LOCUS       NM_178935               3876 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus taxilin gamma (Txlng), transcript variant 1, mRNA.
ACCESSION   NM_178935
VERSION     NM_178935.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3876)
  AUTHORS   Yang,L., Huang,L.Y., Li,L.B., Tang,Z., Chen,K., Chen,L.P.,
            Luo,H.Y., Luo,J. and Zhao,X.L.
  TITLE     miR-98-TXLNG1 (FIAT)/Sp7 function loop mediates osteoblast
            mineralization
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (12), 3676-3688 (2018)
   PUBMED   29949140
  REMARK    GeneRIF: Our study showed that miR-98 was an important regulator in
            osteoblast mineralization and miR-98 carried out its function
            through a novel miR-98-FIAT/Sp7 regulatory loop
REFERENCE   2  (bases 1 to 3876)
  AUTHORS   Hekmatnejad,B., Yu,V.W., Addison,W., Mandic,V., Pellicelli,M.,
            Arabian,A. and St-Arnaud,R.
  TITLE     FIAT Deletion Increases Bone Mass But Does Not Prevent
            High-Fat-Diet-Induced Metabolic Complications
  JOURNAL   Endocrinology 158 (2), 264-276 (2017)
   PUBMED   27906582
  REMARK    GeneRIF: negative regulator of bone mass acting distinctly on bone
            formation without alteration in resorption and affecting both the
            trabecular and the cortical compartments
REFERENCE   3  (bases 1 to 3876)
  AUTHORS   Hekmatnejad,B., Akhouayri,O., Jafarov,T. and St-Arnaud,R.
  TITLE     SUMOylated alphaNAC potentiates transcriptional repression by FIAT
  JOURNAL   J Cell Biochem 115 (5), 866-873 (2014)
   PUBMED   24375853
  REMARK    GeneRIF: We propose that maximal transcriptional repression by FIAT
            requires its interaction with SUMOylated, HDAC2-interacting aNAC
REFERENCE   4  (bases 1 to 3876)
  AUTHORS   Hekmatnejad,B., Mandic,V., Yu,V.W., Akhouayri,O., Arabian,A. and
            St-Arnaud,R.
  TITLE     Altered gene dosage confirms the genetic interaction between FIAT
            and alphaNAC
  JOURNAL   Gene 538 (2), 328-333 (2014)
   PUBMED   24440290
  REMARK    GeneRIF: The bone phenotype of compound Naca(+/-); Fiat(+/-)
            heterozygotes confirms that FIAT and alphaNAC are part of a common
            genetic pathway and support a role for the FIAT/alphaNAC
            interaction in normal bone physiology.
REFERENCE   5  (bases 1 to 3876)
  AUTHORS   Hekmatnejad,B., Gauthier,C. and St-Arnaud,R.
  TITLE     Control of Fiat (factor inhibiting ATF4-mediated transcription)
            expression by Sp family transcription factors in osteoblasts
  JOURNAL   J Cell Biochem 114 (8), 1863-1870 (2013)
   PUBMED   23463631
  REMARK    GeneRIF: an interplay between Sp1 and Sp3 as a mechanism involved
            in the control of Fiat gene expression in osteoblasts.
REFERENCE   6  (bases 1 to 3876)
  AUTHORS   St-Arnaud,R., Mandic,V. and Elchaarani,B.
  TITLE     FIAT, the factor-inhibiting ATF4-mediated transcription, also
            represses the transcriptional activity of the bZIP factor FRA-1
  JOURNAL   Ann N Y Acad Sci 1192, 338-343 (2010)
   PUBMED   20392257
  REMARK    GeneRIF: FIAT can both modulate early osteoblast activity by
            interacting with ATF4 and regulate later osteoblast function
            through inhibition of FRA-1.
