LOCUS       NM_029582               2977 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus thioredoxin domain containing 11 (Txndc11), transcript
            variant 1, mRNA.
ACCESSION   NM_029582
VERSION     NM_029582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Moritani,M., Togawa,K., Yaguchi,H., Fujita,Y., Yamaguchi,Y.,
            Inoue,H., Kamatani,N. and Itakura,M.
  TITLE     Identification of diabetes susceptibility loci in db mice by
            combined quantitative trait loci analysis and haplotype mapping
  JOURNAL   Genomics 88 (6), 719-730 (2006)
   PUBMED   16919419
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC087541.23
            and AC164093.2.
            
            On Nov 17, 2006 this sequence version replaced NM_029582.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029643.1, AK156154.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC087541.23        174409-174673
            266-482             AC164093.2         228320-228536       c
            483-580             AC164093.2         222503-222600       c
            581-710             AC164093.2         216628-216757       c
            711-804             AC164093.2         204399-204492       c
            805-917             AC164093.2         193649-193761       c
            918-1118            AC164093.2         191419-191619       c
            1119-1911           AC164093.2         187610-188402       c
            1912-2054           AC164093.2         184584-184726       c
            2055-2164           AC164093.2         184041-184150       c
            2165-2245           AC164093.2         179537-179617       c
            2246-2977           AC164093.2         174744-175475       c
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 6.33 cM"
     gene            1..2977
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /note="thioredoxin domain containing 11"
                     /db_xref="GeneID:106200"
                     /db_xref="MGI:MGI:1923620"
     exon            1..265
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2870
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thioredoxin domain-containing protein 11; EF-hand binding
                     protein 1"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 11 isoform
                     1"
                     /protein_id="NP_083858.1"
                     /db_xref="CCDS:CCDS27960.1"
                     /db_xref="GeneID:106200"
                     /db_xref="MGI:MGI:1923620"
                     /translation="MSECGGRGGGGGNNSEDAEDEGGGPKGSGSLSPAGAAASLEGRI
                     RRGLRGASLMARQRPELLCGAVALGCALLFALKFTCSRAKDVIIPAKPPVSFFSSRSP
                     VLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAIN
                     CWWNQGKCRKQKHFFYFPVIHLYHRSFGPIEYKGPMSAVYIEKFVRRAMKPLLYIPSQ
                     SALLDFLSSYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVITDKHL
                     ARLVSLVHSGSVYLHRHFNTSLVFPREVMNFTAENIYKWASENQETLFRWLQPHGGKS
                     LLLNNELKKGPALFLFIPFDPLAERHPLLDEITEVALEYNNCHGDQVVERLLQHLRRV
                     EAPVLQSLAPELPASLPDTQLMAASPCCNTVVLPQGPALSRTHNVCELCVNQTVGGTR
                     PSSVSVPQCSFFEMAAALDSFYLKEQTFYHVVSGSIECSNFLTSYSPFSYYTACCRTI
                     SRGMASFTGSEQNVLTAPAIEFSSLEKSCEATAPSSIPHIEENRYRFPQVGLTSTAFT
                     GLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSAPVKEFATIVDVKEESHYILDPKQAL
                     MKFTLESFIQNFSVLYSPLKRHLTGSDSAQFPTQHLITEVTTDTFWEVTLRKQDVLLL
                     YYTQWCGFCPSLNHIFIQLARLLPEDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPCN
                     RKDLSVKYPGDLPITLPNLLRFILHHSDAASAPQDPGISPPTQDCVQSKAVLQREHIS
                     HVENAMQKLRSEMSSLRRTQEQVEGRLLSARRDGHRLLRRQRTLEQQHRLLRRHSQKL
                     QALYLKKARELQELARASGTPLPEHTWLKILVATMERELEGQGGAKEPAPLGKARPNH
                     SKSMGTTQLPGDTPPPSTTSSTLASETKHENRTD"
     exon            266..482
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            483..580
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            581..710
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            711..804
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            805..917
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1118
