LOCUS       NM_023053               4032 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus twisted gastrulation BMP signaling modulator 1
            (Twsg1), mRNA.
ACCESSION   NM_023053
VERSION     NM_023053.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4032)
  AUTHORS   Murgai,A., Altmeyer,S., Wiegand,S., Tylzanowski,P. and Stricker,S.
  TITLE     Cooperation of BMP and IHH signaling in interdigital cell fate
            determination
  JOURNAL   PLoS One 13 (5), e0197535 (2018)
   PUBMED   29771958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4032)
  AUTHORS   Walton,K.D., Whidden,M., Kolterud,A., Shoffner,S.K.,
            Czerwinski,M.J., Kushwaha,J., Parmar,N., Chandhrasekhar,D.,
            Freddo,A.M., Schnell,S. and Gumucio,D.L.
  TITLE     Villification in the mouse: Bmp signals control intestinal villus
            patterning
  JOURNAL   Development 143 (3), 427-436 (2016)
   PUBMED   26721501
REFERENCE   3  (bases 1 to 4032)
  AUTHORS   Huntley,R., Davydova,J., Petryk,A., Billington,C.J. Jr.,
            Jensen,E.D., Mansky,K.C. and Gopalakrishnan,R.
  TITLE     The Function of Twisted Gastrulation in Regulating Osteoclast
            Differentiation is Dependent on BMP Binding
  JOURNAL   J Cell Biochem 116 (10), 2239-2246 (2015)
   PUBMED   25808976
  REMARK    GeneRIF: Our results show that BMP binding is required for
            TWSG1-mediated inhibition of osteoclast formation and function, and
            validate the critical functional regions within the TWSG1 protein
            for these interactions
REFERENCE   4  (bases 1 to 4032)
  AUTHORS   Billington,C.J. Jr., Schmidt,B., Marcucio,R.S., Hallgrimsson,B.,
            Gopalakrishnan,R. and Petryk,A.
  TITLE     Impact of retinoic acid exposure on midfacial shape variation and
            manifestation of holoprosencephaly in Twsg1 mutant mice
  JOURNAL   Dis Model Mech 8 (2), 139-146 (2015)
   PUBMED   25468951
  REMARK    GeneRIF: The goal of this study was to examine whether mice
            carrying a mutation in a gene encoding Twsg1, which is associated
            with a low penetrance of holoprosencephaly, are sensitized to
            retinoic acid teratogenesis.
REFERENCE   5  (bases 1 to 4032)
  AUTHORS   Yamada,S., Nakamura,J., Asada,M., Takase,M., Matsusaka,T.,
            Iguchi,T., Yamada,R., Tanaka,M., Higashi,A.Y., Okuda,T., Asada,N.,
            Fukatsu,A., Kawachi,H., Graf,D., Muso,E., Kita,T., Kimura,T.,
            Pastan,I., Economides,A.N. and Yanagita,M.
  TITLE     Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury
  JOURNAL   PLoS One 9 (2), e89135 (2014)
   PUBMED   24586548
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4032)
  AUTHORS   Nosaka,T., Morita,S., Kitamura,H., Nakajima,H., Shibata,F.,
            Morikawa,Y., Kataoka,Y., Ebihara,Y., Kawashima,T., Itoh,T.,
            Ozaki,K., Senba,E., Tsuji,K., Makishima,F., Yoshida,N. and
            Kitamura,T.
  TITLE     Mammalian twisted gastrulation is essential for
            skeleto-lymphogenesis
  JOURNAL   Mol Cell Biol 23 (8), 2969-2980 (2003)
   PUBMED   12665593
  REMARK    GeneRIF: acts as both a BMP-4 agonist in skeletogenesis and a BMP-4
            antagonist in T-cell development
REFERENCE   7  (bases 1 to 4032)
  AUTHORS   Hager-Theodorides,A.L., Outram,S.V., Shah,D.K., Sacedon,R.,
            Shrimpton,R.E., Vicente,A., Varas,A. and Crompton,T.
  TITLE     Bone morphogenetic protein 2/4 signaling regulates early thymocyte
            differentiation
  JOURNAL   J Immunol 169 (10), 5496-5504 (2002)
   PUBMED   12421925
REFERENCE   8  (bases 1 to 4032)
  AUTHORS   Graf,D., Nethisinghe,S., Palmer,D.B., Fisher,A.G. and
            Merkenschlager,M.
  TITLE     The developmentally regulated expression of Twisted gastrulation
            reveals a role for bone morphogenetic proteins in the control of T
            cell development
  JOURNAL   J Exp Med 196 (2), 163-171 (2002)
   PUBMED   12119341
  REMARK    GeneRIF: The developmentally regulated expression of Twisted
            gastrulation reveals a role for bone morphogenetic proteins in the
            control of T cell development.
REFERENCE   9  (bases 1 to 4032)
  AUTHORS   Graf,D., Timmons,P.M., Hitchins,M., Episkopou,V., Moore,G., Ito,T.,
            Fujiyama,A., Fisher,A.G. and Merkenschlager,M.
