctgtc tggaaaaacc
      601 aaaccaaccc aaaaaagcct gatgattgca attttgtatt gattgcctgg tttgtttaaa
      661 agcagccaca ttattgcttt gaattgatga gtaaatgatg ttattaaatc agtgtatatc
      721 taaacaataa agaattgaaa tacaaaccat taagtttttt aacacgtggc tatctaaaag
      781 atttgagtaa aatgagtctt cagtatggtg gtagtagctc aaaggaaata ttgaagatag
      841 aaagtaactt actaacttcc aaatctgcag caattagtat ctattacctt aagttctgtg
      901 tatttgcaaa accctttctg cctttgaaat ggagaacttc attaaaccat ttaggaaaga
      961 catgggattc atatgcttaa ctcaggcagt tttctttcac aaatgtctaa aatgtgattc
     1021 ttttgttgtg aaacaggctg gttctcctag ccacaggcca agtactatct aaatcttcat
     1081 ttcttcaagt aacaattgtg tcaggcatag tgacacacac ctgtaatatt attttagatg
     1141 ctaaggctag aggataacaa atttaaggca agggtagact acagaaccag accttgtcac
     1201 aaatttaaag cccaactatt attctgcaag taaagcaaga atgtgggctg aagaggtggt
     1261 tcagtgccta agagcactgg ctgttcttcc agaggacatg gtttcagttc ccagcaccca
     1321 catggcagct catgagatgt ccataactac agttccaggg aatgggacac tctcttctgg
     1381 cctctgagag aaccaggaat gcagtgagac atagataaca catgtacgca aaagattaat
     1441 atccat
//
