LOCUS       NM_011660               1051 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus thioredoxin 1 (Txn1), mRNA.
ACCESSION   NM_011660
VERSION     NM_011660.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Jia,J., Liu,H., Sun,L., Xu,Y. and Zeng,X.
  TITLE     Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated
            Neuronal Pyroptosis in Models of Alzheimer's Disease
  JOURNAL   Mol Neurobiol 61 (11), 9723-9734 (2024)
   PUBMED   38976128
  REMARK    GeneRIF: Thioredoxin-1 Protects Neurons Through Inhibiting
            NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's
            Disease.
            Erratum:[Mol Neurobiol. 2024 Sep 28. doi:
            10.1007/s12035-024-04523-8.. PMID: 39333348]
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   Bai,D., Zhou,C., Du,J., Zhao,J., Gu,C., Wang,Y., Zhang,L., Lu,N.
            and Zhao,Y.
  TITLE     TrxR1 is involved in the activation of Caspase-11 by regulating the
            oxidative-reductive status of Trx-1
  JOURNAL   Redox Biol 75, 103277 (2024)
   PUBMED   39059206
  REMARK    GeneRIF: TrxR1 is involved in the activation of Caspase-11 by
            regulating the oxidative-reductive status of Trx-1.
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Perez,V., Zaobornyj,T., Vico,T., Vanasco,V., Marchini,T., Godoy,E.,
            Alvarez,S., Evelson,P., Donato,M., Gelpi,R.J. and D'Annunzio,V.
  TITLE     Middle-age abolishes cardioprotection conferred by thioredoxin-1 in
            mice
  JOURNAL   Arch Biochem Biophys 753, 109880 (2024)
   PUBMED   38171410
  REMARK    GeneRIF: Middle-age abolishes cardioprotection conferred by
            thioredoxin-1 in mice.
REFERENCE   4  (bases 1 to 1051)
  AUTHORS   Huang,J., Zhu,Y., Liu,Y., Zhang,R., Zhang,Z., Liu,J., Zhang,Z.,
            Liang,Y. and Ma,B.
  TITLE     The cold-inducible RNA-binding protein-Thioredoxin 1 pathway
            ameliorates mitochondrial dysfunction and mitochondrial
            dynamin-related protein 1 level in the hippocampus of aged mice
            with perioperative neurocognitive dysfunction
  JOURNAL   CNS Neurosci Ther 30 (3), e14433 (2024)
   PUBMED   37641878
  REMARK    GeneRIF: The cold-inducible RNA-binding protein-Thioredoxin 1
            pathway ameliorates mitochondrial dysfunction and mitochondrial
            dynamin-related protein 1 level in the hippocampus of aged mice
            with perioperative neurocognitive dysfunction.
REFERENCE   5  (bases 1 to 1051)
  AUTHORS   Wu,A., Fang,D., Liu,Y., Shi,X., Zhong,Z., Zhou,B., Ye,L., Sun,X.
            and Jiang,L.
  TITLE     Nuclear translocation of thioredoxin-1 promotes colorectal cancer
            development via modulation of the IL-6/STAT3 signaling axis through
            interaction with STAT3
  JOURNAL   Theranostics 13 (14), 4730-4744 (2023)
   PUBMED   37771783
  REMARK    GeneRIF: Nuclear translocation of thioredoxin-1 promotes colorectal
            cancer development via modulation of the IL-6/STAT3 signaling axis
            through interaction with STAT3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1051)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
REFERENCE   7  (bases 1 to 1051)
  AUTHORS   Matsui,M., Taniguchi,Y., Hirota,K., Taketo,M. and Yodoi,J.
  TITLE     Structure of the mouse thioredoxin-encoding gene and its processed
            pseudogene
  JOURNAL   Gene 152 (2), 165-171 (1995)
   PUBMED   7835695
REFERENCE   8  (bases 1 to 1051)
  AUTHORS   Tagaya,Y., Maeda,Y., Mitsui,A., Kondo,N., Matsui,H., Hamuro,J.,
            Brown,N., Arai,K., Yokota,T., Wakasugi,H. et al.