REFERENCE   7  (bases 1 to 3876)
  AUTHORS   Du,K., Chen,Y., Dai,Z., Bi,Y., Cai,T., Hou,L., Chai,Y., Song,Q.,
            Chen,S., Luo,W. and Chen,J.
  TITLE     Molecular cloning and functional characterization of a mouse gene
            upregulated by lipopolysaccharide treatment reveals alternative
            splicing
  JOURNAL   Biochem Biophys Res Commun 391 (1), 267-271 (2010)
   PUBMED   19913514
  REMARK    GeneRIF: Upregulation of MLrgW and MLrgS may be an important
            component of the LPS inflammatory pathway and of the host response
            to infection with gram-negative bacteria .
REFERENCE   8  (bases 1 to 3876)
  AUTHORS   Yu,V.W., Akhouayri,O. and St-Arnaud,R.
  TITLE     FIAT is co-expressed with its dimerization target ATF4 in early
            osteoblasts, but not in osteocytes
  JOURNAL   Gene Expr Patterns 9 (5), 335-340 (2009)
   PUBMED   19232401
REFERENCE   9  (bases 1 to 3876)
  AUTHORS   Yu,V.W., El-Hoss,J. and St-Arnaud,R.
  TITLE     FIAT inhibition increases osteoblast activity by modulating
            Atf4-dependent functions
  JOURNAL   J Cell Biochem 106 (1), 186-192 (2009)
   PUBMED   19016261
  REMARK    GeneRIF: inhibition of FIAT expression increases ATF4 activity and
            confirm the important role of FIAT in osteoblast function
REFERENCE   10 (bases 1 to 3876)
  AUTHORS   Yu,V.W., Ambartsoumian,G., Verlinden,L., Moir,J.M., Prud'homme,J.,
            Gauthier,C., Roughley,P.J. and St-Arnaud,R.
  TITLE     FIAT represses ATF4-mediated transcription to regulate bone mass in
            transgenic mice
  JOURNAL   J Cell Biol 169 (4), 591-601 (2005)
   PUBMED   15911876
  REMARK    GeneRIF: These results show that FIAT regulates bone mass accrual
            and establish FIAT as a novel transcriptional regulator of
            osteoblastic function.(FIAT protein, mouse)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672123.16, AK044130.1, BC117898.1, AV277312.2 and BQ128960.1.
            
            On Mar 20, 2014 this sequence version replaced NM_178935.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030100.1, DQ316984.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL672123.16        213605-213656       c
            53-2883             AK044130.1         2-2832
            2884-3339           BC117898.1         2678-3133
            3340-3360           AV277312.2         135-155
            3361-3876           BQ128960.1         1-516               c
FEATURES             Location/Qualifiers
     source          1..3876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 74.99 cM"
     gene            1..3876
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /note="taxilin gamma"
                     /db_xref="GeneID:353170"
                     /db_xref="MGI:MGI:3590652"
     exon            1..216
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1689
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-taxilin; lipopolysaccharide-specific response
                     protein 5; factor inhibiting activating transcription
                     factor 4 (ATF4)-mediated transcription;
                     lipopolysaccharide-responsive gene protein"
                     /codon_start=1
                     /product="gamma-taxilin isoform 1"
                     /protein_id="NP_849266.1"
