LOCUS       NP_849266                524 aa            linear   ROD 05-JUN-2024
DEFINITION  gamma-taxilin isoform 1 [Mus musculus].
ACCESSION   NP_849266
VERSION     NP_849266.1
DBSOURCE    REFSEQ: accession NM_178935.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 524)
  AUTHORS   Yang,L., Huang,L.Y., Li,L.B., Tang,Z., Chen,K., Chen,L.P.,
            Luo,H.Y., Luo,J. and Zhao,X.L.
  TITLE     miR-98-TXLNG1 (FIAT)/Sp7 function loop mediates osteoblast
            mineralization
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (12), 3676-3688 (2018)
   PUBMED   29949140
  REMARK    GeneRIF: Our study showed that miR-98 was an important regulator in
            osteoblast mineralization and miR-98 carried out its function
            through a novel miR-98-FIAT/Sp7 regulatory loop
REFERENCE   2  (residues 1 to 524)
  AUTHORS   Hekmatnejad,B., Yu,V.W., Addison,W., Mandic,V., Pellicelli,M.,
            Arabian,A. and St-Arnaud,R.
  TITLE     FIAT Deletion Increases Bone Mass But Does Not Prevent
            High-Fat-Diet-Induced Metabolic Complications
  JOURNAL   Endocrinology 158 (2), 264-276 (2017)
   PUBMED   27906582
  REMARK    GeneRIF: negative regulator of bone mass acting distinctly on bone
            formation without alteration in resorption and affecting both the
            trabecular and the cortical compartments
REFERENCE   3  (residues 1 to 524)
  AUTHORS   Hekmatnejad,B., Akhouayri,O., Jafarov,T. and St-Arnaud,R.
  TITLE     SUMOylated alphaNAC potentiates transcriptional repression by FIAT
  JOURNAL   J Cell Biochem 115 (5), 866-873 (2014)
   PUBMED   24375853
  REMARK    GeneRIF: We propose that maximal transcriptional repression by FIAT
            requires its interaction with SUMOylated, HDAC2-interacting aNAC
REFERENCE   4  (residues 1 to 524)
  AUTHORS   Hekmatnejad,B., Mandic,V., Yu,V.W., Akhouayri,O., Arabian,A. and
            St-Arnaud,R.
  TITLE     Altered gene dosage confirms the genetic interaction between FIAT
            and alphaNAC
  JOURNAL   Gene 538 (2), 328-333 (2014)
   PUBMED   24440290
  REMARK    GeneRIF: The bone phenotype of compound Naca(+/-); Fiat(+/-)
            heterozygotes confirms that FIAT and alphaNAC are part of a common
            genetic pathway and support a role for the FIAT/alphaNAC
            interaction in normal bone physiology.
REFERENCE   5  (residues 1 to 524)
  AUTHORS   Hekmatnejad,B., Gauthier,C. and St-Arnaud,R.
  TITLE     Control of Fiat (factor inhibiting ATF4-mediated transcription)
            expression by Sp family transcription factors in osteoblasts
  JOURNAL   J Cell Biochem 114 (8), 1863-1870 (2013)
   PUBMED   23463631
  REMARK    GeneRIF: an interplay between Sp1 and Sp3 as a mechanism involved
            in the control of Fiat gene expression in osteoblasts.
REFERENCE   6  (residues 1 to 524)
  AUTHORS   St-Arnaud,R., Mandic,V. and Elchaarani,B.
  TITLE     FIAT, the factor-inhibiting ATF4-mediated transcription, also
            represses the transcriptional activity of the bZIP factor FRA-1
  JOURNAL   Ann N Y Acad Sci 1192, 338-343 (2010)
   PUBMED   20392257
  REMARK    GeneRIF: FIAT can both modulate early osteoblast activity by
            interacting with ATF4 and regulate later osteoblast function
            through inhibition of FRA-1.
REFERENCE   7  (residues 1 to 524)
  AUTHORS   Du,K., Chen,Y., Dai,Z., Bi,Y., Cai,T., Hou,L., Chai,Y., Song,Q.,
            Chen,S., Luo,W. and Chen,J.
