LOCUS       NM_001122754            2260 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TXK tyrosine kinase (Txk), transcript variant 1, mRNA.
ACCESSION   NM_001122754
VERSION     NM_001122754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2260)
  AUTHORS   Xu,Q.L. and Wu,J.
  TITLE     Effects of Txk-mediated activation of NF-kappaB signaling pathway
            on neurological deficit and oxidative stress after
            ischemia-reperfusion in rats
  JOURNAL   Mol Med Rep 24 (1) (2021)
   PUBMED   34036382
  REMARK    GeneRIF: Effects of Txkmediated activation of NFkappaB signaling
            pathway on neurological deficit and oxidative stress after
            ischemiareperfusion in rats.
REFERENCE   3  (bases 1 to 2260)
  AUTHORS   Shao,B., Yago,T., Panicker,S.R., Zhang,N., Liu,Z. and McEver,R.P.
  TITLE     Th1 Cells Rolling on Selectins Trigger DAP12-Dependent Signals That
            Activate Integrin alphaLbeta2
  JOURNAL   J Immunol 204 (1), 37-48 (2020)
   PUBMED   31757864
REFERENCE   4  (bases 1 to 2260)
  AUTHORS   Cho,H.S., Shin,H.M., Haberstock-Debic,H., Xing,Y., Owens,T.D.,
            Funk,J.O., Hill,R.J., Bradshaw,J.M. and Berg,L.J.
  TITLE     A Small Molecule Inhibitor of ITK and RLK Impairs Th1
            Differentiation and Prevents Colitis Disease Progression
  JOURNAL   J Immunol 195 (10), 4822-4831 (2015)
   PUBMED   26466958
  REMARK    GeneRIF: Taken together, these data indicate that ITK plus RLK
            inhibition may have therapeutic potential in Th1-mediated
            inflammatory diseases.
REFERENCE   5  (bases 1 to 2260)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2260)
  AUTHORS   Schaeffer,E.M., Debnath,J., Yap,G., McVicar,D., Liao,X.C.,
            Littman,D.R., Sher,A., Varmus,H.E., Lenardo,M.J. and
            Schwartzberg,P.L.
  TITLE     Requirement for Tec kinases Rlk and Itk in T cell receptor
            signaling and immunity
  JOURNAL   Science 284 (5414), 638-641 (1999)
   PUBMED   10213685
REFERENCE   7  (bases 1 to 2260)
  AUTHORS   Ohta,Y., Haire,R.N., Amemiya,C.T., Litman,R.T., Trager,T., Riess,O.
            and Litman,G.W.
  TITLE     Human Txk: genomic organization, structure and contiguous physical
            linkage with the Tec gene
  JOURNAL   Oncogene 12 (4), 937-942 (1996)
   PUBMED   8632917
REFERENCE   8  (bases 1 to 2260)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   9  (bases 1 to 2260)
  AUTHORS   Haire,R.N. and Litman,G.W.
  TITLE     The murine form of TXK, a novel TEC kinase expressed in thymus maps
            to chromosome 5
  JOURNAL   Mamm Genome 6 (7), 476-480 (1995)
   PUBMED   7579892
REFERENCE   10 (bases 1 to 2260)
  AUTHORS   Hu,Q., Davidson,D., Schwartzberg,P.L., Macchiarini,F.,
            Lenardo,M.J., Bluestone,J.A. and Matis,L.A.
  TITLE     Identification of Rlk, a novel protein tyrosine kinase with
            predominant expression in the T cell lineage
  JOURNAL   J Biol Chem 270 (4), 1928-1934 (1995)
   PUBMED   7829530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099698.14, U16145.1, AK138786.1 and AC122733.11.