  TITLE     Evolutionary conservation, developmental expression, and genomic
            mapping of mammalian Twisted gastrulation
  JOURNAL   Mamm Genome 12 (7), 554-560 (2001)
   PUBMED   11420619
REFERENCE   10 (bases 1 to 4032)
  AUTHORS   Scott,I.C., Blitz,I.L., Pappano,W.N., Maas,S.A., Cho,K.W. and
            Greenspan,D.S.
  TITLE     Homologues of Twisted gastrulation are extracellular cofactors in
            antagonism of BMP signalling
  JOURNAL   Nature 410 (6827), 475-478 (2001)
   PUBMED   11260715
  REMARK    Erratum:[Nature 2001 Jun 7;411(6838):720]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121299.16 and CT025659.7.
            
            On Oct 19, 2022 this sequence version replaced NM_023053.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049646.1, AK168633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC121299.16        141395-141500       c
            107-263             AC121299.16        138986-139142       c
            264-363             AC121299.16        128129-128228       c
            364-630             CT025659.7         175986-176252       c
            631-4032            CT025659.7         169504-172905       c
FEATURES             Location/Qualifiers
     source          1..4032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 35.26 cM"
     gene            1..4032
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /note="twisted gastrulation BMP signaling modulator 1"
                     /db_xref="GeneID:65960"
                     /db_xref="MGI:MGI:2137520"
     exon            1..106
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /inference="alignment:Splign:2.1.0"
     exon            107..263
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..812
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /note="twisted gastrulation protein homolog 1; twisted
                     gastrulation homolog 1"
                     /codon_start=1
                     /product="twisted gastrulation protein homolog 1
                     precursor"
                     /protein_id="NP_075540.1"
                     /db_xref="CCDS:CCDS28942.1"
                     /db_xref="GeneID:65960"
                     /db_xref="MGI:MGI:2137520"
                     /translation="MKSHYIVLALASLTFLLCLPVSQSCNKALCASDVSKCLIQELCQ
                     CRPGEGNCPCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSL
                     FRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQLHHQNVSVPSNNVHAPFPS
                     DKERMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCM
                     NCMF"
     exon            264..363
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /inference="alignment:Splign:2.1.0"
     exon            364..630
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /inference="alignment:Splign:2.1.0"
     exon            631..4032
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4009..4014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /note="hexamer: AATAAA"
     polyA_site      4026
                     /gene="Twsg1"
                     /gene_synonym="1810013J15Rik; 9030422N06Rik; D17Ertd403e;
                     Tsg; Twg"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcctgg gagcggccgg ggacagcgcg ggcctgtgtg tccgcggcgc cggggttcgc
       61 gggagctgct tggaggctcg gcggccggga ggaggccggg gccacgcttc ttggaagcta
      121 ctgagtgact tctttgaaga accatgaagt cacactatat tgtgctagct ctagcctccc
      181 tgacgttcct gctgtgtctc cccgtgtccc agagctgtaa caaagcactc tgtgccagcg
      241 atgtgagcaa atgcctcatt caggagctct gccagtgccg gcctggagaa gggaactgcc
      301 cctgctgtaa ggagtgcatg ctgtgcctcg gggccctgtg ggacgagtgc tgcgactgtg
      361 tcggtatgtg caaccctcgg aattacagcg acaccccgcc cacatccaag agcaccgtgg
      421 aggagctgca cgagcccatt ccgtccctgt tcagggcgct gacggagggc gacacccagc
      481 tgaactggaa catcgtctcc ttccctgtgg cagaggagct gtcacaccat gaaaacctag
      541 tctccttcct agaaactgtg aaccagctgc accaccaaaa cgtgtctgtt cccagcaaca
      601 atgtccacgc ccccttcccc agcgacaaag agcgcatgtg cacagtggtt tactttgatg
      661 actgcatgtc catccaccag tgtaagatat cctgcgaatc catgggtgca tccaagtatc