                     /db_xref="CCDS:CCDS30510.1"
                     /db_xref="GeneID:353170"
                     /db_xref="MGI:MGI:3590652"
                     /translation="MATRLEEVTRGRGGGTEEASEGGRGGRRRSPPQKFEIGTMEEAR
                     ICGLGVKADMVCNSQANDILQHQDPSCGGTTKKHSLEGDEGSDFITKNRNLVSSVFCT
                     QEKREEIPGREARTGPPDGQQDSECSRNKEKTLGKEVLLLMQALNTLSTPEEKLAALC
                     KKYADLLEESRNVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRH
                     NKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKL
                     KKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEAT
                     ESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKL
                     EKETIIWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNE
                     KVEVLKEQVSIKAADGDLVSPATQPCAVLDSFKETSRRTLGMHLEARAKSVCEKSAAQ
                     KPSSSGSPAQGIESVD"
     exon            217..520
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            521..612
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            613..783
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            784..978
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1098
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1173
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1266
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1362
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..3864
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3841..3846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /note="hexamer: AGTAAA"
     polyA_site      3864
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /note="major polyA site"
ORIGIN      
        1 cgtgagaaga ctctcacgct acgattggtt ggggtgtaaa gggggcgggg ctgaagcccc
       61 tgagaggttc cgtgcccctg gtccagccgc ttgtttggct gctgccgtca cctcatggcg
      121 actcggcttg aggaggtaac gcgaggaaga ggcggcggta ctgaggaggc tagtgagggc
      181 ggacggggcg gacggcgacg tagccccccg cagaagtttg aaattggcac aatggaagaa
      241 gctagaattt gtgggttagg agtaaaagca gacatggtat gtaactctca agcaaatgat
      301 attcttcaac atcaagaccc cagttgtggt ggcacaacta agaaacattc actggaaggg
      361 gatgaaggca gtgactttat tacaaagaac agaaatttgg tgagctcagt attctgtaca
      421 caggagaaaa gagaagaaat tcctggacga gaagctcgaa caggtcctcc tgatggccag
      481 caagattcag agtgcagcag gaacaaagag aagaccttag gaaaagaagt tttattactg
      541 atgcaagcgc taaacaccct ttcaacccca gaggagaagc tggcagctct ctgtaagaaa
      601 tatgctgatc tcctggaaga aagcaggaat gttcagaaac aaatgaagat tctgcagaag
      661 aagcaagccc agattgtgaa agagaaagtt caccttcaga gtgaacacag caaggccatc
      721 ttggcaagaa gcaaactgga atctctttgc agggaacttc agcgtcataa taagacctta
      781 aaggaggaga atatgcagca ggcacgagag gaggaagaac gacgtaaaga agcaacagca
      841 catttccaga taactctaaa tgaaatccaa gctcagttgg aacaacatga catccacaat
      901 gccaaactgc gacaggagaa cattgaactg ggagagaagt tgaagaagct tattgagcag
      961 tatgcactaa gggaagagca tattgataaa gtattcaaac acaaggaatt gcaacaacag
     1021 cttgtggatg ccaaacttca gcaaacaaca cagctgataa aagaagctga tgaaaaacat
     1081 cagagagaga gagagttttt attaaaagaa gcaacagaat ccaggcacaa atatgaacaa
     1141 atgaaacagc aagaagtaca actaaaacag cagctttctc tttatatgga taaatttgaa
     1201 gaattccaga ctactatggc aaaaagcaat gaacttttta caaccttcag gcaggaaatg