            
            On Jan 23, 2014 this sequence version replaced NM_001122754.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U19607.1, U16145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC099698.14        164343-164378       c
            37-1738             U16145.1           2-1703
            1739-2248           AK138786.1         1753-2262
            2249-2260           AC122733.11        9610-9621
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..2260
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /note="TXK tyrosine kinase"
                     /db_xref="GeneID:22165"
                     /db_xref="MGI:MGI:102960"
     exon            1..99
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1667
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tyrosine-protein kinase TXK; resting lymphocyte kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase TXK isoform 1"
                     /protein_id="NP_001116226.1"
                     /db_xref="CCDS:CCDS51514.1"
                     /db_xref="GeneID:22165"
                     /db_xref="MGI:MGI:102960"
                     /translation="MILSSYSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELSEKHS
                     QRQRPWFAKLMGKTQSNRGGVQPSKRKPLPPLPQEPPDERIQVKALYDFLPREPGNLA
                     LKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHKNITRNQT
                     ERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYITER
                     HLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFVKE
                     IGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCI
                     QQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSCYIHRDLA
                     ARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVW
                     SFGVLMWEVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPK
                     GRPTFAELLQVLTEIAETW"
     exon            100..157
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            158..260
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            261..463
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            464..529
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            530..584
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            585..664
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            665..792
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            793..867
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1039
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1256
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1321
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1440
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1598
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..2260
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /note="hexamer: AATAAA"
     polyA_site      2257
                     /gene="Txk"
                     /gene_synonym="A130089B16Rik; Btkl; PTK-RL-18; PTK4; Rlk"
                     /note="major polyA site"
ORIGIN      
        1 tttcagttga aagatgtgtt accgtgagtg gaacagagct gaagaaccaa ggcttctgtg
       61 tatggccagc aagcagggtc gccatgatcc tgtcctctta tagctccttc cagtctgttc
      121 tctgctgctg ctgttgccgc tgctcagtac agaagagaca ggtgagaact cagataagcc
      181 tgagcagaga ggaagaactc tcagaaaaac attcccagcg tcagaggccg tggttcgcca
      241 aactgatggg caaaactcaa tccaacagag gcggggtgca accctcgaag cgcaagccgc
      301 tgccccccct cccgcaggag cctccagatg agagaatcca ggtcaaggct ctttatgact
      361 tcctgcctcg ggagcctggt aatttggcac tgaagagagc ggaggaatat ctgatattgg
      421 agaggtgtga tcctcactgg tggaaggcca gagaccgctt cgggaatgaa ggcttaatcc
      481 caagcaacta tgtgacagaa aacagactcg ccaacttaga aatctatgaa tggtaccaca
      541 agaacattac gagaaaccag accgaacgcc tattgaggca agaggctaaa gaaggtgcct
      601 ttatcgtgag agattcgaga cacttggggt cttacacaat ctctgtgttt acaagagctc
      661 gaaggcatac acagtcttca ataaaacatt atcagataaa aaagaatgac tccggacagt
      721 ggtacatcac cgaaagacat ctcttcccct cagtccccga gttgatccag tatcaccagt
      781 acaatgcagc tggtctcata tctcgtctcc gctatcccat tgggctcctg ggcagctgtt
      841 taccagccac atctggtttt agctatgaaa agtgggagat agatccatca gagttggctt
      901 ttgtcaagga gatcggaagt ggtcagtttg gggttgtcca cttaggagaa tggagagcac
      961 atatcccggt cgccatcaag gccatcaatg aaggttccat gtctgaagaa gacttcattg
     1021 aggaagccaa ggtgatgatg aaactgtcac attcgaggtt agttcaactt tacggggtgt
     1081 gtatacagca gaagcccctg tacatagtga cggagttcat ggagaacggc tgcctgcttg
     1141 actatctcag ggagaggaaa ggccagcttc agaaggcgct gctcttgagc atgtgccaag
     1201 acatatgtga agggatggcg tacctggaga ggagctgcta tattcacagg gatctggctg
     1261 ccaggaactg tttggtcagt tctgcctgcg tagtaaagat ctcagacttc ggcatggcga
     1321 ggtatgtttt ggacgatgaa tatatcagtt cttctggagc taagttccca gtcaagtggt
     1381 gcccacctga agtctttcat ttcaacaaat acagtagcaa gtctgatgtc tggtcgttcg
     1441 gagttttaat gtgggaagtt tttacagaag gaaaaatgcc ttttgaaaat aagtcaaatt
     1501 tgcaagtggt ggaagccatt tctcaaggtt tccggctgta tcgtcctcac ctggccccca
     1561 tgaccatata cagagtgatg tacagttgct ggcatgagag ccctaaaggc cgtccgacat
     1621 ttgctgagct gcttcaggtt ctcacggaga tcgcagaaac gtggtgacct taaatgcagt
     1681 gccagctcgc aggtgacctt aagtggaact ccagcccaca gggtcatctt gcaaaaaaac
     1741 ggtcgcaagg tgaaatcatg ggcatctcgg atagggagta tctccaccag ggttgttgac
     1801 tcttggcgac gaagcaaagg tcacaggctt gtcacactga tttcaatgca aaatagtctg
     1861 atcgtagtct tgtacaagtg tgagacttct gaactacact tctgagctcc ttccacatcc
     1921 tgtatgtgaa aagagtatgc tccacaccaa ccttccaagt ggctgatgac ccccaggtcc
     1981 cttaagtgta cagagacccc ttattcttca taaggctgag gcaacatcat tcttgagcgc
     2041 tgacatttct ctttcgagtg gtccatgcaa agaggggaaa aaattagatt ctgccaactc
     2101 atgaaatgaa gaaatctttt caacagtttc atgtttgggg ctgtataaat gtttatagga
     2161 aacatagctt tggaaaccta tgtgaacatt ctggaaatgt cttttataat cgtgccatat
     2221 gttatttaat aaactcttct ttctgtttat tgtgggacct
//
