LOCUS       NM_001199695            4586 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus taxilin alpha (Txlna), transcript variant 2, mRNA.
ACCESSION   NM_001199695
VERSION     NM_001199695.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4586)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4586)
  AUTHORS   Jin,X., Zhang,S., Ding,T., Zhao,P., Zhang,C., Zhang,Y. and Li,W.
  TITLE     Testicular Lmcd1 regulates phagocytosis by Sertoli cells through
            modulation of NFAT1/Txlna signaling pathway
  JOURNAL   Aging Cell 19 (10), e13217 (2020)
   PUBMED   32840323
  REMARK    GeneRIF: Testicular Lmcd1 regulates phagocytosis by Sertoli cells
            through modulation of NFAT1/Txlna signaling pathway.
REFERENCE   3  (bases 1 to 4586)
  AUTHORS   Dong,Y.S., Hou,W.G., Li,Y., Liu,D.B., Hao,G.Z., Zhang,H.F.,
            Li,J.C., Zhao,J., Zhang,S., Liang,G.B. and Li,W.
  TITLE     Unexpected requirement for a binding partner of the syntaxin family
            in phagocytosis by murine testicular Sertoli cells
  JOURNAL   Cell Death Differ 23 (5), 787-800 (2016)
   PUBMED   26494466
  REMARK    GeneRIF: The TXLNA may serve as an important feedback mechanism to
            modulate the magnitude of subsequent phagocytotic process of SCs in
            response to testicular injury.
REFERENCE   4  (bases 1 to 4586)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4586)
  AUTHORS   Peng,X., Zhou,C., Wei,D., Luo,Z. and Zhang,C.
  TITLE     Characteristics of a novel monoclonal antibody against
            interleukin-14alpha
  JOURNAL   Hybridoma (Larchmt) 28 (4), 235-239 (2009)
   PUBMED   19663695
  REMARK    GeneRIF: analysis of a novel monoclonal antibody against
            interleukin-14alpha
REFERENCE   6  (bases 1 to 4586)
  AUTHORS   Fallon,P.G., Jolin,H.E., Smith,P., Emson,C.L., Townsend,M.J.,
            Fallon,R., Smith,P. and McKenzie,A.N.
  TITLE     IL-4 induces characteristic Th2 responses even in the combined
            absence of IL-5, IL-9, and IL-13
  JOURNAL   Immunity 17 (1), 7-17 (2002)
   PUBMED   12150887
REFERENCE   7  (bases 1 to 4586)
  AUTHORS   Saito,Y., Ochiai,Y., Kodama,Y., Tamura,Y., Togashi,T.,
            Kosugi-Okano,H., Miyazawa,T., Wakabayashi,Y., Hatakeyama,K.,
            Wakana,S., Niwa,O. and Kominami,R.
  TITLE     Genetic loci controlling susceptibility to gamma-ray-induced thymic
            lymphoma
  JOURNAL   Oncogene 20 (37), 5243-5247 (2001)
   PUBMED   11526516
REFERENCE   8  (bases 1 to 4586)
  AUTHORS   Araujo,L.M., Puel,A., Gouarin,C., Hameg,A., Mevel,J.C., Koezuka,Y.,
            Bach,J.F., Mouton,D. and Herbelin,A.
  TITLE     NKT lymphocyte ontogeny and function are impaired in low
            antibody-producer Biozzi mice: gene mapping in the
            interval-specific congenic strains raised for immunomodulatory
            genes
  JOURNAL   Int Immunol 12 (11), 1613-1622 (2000)
   PUBMED   11058581
REFERENCE   9  (bases 1 to 4586)
  AUTHORS   Jones,B.C., Tarantino,L.M., Rodriguez,L.A., Reed,C.L.,
            McClearn,G.E., Plomin,R. and Erwin,V.G.
  TITLE     Quantitative-trait loci analysis of cocaine-related behaviours and
            neurochemistry
  JOURNAL   Pharmacogenetics 9 (5), 607-617 (1999)
   PUBMED   10591541
REFERENCE   10 (bases 1 to 4586)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ151043.1, AK150240.1 and AW121192.1.
