LOCUS       NM_019913               1282 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus thioredoxin 2 (Txn2), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_019913
VERSION     NM_019913.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1282)
  AUTHORS   Schraps,N., Tirre,M., Pyschny,S., Reis,A., Schlierbach,H.,
            Seidl,M., Kehl,H.G., Schanzer,A., Heger,J., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Cardiomyocyte maturation alters molecular stress response
            capacities and determines cell survival upon mitochondrial
            dysfunction
  JOURNAL   Free Radic Biol Med 213, 248-265 (2024)
   PUBMED   38266827
REFERENCE   2  (bases 1 to 1282)
  AUTHORS   Wei,Z.X., Cai,X.X., Fei,Y.D., Wang,Q., Hu,X.L., Li,C., Hou,J.W.,
            Yang,Y.L., Chen,T.Z., Xu,X.L., Wang,Y.P. and Li,Y.G.
  TITLE     Zbtb16 increases susceptibility of atrial fibrillation in type 2
            diabetic mice via Txnip-Trx2 signaling
  JOURNAL   Cell Mol Life Sci 81 (1), 88 (2024)
   PUBMED   38349408
  REMARK    GeneRIF: Zbtb16 increases susceptibility of atrial fibrillation in
            type 2 diabetic mice via Txnip-Trx2 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1282)
  AUTHORS   Kim,H.J., Cha,S., Choi,J.S., Lee,J.Y., Kim,K.E., Kim,J.K., Kim,J.,
            Moon,S.Y., Lee,S.H.S., Park,K. and Won,S.Y.
  TITLE     scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase
            Prevents Retinal Ganglion Cell Death and Lowers Intraocular
            Pressure in a Mouse Model of Glaucoma
  JOURNAL   Int J Mol Sci 24 (22), 16253 (2023)
   PUBMED   38003443
  REMARK    GeneRIF: scAAV2-Mediated Expression of Thioredoxin 2 and C3
            Transferase Prevents Retinal Ganglion Cell Death and Lowers
            Intraocular Pressure in a Mouse Model of Glaucoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1282)
  AUTHORS   Zhang,H., Li,B., Huang,Q., Lopez-Giraldez,F., Tanaka,Y., Lin,Q.,
            Mehta,S., Wang,G., Graham,M., Liu,X., Park,I.H., Eichmann,A.,
            Min,W. and Zhou,J.H.
  TITLE     Mitochondrial dysfunction induces ALK5-SMAD2-mediated
            hypovascularization and arteriovenous malformations in mouse
            retinas
  JOURNAL   Nat Commun 13 (1), 7637 (2022)
   PUBMED   36496409
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1282)
  AUTHORS   Huang,Y., Zhou,J.H., Zhang,H., Canfran-Duque,A., Singh,A.K.,
            Perry,R.J., Shulman,G.I., Fernandez-Hernando,C. and Min,W.
  TITLE     Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair
            thermogenesis and protect against diet-induced insulin resistance
  JOURNAL   J Clin Invest 132 (9) (2022)
   PUBMED   35202005
  REMARK    GeneRIF: Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to
            impair thermogenesis and protect against diet-induced insulin
            resistance.
REFERENCE   6  (bases 1 to 1282)
  AUTHORS   Testa,G., Schaft,J., van der Hoeven,F., Glaser,S.,
            Anastassiadis,K., Zhang,Y., Hermann,T., Stremmel,W. and
            Stewart,A.F.
  TITLE     A reliable lacZ expression reporter cassette for multipurpose,
            knockout-first alleles
  JOURNAL   Genesis 38 (3), 151-158 (2004)
   PUBMED   15048813
REFERENCE   7  (bases 1 to 1282)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1282)
  AUTHORS   Nonn,L., Williams,R.R., Erickson,R.P. and Powis,G.
  TITLE     The absence of mitochondrial thioredoxin 2 causes massive
            apoptosis, exencephaly, and early embryonic lethality in homozygous
            mice
  JOURNAL   Mol Cell Biol 23 (3), 916-922 (2003)
   PUBMED   12529397
  REMARK    GeneRIF: Homozygous mutant embryos do not survive to birth and die
            after implantation at Theiler stage 15/16.
REFERENCE   9  (bases 1 to 1282)
  AUTHORS   Kobayashi,M., Nakamura,H., Yodoi,J. and Shiota,K.
  TITLE     Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses:
            an immunohistochemical study
  JOURNAL   Ital J Anat Embryol 106 (2 Suppl 2), 137-142 (2001)
   PUBMED   11732570
REFERENCE   10 (bases 1 to 1282)
  AUTHORS   Kobayashi,M., Nakamura,H., Yodoi,J. and Shiota,K.