     1261 gaaaagatga caaagaaaat taaaaaactg gaaaaagaaa caataatatg gcgtaccaaa
     1321 tgggaaaaca ataataaagc acttctgcag atggccgaag agaaaactgt ccgtgataaa
     1381 gagtacaagg cttttcaaat aaaactggaa cggttagaga agctgtgcag ggctcttcag
     1441 acagagagaa atgagctcaa cgagaaggtc gaagtcctga aagagcaggt ctctatcaaa
     1501 gcagcagatg gggacttggt gtcacctgca acgcagccct gtgctgtcct ggattccttc
     1561 aaagagactt caagaagaac cctgggaatg cacttggagg ctagagccaa gtcagtgtgt
     1621 gagaaaagtg ctgcacaaaa gccctcatct tcaggttctc ctgctcaagg cattgagtca
     1681 gttgactagg gtgaagtatg atcactgtat tgagagatat attttgtgta taacttcctc
     1741 tgttagtagt aactattggt tttgtggtga agattttctt actttttcta ccatatctgt
     1801 attttcttag aactactgga cttatgtggt acaggaggct gcttagcagt ttggaatagt
     1861 tttactctat aaatttccct caactatgtt gcacatctgc ctcattttcc ccctttggag
     1921 tgcatgcctt cagcacataa ttttcataac taaaaaacaa ggccattaga ggaattatat
     1981 tctcccgatg gttccttgat gtgaaaacaa tatcccacta atattagtga aaggaaaata
     2041 cctttaataa cccatttaaa tacgggatta gaattcggga actggtcaga aacatttttc
     2101 atttgaatca gcttttcttg attcacttga caaagtaaaa taaccttgaa gttctgacaa
     2161 aactaactta gtactcataa agtagtccta atatattgat ttgaggatag atgacataaa
     2221 aaggtgatta ttccttgaaa agtgcttttt tgcagtttcc agcaaaaaca taaaagctcc
     2281 cttcctcacc atacattctg gctttgttga agttttgtgt tcatttgcat taagactcaa
     2341 caagcagggc tgtacatgtg tgtagctcag tggcaagcat ttgcctatca taagaggctc
     2401 tgggttgaca agtttcatca gcaaagaaca ctagttattt tgtttcctaa tagagaattt
     2461 aaattataga tcagataaca taagataaca tttccaaagt aaaaacactg gaaccagctt
     2521 gggaaaactt ggcagattgt ttacatagtc aaaaagacgc ctagctttct agtctatttc
     2581 tccgtttttt gatgctatca ctttaaaaca ataaaaacca gtattaatgt ttgacacttt
     2641 gatatttatg gctcagccat gcaaattact aggtctttgg taaagtaaat ttattaaagg
     2701 ttctagtaaa gcaccatatt cagagactga cttgttcaat tggctaaaaa tttcatttat
     2761 actccttagc acattttatt tttatggtca aatctaggtt caaataattg aaaaaatggc
     2821 caaaagccag aaaacagtcc ctgtagatgg ttatttttct aaactaatca aggggtcaaa
     2881 agtaaaagaa gtgaaaaaag tgaagtcaga aacaacaaaa aaaccctttc agtagcctct
     2941 tatcaaatac tggacttttt ccccatgaac gtgtcagaaa tattgaaatt actactaatg
     3001 attacatttc acaagtctgc tggatacaca gctcttaaca tttgattaag ccatgtgtgt
     3061 agcctgccac atttttgtgg tacttgtcct gtgtggaata ttgcatattt tcaagggctt
     3121 tataaagcaa tgcgattaac agtcctggcc tgctgctttc ggcttacatg cattttcagc
     3181 tagatcttta gaggacagag attctgtatg aaatatgcat atgcaaaatc tctcctcctg
     3241 tgaatgaaaa cagatgggac ctcaaagaag gatgccctcc ctccctccct taaagtgatc
     3301 acctcagcag cccagtgttg tggctttgta gcacgccctg tactaccgta ttctagaaca
     3361 ctgtaatgct actgtgctgg cccagaaaag atttctatgt tgaattcact tactgcatat
     3421 ggtgcactac catgcaatct tgatgtatat ttttagtgtc agtagacccc aaaatgtagc
     3481 gaaacttggg tatcaggcca tttcatcctc agacttgtag aagtacattt tctggtcttg
     3541 agacctgtat tttttagtta tgtatgcaac tgcctttatt acacacctgg ttatcacaat
     3601 tcaactctca ggtgttgcag aaaaaaaaat ctacctcttt cagactgtag atggaaataa
     3661 ctgtgaaaaa atgatgcaga tatagtttgt gctaaacaca ctgctttatt tttacagccc
     3721 acgtctttca tgaggatatg aattgttaag aggcagtctt gttttgcttt tcaaagacat
     3781 tttgtagaga tttttcacta ccgtaaatct gattttatct actcaattct gtagagatta
     3841 agtaaatatg tatgatgaaa ttaaaaaaaa aaaaaa
//