            
            Transcript Variant: This variant (2) contains a different segment
            for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150240.1, AK161649.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                CJ151043.1         2-45
            45-4561             AK150240.1         2-4518
            4562-4586           AW121192.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..4586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.26 cM"
     gene            1..4586
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /note="taxilin alpha"
                     /db_xref="GeneID:109658"
                     /db_xref="MGI:MGI:105968"
     exon            1..95
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            96..267
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1766
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /note="interleukin 14; taxilin Txln"
                     /codon_start=1
                     /product="alpha-taxilin"
                     /protein_id="NP_001186624.1"
                     /db_xref="CCDS:CCDS38887.1"
                     /db_xref="GeneID:109658"
                     /db_xref="MGI:MGI:105968"
                     /translation="MKNQDKKNGPAKHSNSKGSPGQREAGPEGAHGRPRQTAPGAEAE
                     GSTSQAPGKTEGARAKAAQPGALCDVSEELSRQLEDILSTYCVDNNQGGPAEEGAQGE
                     PTEPEDTEKSRTYAARNGEPEPGIPVVNGEKETSKGEPGTEEIRASDEVGDRDHRRPQ
                     EKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQS
                     QLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSH
                     FQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQ
                     QLVDAKLQQAQEMLKEAEERHQREKEFLLKEAVESQRMCELMKQQETHLKQQLALYTE
                     KFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEK
                     TVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLTAGGITDIGSERRPEATTAS
                     KEQGVESPGAQPASSPRATDAPCCSGAPSTGTAGQTGPGEPTPATA"
     exon            268..606
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            607..698
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            699..869
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1064
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1184
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1259
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1352
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1448
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..4570
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /note="hexamer: ATTAAA"
     polyA_site      2509
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
     regulatory      4543..4548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /note="hexamer: ATTAAA"
     polyA_site      4564
                     /gene="Txlna"
                     /gene_synonym="2600010N21Rik; Il14; Txln"
                     /note="major polyA site"
ORIGIN      
        1 ggctgcggca ggagagggcg gtcctgttgg cagcagttac ctaggtttcc ggtgctcggc
       61 cggagaggag gacgccgccg gacgtccgtg gtgaaatcac aatgaagaac caagacaaaa
      121 agaatgggcc tgccaaacac tccaactcga agggcagccc ggggcaacgg gaagcaggac
      181 cggagggagc ccatggacga cccagacaga cagctcctgg ggcggaagcc gaaggttcca
      241 caagccaggc tcctgggaag accgaggggg ctcgagctaa agcagctcag cctggggccc
      301 tctgtgacgt ctctgaggag ctgagccggc agttggaaga catcctgagt acatactgtg
      361 tggacaacaa tcagggaggc ccggctgagg agggagcaca gggtgagccc actgagccgg
      421 aagacacgga gaagtcccga acctatgcag ccaggaatgg ggagcctgaa ccaggcattc
      481 cagtcgtcaa cggcgagaag gagacctcta agggagagcc tggaacagag gagatccgag
      541 cgagtgatga agttggagac cgagaccatc ggaggccaca ggagaagaag aaagccaagg
      601 gtctagggaa ggagatcact ctgctgatgc agacactgaa cacgctgagt accccagagg
      661 agaagctggc tgcactgtgc aagaagtatg ctgagctgct ggaagagcat cggaactcgc
      721 agaagcagat gaagctcctg cagaagaagc agagccagct cgtgcaggag aaggaccatc
      781 tgcgagggga acacagcaag gctgtcctgg cccgaagcaa gcttgagagt ctgtgccggg
      841 agctgcaacg gcacaaccgg tccctgaagg aagaaggcgt gcagcgagcc cgtgaggagg
      901 aggagaagcg caaagaagtg acttcacact tccaggtgac actgaatgac attcagctgc
      961 agatggaaca gcataacgag cgaaactcca agctgcgcca ggagaatatg gagctagccg
     1021 agaggctcaa gaagttgatc gagcaatacg agcttcgtga ggagcatatc gacaaagtct
     1081 tcaaacataa ggacctgcag cagcagctag tggacgccaa gctccagcag gcccaggaga
