LOCUS       NM_007855               1335 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus twist basic helix-loop-helix transcription factor 2
            (Twist2), mRNA.
ACCESSION   NM_007855
VERSION     NM_007855.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Ben-Shaanan,T.L., Knopper,K., Duan,L., Liu,R., Taglinao,H., Xu,Y.,
            An,J., Plikus,M.V. and Cyster,J.G.
  TITLE     Dermal TRPV1 innervations engage a macrophage- and
            fibroblast-containing pathway to activate hair growth in mice
  JOURNAL   Dev Cell 59 (21), 2818-2833 (2024)
   PUBMED   38851191
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 1335)
  AUTHORS   Huycke,T.R., Hakkinen,T.J., Miyazaki,H., Srivastava,V., Barruet,E.,
            McGinnis,C.S., Kalantari,A., Cornwall-Scoones,J., Vaka,D., Zhu,Q.,
            Jo,H., Oria,R., Weaver,V.M., DeGrado,W.F., Thomson,M.,
            Garikipati,K., Boffelli,D., Klein,O.D. and Gartner,Z.J.
  TITLE     Patterning and folding of intestinal villi by active mesenchymal
            dewetting
  JOURNAL   Cell 187 (12), 3072-3089 (2024)
   PUBMED   38781967
REFERENCE   5  (bases 1 to 1335)
  AUTHORS   Takaya,K., Sunohara,A., Sakai,S., Aramaki-Hattori,N., Okabe,K. and
            Kishi,K.
  TITLE     Twist2 contributes to skin regeneration and hair follicle formation
            in mouse fetuses
  JOURNAL   Sci Rep 14 (1), 10854 (2024)
   PUBMED   38740788
  REMARK    GeneRIF: Twist2 contributes to skin regeneration and hair follicle
            formation in mouse fetuses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1335)
  AUTHORS   Buchner,G., Broccoli,V., Bulfone,A., Orfanelli,U., Gattuso,C.,
            Ballabio,A. and Franco,B.
  TITLE     MAEG, an EGF-repeat containing gene, is a new marker associated
            with dermatome specification and morphogenesis of its derivatives
  JOURNAL   Mech Dev 98 (1-2), 179-182 (2000)
   PUBMED   11044626
REFERENCE   7  (bases 1 to 1335)
  AUTHORS   Houzelstein,D., Cheraud,Y., Auda-Boucher,G., Fontaine-Perus,J. and
            Robert,B.
  TITLE     The expression of the homeobox gene Msx1 reveals two populations of
            dermal progenitor cells originating from the somites
  JOURNAL   Development 127 (10), 2155-2164 (2000)
   PUBMED   10769239
REFERENCE   8  (bases 1 to 1335)
  AUTHORS   Dear,T.N., Hainzl,T., Follo,M., Nehls,M., Wilmore,H., Matena,K. and
            Boehm,T.
  TITLE     Identification of interaction partners for the
            basic-helix-loop-helix protein E47
  JOURNAL   Oncogene 14 (8), 891-898 (1997)
   PUBMED   9050988
REFERENCE   9  (bases 1 to 1335)
  AUTHORS   Tajbakhsh,S., Rocancourt,D. and Buckingham,M.
  TITLE     Muscle progenitor cells failing to respond to positional cues adopt
            non-myogenic fates in myf-5 null mice
  JOURNAL   Nature 384 (6606), 266-270 (1996)
   PUBMED   8918877
REFERENCE   10 (bases 1 to 1335)
  AUTHORS   Li,L., Cserjesi,P. and Olson,E.N.
  TITLE     Dermo-1: a novel twist-related bHLH protein expressed in the
            developing dermis
  JOURNAL   Dev Biol 172 (1), 280-292 (1995)
   PUBMED   7589808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011861.1, BC090636.1 and AV140163.1.
            
            On Aug 25, 2015 this sequence version replaced NM_007855.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011180.1, AK011861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK011861.1         2-12
            12-1326             BC090636.1         1-1315
            1327-1335           AV140163.1         268-276
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.24 cM"
     gene            1..1335
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /note="twist basic helix-loop-helix transcription factor
                     2"
                     /db_xref="GeneID:13345"
                     /db_xref="MGI:MGI:104685"
     exon            1..689
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..649
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /note="dermis-expressed protein 1; twist homolog 2"
                     /codon_start=1
                     /product="twist-related protein 2"
                     /protein_id="NP_031881.1"
                     /db_xref="CCDS:CCDS15166.1"
                     /db_xref="GeneID:13345"
                     /db_xref="MGI:MGI:104685"
                     /translation="MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGS
                     PTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLS
                     KIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH
                     "
     exon            690..1335
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /note="hexamer: AATAAA"
     polyA_site      1050
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /note="major polyA site"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
                     /note="hexamer: AATAAA"
     polyA_site      1329
                     /gene="Twist2"
                     /gene_synonym="bHLHa39; Dermo1"
ORIGIN      
        1 aaaaaagtta gaataacttc ctctcccgga gacctcggtt ttgcacaagc cggcctcgaa
       61 atcagagcct ttgagagcga cccgggagcc tgtgctcggc ggccgcgggc ttggccagtg
      121 gcgtgcgctc ggcgcccccc agccccacgc gcgccgggcg ggcgccatgg aggagggctc
      181 cagctcgccg gtgtcccccg tggacagtct gggcaccagt gaggaagagc tggagaggca
      241 gcccaagcgc ttcggccgga agcggcgcta cagcaagaaa tcgagcgaag atggcagccc
      301 gaccccgggt aagcgcggca agaagggcag cccgagcgcg cagtctttcg aggagctgca
      361 gagccagcgc atcctggcca acgtgcgcga gcgccagcgc acccagtcgc tcaacgaggc
      421 cttcgccgcg ctgcgcaaga tcatccccac gctcccctct gacaagctca gcaagatcca
      481 gacgctcaag ctggccgcca ggtacataga cttcctctac caggttctcc agagcgacga
      541 gatggacaat aagatgacca gctgcagcta cgtggctcac gagcgtctca gctacgcctt
      601 ctccgtgtgg cgcatggagg gcgcgtggtc catgtccgcc tcccactagc gccgcgccgt
      661 gccatccacc tccggagccg caagccagga cccacctgca catctcaggc gcatgcggaa
      721 ctggatgcgg ccacggctgt gactttcggc acctggacaa ccttgtggct cctcatgacc
      781 ccagtgccca agtgtttggc aggggacaga gacccaggtt cacatcctcc tcagataccc
      841 aggggatggg catcagcctt cctgccagtg acttctgtgc cctcatctcc tcactgttgg
      901 attttcctcc tgggttttag tttgggggaa tctttctgga aagttctagc ttcaggaatg
      961 catttgtaag gatatatatt ggattgtatt tccctctaag tgcctttttt taatgtatat
     1021 ttttaaataa aacagaaatg cattcttgta gaacctgttt aaactggacc aaggctctca
     1081 gaacaagaac ccaagatccc tcccgcccca gacctcccgt gactgtttcg aggaagcctg
     1141 gaattcttgc ccgcatactc ctgttcttta cgtctccatg gcctgctcag ctagccgtgt
     1201 tttctattcc ctgttcagtg tatatgttgc ttatttgttt atttattgag atattttacc
     1261 agctaagtga ctgccacgcg ttgtgtataa cgctccacac ccaggaacaa taaagaggcc
     1321 tgcacagccc cgcgt
//