  TITLE     Molecular cloning and functional characterization of a mouse gene
            upregulated by lipopolysaccharide treatment reveals alternative
            splicing
  JOURNAL   Biochem Biophys Res Commun 391 (1), 267-271 (2010)
   PUBMED   19913514
  REMARK    GeneRIF: Upregulation of MLrgW and MLrgS may be an important
            component of the LPS inflammatory pathway and of the host response
            to infection with gram-negative bacteria .
REFERENCE   8  (residues 1 to 524)
  AUTHORS   Yu,V.W., Akhouayri,O. and St-Arnaud,R.
  TITLE     FIAT is co-expressed with its dimerization target ATF4 in early
            osteoblasts, but not in osteocytes
  JOURNAL   Gene Expr Patterns 9 (5), 335-340 (2009)
   PUBMED   19232401
REFERENCE   9  (residues 1 to 524)
  AUTHORS   Yu,V.W., El-Hoss,J. and St-Arnaud,R.
  TITLE     FIAT inhibition increases osteoblast activity by modulating
            Atf4-dependent functions
  JOURNAL   J Cell Biochem 106 (1), 186-192 (2009)
   PUBMED   19016261
  REMARK    GeneRIF: inhibition of FIAT expression increases ATF4 activity and
            confirm the important role of FIAT in osteoblast function
REFERENCE   10 (residues 1 to 524)
  AUTHORS   Yu,V.W., Ambartsoumian,G., Verlinden,L., Moir,J.M., Prud'homme,J.,
            Gauthier,C., Roughley,P.J. and St-Arnaud,R.
  TITLE     FIAT represses ATF4-mediated transcription to regulate bone mass in
            transgenic mice
  JOURNAL   J Cell Biol 169 (4), 591-601 (2005)
   PUBMED   15911876
  REMARK    GeneRIF: These results show that FIAT regulates bone mass accrual
            and establish FIAT as a novel transcriptional regulator of
            osteoblastic function.(FIAT protein, mouse)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672123.16, AK044130.1, BC117898.1, AV277312.2 and BQ128960.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030100.1, DQ316984.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 74.99 cM"
     Protein         1..524
                     /product="gamma-taxilin isoform 1"
                     /note="gamma-taxilin; lipopolysaccharide-specific response
                     protein 5; factor inhibiting activating transcription
                     factor 4 (ATF4)-mediated transcription;
                     lipopolysaccharide-responsive gene protein"
                     /calculated_mol_wt=60178
     Region          1..37
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Site            12
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Site            24
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Region          64..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Site            97
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Region          106..130
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Region          137..444
                     /region_name="Taxilin"
                     /note="Myosin-like coiled-coil protein; pfam09728"
                     /db_xref="CDD:462861"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Region          501..524
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHN1.1)"
     Site            512
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NUQ3; propagated from
                     UniProtKB/Swiss-Prot (Q8BHN1.1)"
     CDS             1..524
                     /gene="Txlng"
                     /gene_synonym="4932441K18Rik; Fiat; Lrp"
                     /coded_by="NM_178935.5:115..1689"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS30510.1"
                     /db_xref="GeneID:353170"
                     /db_xref="MGI:MGI:3590652"
ORIGIN      
        1 matrleevtr grgggteeas eggrggrrrs ppqkfeigtm eearicglgv kadmvcnsqa
       61 ndilqhqdps cggttkkhsl egdegsdfit knrnlvssvf ctqekreeip greartgppd
      121 gqqdsecsrn kektlgkevl llmqalntls tpeeklaalc kkyadllees rnvqkqmkil
      181 qkkqaqivke kvhlqsehsk ailarskles lcrelqrhnk tlkeenmqqa reeeerrkea
      241 tahfqitlne iqaqleqhdi hnaklrqeni elgeklkkli eqyalreehi dkvfkhkelq
      301 qqlvdaklqq ttqlikeade khqrerefll keatesrhky eqmkqqevql kqqlslymdk
      361 feefqttmak snelfttfrq emekmtkkik kleketiiwr tkwennnkal lqmaeektvr
      421 dkeykafqik lerleklcra lqternelne kvevlkeqvs ikaadgdlvs patqpcavld
      481 sfketsrrtl gmhlearaks vceksaaqkp sssgspaqgi esvd
//