     1141 tgctgaagga ggcagaggag cggcaccagc gagagaagga gtttctcctg aaggaagcgg
     1201 tggagtccca gaggatgtgc gagctgatga agcagcagga gacccaccta aagcagcagc
     1261 tcgccctgta cacggagaag tttgaggagt tccagaacac actttccaaa agcagtgaag
     1321 tgttcaccac gttcaaacag gagatggaaa agatgacaaa gaagatcaag aagctggaga
     1381 aagaaaccac catgtatcga tcccggtggg aaagcagcaa caaggctctg ctggagatgg
     1441 ctgaagagaa aaccgtccgg gacaaagagc tggagggcct gcaggtgaaa atccagcggc
     1501 tggagaagct gtgccgagca ctgcagaccg agcgcaatga cctcaacaag agggtacagg
     1561 acctgactgc agggggcatc actgacattg gctctgagcg gaggccagag gccaccactg
     1621 cctccaagga acaaggggtt gaaagtcctg gggctcaacc agccagctct ccaagggcca
     1681 cagacgctcc ttgctgctcg ggagccccga gcacaggaac agcaggccag acagggcctg
     1741 gagagcccac ccctgccact gcctagagat cacggtgctt gggcatgctg ggacaggagc
     1801 agcagcccag tcaggcctcg tccatgcaag gcttccacac ggagcagccc agggctgagg
     1861 ccgtcggaca cttggcaatt gtgaattttg tgggttagtc ttacatggat gggcaggcgt
     1921 gcagaccctc atgcggttct atagtcaaca cctgtaggtg cactgtgggc tttcacctcg
     1981 gacagtgtgc agatgaagtt ggagactctg aaaacggaag agtcatagaa gatgtcatct
     2041 gaagctgccg tcacagtaag ctggcaggtc agatgactcc aatattttcc tacccagctc
     2101 taaggctcag acccctcttg gccttttcag agctcatgac aagtgaaagc acccaggcct
     2161 ggactcctcc tttttgtgag cagaacttgg gcgatttggg ctctcgtccc tccctcgctg
     2221 ccctggaggt tccattgctt ctcttaacct gggaatggtg tccctggcag agtctttgtg
     2281 gggcagaagt ggaggtgtgc ctgtgtggga gggaatccct caggcccact tctcctccga
     2341 tagtgccagg tccaggccag tgtcgcttct cagttctcag tagccttatc attcacaggt
     2401 gcctctagcc tgcacaaata attgacaaat gtcacccaaa ggattctttt gggagggttt
     2461 ttgtttgctt gttttgcata agagtttgta ttaaagaact tcaaaggaag gaacagggat
     2521 actctagcag tggtcctcag gtgcctggcc tccagtaccc cacttggaac caccctgtca
     2581 gggtcctttg ccatgtgggt gccaaggtat cctgcttggg aagatgagat atttcagaga
     2641 agggaagagg cttctaatgg ctttgccaca agcttgccta tgggcttcag cctaggaggc
     2701 aaccactggt tcccatcact tctccatgca gcctttgctg gaccgcaggc ccacgtgccc
     2761 cttggcgcat ggtcgtttct tggctcctgc ccctcacctc catctcagag gtgtggtttt
     2821 tgaggactgc tcttgtgcca tttccttcga accctcttgg ccaaaaagtg agtccttggg
     2881 atttcacttc ttcctgccta agctggctgg taggtcaaga acagacatcc caggaaccaa
     2941 aatagctgtg aggagttgtc ttcaccgtcc ctccccaccc tcctcagtgt tactgtggtc
     3001 tcggggctct gctgaagctc tcgtgactgc acacctgcca aggtgttgag tcagtttcca
     3061 caacagcttt tctggagtga ccgtctggga agctgaggct tctcttccat acactgagac
     3121 tggatggaat tttgcttctt gtatttcaac tattgcaagt ttatctttca taactagcct
     3181 ctaagccccc acacactcaa attaaacatt gagctgggtg tgtgatatat tcctgtaatc
     3241 ccagagctca gcagagctag gaagcaggac cccttgtcag gaaaccaaaa agtaaacagc
     3301 tggaagaaaa catctcgtgc tgatgatcat gtgtttaaat ccagaaatta caaattaatg
     3361 acccctttcc catgtcacag gctctaccat ttcaaatact tgctaccctg gtatatttat
     3421 tcactcaggg tgcccagcag ctgtgtgttg aggctttgcc atctccagct ggaatctgtt
     3481 gtcctgtgga atttctccca aggtcttata tcttggaaat catagtattc ttccggttcc
     3541 agtgaggcct cagcccacac tccaggctga gatctgacct gttaacccat ggggctcctt
     3601 aggccacaga gatgtaaggg tgaggcatct tcctgcctcc ttgaagacag aaggaccttg
     3661 tgtggtccac tacattggct tgcctcactt cagctacctc ttaaagcttg tgcagggtga
     3721 cagctgctgg gtctcagtgt ggcaggccag agaaccttgg ctttccctcc atccacttgt
     3781 aggcacccag ggcaatgcag atagtaatct ctcccttcta ccttctcccc tctgaccata
     3841 tctacagtca ctacagctgc tctgctttcc aaagtcagcc caggagactg ggccagcttc
     3901 agggaggctg cctgtctgtg agagggccag cgccttcctc acttgggcaa gtcccctgca
     3961 catgacctca ttttaggacc aagagctatg ttggtttctt agattgttag ctttttctct
     4021 agaggaccac agtgggtatg gcttggagtc cagggccctt ggctatacaa acaatattta
     4081 ggtccttgtc caggggagaa cttcgtgtat gccatgtcag ccccactttt tgtcgttgtt
     4141 ttccatgagg cttttttgga ccatggtcgg agcttaggca ctttctgtaa gaatgtttct
     4201 gtaaagatgg ttatttaacg cttcctagtc cccatcatgt tagtcctcca gagcgctaac
     4261 ccagaggcca gtggaactgc ccaggtgtcc acagaggggc tgcagcctgc agagaactgc
     4321 tccagccccc ctccacctta gtagcatgtg tggaccacca ggcatctgac tgcccttgac
     4381 cagcctcggg taggagggct gcctctgtcc ccatgactgc tttcctttgc cacccatact
     4441 tgtttgaagt tgtgctgaca gctttttttt ttgtaccctt tcccgttccc agtttgcgtt
     4501 ggaattggca gcagccaggg acttgctatt gatgaatttt acattaaata gtcctgttgc
     4561 cttacctgta aaaaaaaaaa aaaaaa
//