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1911
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2054
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2164
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2245
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2977
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /note="hexamer: AATAAA"
     polyA_site      2977
                     /gene="Txndc11"
                     /gene_synonym="2810408E11Rik; EFP1; Txdc11"
                     /note="major polyA site"
ORIGIN      
        1 aagccggcca cggggagcat gtaatgtcgg aatgcggagg ccgcggcggc ggcggcggga
       61 acaacagcga ggacgccgag gacgagggtg gcggccccaa gggctcaggc tccctcagcc
      121 ctgccggggc ggcggcgtcc ttggagggcc ggatccgccg cggcttgcgc ggcgcctcgc
      181 ttatggcgcg ccagcggcca gagctgctgt gcggggccgt ggctctcggc tgcgccctgc
      241 tcttcgccct caagttcact tgcagtcgag caaaagacgt gataatacca gcaaagccgc
      301 ctgtcagctt tttctcctcg agatctccgg tccttgacct cttccagggg cagctggact
      361 atgctgacca tgtccgccag gattctgagg tggtggtgct gttcttctat gccccgtggt
      421 gtggccagtc catcgctgcc agggcagaaa ttgagcaggc agccagccgg ctttctgatc
      481 aggtgttgtt tgtggcaata aactgttggt ggaaccaggg gaaatgcaga aaacagaagc
      541 atttcttcta ttttcctgtg atacatctgt atcatcggag ttttggacca atcgaataca
      601 aaggccccat gagtgctgtt tacattgaga agtttgtccg ccgggcgatg aagccgcttc
      661 tctacatccc gtctcaatca gcattgctag actttctctc cagctatgag cctggagtac
      721 tcggatactt tgaattcagc ggttcacccc agcctcctgg ttacttgacc ttcttcacct
      781 cagcactgca ttcgttaaag aaagattacc taggaacagt gcgatttggg gttatcacag
      841 ataaacacct tgcgagactg gtatccttag tgcactctgg aagtgtgtat ttacatagac
      901 atttcaacac atcacttgtc ttccccaggg aagtcatgaa cttcacagct gagaacatct
      961 ataagtgggc ctcagaaaac caggagaccc tcttccgatg gctacagcct catggaggca
     1021 agagtctgct gttgaacaat gagctgaaga aaggaccagc actcttcctg ttcataccgt
     1081 ttgatcccct agccgagaga catcctcttc tagatgagat caccgaagtg gccttggaat
     1141 acaataactg tcatggggac caggtggtag agcgcctcct tcagcacctg cggcgggtag
     1201 aggcacctgt gctccagtcc ctggcaccag agctgccagc ttcactgcct gatactcagc
     1261 tgatggcagc atccccctgc tgtaacacgg tggtgctgcc acaggggcca gccctctcca
     1321 ggactcacaa tgtctgtgag ctgtgtgtca accagacagt gggtggtacc aggcctagct
     1381 cagtgagtgt gccacagtgc agcttcttcg agatggcagc cgctctggat tctttctacc
     1441 tcaaggagca gactttttat catgtggtgt cgggcagcat agaatgcagc aattttttaa
     1501 cctcctatag ccctttcagc tactacactg catgttgcag gaccatatcc cggggcatgg
     1561 caagctttac tggctctgaa cagaatgtct tgacagcccc agccatcgag ttctcttcct
     1621 tagagaagag ctgtgaggcc actgccccga gctccattcc tcacattgag gagaacaggt
     1681 accgctttcc tcaagtgggc ctcactagca cagccttcac gggcctgagc tgcagaacca
     1741 acaagaccct gaacatctac cttttggatt ccaatttatt ttggttatat gcagaaagac
     1801 tgggtgcccc gagctctgct cctgtgaagg agtttgccac aattgttgat gtgaaagaag
     1861 aatctcacta tatcctggat cccaaacaag ccctcatgaa gttcactcta gagtctttta
     1921 ttcaaaactt cagtgttctc tacagcccct tgaaaaggca tctcactgga agtgattctg
     1981 ctcagtttcc cactcagcat ttgatcacgg aagtgacgac tgataccttc tgggaagtaa
     2041 cccttcggaa acaggacgtt ctgctgctct attatacaca gtggtgtggc ttttgcccgt
     2101 ctctcaatca catcttcatc cagctagctc ggctcctgcc agaggacaca tttactgtgg
     2161 ccaggatcga cgtgtctcag aatgatcttc cttgggaatt catggttgac cgtcttccta
     2221 ccgttttgtt ttttccctgc aatagaaagg acctaagtgt gaaataccct ggagacctcc
     2281 ctatcaccct cccgaatctg ctgcggttca ttctgcatca ctcagacgct gcctctgccc
     2341 cccaggaccc tggcatcagc cctcctaccc aagactgtgt ccagagcaag gcagtgctgc
     2401 agcgcgaaca catctctcac gtggagaatg cgatgcagaa gctgagatct gagatgagca
     2461 gcctacgccg tacacaggag caggtggagg gcaggctcct tagtgcccgc agggatgggc
     2521 accgcctgct gcgccggcag cggaccctgg agcagcagca caggctactc cggcgccaca
     2581 gccagaaact gcaggctctg tatttaaaga aggcgcgaga gctccaagag ctggctagag
     2641 cctcaggaac ccccctcccc gagcacacat ggctcaagat ccttgtggcc actatggaga
     2701 gggagctgga aggccaaggt ggggctaagg aaccagcccc tctgggaaag gctcgaccga
     2761 accactccaa gtccatgggt acaactcagt tacctggtga cacccctccg ccctccacca
     2821 ccagctccac tttggcttca gagacgaagc atgagaatag gacagactaa cttttgaagg
     2881 agccagaggt gaagactgta cattgggaat atagttatgc aaattttatt gaaatttatt
     2941 gtaaataaag atctttctca gtggtctaca aaatgaa
//