      721 gctggtttca caacgcctgc tgcgagtgca tcggtccaga gtgcattgac tatgggagta
      781 aaactgtcaa gtgtatgaac tgcatgtttt aaagaggggg aagaaatgca aaccaaagca
      841 gtaagtcatg aagtgtgcag aaatcttggt tctggtatgc taggagtgtg ttaagttata
      901 tgattgtaac tgtgcttttt atatctggtg cctattagtg taggtctttt ccattggatt
      961 caatggaact ttagtcacat gaggatcggg agttcagagg agtcctggga aaacctgaca
     1021 tgctgacaga aggtgccgtc ttcttccagc tttccaaaca cttctcgttt tgaacgtgat
     1081 agcacaagcc tggtacatgt gtggttctca cctgccagtt gtagaacact aggtccctat
     1141 agtcacacat ctcttaattg tgccttggct ggcttacctg ttttgtatga gtaaatatta
     1201 cagtttataa ttctaacaac tcacattcaa gccatgctga aacttaattt caaaccactt
     1261 tacattggtt ttagaaagta aatatttact atattttaca acagaagagt tttgcctagg
     1321 gccagcgagc tgactcagtg gataaaggcg cttgctacca agcctgataa cctgagttcc
     1381 atccccagag cccgtacagt ggaaggacag gaccagctgc tgggagttgt cctctgacct
     1441 ccagacaggc acagtatcat gcgtggaggt gtgcttgtgt gtgcacacac ataactaact
     1501 gtttttaaaa atataaacct cttacatggt gaaatctaaa tctgtcgtgt agctctcaca
     1561 ctgacagtgg tttggatgtt atgtcccctg tccgcctgta gtgctggtgt ggtgagacac
     1621 agagtcgtca ctgctctggt atagaagagt tttgtctacc aagagtgtca tggcatacct
     1681 ttggaacttc atcaaatgca cttgaggatg acctgggtca ggaagtagcc aggtaaaagc
     1741 agcgggactg taggcgatgc tccattagac tccgtgcaga gcagcaggtg cacagcatag
     1801 ctgggtgtgc ggctgaccag gagagggtct gactccgcac cagcagaaca gcagggtctc
     1861 cagcacgtgt gggaagcacg tgggagaggg ttgaggaagg atgcacagat gtggacagag
     1921 aagcataaaa atgtcgggaa ctcctagtag ggtccacctt aaaatcgctt tatagtctct
     1981 ggctttgtta ctctgtaaga ttacacttgt ttctggatat ctgaatccaa ataagcatca
     2041 tattttaaga agctctgttt ctgaacttcc agggggaaat ctgtttaatg tgtttactcc
     2101 tagcatacta cagaattttc tagctctata gcttcttacc tagcgtttcc atagtgctga
     2161 gcttcattac tacacgccct tcctagtaat aaaattctca ccttcaagca tgaatcaaaa
     2221 acaaatatct ataatacaca ggttcaattt tatagaattg ctattttctc tagtgcatat
     2281 ctcattaaaa gtaacttttt aggaataatc tttatatggg tacatatttt ggtacataaa
     2341 atagaaaatg ttcttaaact cattttgtat tatttgaata gttacaagat gatttgtggt
     2401 atcatgggta cccattataa accatgctct tcccagtagc tgacgaactc aaggtatcac
     2461 agccttctaa gaagccgact tagaacatgg ctgtacatga atattataca ttaaggtgtc
     2521 ctctcacttc tacccagagt gcctctgttc aaaggtgcct tggaaacatt tcagcccctt
     2581 ccttcttagc tcccacaggg ctgtgggtgt tcttgaaatc aggaggcgtt ttgaaggacc
     2641 acagctgctc catttcagcc gctgattctt aggaaagttc atgctctgac agaagtgtgc
     2701 tttgatggct tctagcggtg catctcgtct cgttttcttt gtttgttttt gttgttgcta
     2761 tcatggtttg gtttggtttt gagacaggat ctctgtgcag ccctggctgg cctggaatgt
     2821 actatgtaga ccaggctggc tctcctcatg ttttcttagt gatggccata aacattgtta
     2881 aaatacatca ccatctttta aaaacttttc attattaaaa tttaaaatat agcatgtcat
     2941 ttttttaccc catacatttg ctatgaaaaa ttttttaaac cacctgcttt aactttttta
     3001 ttgccctgtt tttcctatta gaattgatcc ccactgaggt aaattttata atcatgtttt
     3061 gtgtattttt cctggctcgc caaggcttat gaagaaatag cagccattcc ctgacaggtt
     3121 tgcgctccca ccacagagag gctgagcaag atgatcagag gatcaaggcc agccagagca
     3181 aggcactgcc cagaaagcac aagtcctgtg ctcagcgttt tgcgtagcgt tttattccta
     3241 attgaaatgt aatatttcag aagctagcag cctcgctcag tctagacctt ccacaccaat
     3301 ctagcagcga ttctcccgta ctaaagcctt tgtaagagtt tacggttctt cctcagtgaa
     3361 aaatgatctt gtttttctta cagccggatc caaagacgct agatgttaag ggctgaggct
     3421 gaagcccggt gacggggcgc tcacctgtca tggtgcagcc ctcgttccac cgtgagcacc
     3481 agcaagagac aaacacaagc ttgtgagtca gaggccgtta ttaaattcat acgcacatac
     3541 tccctatagc gagacatggg cttatgggca ggcttttttt tcataacatt tatgagaaaa
     3601 caatgttttc cccataacat ttaattagga ctgtagctta ttggtaatta aggtacaaaa
     3661 tcaaagtcga gtagaatgta ctgttcacac agcgtgttgt gaaaggggtc ctcacaccaa
     3721 agtttaactg taaagtttag aaaaataaca ttgtcattag catatttgaa cacatatttg
     3781 gaatttctaa aaagcatcaa aatagaaaaa gaaagtgaaa ctctggagaa tgagatgctg
     3841 aagatgggct atgatttaaa ggtctgttct gtagttagaa agcacctttt aaagactttg
     3901 ttcattccca agagtctatg ttgattgcat ttaacatgac cgacaactta tatatgtaat
     3961 tgtgtacatt ttcattggtt gtctctgtag tccaaaagaa ggtattttaa taaaaaatag
     4021 aaatgactgt ga
//