  TITLE     Immunohistochemical localization of thioredoxin and glutaredoxin in
            mouse embryos and fetuses
  JOURNAL   Antioxid Redox Signal 2 (4), 653-663 (2000)
   PUBMED   11213470
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL583886.11.
            
            On Apr 29, 2007 this sequence version replaced NM_019913.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010917.1, BC068182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AL583886.11        12986-13073
            89-351              AL583886.11        14026-14288
            352-475             AL583886.11        17314-17437
            476-1282            AL583886.11        26123-26929
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.92 cM"
     gene            1..1282
                     /gene="Txn2"
                     /gene_synonym="2510006J11Rik; Trx2"
                     /note="thioredoxin 2"
                     /db_xref="GeneID:56551"
                     /db_xref="MGI:MGI:1929468"
     exon            1..88
                     /gene="Txn2"
                     /gene_synonym="2510006J11Rik; Trx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..589
                     /gene="Txn2"
                     /gene_synonym="2510006J11Rik; Trx2"
                     /note="thioredoxin, mitochondrial; thioredoxin nuclear
                     gene encoding mitochondrial protein; MTRX; mt-Trx"
                     /codon_start=1
                     /product="thioredoxin, mitochondrial precursor"
                     /protein_id="NP_064297.1"
                     /db_xref="CCDS:CCDS27606.1"
                     /db_xref="GeneID:56551"
                     /db_xref="MGI:MGI:1929468"
                     /translation="MAQRLLLGRFLTSVISRKPPQGVWASLTSKTLQTPQYNAGGLTV
                     MPSPARTVHTTRVCLTTFNVQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEK
                     MVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAIKNGDVVDKFVGIKDEDQLEAF
                     LKKLIG"
     exon            89..351
                     /gene="Txn2"
                     /gene_synonym="2510006J11Rik; Trx2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..475
                     /gene="Txn2"
                     /gene_synonym="2510006J11Rik; Trx2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1282
                     /gene="Txn2"
                     /gene_synonym="2510006J11Rik; Trx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctgccc ctgaggaagt gacaacagga gtgcccttga cgggcaggcc ggctgggctc
       61 tgcatccctc tgctcgcact gccgggagat ggctcagcgg ctcctcctgg ggaggttcct
      121 gacctcagtc atctccagga agcctcctca gggtgtgtgg gcttccctca cctctaagac
      181 cctgcagacc cctcagtaca atgctggtgg tctaacagta atgcccagcc cagcccggac
      241 agtacacacc accagagtct gtttgacgac ctttaacgtc caggatggac ctgactttca
      301 agacagagtt gtcaacagtg agacaccagt tgttgtggac tttcatgcac agtggtgtgg
      361 cccctgcaag atcctaggac cgcggctaga gaagatggtc gccaagcagc acgggaaggt
      421 ggtcatggcc aaagtggaca ttgacgatca cacagacctt gccattgaat atgaggtgtc
      481 agctgtgcct accgtgctag ccatcaagaa cggggacgtg gtggacaagt ttgtggggat
      541 caaggacgag gaccagctag aagccttcct gaagaagctg attggctgac gagcagagag
      601 gaggcctgac tacccttgcc tgctggaagt ctgttttggg gagaagccta gtagaactcc
      661 cagccctcag ctgtcatcct tcctgccctg cccctctgtt ttatcctggt gggtcttgcc
      721 tgtgacagca gaccctccaa acctaagagc caccagcact tcagagccag ccctcagccc
      781 gggtggcctg gagagggcca gtgctgccac tggtgtgggg gtcattcttg tgcaccccct
      841 actgtgtgct cctcttgtgc acctactgtg tgcttcttcc ggggcttgtt gccattcccc
      901 tagatgctgg agaaagcctg ggccagcctg tagcctgacc gcactagtgg tcgcccagtc
      961 cccatctctg tggccctctg aagccccagc ccccatgcat cagcctctgg cacatttcct
     1021 ctcctgcctc tgcttgaaaa ggaaaccaga agccgaacaa gtgagagtaa tgtataattc
     1081 tctcattttt ttgtaggtct ctaataaaga actttatgtg gtccttctac ctcttgctgt
     1141 gaagaacaga gcccacccca tagcctaaat ctgtcccttc tattccttgt cccctccctg
     1201 agttagctgg gccttggttc tgggtccctg agcaggagga ggagctgtga acaagtcaga
     1261 ccaataaaac caggtttgca ct
//