  TITLE     ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous
            to thioredoxin; possible involvement of dithiol-reduction in the
            IL-2 receptor induction
  JOURNAL   EMBO J 13 (9), 2244 (1994)
   PUBMED   8187776
  REMARK    Correction to:[EMBO J. 1989 Mar;8(3):757-64. doi:
            10.1002/j.1460-2075.1989.tb03436.x.. PMID: 2785919]
REFERENCE   9  (bases 1 to 1051)
  AUTHORS   Taketo,M., Matsui,M., Rochelle,J.M., Yodoi,J. and Seldin,M.F.
  TITLE     Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene
            maps on chromosome 1
  JOURNAL   Genomics 21 (1), 251-253 (1994)
   PUBMED   8088797
REFERENCE   10 (bases 1 to 1051)
  AUTHORS   Tagaya,Y., Maeda,Y., Mitsui,A., Kondo,N., Matsui,H., Hamuro,J.,
            Brown,N., Arai,K., Yokota,T., Wakasugi,H. et al.
  TITLE     ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous
            to thioredoxin; possible involvement of dithiol-reduction in the
            IL-2 receptor induction
  JOURNAL   EMBO J 8 (3), 757-764 (1989)
   PUBMED   2785919
  REMARK    Erratum:[EMBO J. 1994 May 1;13(9):2244. doi:
            10.1002/j.1460-2075.1994.tb06502.x.. PMID: 8187776]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929406.10 and AK007537.1.
            
            On Jan 20, 2007 this sequence version replaced NM_011660.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007537.1, BY707596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL929406.10        27605-27724         c
            121-833             AK007537.1         2-714
            834-1051            AL929406.10        14686-14903         c
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.87 cM"
     gene            1..1051
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /note="thioredoxin 1"
                     /db_xref="GeneID:22166"
                     /db_xref="MGI:MGI:98874"
     exon            1..225
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..519
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /note="trx; ATL-derived factor"
                     /codon_start=1
                     /product="thioredoxin"
                     /protein_id="NP_035790.1"
                     /db_xref="CCDS:CCDS18207.1"
                     /db_xref="GeneID:22166"
                     /db_xref="MGI:MGI:98874"
                     /translation="MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHS
                     LCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEASIT
                     EYA"
     exon            226..330
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            331..390
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            391..456
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1051
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      638..643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /note="hexamer: AATAAA"
     polyA_site      667
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /note="major polyA site"
     regulatory      932..937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /note="hexamer: CATAAA"
     polyA_site      965
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
ORIGIN      
        1 ccaggcgcct tggcggacgc gggaggcggg aagcgcgtcc ccgccgcgcg tgcccgtccg
       61 ccccgccctg ctgcgctccg ccctatttct ataaagagaa ggcgggcgcc gcactcggtt
      121 gcaagctccg ttgggcgcct tggatccatt tccatctggt tctgctgaga cgcgtgtggc
      181 tccctccccg caacagccaa aatggtgaag ctgatcgaga gcaaggaagc ttttcaggag
      241 gccctggccg ccgcgggaga caagcttgtc gtggtggact tctctgctac gtggtgtgga
      301 ccttgcaaaa tgatcaagcc cttcttccat tccctctgtg acaagtattc caatgtggtg
      361 ttccttgaag tggatgtgga tgactgccag gatgttgctg cagactgtga agtcaaatgc
      421 atgccgacct tccagtttta taaaaagggt caaaaggtgg gggagttctc cggtgctaac
      481 aaggaaaagc ttgaagcctc tattactgaa tatgcctaat catgctctga aaagtgtaac
      541 cagctaccag ctgtttaaaa cctgtacctt ttttaatttg caaaaaacta tgaagtgtgg
      601 agagtctata cccaactgcc atctgattat aaatgacaat aaaatattaa ttctaccctt
      661 tttaaaactg cctgatgtgt tttaatataa atgagaaatg gcctgattta gtcccctaag
      721 ccactgcttt aaggcaaaaa gataggagct ggagaggtgg ctcagtcgtt tagaacattg
      781 cctgttcttg cagagggcca aagttcagtt ctcagcatcc atacggcagc tacctgttcc
      841 tccagttcca gggaatctga tgtcctctac tggccaccat gggcaccaag catgtctgaa
      901 gtacatgtac attacatgta actaacatac acataaactt tttaaaatct ttttttaaaa
      961 cttaatattt agttgtagaa aatctcgttt attcggttac attaaaagtc ttgggggggg
     1021 ggtattttac cttaataaat aaacatggtc c
//
