LOCUS       NM_025334               1275 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus thioredoxin domain containing 12 (endoplasmic
            reticulum) (Txndc12), mRNA.
ACCESSION   NM_025334
VERSION     NM_025334.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Jeong,W., Lee,D.Y., Park,S. and Rhee,S.G.
  TITLE     ERp16, an endoplasmic reticulum-resident thiol-disulfide
            oxidoreductase: biochemical properties and role in apoptosis
            induced by endoplasmic reticulum stress
  JOURNAL   J Biol Chem 283 (37), 25557-25566 (2008)
   PUBMED   18628206
  REMARK    GeneRIF: ERp16 mediates disulfide bond formation in the ER and
            plays an important role in cellular defense against prolonged ER
            stress
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Rossi,S., Sevignani,C., Nnadi,S.C., Siracusa,L.D. and Calin,G.A.
  TITLE     Cancer-associated genomic regions (CAGRs) and noncoding RNAs:
            bioinformatics and therapeutic implications
  JOURNAL   Mamm Genome 19 (7-8), 526-540 (2008)
   PUBMED   18636290
  REMARK    Review article
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Knoblach,B., Keller,B.O., Groenendyk,J., Aldred,S., Zheng,J.,
            Lemire,B.D., Li,L. and Michalak,M.
  TITLE     ERp19 and ERp46, new members of the thioredoxin family of
            endoplasmic reticulum proteins
  JOURNAL   Mol Cell Proteomics 2 (10), 1104-1119 (2003)
   PUBMED   12930873
  REMARK    GeneRIF: both ERp19 and ERp46 and their respective mRNAs are highly
            expressed in the liver as compared with other tissues
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Alanen,H.I., Williamson,R.A., Howard,M.J., Lappi,A.K., Jantti,H.P.,
            Rautio,S.M., Kellokumpu,S. and Ruddock,L.W.
  TITLE     Functional characterization of ERp18, a new endoplasmic
            reticulum-located thioredoxin superfamily member
  JOURNAL   J Biol Chem 278 (31), 28912-28920 (2003)
   PUBMED   12761212
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL607070.19.
            
            On Nov 17, 2006 this sequence version replaced NM_025334.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006857.1, AK003481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AL607070.19        91720-91898
            180-240             AL607070.19        102993-103053
            241-293             AL607070.19        110211-110263
            294-367             AL607070.19        113190-113263
            368-437             AL607070.19        114967-115036
            438-521             AL607070.19        116317-116400
            522-1275            AL607070.19        118409-119162
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.64 cM"
     gene            1..1275
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /note="thioredoxin domain containing 12 (endoplasmic
                     reticulum)"
                     /db_xref="GeneID:66073"
                     /db_xref="MGI:MGI:1913323"
     exon            1..179
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..601
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /EC_number="1.8.4.2"
                     /note="thioredoxin domain-containing protein 12;
                     endoplasmic reticulum protein ERp19; ortholog of
                     endoplasmic reticulum thioredoxin superfamily member, 18
                     kDa TLP19; thioredoxin-like protein p19; ER protein 19;
                     endoplasmic reticulum resident protein 19"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 12
                     precursor"
                     /protein_id="NP_079610.1"
                     /db_xref="CCDS:CCDS18457.1"
                     /db_xref="GeneID:66073"
                     /db_xref="MGI:MGI:1913323"
                     /translation="MSLRFGATCLLSFSFLLLITSSDGRTGLGKGFGDHIHWRTLEDG
                     KKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPRDED
                     FSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYVSAEQVVQGMKEAQERLTGDA
                     FREKHFQDEL"
     exon            180..240
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     exon            241..293
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     exon            294..367
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     exon            368..437
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     exon            438..521
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     exon            522..1275
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /note="hexamer: ATTAAA"
     polyA_site      1275
                     /gene="Txndc12"
                     /gene_synonym="0610040B21Rik; ERp16; ERp19"
                     /note="major polyA site"
ORIGIN      
        1 ctgaacggcg ataagggggc agagcggagc ttctgctgga aatcctgttc cctcaatccg
       61 gtggctctgt gcaactacca ccgtggagat gtcgcttcgt ttcggggcca cctgtttgct
      121 gagcttcagt ttcctgctcc tcatcacttc ttcagacgga cgcactgggc ttggaaaggg
      181 ttttggagat cacattcact ggaggactct ggaagatggc aagaaggaag cagctgcaag
      241 tggcttgccg ctgatggtga tcatccataa atcttggtgt ggagcctgca aagctttaaa
      301 acccaaattt gcagaatcta cagaaatttc agaactgtcc cataattttg ttatggtaaa
      361 tctggaggat gaagaggagc ccagggatga agacttcagc cctgatgggg gttatatccc
      421 acgcatcctt ttcttggatc ccagtggcaa ggtgcgtcct gaaatcatca atgagagtgg
      481 aaaccccagc tacaagtatt tctacgtcag tgctgagcaa gttgttcaag ggatgaagga
      541 agctcaggag aggctgacgg gcgacgcctt cagagagaaa cactttcagg atgagttgtg
      601 acatgaatga gtgttctgga agaaaagcag cagagagcga atcctaaaga atcacccaga
      661 accgctaagc caccagaaac catgcttcta cctacactgg caggagctct cactgtggag
      721 aggccactga cagaagctgc tctgtggagc cagcagcggg gccgactgac tctcatctgc
      781 tccctttcct aagtatccat tcctttgaat gtaaagaatg aaactctttg atactaactt
      841 tgagccactt ggggattaac tccatgtcag tatttgagtc tttacccatt ttctcctact
      901 gtactcaagc tgaagtgaaa caaaccagaa cgatcttttc tatagtgtac aaattgcagg
      961 agttaccaat tttgaaaggt ggcattctcc ttttgtcttg gtaaccctcc tggacttctc
     1021 ccggaacccc tgcgcccgcc caccctttgc tcaggcatcc ccgtttgcac gaatgcgtgt
     1081 caagaatggc tgtgcactga gacagcccca actggaagca tgctttccct gttgctgtta
     1141 gagaaactct caagtctgca aaccctacat gaagccattt tgtcaattca ccaactgtat
     1201 ttttgtactg gggttaaaac aaacacaaga gataaaatat gtttcattaa gctttattaa
     1261 aacttgaaat ggaaa
//
